{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T22:16:04Z","timestamp":1783376164871,"version":"3.54.6"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/02164, PI21\/01339"],"award-info":[{"award-number":["PI17\/02164, PI21\/01339"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Skin wound healing is a physiological process that involves several cell types. Among them, endothelial cells are required for inflammation resolution and neo\u2010angiogenesis, both necessary for tissue restoration after injury. Primary human umbilical vein endothelial cells (C\u2010HUVECs) are derived from the umbilical cord. When women develop gestational diabetes, chronic exposure to hyperglycemia induces epigenetic modifications in these cells (GD\u2010HUVECs), leading to a permanent pro\u2010inflammatory phenotype and impaired angiogenesis in contrast to control cells. Oleanolic acid (OA) is a bioactive triterpenoid known for its epithelial cell migration promotion stimulation and higher tensile strength of wounds. However, the potentially anti\u2010inflammatory and pro\u2010angiogenic properties of OA are still under investigation. We tested OA on C\u2010 and GD\u2010HUVECs under inflammatory conditions induced by low levels of the inflammatory cytokine TNF-\u03b1. Reduced expression of adhesion molecules <jats:italic>VCAM1<\/jats:italic>, <jats:italic>ICAM1<\/jats:italic>, and <jats:italic>SELE<\/jats:italic> was obtained in OA\u2010pre\u2010treated C\u2010 and GD\u2010HUVECs. Additionally, protein VCAM1 levels were also decreased by OA. Coherently, monocyte adhesion assays showed that a lower number of monocytes adhered to GD\u2010HUVEC endothelium under OA pre\u2010treatment when compared to untreated ones. It is noteworthy that OA improved angiogenesis parameters in both phenotypes, being especially remarkable in the case of GD\u2010HUVECs, since OA strongly rescued their poor tube formation behavior. Moreover, endothelial cell migration was improved in C\u2010 and GD\u2010HUVECs in scratch assays, an effect that was further confirmed by focal adhesion (FA) remodeling, revealed by paxillin staining on immunocytochemistry assays. Altogether, these results suggest that OA could be an emergent wound healing agent due to its capacity to rescue endothelial malfunction caused by hyperglycemia.<\/jats:p>","DOI":"10.3389\/fendo.2023.1308606","type":"journal-article","created":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T04:55:10Z","timestamp":1702443310000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Oleanolic acid rescues critical features of umbilical vein endothelial cells permanently affected by hyperglycemia"],"prefix":"10.3389","volume":"14","author":[{"given":"Javier","family":"Stelling-F\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Cappellacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assunta","family":"Pandolfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Gabald\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Pipino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9","family":"Nicol\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-1-61779-207-6_1","article-title":"Cell migration: an overview","volume":"769","author":"Vicente-Manzanares","year":"2011","journal-title":"Methods Mol Biol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110012","article-title":"Cell migration","volume":"2","author":"Trepat","year":"2012","journal-title":"Compr Physiol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1021\/np0601152","article-title":"In vivo wound-healing activity of oleanolic acid derived from the acid hydrolysis of Anredera diffusa","volume":"69","author":"Moura-Letts","year":"2006","journal-title":"J Nat Prod"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2011.12.022","article-title":"Oleanolic acid","volume":"77","author":"Pollier","year":"2012","journal-title":"Phytochemistry"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22111915","article-title":"Oleanolic acid and its derivatives: biological activities and therapeutic potential in chronic diseases","volume":"22","author":"Ayeleso","year":"2017","journal-title":"Molecules"},{"key":"B6","doi-asserted-by":"publisher","first-page":"718105","DOI":"10.1155\/2013\/718105","article-title":"Effects of lipophilic extract of viscum album L. and oleanolic acid on migratory activity of NIH\/3T3 fibroblasts and on haCat keratinocytes","volume":"2013","author":"Kuonen","year":"2013","journal-title":"Evid Based Complement Alternat Med"},{"key":"B7","doi-asserted-by":"publisher","first-page":"15065","DOI":"10.1038\/s41598-022-17553-w","article-title":"Oleanolic acid stimulation of cell migration involves a biphasic signaling mechanism","volume":"12","author":"Stelling-Ferez","year":"2022","journal-title":"Sci Rep"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172574","article-title":"Oleanolic acid induces migration in Mv1Lu and MDA-MB-231 epithelial cells involving EGF receptor and MAP kinases activation","volume":"12","author":"Bernabe-Garcia","year":"2017","journal-title":"PloS One"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1038\/35046659","article-title":"Paxillin and focal adhesion signalling","volume":"2","author":"Turner","year":"2000","journal-title":"Nat Cell Biol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204786","article-title":"Paxillin: a focal adhesion-associated adaptor protein","volume":"20","author":"Schaller","year":"2001","journal-title":"Oncogene"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1042\/EBC20190015","article-title":"Actin dynamics in cell migration","volume":"63","author":"Schaks","year":"2019","journal-title":"Essays