{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T09:54:20Z","timestamp":1793872460165,"version":"4.6.1"},"reference-count":194,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T00:00:00Z","timestamp":1723075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Non-alcoholic fatty liver disease (NAFLD) is a clinicopathologic syndrome characterized by excessive fat deposition in hepatocytes and a major cause of end-stage liver disease. Autophagy is a metabolic pathway responsible for degrading cytoplasmic products and damaged organelles, playing a pivotal role in maintaining the homeostasis and functionality of hepatocytes. Recent studies have shown that pharmacological intervention to activate or restore autophagy provides benefits for liver function recovery by promoting the clearance of lipid droplets (LDs) in hepatocytes, decreasing the production of pro-inflammatory factors, and inhibiting activated hepatic stellate cells (HSCs), thus improving liver fibrosis and slowing down the progression of NAFLD. This article summarizes the physiological process of autophagy, elucidates the close relationship between NAFLD and autophagy, and discusses the effects of drugs on autophagy and signaling pathways from the perspectives of hepatocytes, kupffer cells (KCs), and HSCs to provide assistance in the clinical management of NAFLD.<\/jats:p>","DOI":"10.3389\/fendo.2024.1374644","type":"journal-article","created":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T04:38:47Z","timestamp":1723091927000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":17,"title":["The pivotal role of dysregulated autophagy in the progression of non-alcoholic fatty liver disease"],"prefix":"10.3389","volume":"15","author":[{"given":"Qiaohui","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12060824","article-title":"NAFLD: mechanisms, treatments, and biomarkers","volume":"12","author":"Nassir","year":"2022","journal-title":"Biomolecules"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24032844","article-title":"Advances in the diagnosis and treatment of non-alcoholic fatty liver disease","volume":"24","author":"Yin","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1053\/j.gastro.2019.11.312","article-title":"MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease","volume":"158","author":"Eslam","year":"2020","journal-title":"Gastroenterology"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1111\/imj.14709","article-title":"Non-alcoholic fatty liver disease: a review of epidemiology, risk factors, diagnosis and management","volume":"50","author":"Huang","year":"2020","journal-title":"Intern Med J"},{"key":"B5","doi-asserted-by":"publisher","first-page":"S5","DOI":"10.3350\/cmh.2022.0424","article-title":"Non-alcoholic fatty liver disease: Definition and subtypes","volume":"29","author":"Han","year":"2023","journal-title":"Clin Mol Hepatol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.2741\/4892","article-title":"Current treatment paradigms and emerging therapies for NAFLD\/NASH","volume":"26","author":"Raza","year":"2021","journal-title":"Front Biosci (Landmark Ed)"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad095","article-title":"Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options","volume":"119","author":"Grander","year":"2023","journal-title":"Cardiovasc Res"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220572","article-title":"Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways","volume":"136","author":"Badmus","year":"2022","journal-title":"Clin Sci (Lond)"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2022.00067","article-title":"Reactive oxygen species and oxidative stress in the pathogenesis of MAFLD","volume":"10","author":"Clare","year":"2022","journal-title":"J Clin Transl Hepatol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.11.014","article-title":"Lipotoxicity and the gut-liver axis in NASH pathogenesis","volume":"68","author":"Marra","year":"2018","journal-title":"J Hepatol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.47143","article-title":"Kupffer cells in non-alcoholic fatty liver disease: friend or foe","volume":"16","author":"Chen","year":"2020","journal-title":"Int J Biol Sci"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.add3949","article-title":"An autocrine signaling circuit in hepatic stellate cells underlies advanced fibrosis in nonalcoholic steatohepatitis","volume":"15","author":"Wang","year":"2023","journal-title":"Sci Transl Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00542-2","article-title":"The mechanisms and roles of selective autophagy in mammals","volume":"24","author":"Vargas","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00551-9","article-title":"Autophagy in metabolic disease and ageing","volume":"17","author":"Kitada","year":"2021","journal-title":"Nat