{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:07:36Z","timestamp":1793066856681,"version":"4.5.0"},"reference-count":58,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>A Mediterranean dietary pattern, sleeping habits, physical activity, and lifestyle appear to affect reproductive health. There are few reports about whether fertility-specific quality of life (QOL) is linked to infertility treatment outcomes. The aim of this study is to investigate when lifestyle factors and fertility-specific QOL are comprehensively considered, which factors influence assisted reproductive technology (ART) outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort includes 291 women undergoing a first ART treatment at multiple centers in Japan and was designed to evaluate the influence of diet, physical activity, sleeping pattern, computer use duration, and fertility-specific quality of life tool (FertiQoL) score on ART treatment outcomes using a questionnaire. The primary endpoint was the good-quality blastocyst rate per oocyte retrieval and the secondary endpoints were a positive pregnancy test and gestational sac (GS) detection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The good-quality blastocyst rate per oocyte retrieval tended to be negatively associated with frequent fish consumption. After all embryo transfer (ET) cycles, a positive pregnancy test tended to be positively associated with longer sleep and longer computer use (OR = 1.6, 95% CI = 0.9\u20132.7 and OR = 1.7, CI = 1.0\u20132.8, respectively) and negatively associated with a smoking partner (OR\u00a0= 0.6, CI = 0.3\u20131.0). GS detection was positively and significantly associated with frequent olive oil intake and longer computer use (OR = 1.7, CI = 1.0\u20133.0 and OR = 1.7, CI = 1.0\u20133.0, respectively). After ET cycles with a single blastocyst, a positive pregnancy test was positively and significantly associated with longer computer use (OR = 2.0, CI = 1.1\u20133.7), while GS detection was significantly more likely in women with longer computer use (OR = 2.1, CI = 1.1\u20133.8) and tended to be more likely in women with a higher FertiQoL Total scaled treatment score (OR\u00a0= 1.8, CI = 1.0\u20133.3). p &amp;lt; 0.05 was considered statistically significant and 0.05\u00a0\u2264 p &amp;lt;0.01 as tendency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Olive oil may be an important factor in dietary habits. Fertility-specific QOL and smoking cessation guidance for partners are important for infertile couples.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1346084","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T05:09:51Z","timestamp":1710911391000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":14,"title":["Lifestyle and fertility-specific quality of life affect reproductive outcomes in couples undergoing in vitro fertilization"],"prefix":"10.3389","volume":"15","author":[{"given":"Yoko","family":"Urata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinnosuke","family":"Komiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikumi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chihiro","family":"Tuchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Nakaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisaku","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Kawahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutaka","family":"Osuga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,3,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001356","article-title":"National, regional, and global trends in infertility prevalence since 1990: A systematic analysis of 277 health surveys","volume":"9","author":"Mascarenhas","year":"2012","journal-title":"PloS Med"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/padr.12334","article-title":"Latest-late fertility? Decline and resurgence of late parenthood across the low-fertility countries","volume":"46","author":"Beaujouan","year":"2020","journal-title":"Popul Dev Rev"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/hropen\/hoaa032","article-title":"Art in europe, 2016: results generated from european registries by eshre","volume":"2020","author":"Wyns","year":"2020","journal-title":"Hum Reprod Open"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2018.12.001","article-title":"Towards the global coverage of a unified registry of ivf outcomes","volume":"38","author":"Fauser","year":"2019","journal-title":"Reprod BioMed Online"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00385","article-title":"Seafood intake, sexual activity, and time to pregnancy","volume":"103","author":"Gaskins","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"B6","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12958-019-0520-9","article-title":"Mediterranean diet improves embryo yield in ivf: A prospective cohort study","volume":"17","author":"Sun","year":"2019","journal-title":"Reprod Biol Endocrinol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1093\/humrep\/dey003","article-title":"Adherence to the mediterranean diet and ivf success rate among non-obese women attempting fertility","volume":"33","author":"Karayiannis","year":"2018","journal-title":"Hum Reprod"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(02)04582-x","article-title":"Effects of maternal and paternal alcohol consumption on the success rates of in vitro fertilization and gamete intrafallopian transfer","volume":"79","author":"Klonoff-Cohen","year":"2003","journal-title":"Fertil Steril"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.10.011","article-title":"Food intake and social habits in male patients and its relationship to intracytoplasmic sperm injection outcomes","volume":"97","author":"Braga","year":"2012","journal-title":"Fertil Steril"},{"key":"B10","article-title":"The effect of caffeine consumption on the success rate of pregnancy as well various performance parameters of in-vitro fertilization treatment","volume":"16","author":"Al-Saleh","year":"2010","journal-title":"Med Sci Monit"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey372","article-title":"Prospective study of cigarette smoking and fecundability","volume":"34","author":"Wesselink","year":"2019","journal-title":"Hum Reprod"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-011-2172-7","article-title":"Ovarian reserve and in vitro fertilization cycles outcome according to women smoking status and stimulation