Biochem"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411006","article-title":"Cutaneous wound healing","volume":"341","author":"Singer","year":"1999","journal-title":"N Engl J Med"},{"key":"B13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.suc.2016.08.013","article-title":"Overview of wound healing and management","volume":"97","author":"Childs","year":"2017","journal-title":"Surg Clin North Am"},{"key":"B14","doi-asserted-by":"publisher","first-page":"4917","DOI":"10.3390\/molecules26164917","article-title":"Skin wound healing: normal macrophage function and macrophage dysfunction in diabetic wounds","volume":"26","author":"Aitcheson","year":"2021","journal-title":"Molecules"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2000.00014.x","article-title":"Angiogenesis in wound healing","volume":"5","author":"Tonnesen","year":"2000","journal-title":"J Investig Dermatol Symp Proc"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jtbi.2018.09.020","article-title":"Modelling skin wound healing angiogenesis: A review","volume":"459","author":"Guerra","year":"2018","journal-title":"J Theor Biol"},{"key":"B17","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.clindermatol.2006.12.005","article-title":"Impaired wound healing","volume":"25","author":"Menke","year":"2007","journal-title":"Clin Dermatol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjtee.2017.06.001","article-title":"The molecular biology in wound healing & non-healing wound","volume":"20","author":"Qing","year":"2017","journal-title":"Chin J Traumatol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1046\/j.1524-475X.11.s2.1.x","article-title":"Wound bed preparation: a systematic approach to wound management","author":"Schultz","year":"2003","journal-title":"Wound Repair Regen."},{"key":"B20","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/S0094-1298(02)00066-4","article-title":"Wound healing and diabetes mellitus","volume":"30","author":"Greenhalgh","year":"2003","journal-title":"Clin Plast Surg"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1590\/S1807-59322006000600014","article-title":"Complex wounds","volume":"61","author":"Ferreira","year":"2006","journal-title":"Clinics (Sao Paulo)."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.3390\/medicina57101072","article-title":"Diabetic wound-healing science","volume":"57","author":"Burgess","year":"2021","journal-title":"Medicina (Kaunas)."},{"key":"B23","doi-asserted-by":"publisher","first-page":"8621","DOI":"10.3390\/ijms23158621","article-title":"Wound healing impairment in type 2 diabetes model of leptin-deficient mice-A mechanistic systematic review","volume":"23","author":"Stachura","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.3390\/ijms18071419","article-title":"Diabetes and wound angiogenesis","volume":"18","author":"Okonkwo","year":"2017","journal-title":"Int J Mol Sci"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2014.06.005","article-title":"Features of endothelial dysfunction in umbilical cord vessels of women with gestational diabetes","volume":"24","author":"Di Fulvio","year":"2014","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002072RR","article-title":"Endothelial cells from umbilical cord of women affected by gestational diabetes: A suitable in vitro model to study mechanisms of early vascular senescence in diabetes","volume":"35","author":"Di Tomo","year":"2021","journal-title":"FASEB J"},{"key":"B27","doi-asserted-by":"publisher","first-page":"938","DOI":"10.3390\/app10030938","article-title":"Use of human umbilical vein endothelial cells (HUVEC) as a model to study cardiovascular disease: A review","volume":"10","author":"Medina-Leyte","year":"2020","journal-title":"Appl Sci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.854845","article-title":"Effect of the human amniotic membrane on the umbilical vein endothelial cells of gestational diabetic mothers: new insight on inflammation and angiogenesis","volume":"10","author":"Pipino","year":"2022","journal-title":"Front Bioeng Biotechnol"},{"key":"B29","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1007\/s10753-012-9523-9","article-title":"Anti-inflammatory effects of oleanolic acid on LPS-induced inflammation in vitro and in vivo","volume":"36","author":"Lee","year":"2013","journal-title":"Inflammation"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2010.04.006","article-title":"Ursolic acid and oleanolic acid, members of pentacyclic triterpenoid acids, suppress TNF-alpha-induced E-selectin expression by cultured umbilical vein endothelial cells","volume":"17","author":"Takada","year":"2010","journal-title":"Phytomedicine"},{"key":"B31","doi-asserted-by":"publisher","first-page":"8184656","DOI":"10.1155\/2019\/8184656","article-title":"Anti-inflammatory role of carotenoids in endothelial cells derived from umbilical cord of women affected by gestational diabetes mellitus","volume":"2019","author":"Ucci","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.2002.2434","article-title":"In vitro expression of the endothelial phenotype: comparative study of primary isolated cells and cell lines, including the novel cell line HPMEC-ST1.6R","volume":"64","author":"Unger","year":"2002","journal-title":"Microvasc Res"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1002\/mnfr.201100500","article-title":"beta-Carotene and lycopene affect endothelial response to TNF-alpha reducing nitro-oxidative stress and interaction with monocytes","volume":"56","author":"Di Tomo","year":"2012","journal-title":"Mol Nutr Food Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.numecd.2015.04.002","article-title":"Centella