{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:27:21Z","timestamp":1791584841093,"version":"4.3.4"},"reference-count":35,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the effects of \u03b2-cell dysfunction on IVF outcomes in women with PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study includes 1,212 women with PCOS undergoing their first IVF cycle between September 2010 and December 2019. Beta-cell dysfunction was measured by homeostasis model assessment of \u03b2-cell function (HOMA-\u03b2) index.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In quartiles of HOMA-\u03b2, the incidence of miscarriage dramatically increased from 10.2% (Q1) to 31.1% (Q4) (<jats:italic>P<\/jats:italic><jats:sub>for trend<\/jats:sub> &amp;lt;0.001). Likewise, the incidence of miscarriage in quartiles of HOMA-\u03b2 also showed a similar trend (<jats:italic>P<\/jats:italic><jats:sub>for trend<\/jats:sub> &amp;lt;0.001). After adjusting for confounding factors, logistic regression analyses showed that high HOMA-IR values were independently associated with a high risk of miscarriage, with the odds ratios (OR) and 95% confidence intervals for quartiles 2\u20134 versus quartile 1 were 1.30 (0.69-2.46), 1.82 (0.97-3.43), and 3.57 (1.86-6.85), respectively (<jats:italic>P<\/jats:italic><jats:sub>for trend<\/jats:sub> &amp;lt;0.001). When analyzed jointly, women in the highest HOMA-IR and highest HOMA-\u03b2 group exhibited the highest risk for miscarriage compared with all other groups. Furthermore, higher HOMA-IR values were associated with higher risks of miscarriage among PCOS women regardless of HOMA-\u03b2 values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>\u03b2-cell dysfunction is independently associated with increased miscarriage rate and decreased live birth rate in women with PCOS. It also plays a synergistic role with IR in terms of the reproductive outcomes, while the influence of IR overweighs that of \u03b2-cell dysfunction.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1327041","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T04:55:13Z","timestamp":1709614513000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["The effect of \u03b2-cell dysfunction on reproductive outcomes of PCOS undergoing IVF or ICSI embryo transfer cycles: a retrospective cohort study"],"prefix":"10.3389","volume":"15","author":[{"given":"Wenle","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00163-2","article-title":"Polycystic ovary syndrome","volume":"10","author":"Joham","year":"2022","journal-title":"Lancet Diabetes Endocrinology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"14914","DOI":"10.3390\/ijerph192214914","article-title":"Polycystic ovarian syndrome (PCOS): does the challenge end at conception","volume":"19","author":"Mirza","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.982200","article-title":"Potential biomarkers for clinical outcomes of IVF cycles in women with\/without PCOS: Searching with metabolomics","volume":"13","author":"Guan","year":"2022","journal-title":"Front Endocrinology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmv029","article-title":"Pregnancy complications in women with polycystic ovary syndrome","volume":"21","author":"Palomba","year":"2015","journal-title":"Hum Reprod Update"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2019.03.203","article-title":"A meta-analysis of pregnancy-related outcomes and complications in women with polycystic ovary syndrome undergoing IVF","volume":"39","author":"Sha","year":"2019","journal-title":"Reprod Biomedicine Online"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12829","article-title":"Increased maternal pregnancy complications in polycystic ovary syndrome appear to be independent of obesity-A systematic review, meta-analysis, and meta-regression","volume":"20","author":"Bahri Khomami","year":"2019","journal-title":"Obes Rev"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.08.007","article-title":"Pregnancy complications in spontaneous and assisted conceptions of women with infertility and subfertility factors","volume":"33","author":"Palomba","year":"2016","journal-title":"A Compr Review. 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