Rev Endocrinol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.33.2.437","article-title":"Influence of glucagon, an inducer of cellular autophagy, on some physical properties of rat liver lysosomes","volume":"33","author":"Deter","year":"1967","journal-title":"J Cell Biol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2021108863","article-title":"Autophagy in major human diseases","volume":"40","author":"Klionsky","year":"2021","journal-title":"EMBO J"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0003-4","article-title":"Mechanism and medical implications of mammalian autophagy","volume":"19","author":"Dikic","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2254191","article-title":"Dysfunction of autophagy in high-fat diet-induced non-alcoholic fatty liver disease","volume":"20","author":"Ren","year":"2024","journal-title":"Autophagy"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071813-105336","article-title":"Autophagy and lipid droplets in the liver","volume":"35","author":"Martinez-Lopez","year":"2015","journal-title":"Annu Rev Nutr"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3390\/cells8010016","article-title":"Relevance of autophagy in parenchymal and non-parenchymal liver cells for health and disease","volume":"8","author":"Weiskirchen","year":"2019","journal-title":"Cells"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2021.100973","article-title":"Autophagy in liver diseases: A review","volume":"82","author":"Qian","year":"2021","journal-title":"Mol Aspects Med"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2013.5371","article-title":"An overview of autophagy: morphology, mechanism, and regulation","volume":"20","author":"Parzych","year":"2014","journal-title":"Antioxid Redox Signal"},{"key":"B23","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1038\/s41580-022-00529-z","article-title":"The emerging mechanisms and functions of microautophagy","volume":"24","author":"Wang","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0001-6","article-title":"The coming of age of chaperone-mediated autophagy","volume":"19","author":"Kaushik","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2014.35","article-title":"Autophagy\u2013a key player in cellular and body metabolism","volume":"10","author":"Kim","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41392-022-01300-8","article-title":"Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets","volume":"8","author":"Shu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.cell.2018.09.048","article-title":"Biological functions of autophagy genes: A disease perspective","volume":"176","author":"Levine","year":"2019","journal-title":"Cell"},{"key":"B28","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1146\/annurev-pharmtox-010611-134537","article-title":"AMPK and mTOR in cellular energy homeostasis and drug targets","volume":"52","author":"Inoki","year":"2012","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308061100","article-title":"The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress","volume":"101","author":"Shaw","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-021-02125-8","article-title":"AMPK: a key regulator of energy stress and calcium-induced autophagy","volume":"99","author":"Saikia","year":"2021","journal-title":"J Mol Med (Berl)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1128\/MCB.06159-11","article-title":"Role of AMPK-mTOR-Ulk1\/2 in the regulation of autophagy: cross talk, shortcuts, and feedbacks","volume":"32","author":"Alers","year":"2012","journal-title":"Mol Cell Biol"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2023.114358","article-title":"UBE3A deficiency-induced autophagy is associated with activation of AMPK-ULK1 and p53 pathways","volume":"363","author":"Hao","year":"2023","journal-title":"Exp Neurol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.1011918","article-title":"WIPI proteins: Biological functions and related syndromes","volume":"15","author":"Almannai","year":"2022","journal-title":"Front Mol Neurosci"},{"key":"B34","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1038\/s41467-019-14086-1","article-title":"PI3KC2\u03b1-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress","volume":"11","author":"Boukhalfa","year":"2020","journal-title":"Nat Commun"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2021.158956","article-title":"Atg2 and Atg9: Intermembrane and interleaflet lipid transporters driving autophagy","volume":"1866","author":"Noda","year":"2021","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"B36","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1042\/bse0550039","article-title":"Two ubiquitin-like conjugation systems that mediate membrane formation during