{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T19:36:27Z","timestamp":1769024187966,"version":"3.49.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T00:00:00Z","timestamp":1696896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010381","name":"European Society for Paediatric Endocrinology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010381","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Isolated childhood growth hormone deficiency (GHD) can persist into adulthood, and re-testing at the transition period is needed to determine whether continued growth hormone therapy is indicated. Here, our objective was to identify predictors of permanent GHD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Retrospective single-centre study of patients with childhood-onset GHD who were re-tested after adult height attainment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Auxological, clinical, laboratory, and MRI data throughout follow-up were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 101 patients. At GH treatment initiation, age was 8.1 \u00b1 0.4 years, height -2.25 \u00b1 0.8, and BMI -0.27 \u00b1 0.1 SDS. The 29 (28.7%) patients with persistent GHD had lower height SDS (-2.57 \u00b1 0.1 vs. -2.11 \u00b1 0.1, <jats:italic>p<\/jats:italic>&amp;lt;0.001) and mean GH peaks (8.4 \u00b1 1.0 vs.13.2 \u00b1 0.5 mIU\/L, <jats:italic>p<\/jats:italic>&amp;lt;0.001) at GHD diagnosis; at adult height, they had lower IGF1 (232 \u00b1 19.9 vs. 331 \u00b1 9.1 ng\/mL, <jats:italic>p<\/jats:italic>&amp;lt;0.001) and higher BMI SDS (-0.15 \u00b1 0.27 vs. -0.73 \u00b1 0.13, <jats:italic>p<\/jats:italic>&amp;lt;0.005). By multivariate analysis, the best predictive model included height and BMI SDS, both GH peaks, and MRI findings at diagnosis. Patients with height at diagnosis &amp;lt;-3 SDS had a 7.7 (95% IC 1.4-43.1, p=0.02) fold higher risk of persistent GHD after adjustment on BMI SDS. An abnormal pituitary region by MRI was the strongest single predictor (7.2 times, 95% CI 2.7-19.8) and after multivariate analysis adjustment for GH peaks and height SDS at diagnosis, the risk increased to 10.6 (1.8 - 61.3) times.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Height &amp;lt;-3 SDS at GHD diagnosis and pituitary MRI abnormalities should lead to a high index of suspicion for persistent GHD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2023.1270845","type":"journal-article","created":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T06:27:40Z","timestamp":1696919260000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Identifying patient-related predictors of permanent growth hormone 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