{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:12:07Z","timestamp":1793329927129,"version":"4.5.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T00:00:00Z","timestamp":1701216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Intracerebral hemorrhage (ICH) has a mortality rate which can reach 30\u201340%. Compared with other diseases, obesity is often associated with lower mortality; this is referred to as the \u2018obesity paradox\u2019. Herein, we aimed to summarize the studies of the relations between obesity and mortality after ICH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>For this systematic review and meta-analysis (PROSPERO registry CRD42023426835), we conducted searches for relevant articles in both PubMed and Embase. Non-English language literature, irrelevant literature, and non-human trials were excluded. All included publications were then qualitatively described and summarized. Articles for which quantitative analyses were possible were evaluated using Cochrane\u2019s Review Manager.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ten studies were included. Qualitative analysis revealed that each of the 10 studies showed varying degrees of a protective effect of obesity, which was statistically significant in 8 of them. Six studies were included in the quantitative meta-analysis, which showed that obesity was significantly associated with lower short-term (0.69 [0.67, 0.73], p&amp;lt;0.00001) and long-term (0.62 [0.53, 0.73], p&amp;lt;0.00001) mortality. (Data identified as (OR [95%CI], p)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Obesity is likely associated with lower post-ICH mortality, reflecting the obesity paradox in this disease. These findings support the need for large-scale trials using standardized obesity classification methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Systematic review registration<\/jats:title><jats:p><jats:ext-link>https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42023426835<\/jats:ext-link>, identifier CRD42023426835.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1255538","type":"journal-article","created":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T05:53:11Z","timestamp":1701237191000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["The obesity paradox in intracerebral hemorrhage: a systematic review and 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