autophagy","volume":"55","author":"Nakatogawa","year":"2013","journal-title":"Essays Biochem"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.166809","article-title":"Membrane binding and homodimerization of atg16 via two distinct protein regions is essential for autophagy in yeast","volume":"433","author":"Popelka","year":"2021","journal-title":"J Mol Biol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1618100","article-title":"Toward the function of mammalian ATG12-ATG5-ATG16L1 complex in autophagy and related processes","volume":"15","author":"Lystad","year":"2019","journal-title":"Autophagy"},{"key":"B39","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1038\/s41421-020-0155-1","article-title":"Activation and targeting of ATG8 protein lipidation","volume":"6","author":"Martens","year":"2020","journal-title":"Cell Discovery"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.021","article-title":"Atg8, a ubiquitin-like protein required for autophagosome formation, mediates membrane tethering and hemifusion","volume":"130","author":"Nakatogawa","year":"2007","journal-title":"Cell"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201643146","article-title":"Conserved Atg8 recognition sites mediate Atg4 association with autophagosomal membranes and Atg8 deconjugation","volume":"18","author":"Abreu","year":"2017","journal-title":"EMBO Rep"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.4161\/auto.22931","article-title":"Dissecting the role of the Atg12-Atg5-Atg16 complex during autophagosome formation","volume":"9","author":"Walczak","year":"2013","journal-title":"Autophagy"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/febs.13540","article-title":"p62\/SQSTM1 functions as a signaling hub and an autophagy adaptor","volume":"282","author":"Katsuragi","year":"2015","journal-title":"FEBS J"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.192260","article-title":"Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus","volume":"129","author":"Jaber","year":"2016","journal-title":"J Cell Sci"},{"key":"B46","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.devcel.2013.03.005","article-title":"The TBC\/RabGAP Armus coordinates Rac1 and Rab7 functions during autophagy","volume":"25","author":"Carroll","year":"2013","journal-title":"Dev Cell"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2291938","article-title":"The hookup model of the HOPS complex in autophagosome-lysosome fusion","volume":"20","author":"Zhang","year":"2024","journal-title":"Autophagy"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1016\/j.molcel.2017.02.010","article-title":"Pacer mediates the function of class III PI3K and HOPS complexes in autophagosome maturation by engaging Stx17","volume":"65","author":"Cheng","year":"2017","journal-title":"Mol Cell"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00392-4","article-title":"Machinery, regulation and pathophysiological implications of autophagosome maturation","volume":"22","author":"Zhao","year":"2021","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-111315-125407","article-title":"TFEB and TFE3: linking lysosomes to cellular adaptation to stress","volume":"32","author":"Raben","year":"2016","journal-title":"Annu Rev Cell Dev Biol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.202102001","article-title":"Lysosome biogenesis: Regulation and functions","volume":"220","author":"Yang","year":"2021","journal-title":"J Cell Biol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0037-z","article-title":"Cargo recognition and degradation by selective autophagy","volume":"20","author":"Gatica","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.09.005","article-title":"A diversity of selective autophagy receptors determines the specificity of the autophagy pathway","volume":"76","author":"Kirkin","year":"2019","journal-title":"Mol Cell"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.7150\/thno.49860","article-title":"Selective autophagy of intracellular organelles: recent research advances","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"B55","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.cmet.2011.04.004","article-title":"Autophagy in the cellular energetic balance","volume":"13","author":"Singh","year":"2011","journal-title":"Cell Metab"},{"key":"B56","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1186\/s12967-023-04367-1","article-title":"Mitochondrial metabolic dysfunction and non-alcoholic fatty liver disease: new insights from pathogenic mechanisms to clinically targeted therapy","volume":"21","author":"Zheng","year":"2023","journal-title":"J Transl Med"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1149809","article-title":"Emerging mechanistic insights of selective autophagy in hepatic diseases","volume":"14","author":"Alim