{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T17:56:45Z","timestamp":1793642205740,"version":"4.5.1"},"reference-count":53,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Bariatric surgery is an effective approach to weight loss, which may also affect thyroid function. However, alteration in thyroid-stimulating hormone (\u0394TSH) and thyroid hormones after bariatric surgery and the relationship between thyroid function and postoperative weight loss still remains controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were collected from euthyroid patients with obesity who underwent sleeve gastrectomy and Roux-en-Y gastric bypass from 2017 to 2022. The alterations of free thyroxine (FT4), free triiodothyronine (FT3), total thyroxine (TT4), total triiodothyronine (TT3), and TSH were calculated 1 year after surgery. Pearson correlation analysis was used to assess the correlation between the percentage of total weight loss (%TWL) and \u0394TSH. Multivariable linear regression was utilized to determine the association between %TWL and \u0394TSH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 256 patients were included in our study. The mean %TWL was 28.29% after 1 year. TSH decreased from 2.33 (1.67, 3.04) uIU\/mL to 1.82 (1.21, 2.50) uIU\/mL (<jats:italic>P<\/jats:italic> &amp;lt; 0.001), FT3 decreased from 3.23 \u00b1 0.42 pg\/mL to 2.89 \u00b1 0.41 pg\/mL (P &amp;lt; 0.001), FT4 decreased from 1.11 \u00b1 0.25 ng\/dL to 1.02 \u00b1 0.25 ng\/dL (<jats:italic>P<\/jats:italic> &amp;lt; 0.001), TT3 decreased from 1.13 (1.00, 1.25) ng\/mL to 0.89 (0.78, 1.00) ng\/mL (<jats:italic>P<\/jats:italic> &amp;lt; 0.001), and TT4 decreased from 8.28 \u00b1 1.69 ug\/mL to 7.82 \u00b1 1.68 ug\/mL 1 year postoperatively (<jats:italic>P<\/jats:italic> &amp;lt; 0.001). %TWL was found to be significantly correlated to \u0394TSH by Pearson correlation analysis (Pearson correlation coefficient = 0.184, <jats:italic>P<\/jats:italic> = 0.003), indicating that the more weight loss, the more TSH declined. After adjusting for covariates in multivariable linear regression, %TWL was found to be independently associated with \u0394TSH (\u03b2 = 0.180 [95% confidence interval (CI), 0.048 \u2013 0.312], <jats:italic>P<\/jats:italic> = 0.008). Moreover, %TWL was divided into 3 categorical groups (%TWL \u2264 25%, 25% &amp;lt; %TWL \u2264 35%, and %TWL &amp;gt; 35%) for further exploration, and was also found to be an independent predictor for \u0394TSH after adjusting for covariates in multivariable linear regression (\u03b2 = 0.153 [95% CI, 0.019 \u2013 0.287], <jats:italic>P<\/jats:italic> = 0.025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TSH, FT4, FT3, TT4, and TT3 decrease significantly 1 year after bariatric surgery. The decline in TSH is independently mediated by postoperative weight loss; the more the weight loss, the more the TSH decrease.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1333033","type":"journal-article","created":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T04:31:33Z","timestamp":1706589093000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":31,"title":["Total weight loss induces the alteration in thyroid function after bariatric 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