{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:55:54Z","timestamp":1791053754704,"version":"4.1.0"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T00:00:00Z","timestamp":1698105600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to evaluate the efficacy and safety of monthly vitamin D3 administration compared to a daily dosing regimen in healthy children with vitamin D deficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study included vitamin D deficient (serum 25-hydroxyvitamin D [25(OH)D] &amp;lt; 20 ng\/mL) children with precocious puberty who received gonadotropin-releasing hormone agonist every 4 weeks between December 2019 and November 2022. We used propensity scores to 1:1 match daily (1,000 IU daily) and monthly (25,000 IU per 4 weeks) administration of vitamin D3 based on age, sex, body mass index Z-scores, season of blood collection, and baseline serum 25(OH)D concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 299 children, 192 were matched based on propensity scores (126 girls and 66 boys, 10.5 \u00b1 1.4years). After a mean follow-up of 5.9 months (standard deviation [SD] 2.5 months), the monthly group showed a statistically significant increase in serum 25(OH)D concentrations (10.9 \u00b1 5.3 vs. 8.2 \u00b1 7.2 ng\/mL; p = 0.018), higher corrected dose-response (12.3 \u00b1 5.9 vs. 8.2 \u00b1 7.2 ng\/mL increase per 1,000 IU daily; p = 0.002), and a higher proportion of patients attaining 25(OH)D &amp;gt; 20 ng\/mL (78.1% vs. 58.3%,; p=0.005) compared with the daily group. No cases of hypercalcemia were observed in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Monthly administration of vitamin D3 may be an effective and safe alternative to correct hypovitaminosis D in pediatric population, possibly attributed to enhanced compliance.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1265943","type":"journal-article","created":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T23:50:02Z","timestamp":1698191402000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Monthly versus daily administration of vitamin D3 in children: a retrospective propensity score-matched study"],"prefix":"10.3389","volume":"14","author":[{"given":"Jinjoo","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsoo","family":"Choe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-021-09679-5","article-title":"Vitamin D, infections and immunity","volume":"23","author":"Ismailova","year":"2022","journal-title":"Rev Endocr Metab Disord"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2007.12.001","article-title":"Vitamin D status: measurement, interpretation, and clinical application","volume":"19","author":"Holick","year":"2009","journal-title":"Ann 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