{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:22:30Z","timestamp":1781662950799,"version":"3.54.5"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In 2020, 38% of adults were affected by obesity, while infertility globally affected 1 in 6 people at some stage of their lives.<\/jats:p><jats:p>Body mass index (BMI) provides an easy but occasionally inaccurate estimation of body composition. To achieve a more precise assessment, bioelectric impedance analysis serves as a validated tool that administers electrical energy through surface electrodes. Phase angle as a function of the relationship between tissues resistance and reactance, is a trustworthy predictor of body composition and cell membrane integrity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aim to assess whether there is an association between phase angle and seminal parameters, as well as sperm DNA fragmentation percentage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Semen samples of 520 idiopathic infertile patients were analyzed according to 2021 World Health Organization guidelines and evaluated for sperm DNA fragmentation rate. Each participants underwent bioelectric impedance analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 40 years old, median BMI was 26.3 kg\/m2, median phase angle was 6.2\u00b0. In the logistic regression analysis adjusted for age and total intracorporeal water, phase angle (continuous) was significantly associated with oligozoospermia (odds ratio [OR]:0.4; p&amp;lt;0.01) and sperm morphology (OR: 0.65; p=0.05) and slightly with sperm DNA fragmentation (OR: 0.98; p=0.07). In subgroup analysis, the logistic regression analysis adjusted for the mentioned parameters showed that a phase angle between 6.2 and 7 (\u00b0) (OR: 0.63; p=0.02) and &amp;gt;7 (\u00b0) (OR: 0.12; p&amp;lt;0.01) were associated with a reduced risk of oligozoospermia compared to values &amp;lt;6.2 (\u00b0). Similarly, a phase angle between 6.2 and 7 (\u00b0) (OR: 0.57; p&amp;lt; 0.01 and OR: 0.58; p= 0.01) and PA &amp;gt; 7 (\u00b0) (OR: 0.12; p= 0.03 and OR: 0.21; p&amp;lt; 0.01) were associated with a reduced risk of lower sperm concentration and lower total sperm count, respectively, compared to a phase angle &amp;lt; 6.2 (\u00b0).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests a negative association between phase angle and detrimental sperm parameters in male idiopathic infertility.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1354733","type":"journal-article","created":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T04:31:46Z","timestamp":1713933106000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Phase angle at bioelectric impedance analysis is associated with detrimental sperm quality in idiopathic male infertility: a preliminary clinical 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