Al-Bari","year":"2023","journal-title":"Front Pharmacol"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13010101","article-title":"Metabolic role of autophagy in the pathogenesis and development of NAFLD","volume":"13","author":"An","year":"2023","journal-title":"Metabolites"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176113","article-title":"Lipophagy and lipolysis status in lipid storage and lipid metabolism diseases","volume":"21","author":"Kloska","year":"2020","journal-title":"Int J Mol Sci"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201803153","article-title":"Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes","volume":"218","author":"Schott","year":"2019","journal-title":"J Cell Biol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.76","article-title":"Cytosolic lipolysis and lipophagy: two sides of the same coin","volume":"18","author":"Zechner","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3166","article-title":"Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis","volume":"17","author":"Kaushik","year":"2015","journal-title":"Nat Cell Biol"},{"key":"B63","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.freeradbiomed.2017.01.007","article-title":"ATG14 facilitated lipophagy in cancer cells induce ER stress mediated mitoptosis through a ROS dependent pathway","volume":"104","author":"Mukhopadhyay","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2718","article-title":"TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop","volume":"15","author":"Settembre","year":"2013","journal-title":"Nat Cell Biol"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17030387","article-title":"TFE3 alleviates hepatic steatosis through autophagy-induced lipophagy and PGC1\u03b1-mediated fatty acid \u03b2-oxidation","volume":"17","author":"Xiong","year":"2016","journal-title":"Int J Mol Sci"},{"key":"B66","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1038\/s41419-022-04593-3","article-title":"The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6675762","article-title":"Emerging roles of impaired autophagy in fatty liver disease and hepatocellular carcinoma","volume":"2021","author":"Niture","year":"2021","journal-title":"Int J Hepatol"},{"key":"B68","doi-asserted-by":"publisher","first-page":"7575","DOI":"10.1038\/s41598-023-34710-x","article-title":"Reduced mitophagy is an early feature of NAFLD and liver-specific PARKIN knockout hastens the onset of steatosis, inflammation and fibrosis","volume":"13","author":"Undamatla","year":"2023","journal-title":"Sci Rep"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.7150\/thno.79876","article-title":"Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation","volume":"13","author":"Lu","year":"2023","journal-title":"Theranostics"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1643185","article-title":"SQSTM1\/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN\/parkin in mitophagy","volume":"15","author":"Yamada","year":"2019","journal-title":"Autophagy"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-016-0807-8","article-title":"Autophagy in the liver: cell's cannibalism and beyond","volume":"39","author":"Flores-Toro","year":"2016","journal-title":"Arch Pharm Res"},{"key":"B72","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/embor.2009.256","article-title":"Nix is a selective autophagy receptor for mitochondrial clearance","volume":"11","author":"Novak","year":"2010","journal-title":"EMBO Rep"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.322933","article-title":"Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy","volume":"287","author":"Hanna","year":"2012","journal-title":"J Biol Chem"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101299","article-title":"Corrigendum to \"Mst1 inhibition attenuates non-alcoholic fatty liver disease via reversing Parkin-related mitophagy","volume":"28","author":"Zhou","year":"2020","journal-title":"Redox Biol"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15083","article-title":"Cyanidin-3-O-glucoside improves non-alcoholic fatty liver disease by promoting PINK1-mediated mitophagy in mice","volume":"177","author":"Li","year":"2020","journal-title":"Br J Pharmacol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.4161\/auto.3930","article-title":"ER-phagy: selective autophagy of the endoplasmic reticulum","volume":"3","author":"Bernales","year":"2007","journal-title":"Autophagy"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.06.008","article-title":"Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease","volume":"69","author":"Lebeaupin","year":"2018","journal-title":"J Hepatol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"e55192","DOI":"10.15252\/embr.202255192","article-title":"ER-phagy: selective autophagy of the endoplasmic