Asiatica and Lipoic Acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women","volume":"25","author":"Di Tomo","year":"2015","journal-title":"Nutrition Metab Cardiovasc Dis"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot095505","article-title":"Analysis of cell viability by the MTT assay","volume":"2018","author":"Kumar","year":"2018","journal-title":"Cold Spring Harb Protoc"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3791\/1918-v","article-title":"Linearization of the bradford protein assay","author":"Ernst","year":"2010","journal-title":"J Vis Exp"},{"key":"B38","doi-asserted-by":"publisher","first-page":"11568","DOI":"10.1038\/s41598-020-67289-8","article-title":"Angiogenesis Analyzer for ImageJ \u2014 A comparative morphometric analysis of \u201cEndothelial Tube Formation Assay\u201d and \u201cFibrin Bead Assay\u201d","volume":"10","author":"Carpentier","year":"2020","journal-title":"Sci Rep"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3791\/56799","article-title":"Microscopy based methods for the assessment of epithelial cell migration during in vitro wound healing","author":"Liarte","year":"2018","journal-title":"J Vis Exp"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.mex.2014.06.004","article-title":"Step-by-step quantitative analysis of focal adhesions","volume":"1","author":"Horzum","year":"2014","journal-title":"MethodsX"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307610","article-title":"Endothelial cell junctional adhesion molecules: role and regulation of expression in inflammation","volume":"36","author":"Reglero-Real","year":"2016","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"781","DOI":"10.3390\/biomedicines9070781","article-title":"Inflammatory mechanisms contributing to endothelial dysfunction","volume":"9","author":"Theofilis","year":"2021","journal-title":"Biomedicines"},{"key":"B43","doi-asserted-by":"publisher","first-page":"a001651","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B44","doi-asserted-by":"publisher","first-page":"166170","DOI":"10.1016\/j.bbadis.2021.166170","article-title":"VCAM-1 as a predictor biomarker in cardiovascular disease","volume":"1867","author":"Troncoso","year":"2021","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301598200","article-title":"Tumor Necrosis Factor-\u03b1-induced IKK Phosphorylation of NF-\u03baB p65 on Serine 536 Is Mediated through the TRAF2, TRAF5, and TAK1 Signaling Pathway*","volume":"278","author":"Sakurai","year":"2003","journal-title":"J Biol Chem"},{"key":"B46","doi-asserted-by":"publisher","first-page":"965006","DOI":"10.3389\/fbioe.2022.965006","article-title":"Perinatal derivatives: How to best characterize their multimodal functions in vitro","volume":"10","author":"Flores","year":"2022","journal-title":"Part C: Inflammation angiogenesis Wound healing. Front Bioeng Biotechnol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000259593.07661.1e","article-title":"Endothelial cell migration during angiogenesis","volume":"100","author":"Lamalice","year":"2007","journal-title":"Circ Res"},{"key":"B48","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1038\/nrm1549","article-title":"Focal adhesion kinase: in command and control of cell motility","volume":"6","author":"Mitra","year":"2005","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"6024","DOI":"10.1038\/srep06024","article-title":"FAK and paxillin dynamics at focal adhesions in the protrusions of migrating cells","volume":"4","author":"Hu","year":"2014","journal-title":"Sci Rep"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.104.2.151","article-title":"Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease","volume":"104","author":"Duffy","year":"2001","journal-title":"Circulation"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.03.035","article-title":"Genistein inhibits TNF-alpha-induced endothelial inflammation through the protein kinase pathway A and improves vascular inflammation in C57BL\/6 mice","volume":"168","author":"Jia","year":"2013","journal-title":"Int J Cardiol"},{"key":"B52","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/ejcn.2012.178","article-title":"Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial","volume":"67","author":"Ried","year":"2013","journal-title":"Eur J Clin Nutr"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.311","article-title":"Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo","volume":"155","author":"Kanitkar","year":"2008","journal-title":"Br J Pharmacol"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2012.05.003","article-title":"Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats","volume":"66","author":"Bagul","year":"2012","journal-title":"Pharmacol Res"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2015.02.008","article-title":"Oxidative stress and human hypertension: vascular mechanisms, biomarkers, and novel therapies","volume":"31","author":"Montezano","year":"2015","journal-title":"Can J Cardiol"},{"key":"B56","doi-asserted-by":"publisher","first-page":"4204","DOI":"10.3390\/ijms20174204","article-title":"Multifunctional peptides from spanish dry-cured pork ham: endothelial responses and molecular modeling studies","volume":"20","author":"Martinez-Sanchez","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3390\/molecules200916908","article-title":"Glossogyne tenuifolia Extract Inhibits TNF-alpha-Induced Expression of Adhesion Molecules in Human Umbilical Vein Endothelial Cells via Blocking the NF-kB Signaling Pathway","volume":"20","author":"Hsuan","year":"2015","journal-title":"Molecules"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1691\/ph.2021.1366","article-title":"Oleanolic