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Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Both alanine aminotransferase (ALT) and high-density lipoprotein cholesterol (HDL-C) are closely related to glucose homeostasis in the body, and the main objective of this study was to investigate the association between ALT to HDL-C ratio (ALT\/HDL-C ratio) and the risk of diabetes in a Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current study included 116,251 participants who underwent a healthy physical examination, and the study endpoint was defined as a diagnosis of new-onset diabetes. Multivariate Cox regression models and receiver operator characteristic curves were used to assess the association of the ALT\/HDL-C ratio with diabetes onset.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During the average observation period of 3.10 years, a total of 2,674 (2.3%) participants were diagnosed with new-onset diabetes, including 1,883 (1.62%) males and 791 (0.68%) females. After fully adjusting for confounding factors, we found a significant positive association between the ALT\/HDL-C ratio and the risk of diabetes [Hazard ratios 1.06, 95% confidence intervals: 1.05, 1.06], and this association was significantly higher in males, obese individuals [body mass index \u2265 28 kg\/m<jats:sup>2<\/jats:sup>] and individuals aged &amp;lt; 60 years (All <jats:italic>P<\/jats:italic> interaction &amp;lt; 0.05). In addition, the ALT\/HDL-C ratio was significantly better than its components ALT and HDL-C in predicting diabetes in the Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There was a positive relationship between ALT\/HDL-C ratio and diabetes risk in the Chinese population, and this relationship was significantly stronger in males, obese individuals, and individuals younger than 60 years old.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1266692","type":"journal-article","created":{"date-parts":[[2023,11,28]],"date-time":"2023-11-28T10:01:49Z","timestamp":1701165709000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Alanine aminotransferase to high- density lipoprotein cholesterol ratio is positively correlated with the occurrence of diabetes in the Chinese population: a population-based cohort 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