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Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>It is currently unclear whether and how the association between body composition and hypertension varies based on the presence and severity of fatty liver disease (FLD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FLD was diagnosed using ultrasonography among 6,358 participants. The association between body composition and hypertension was analyzed separately in the whole population, as well as in subgroups of non-FLD, mild FLD, and moderate\/severe FLD populations, respectively. The mediation effect of FLD in their association was explored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fat-related anthropometric measurements and lipid metabolism indicators were positively associated with hypertension in both the whole population and the non-FLD subgroup. The strength of this association was slightly reduced in the mild FLD subgroup. Notably, only waist-to-hip ratio and waist-to-height ratio showed significant associations with hypertension in the moderate\/severe FLD subgroup. Furthermore, FLD accounted for 17.26% to 38.90% of the association between multiple body composition indicators and the risk of hypertension.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association between body composition and hypertension becomes gradually weaker as FLD becomes more severe. FLD plays a significant mediating role in their association.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1247110","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T09:27:22Z","timestamp":1701163642000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Associations between body composition profile and hypertension in different fatty liver phenotypes"],"prefix":"10.3389","volume":"14","author":[{"given":"Xiaoyin","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangguang","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingdan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ling","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruimei","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moufeng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijian","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weimin","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13190","article-title":"Diagnosis of obesity based on body composition-associated health risks\u2014Time for a change in paradigm","volume":"22","author":"Bosy-Westphal","year":"2021","journal-title":"Obes Rev"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2337\/dcS13-2023","article-title":"Obesity paradox does exist","volume":"36","author":"Hainer","year":"2013","journal-title":"Diabetes Care"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2174\/0929867326666190326113607","article-title":"Obesity and body composition in man and woman: associated diseases and the new role of gut microbiota","volume":"27","author":"Avolio","year":"2020","journal-title":"Curr medicinal Chem"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.3390\/jcm10091975","article-title":"The role of different indexes of adiposity and body composition for the identification of metabolic syndrome in women with obesity","volume":"10","author":"Radetti","year":"2021","journal-title":"J Clin Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00053","article-title":"Obesity or bmi paradox? 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