{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T17:39:48Z","timestamp":1787161188488,"version":"build-2736575974"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>\n                    Bursicon, a neuropeptide hormone comprising two subunits-bursicon (burs) and partner of burs (pburs), belongs to the cystine-knot protein family. Bursicon heterodimers and homodimers bind to the lucine-rich G-protein coupled receptor (LGR) encoded by\n                    <jats:italic>ricket<\/jats:italic>\n                    s to regulate multiple physiological processes in arthropods. Notably, these processes encompass the regulation of female reproduction, a recent revelation in\n                    <jats:italic>Tribolium castaneum<\/jats:italic>\n                    . In this study we investigated the role of burs\/pburs\/rickets in mediating female vitellogenesis and reproduction in a hemipteran insect, the whitefly,\n                    <jats:italic>Bemisia tabaci<\/jats:italic>\n                    . Our investigation unveiled a synchronized expression of\n                    <jats:italic>burs, pburs<\/jats:italic>\n                    and\n                    <jats:italic>rickets<\/jats:italic>\n                    , with their transcripts persisting detectable in the days following eclosion. RNAi-mediated knockdown of\n                    <jats:italic>burs<\/jats:italic>\n                    ,\n                    <jats:italic>pburs<\/jats:italic>\n                    or\n                    <jats:italic>rickets<\/jats:italic>\n                    significantly suppressed the transcript levels of\n                    <jats:italic>vitellogenin<\/jats:italic>\n                    (\n                    <jats:italic>Vg<\/jats:italic>\n                    ) and\n                    <jats:italic>Vg receptor<\/jats:italic>\n                    in the female whiteflies. These effects also impaired ovarian maturation and female fecundity, as evidenced by a reduction in the number of eggs laid per female, a decrease in egg size and a decline in egg hatching rate. Furthermore, knockdown of\n                    <jats:italic>burs<\/jats:italic>\n                    ,\n                    <jats:italic>pburs<\/jats:italic>\n                    or\n                    <jats:italic>rickets<\/jats:italic>\n                    led to diminished juvenile hormone (JH) titers and reduced transcript level of\n                    <jats:italic>Kruppel homolog-1<\/jats:italic>\n                    . However, this impact did not extend to genes in the insulin pathway or target of rapamycin pathway, deviating from the results observed in\n                    <jats:italic>T. castaneum<\/jats:italic>\n                    . Taken together, we conclude that burs\/pburs\/rickets regulates the vitellogenesis and reproduction in the whiteflies by coordinating with the JH signaling pathway.\n                  <\/jats:p>","DOI":"10.3389\/fendo.2023.1277439","type":"journal-article","created":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:13:15Z","timestamp":1696313595000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Neuropeptide hormone bursicon mediates female reproduction in the whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae)"],"prefix":"10.3389","volume":"14","author":[{"given":"Hao","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuhao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qisheng","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,10,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.593613","article-title":"Regulatory 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