reticulum","volume":"23","author":"Mochida","year":"2022","journal-title":"EMBO Rep"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nature14498","article-title":"Regulation of endoplasmic reticulum turnover by selective autophagy","volume":"522","author":"Khaminets","year":"2015","journal-title":"Nature"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.11.007","article-title":"Regulation of autophagy by canonical and non-canonical ER stress responses","volume":"66","author":"Bhardwaj","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1051","DOI":"10.1038\/s41419-022-05444-x","article-title":"Endoplasmic reticulum stress-mediated cell death in liver injury","volume":"13","author":"Zhang","year":"2022","journal-title":"Cell Death Dis"},{"key":"B82","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1111\/jpi.12264","article-title":"Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis","volume":"59","author":"Fern\u00e1ndez","year":"2015","journal-title":"J Pineal Res"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.129","article-title":"Endoplasmic reticulum stress, the unfolded protein response and autophagy in kidney diseases","volume":"13","author":"Cybulsky","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/nature07203","article-title":"From endoplasmic-reticulum stress to the inflammatory response","volume":"454","author":"Zhang","year":"2008","journal-title":"Nature"},{"key":"B85","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1186\/s12929-015-0206-3","article-title":"Caffeine reduces hepatic lipid accumulation through regulation of lipogenesis and ER stress in zebrafish larvae","volume":"22","author":"Zheng","year":"2015","journal-title":"J BioMed Sci"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23680","article-title":"Per- and polyfluoroalkyl substances activate UPR pathway, induce steatosis and fibrosis in liver cells","volume":"38","author":"Qi","year":"2023","journal-title":"Environ Toxicol"},{"key":"B87","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.bbrc.2019.03.077","article-title":"Metformin alleviates inflammatory response in non-alcoholic steatohepatitis by restraining signal transducer and activator of transcription 3-mediated autophagy inhibition in\u2002vitro and in\u2002vivo","volume":"513","author":"Li","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"key":"B88","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/01913123.2022.2156639","article-title":"Effects of metformin and simvastatin treatment on ultrastructural features of liver macrophages in HFD mice","volume":"47","author":"Ciric","year":"2023","journal-title":"Ultrastruct Pathol"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32048","article-title":"A mammalian target of rapamycin-perilipin 3 (mTORC1-plin3) pathway is essential to activate lipophagy and protects against hepatosteatosis","volume":"74","author":"Garcia-Macia","year":"2021","journal-title":"Hepatology"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231710055","article-title":"Autophagy dysregulation in metabolic associated fatty liver disease: A new therapeutic target","volume":"23","author":"Chen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2021.173976","article-title":"Research progress in use of traditional Chinese medicine monomer for treatment of non-alcoholic fatty liver disease","volume":"898","author":"Zhou","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2021.113869","article-title":"Pathophysiological communication between hepatocytes and non-parenchymal cells in liver injury from NAFLD to liver fibrosis","volume":"176","author":"Kumar","year":"2021","journal-title":"Adv Drug Delivery Rev"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23094","article-title":"Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis","volume":"50","author":"Fujita","year":"2009","journal-title":"Hepatology"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.04.004","article-title":"Adaptation of hepatic mitochondrial function in humans with non-alcoholic fatty liver is lost in steatohepatitis","volume":"21","author":"Koliaki","year":"2015","journal-title":"Cell Metab"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i14.1419","article-title":"Lipotoxic hepatocyte-derived exosomal miR-1297 promotes hepatic stellate cell activation through the PTEN signaling pathway in metabolic-associated fatty liver disease","volume":"27","author":"Luo","year":"2021","journal-title":"World J Gastroenterol"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1038\/nature07976","article-title":"Autophagy regulates lipid metabolism","volume":"458","author":"Singh","year":"2009","journal-title":"Nature"},{"key":"B97","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1080\/15548627.2021.1895658","article-title":"The m\u00e9nage \u00e0 trois of autophagy, lipid