acid inhibits the migration and invasion of hepatocellular carcinoma cells by promoting microRNA-122 expression","volume":"76","author":"He","year":"2021","journal-title":"Pharmazie"},{"key":"B59","doi-asserted-by":"publisher","first-page":"18228","DOI":"10.1038\/s41598-021-97648-y","article-title":"The expression and significance of AKR1B10 in laryngeal squamous cell carcinoma","volume":"11","author":"Liu","year":"2021","journal-title":"Sci Rep"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.2MR0220-549R","article-title":"ICAM-1: A master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis","volume":"108","author":"Bui","year":"2020","journal-title":"J Leukoc Biol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1089\/wound.2021.0161","article-title":"Inflammation in wound healing and pathological scarring","volume":"12","author":"Hong","year":"2023","journal-title":"Adv Wound Care (New Rochelle)."},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.fob.2014.02.009","article-title":"Ursolic acid, a natural pentacyclic triterpenoid, inhibits intracellular trafficking of proteins and induces accumulation of intercellular adhesion molecule-1 linked to high-mannose-type glycans in the endoplasmic reticulum","volume":"4","author":"Mitsuda","year":"2014","journal-title":"FEBS Open Bio."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01878","article-title":"E-selectin ligands in the human mononuclear phagocyte system: implications for infection, inflammation, and immunotherapy","volume":"8","author":"Silva","year":"2017","journal-title":"Front Immunol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1196033","article-title":"Monocyte-endothelial cell interactions in vascular and tissue remodeling","volume":"14","author":"Medrano-Bosch","year":"2023","journal-title":"Front Immunol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-008-9125-1","article-title":"Morphological and molecular aspects of physiological vascular morphogenesis","volume":"12","author":"Ribatti","year":"2009","journal-title":"Angiogenesis"},{"key":"B66","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1007\/s10456-018-9613-x","article-title":"Consensus guidelines for the use and interpretation of angiogenesis assays","volume":"21","author":"Nowak-Sliwinska","year":"2018","journal-title":"Angiogenesis"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1124\/pr.56.4.3","article-title":"Vascular endothelial growth factor and angiogenesis","volume":"56","author":"Hoeben","year":"2004","journal-title":"Pharmacol Rev"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.021","article-title":"VEGF in signaling and disease: beyond discovery and development","volume":"176","author":"Apte","year":"2019","journal-title":"Cell"},{"key":"B69","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur Surg Res"},{"key":"B70","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1515\/CCLM.2000.013","article-title":"Markers of endothelial dysfunction","volume":"38","author":"Muller","year":"2000","journal-title":"Clin Chem Lab Med"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.2147\/IJICMR.S40102","article-title":"TGR5 ligands as potential therapeutics in inflammatory diseases","volume":"2014","author":"Pols","year":"2014","journal-title":"Int J Interferon Cytokine Mediator Res"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00646","article-title":"TGR5, not only a metabolic regulator","volume":"7","author":"Guo","year":"2016","journal-title":"Front Physiol"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.12.168","article-title":"Involvement of membrane-type bile acid receptor M-BAR\/TGR5 in bile acid-induced activation of epidermal growth factor receptor and mitogen-activated protein kinases in gastric carcinoma cells","volume":"354","author":"Yasuda","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01678-3","article-title":"G-protein-coupled receptors and signaling networks: emerging paradigms","volume":"22","author":"Marinissen","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2007.06.130","article-title":"Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea","volume":"362","author":"Sato","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"B76","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1007\/s10456-018-9632-7","article-title":"Regulation of angiogenesis by microRNAs in cardiovascular diseases","volume":"21","author":"Kir","year":"2018","journal-title":"Angiogenesis"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz144","article-title":"RNA binding protein and microRNA control of endothelial cell function","volume":"115","author":"Felicetta","year":"2019","journal-title":"Cardiovasc Res"},{"key":"B78","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3390\/biology12030459","article-title":"miR-4432 targets FGFBP1 in human endothelial cells","volume":"12","author":"Avvisato","year":"2023","journal-title":"Biol (Basel)"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.122.001209","article-title":"Exosomal miR-145 and miR-885 Regulate Thrombosis in COVID-19","volume":"384","author":"Gambardella","year":"2023","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1308606\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T04:55:15Z","timestamp":1702443315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2023.1308606\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":79,"alternative-id":["10.3389\/fendo.2023.1308606"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2023.1308606","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"article-number":"1308606"}}