{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T06:50:09Z","timestamp":1791874209681,"version":"4.3.4"},"reference-count":70,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T00:00:00Z","timestamp":1707350400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014717","name":"National Outstanding Youth Science Fund Project of National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014717","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Beta-amyloid accumulation in the brain appears to be a key initiating event in Alzheimer\u2019s disease (AD), and factors associated with increased deposition of beta-amyloid are of great interest. Enhanced deposition of amyloid-\u03b2 peptides is due to an imbalance between their production and elimination. Previous studies show that diminished levels of CSF amyloid beta 42 (A\u03b242) is a biomarker in AD; however, the role of serum A\u03b242 in AD is contradictory. BMI and obesity have been reported to be related to increased serum A\u03b242 levels. Therefore, we aimed to investigate the relation between metabolic syndrome (MetS), its clinical measures (abdominal obesity, high glucose, high triglyceride, low high-density lipoprotein cholesterol level, and hypertension), and serum A\u03b242 levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 1261 subjects, aged 18\u201389 years in Chengdu, China, were enrolled from January 2020 to January 2021 to explore the correlation of serum A\u03b242 levels with body mass index (BMI), blood lipids, and blood pressure. Furthermore, as the risk of MetS is closely related to age, 1,212 participants (<jats:italic>N<\/jats:italic> = 49 with age \u2265 80 years old were excluded) were analyzed for the correlation of serum A\u03b242 level and MetS clinical measures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed that log-transformed serum A\u03b242 level was positively correlated with BMI (<jats:italic>R<\/jats:italic> = 0.29; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), log-transformed triglyceride (<jats:italic>R<\/jats:italic> = 0.14; <jats:italic>p<\/jats:italic> &amp;lt; 0.001), and diastolic blood pressure (DBP) (<jats:italic>R<\/jats:italic> = 0.12; <jats:italic>p<\/jats:italic> &amp;lt; 0.001) and negatively correlated with high-density lipoprotein (HDL-c) (<jats:italic>R<\/jats:italic> = \u22120.18; <jats:italic>p<\/jats:italic> &amp;lt; 0.001). After adjusting for age, sex, and other covariates, elevated serum A\u03b242 level was correlated with higher values of BMI (\u03b2model1\u00a0=\u00a02.694, \u03b2model2\u00a0=\u00a02.703) and DBP (\u03b2model1\u00a0=\u00a00.541, \u03b2model2\u00a0=\u00a00.546) but a lower level of HDL-c (\u03b2model2 = \u22121.741). Furthermore, serum A\u03b242 level was positively correlated with MetS and its clinical measures, including BMI and DBP, and negatively correlated with HDL-c level in the Han Chinese population. However, the level of serum A\u03b242 did not show a significant correlation with high glucose or high triglyceride.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These observations indicate that MetS and its components are associated with higher levels of serum A\u03b242 and hence limit the potential of serum A\u03b242 as a suitable diagnostic biomarker for AD. As such, we recommend serum A\u03b242 serve as a direct risk biomarker for MetS rather than for AD.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1278477","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T10:19:14Z","timestamp":1707473954000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["Serum amyloid beta 42 levels correlated with metabolic syndrome and its 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