droplets and liver disease","volume":"18","author":"Filali-Mouncef","year":"2022","journal-title":"Autophagy"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3760\/cma.j.cn501113-20220428-00223","article-title":"[Macrophage heterogeneity role in NAFLD and NASH disease progression]","volume":"31","author":"Yang","year":"2023","journal-title":"Zhonghua Gan Zang Bing Za Zhi"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1055\/s-0030-1255354","article-title":"Macrophages: master regulators of inflammation and fibrosis","volume":"30","author":"Wynn","year":"2010","journal-title":"Semin Liver Dis"},{"key":"B100","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/s41423-020-00558-8","article-title":"Hepatic macrophages in liver homeostasis and diseases-diversity, plasticity and therapeutic opportunities","volume":"18","author":"Wen","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/srep44612","article-title":"Effect of modulation of PPAR-\u03b3 activity on Kupffer cells M1\/M2 polarization in the development of non-alcoholic fatty liver disease","volume":"7","author":"Luo","year":"2017","journal-title":"Sci Rep"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2018.08.006","article-title":"Fatty acid activates NLRP3 inflammasomes in mouse Kupffer cells through mitochondrial DNA release","volume":"332","author":"Pan","year":"2018","journal-title":"Cell Immunol"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.v8i23","article-title":"Inhibition of NLRP3 inflammasome by thioredoxin-interacting protein in mouse Kupffer cells as a regulatory mechanism for non-alcoholic fatty liver disease development","volume":"8","author":"He","year":"2017","journal-title":"Oncotarget"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110304","article-title":"ATRA-mediated-crosstalk between stellate cells and Kupffer cells inhibits autophagy and promotes NLRP3 activation in acute liver injury","volume":"93","author":"Yu","year":"2022","journal-title":"Cell Signal"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1150118","article-title":"Major roles of kupffer cells and macrophages in NAFLD development","volume":"14","author":"Park","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B106","doi-asserted-by":"publisher","first-page":"e33698","DOI":"10.1097\/MD.0000000000033698","article-title":"Autophagy in hepatic macrophages can be regulator and potential therapeutic target of liver diseases: A review","volume":"102","author":"Ge","year":"2023","journal-title":"Med (Baltimore)"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00013.2007","article-title":"Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver","volume":"88","author":"Friedman","year":"2008","journal-title":"Physiol Rev"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.24.8681","article-title":"Hepatic lipocytes: the principal collagen-producing cells of normal rat liver","volume":"82","author":"Friedman","year":"1985","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B109","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1038\/nrgastro.2017.38","article-title":"Mechanisms of hepatic stellate cell activation","volume":"14","author":"Tsuchida","year":"2017","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2023.02.010","article-title":"Hepatic stellate cells: dictating outcome in nonalcoholic fatty liver disease","volume":"15","author":"Wiering","year":"2023","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.47162\/rjme.61.3.01","article-title":"Hepatic stellate cells - from past till present: morphology, human markers, human cell lines, behavior in normal and liver pathology","volume":"61","author":"Sufle\u0163el","year":"2020","journal-title":"Rom J Morphol Embryol"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.11.311","article-title":"Mechanisms of fibrosis development in nonalcoholic steatohepatitis","volume":"158","author":"Schwabe","year":"2020","journal-title":"Gastroenterology"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.867940","article-title":"Hepatic stellate cell-immune interactions in NASH","volume":"13","author":"Carter","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aal3694","article-title":"Type 2 immunity is protective in metabolic disease but exacerbates NAFLD collaboratively with TGF-\u03b2","volume":"9","author":"Hart","year":"2017","journal-title":"Sci Transl Med"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.044","article-title":"Hepatic stellate cell autophagy inhibits extracellular vesicle release to attenuate liver fibrosis","volume":"73","author":"Gao","year":"2020","journal-title":"J Hepatol"},{"key":"B116","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1007\/s00018-022-04319-w","article-title":"Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2\/EP4 