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Endocrinol."],"abstract":"<jats:sec><jats:title>Study objective<\/jats:title><jats:p>To investigate whether different timings of GnRH-a downregulation affected assisted reproductive outcomes in infertile women with moderate-to-severe intrauterine adhesions (IUAs) accompanied by adenomyosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A retrospective case series.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>An assisted reproductive technology center.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>The study reviewed 123 infertile women with moderate-to-severe IUAs accompanied by adenomyosis undergoing their first frozen-thawed embryo transfer (FET) cycles between January 2019 and December 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Measurements and main results<\/jats:title><jats:p>The majority of patients had moderate IUA (n=116, 94.31%). The average Basal uterine volume was 73.58 \u00b1 36.50 cm<jats:sup>3<\/jats:sup>. The mean interval from operation to the first downregulation was 21.07 \u00b1 18.02 days (range, 1\u201379 days). The mean duration of hormone replacement therapy (HRT) was 16.93 \u00b1 6.29 days. The average endometrial thickness on the day before transfer was 10.83 \u00b1 1.75 mm. A total of 70 women achieved clinical pregnancy (56.91%). Perinatal outcomes included live birth (n=47, 67.14%), early miscarriage (n=18, 25.71%), and late miscarriage (n=5, 7.14%). The time interval between uterine operation and the first downregulation was not a significant variable affecting live birth. Maternal age was the only risk factor associated with live birth (OR:0.89; 95% CI: 0.79\u20130.99, P=0.041).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The earlier initiation of GnRH-a to suppress adenomyosis prior to endometrial preparation for frozen embryo transfer did not negatively impact repair of the endometrium after resection.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1343176","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T04:32:10Z","timestamp":1714365130000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Early GnRH-agonist therapy does not negatively impact the endometrial repair process or live birth 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