{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T04:37:41Z","timestamp":1777091861560,"version":"3.51.4"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T00:00:00Z","timestamp":1712016000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>More than 700 million people worldwide suffer from diseases of the pancreas, such as diabetes, pancreatitis and pancreatic cancer. Often dysregulation of potassium (K<jats:sup>+<\/jats:sup>) channels, co-transporters and pumps can promote development and progression of many types of these diseases. The role of K<jats:sup>+<\/jats:sup> transport system in pancreatic cell homeostasis and disease development remains largely unexplored. Potassium isotope analysis (\u03b4<jats:sup>41<\/jats:sup>K), however, might have the potential to detect minute changes in metabolic processes relevant for pancreatic diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed urinary K isotope composition in a case-control study by measuring K concentrations and \u03b4<jats:sup>41<\/jats:sup>K in spot urines collected from patients diagnosed with pancreatic cancer (n=18), other pancreas-related diseases (n=14) and compared those data to healthy controls (n=16). <\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results show that urinary K<jats:sup>+<\/jats:sup> levels for patients with diseased pancreas (benign and pancreatic cancer) are significantly lower than the healthy controls. For \u03b4<jats:sup>41<\/jats:sup>K, the values tend to be higher for individuals with pancreatic cancer (mean \u03b4<jats:sup>41<\/jats:sup>K = -0.58 \u00b1 0.33\u2030) than for healthy individuals (mean \u03b4<jats:sup>41<\/jats:sup>K = -0.78 \u00b1 0.19\u2030) but the difference is not significant (p=0.08). For diabetics, urinary K<jats:sup>+<\/jats:sup> levels are significantly lower (p=0.03) and \u03b4<jats:sup>41<\/jats:sup>K is significantly higher (p=0.009) than for the healthy controls. These results suggest that urinary K<jats:sup>+<\/jats:sup> levels and K isotopes can help identify K disturbances related to diabetes, an associated factors of all-cause mortality for diabetics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although the K isotope results should be considered exploratory and hypothesis-generating and future studies should focus on larger sample size and \u03b4<jats:sup>41<\/jats:sup>K analysis of other K-disrupting diseases (e.g., chronic kidney disease), our data hold great promise for K isotopes as disease marker.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1332895","type":"journal-article","created":{"date-parts":[[2024,4,2]],"date-time":"2024-04-02T04:49:23Z","timestamp":1712033363000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Analysis of urinary potassium isotopes and association with pancreatic health: healthy, diabetic and cancerous states"],"prefix":"10.3389","volume":"15","author":[{"given":"Kathrin","family":"Schilling","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald A.","family":"Glabonjat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Debernardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Blyuss","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Navas-Acien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex N.","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Crnogorac-Jurcevic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1039\/C4MT00260A","article-title":"Zinc isotopic compositions of breast cancer tissue","volume":"7","author":"Larner","year":"2015","journal-title":"Metallomics"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2020.126611","article-title":"Cu isotope ratios are meaningful in ovarian cancer diagnosis","volume":"62","author":"Toubhans","year":"2020","journal-title":"J Trace Elem Med Bio"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfab020","article-title":"Zinc stable isotopes in urine as diagnostic for cancer of secretory organs","volume":"13","author":"Schilling","year":"2021","journal-title":"Metallomics"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1039\/d0mt00061b","article-title":"Urine metallomics signature as an indicator of pancreatic cancer","volume":"12","author":"Schilling","year":"2020","journal-title":"Metallomics"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfab027","article-title":"Zinc stable isotope analysis reveals Zn dyshomeostasis in benign tumours, breast cancer, and adjacent histologically normal tissue","volume":"13","author":"Sullivan","year":"2021","journal-title":"Metallomics"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.698167","article-title":"Copper isotopes and copper to zinc ratio as possible biomarkers for thyroid cancer","volume":"8","author":"Tani","year":"2021","journal-title":"Front Med-Lausanne"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1039\/D1JA00294E","article-title":"Potassium isotopic composition of seven widely available biological standards using collision cell (CC)-MC-ICP-MS","volume":"36","author":"Moynier","year":"2021","journal-title":"J Anal Atom Spectrom"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1093\/mtomcs\/mfac090","article-title":"Exploring the K isotope composition of Gottingen minipig brain regions, and implications for Alzheimer's disease","volume":"14","author":"Mahan","year":"2022","journal-title":"Metallomics"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.1c01087","article-title":"Robust potassium isotopic analysis of geological and biological samples via multicollector ICP-mass spectrometry using the \"Extra-high resolution mode\"","volume":"93","author":"Hobin","year":"2021","journal-title":"Anal Chem"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1029\/2021JG006682","article-title":"HG. 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