pathway","volume":"79","author":"Cao","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1002\/(ISSN)1527-3350","article-title":"The liver sieve: considerations concerning the structure and function of endothelial fenestrae, the sinusoidal wall and the space of Disse","volume":"5","author":"Wisse","year":"1985","journal-title":"Hepatology"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00062.2020","article-title":"New aspects of hepatic endothelial cells in physiology and nonalcoholic fatty liver disease","volume":"318","author":"Sun","year":"2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.3390\/cells11162511","article-title":"Endothelial cell dysfunction and nonalcoholic fatty liver disease (NAFLD): A concise review","volume":"11","author":"Nasiri-Ansari","year":"2022","journal-title":"Cells"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.655557","article-title":"Targeting liver sinusoidal endothelial cells: an attractive therapeutic strategy to control inflammation in nonalcoholic fatty liver disease","volume":"12","author":"Wang","year":"2021","journal-title":"Front Pharmacol"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3390\/cells9040929","article-title":"The endothelium as a driver of liver fibrosis and regeneration","volume":"9","author":"Lafoz","year":"2020","journal-title":"Cells"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0032785","article-title":"Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD","volume":"7","author":"Pasar\u00edn","year":"2012","journal-title":"PloS One"},{"key":"B123","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1186\/s12964-024-01720-9","article-title":"Role of liver sinusoidal endothelial cell in metabolic dysfunction-associated fatty liver disease","volume":"22","author":"He","year":"2024","journal-title":"Cell Commun Signal"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2015.95","article-title":"Pivotal role of liver sinusoidal endothelial cells in NAFLD\/NASH progression","volume":"95","author":"Miyao","year":"2015","journal-title":"Lab Invest"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.671735","article-title":"Exosome adherence and internalization by hepatic stellate cells triggers sphingosine 1-phosphate-dependent migration","volume":"290","author":"Wang","year":"2015","journal-title":"J Biol Chem"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2008.07.008","article-title":"Cellular sources of extracellular matrix in hepatic fibrosis","volume":"12","author":"Wells","year":"2008","journal-title":"Clin Liver Dis"},{"key":"B127","doi-asserted-by":"publisher","first-page":"e0159217","DOI":"10.1371\/journal.pone.0159217","article-title":"Free fatty acids differentially downregulate chemokines in liver sinusoidal endothelial cells: insights into non-alcoholic fatty liver disease","volume":"11","author":"McMahan","year":"2016","journal-title":"PloS One"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.02.012","article-title":"Role of liver sinusoidal endothelial cells in non-alcoholic fatty liver disease","volume":"70","author":"Hammoutene","year":"2019","journal-title":"J Hepatol"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmgh.2015.05.005","article-title":"Functional and structural features of cholangiocytes in health and disease","volume":"1","author":"Maroni","year":"2015","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.06.024","article-title":"Pathobiology of biliary epithelia","volume":"1864","author":"Cheung","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.06.017","article-title":"Mechanisms of cholangiocyte responses to injury","volume":"1864","author":"Sato","year":"2018","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27341","article-title":"Cholangiocyte lipoapoptosis: implications for biliary damage during nonalcoholic fatty liver disease","volume":"60","author":"Mart\u00ednez","year":"2014","journal-title":"Hepatology"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3390\/cells10082072","article-title":"Feedback signaling between cholangiopathies, ductular reaction, and non-alcoholic fatty liver disease","volume":"10","author":"Zhou","year":"2021","journal-title":"Cells"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2011.090175","article-title":"Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease","volume":"64","author":"Chiba","year":"2011","journal-title":"J Clin Pathol"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/s41374-018-0093-9","article-title":"Knockout of secretin receptor reduces biliary damage and liver fibrosis in Mdr2(-\/-) mice by diminishing senescence of cholangiocytes","volume":"98","author":"Zhou","year":"2018","journal-title":"Lab Invest"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.07.023","article-title":"Proliferating cholangiocytes: a neuroendocrine compartment in the diseased