regimen","volume":"285","author":"Freour","year":"2012","journal-title":"Arch Gynecol Obstet"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000235704.45652.0b","article-title":"Effects of lifetime exercise on the outcome of in vitro fertilization","volume":"108","author":"Morris","year":"2006","journal-title":"Obstet Gynecol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-022-06606-0","article-title":"The role of maternal physical activity on in vitro fertilization outcomes: A systematic review and meta-analysis","volume":"207","author":"Kakargia","year":"2022","journal-title":"Arch Gynecol Obstet"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.fertnstert.2019.01.037","article-title":"Female sleep patterns, shift work, and fecundability in a north american preconception cohort study","volume":"111","author":"Willis","year":"2019","journal-title":"Fertil Steril"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac040","article-title":"Associations of sleep characteristics with outcomes of ivf\/icsi treatment: A prospective cohort study","volume":"37","author":"Yao","year":"2022","journal-title":"Hum Reprod"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(95)00112-k","article-title":"The world health organization quality of life assessment (Whoqol): position paper from the world health organization","volume":"41","year":"1995","journal-title":"Soc Sci Med"},{"key":"B18","article-title":"Assessment of questionnaires measuring quality of life in infertile couples: A systematic review","volume":"14","author":"Mousavi","year":"2013","journal-title":"J Reprod Infertil"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-017-0666-0","article-title":"A review of patient-reported outcome measures to assess female infertility-related quality of life","volume":"15","author":"Kitchen","year":"2017","journal-title":"Health Qual Life Outcomes"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der171","article-title":"The fertility quality of life (Fertiqol) tool: development and general psychometric properties","volume":"26","author":"Boivin","year":"2011","journal-title":"Hum Reprod"},{"key":"B21","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.fertnstert.2011.02.046","article-title":"The fertility quality of life (Fertiqol) tool: development and general psychometric properties","volume":"96","author":"Boivin","year":"2011","journal-title":"Fertil Steril"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/14647273.2022.2081095","article-title":"Does male fertility-related quality of life differ when undergoing evaluation by reproductive urologist versus reproductive endocrinologist","volume":"26","author":"Danis","year":"2022","journal-title":"Hum Fertil (Camb)"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12406","article-title":"Influence of a patient education and care program on women undergoing non-assisted reproductive technology fertility treatment","volume":"20","author":"Mori","year":"2021","journal-title":"Reprod Med Biol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.2147\/PRBM.S357301","article-title":"Quality of infertility care services and emotional health of south asian women","volume":"15","author":"Hassan","year":"2022","journal-title":"Psychol Res Behav Manag"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19052950","article-title":"Assessment of quality of life in men treated for infertility in Poland","volume":"19","author":"Makara-Studzinska","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dew175","article-title":"Fertility-related quality of life from two rct cohorts with infertility: unexplained infertility and polycystic ovary syndrome","volume":"31","author":"Santoro","year":"2016","journal-title":"Hum Reprod"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2006.12.009","article-title":"Adherence to the mediterranean food pattern predicts the prevalence of hypertension, hypercholesterolemia, diabetes and obesity, among healthy adults; the accuracy of the meddietscore","volume":"44","author":"Panagiotakos","year":"2007","journal-title":"Prev Med"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2021-141016","article-title":"Effect of cigarette smoking on smoking biomarkers, blood pressure and blood lipid levels among Sri Lankan male smokers","volume":"98","author":"Herath","year":"2022","journal-title":"Postgrad Med J"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955","article-title":"World health organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br J Sports Med"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200009001-00009","article-title":"Compendium of physical activities: an update of activity codes and met intensities","volume":"32","author":"Ainsworth","year":"2000","journal-title":"Med Sci Sports Exerc"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.201700067","article-title":"Variable selection - a review and recommendations for the practicing statistician","volume":"60","author":"Heinze","year":"2018","journal-title":"Biom J"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh304","article-title":"Can assisted reproduction technology compensate for the natural decline in fertility with age? A model assessment","volume":"19","author":"Leridon","year":"2004","journal-title":"Hum Reprod"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1159\/000323500","article-title":"Aneuploidy in the human blastocyst","volume":"133","author":"Fragouli","year":"2011","journal-title":"Cytogenet Genome Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp2116488","article-title":"Primary ovarian insufficiency","volume":"388","author":"Stuenkel","year":"2023","journal-title":"N Engl J Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.12.032","article-title":"Female obesity impairs in vitro fertilization outcome without affecting embryo quality","volume":"93","author":"Bellver","year":"2010","journal-title":"Fertil Steril"},{"key":"B36","doi-asserted-by":"publisher","first-page":"18858","DOI":"10.1038\/s41598-022-23576-0","article-title":"Impact of elevated body mass index on cumulative live birth rate and obstetric safety in women undergoing assisted reproductive technology","volume":"12","author":"Hu","year":"2022","journal-title":"Sci Rep"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2015.03.007","article-title":"The impact of food intake and social habits on embryo quality and the likelihood of blastocyst