{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:00:32Z","timestamp":1793829632263,"version":"4.6.1"},"reference-count":146,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p><jats:italic>GNAS<\/jats:italic>is a complex locus characterized by multiple transcripts and an imprinting effect. It orchestrates a variety of physiological processes via numerous signaling pathways. Human diseases associated with the <jats:italic>GNAS<\/jats:italic> gene encompass fibrous dysplasia (FD), Albright\u2019s Hereditary Osteodystrophy (AHO), parathyroid hormone(PTH) resistance, and Progressive Osseous Heteroplasia (POH), among others. To facilitate the study of the <jats:italic>GNAS<\/jats:italic> locus and its associated diseases, researchers have developed a range of mouse models. In this review, we will systematically explore the <jats:italic>GNAS<\/jats:italic> locus, its related signaling pathways, the bone diseases associated with it, and the mouse models pertinent to these bone diseases.<\/jats:p>","DOI":"10.3389\/fendo.2023.1255864","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T09:30:25Z","timestamp":1697621425000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["GNAS locus: bone related diseases and mouse 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