formation","volume":"31","author":"Braga","year":"2015","journal-title":"Reprod BioMed Online"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082276","article-title":"The association between seafood intake and fecundability: analysis from two prospective studies","volume":"12","author":"Wise","year":"2020","journal-title":"Nutrients"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200007000-00005","article-title":"Parental consumption of contaminated sport fish from lake ontario and predicted fecundability","volume":"11","author":"Buck","year":"2000","journal-title":"Epidemiology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1530\/REP-09-0219","article-title":"Dietary omega-3 and -6 polyunsaturated fatty acids affect the composition and development of sheep granulosa cells, oocytes and embryos","volume":"139","author":"Wonnacott","year":"2010","journal-title":"Reproduction"},{"key":"B41","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1095\/biolreprod.107.060558","article-title":"Polyunsaturated fatty acids in male and female reproduction","volume":"77","author":"Wathes","year":"2007","journal-title":"Biol Reprod"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3390\/pathogens12040520","article-title":"Anti-inflammatory benefits of food ingredients in periodontal diseases","volume":"12","author":"Papathanasiou","year":"2023","journal-title":"Pathogens"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.11.021","article-title":"Increased preconception omega-3 polyunsaturated fatty acid intake improves embryo morphology","volume":"95","author":"Hammiche","year":"2011","journal-title":"Fertil Steril"},{"key":"B44","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1289\/ehp.0901347","article-title":"Perfluorinated compounds, polychlorinated biphenyls, and organochlorine pesticide contamination in composite food samples from dallas, texas, USA","volume":"118","author":"Schecter","year":"2010","journal-title":"Environ Health Perspect"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1080\/19440049.2011.553844","article-title":"Assessment of seasonality in exposure to dioxins, furans and dioxin-like pcbs by using long-term food-consumption data","volume":"28","author":"Feinberg","year":"2011","journal-title":"Food Addit Contam Part A Chem Anal Control Expo Risk Assess"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.7046","article-title":"Hair mercury levels in U.S. Children and women of childbearing age: reference range data from nhanes 1999-2000","volume":"112","author":"McDowell","year":"2004","journal-title":"Environ Health Perspect"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2019.09.041","article-title":"Effect of a 6-week \"Mediterranean\" Dietary intervention on in vitro human embryo development: the preconception dietary supplements in assisted reproduction double-blinded randomized controlled trial","volume":"113","author":"Kermack","year":"2020","journal-title":"Fertil Steril"},{"key":"B48","doi-asserted-by":"publisher","first-page":"17477","DOI":"10.1038\/s41598-022-22534-0","article-title":"Women's quality of sleep and in vitro fertilization success","volume":"12","author":"Reschini","year":"2022","journal-title":"Sci Rep"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2016.12.007","article-title":"Sleep in women undergoing in vitro fertilization: A pilot study","volume":"32","author":"Goldstein","year":"2017","journal-title":"Sleep Med"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1418490112","article-title":"Evening use of light-emitting ereaders negatively affects sleep, circadian timing, and next-morning alertness","volume":"112","author":"Chang","year":"2015","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/and.13090","article-title":"Paternal lifestyle factors in relation to semen quality and in vitro reproductive outcomes","volume":"50","author":"Borges","year":"2018","journal-title":"Andrologia"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.6.1506","article-title":"Evidence that male smoking affects the likelihood of a pregnancy following ivf treatment: application of the modified cumulative embryo score","volume":"13","author":"Joesbury","year":"1998","journal-title":"Hum Reprod"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00220-8","article-title":"Preconceptional maternal vegetable intake and paternal smoking are associated with pre-implantation embryo quality","volume":"27","author":"Hoek","year":"2020","journal-title":"Reprod Sci"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1071\/RD22093","article-title":"Effect of paternal smoking on pre-implantation embryonic development: A prospective cohort study","volume":"34","author":"Frappier","year":"2022","journal-title":"Reprod Fertil Dev"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der246","article-title":"Stress, distress and outcome of assisted reproductive technology (Art): A meta-analysis","volume":"26","author":"Matthiesen","year":"2011","journal-title":"Hum Reprod"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d223","article-title":"Emotional distress in infertile women and failure of assisted reproductive technologies: meta-analysis of prospective psychosocial studies","volume":"342","author":"Boivin","year":"2011","journal-title":"BMJ"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006592","article-title":"Efficacy of psychosocial interventions for psychological and pregnancy outcomes in infertile women and men: A systematic review and meta-analysis","volume":"5","author":"Frederiksen","year":"2015","journal-title":"BMJ Open"},{"key":"B58","doi-asserted-by":"publisher","first-page":"440","DOI":"10.1016\/j.fertnstert.2015.05.009","article-title":"Exploratory randomized trial on the effect of a brief psychological intervention on emotions, quality of life, discontinuation, and pregnancy rates in in vitro fertilization patients","volume":"104","author":"Domar","year":"2015","journal-title":"Fertil Steril"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1346084\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T05:09:57Z","timestamp":1710911397000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1346084\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,20]]},"references-count":58,"alternative-id":["10.3389\/fendo.2024.1346084"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2024.1346084","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,20]]},"article-number":"1346084"}}