liver","volume":"132","author":"Alvaro","year":"2007","journal-title":"Gastroenterology"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27592","article-title":"Conjugated bile acid-activated S1P receptor 2 is a key regulator of sphingosine kinase 2 and hepatic gene expression","volume":"61","author":"Nagahashi","year":"2015","journal-title":"Hepatology"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.784322","article-title":"Farnesoid X receptor induces Takeda G-protein receptor 5 cross-talk to regulate bile acid synthesis and hepatic metabolism","volume":"292","author":"Pathak","year":"2017","journal-title":"J Biol Chem"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31871","article-title":"Inhibition of secretin\/secretin receptor axis ameliorates NAFLD phenotypes","volume":"74","author":"Chen","year":"2021","journal-title":"Hepatology"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155200","article-title":"Schisandrin B mitigates hepatic steatosis and promotes fatty acid oxidation by inducing autophagy through AMPK\/mTOR signaling pathway","volume":"131","author":"Yan","year":"2022","journal-title":"Metabolism"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.07.094","article-title":"Autophagy is involved in acetylshikonin ameliorating non-alcoholic steatohepatitis through AMPK\/mTOR pathway","volume":"503","author":"Zeng","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020818","article-title":"Empagliflozin attenuates non-alcoholic fatty liver disease (NAFLD) in high fat diet fed ApoE((-\/-)) mice by activating autophagy and reducing ER stress and apoptosis","volume":"22","author":"Nasiri-Ansari","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B143","doi-asserted-by":"publisher","first-page":"46","DOI":"10.4161\/15548627.2014.984271","article-title":"Metformin alleviates hepatosteatosis by restoring SIRT1-mediated autophagy induction via an AMP-activated protein kinase-independent pathway","volume":"11","author":"Song","year":"2015","journal-title":"Autophagy"},{"key":"B144","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1039\/D0FO02501A","article-title":"Berbamine induced activation of the SIRT1\/LKB1\/AMPK signaling axis attenuates the development of hepatic steatosis in high-fat diet-induced NAFLD rats","volume":"12","author":"Sharma","year":"2021","journal-title":"Food Funct"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.589273","article-title":"Dapagliflozin alleviates hepatic steatosis by restoring autophagy via the AMPK-mTOR pathway","volume":"12","author":"Li","year":"2021","journal-title":"Front Pharmacol"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114005","article-title":"Induction of autophagy via the PI3K\/Akt\/mTOR signaling pathway by Pueraria flavonoids improves non-alcoholic fatty liver disease in obese mice","volume":"157","author":"Sun","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B147","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12944-023-01787-2","article-title":"Ginsenoside Rg1 attenuates the NASH phenotype by regulating the miR-375-3p\/ATG2B\/PTEN-AKT axis to mediate autophagy and pyroptosis","volume":"22","author":"Chen","year":"2023","journal-title":"Lipids Health Dis"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158267","article-title":"COX-2\/sEH dual inhibitor alleviates hepatocyte senescence in NAFLD mice by restoring autophagy through Sirt1\/PI3K\/AKT\/mTOR","volume":"23","author":"Zhang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B149","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bbrc.2016.05.086","article-title":"GLP-1 analogue improves hepatic lipid accumulation by inducing autophagy via AMPK\/mTOR pathway","volume":"476","author":"He","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10304","article-title":"LRG ameliorates steatohepatitis by activating the AMPK\/mTOR\/SREBP1 signaling pathway in C57BL\/6J mice fed a high\u2212fat diet","volume":"20","author":"Hao","year":"2019","journal-title":"Mol Med Rep"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.05.128","article-title":"Ursodeoxycholic acid alleviates nonalcoholic fatty liver disease by inhibiting apoptosis and improving autophagy via activating AMPK","volume":"529","author":"Wu","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"key":"B152","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.ejphar.2019.02.005","article-title":"Acetaminophen aggravates fat accumulation in NAFLD by inhibiting autophagy via the AMPK\/mTOR pathway","volume":"850","author":"Shi","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2020.170422","article-title":"Chemerin\/CMKLR1 ameliorates nonalcoholic steatohepatitis by promoting autophagy and alleviating oxidative stress through the JAK2-STAT3 pathway","volume":"135","author":"An","year":"2021","journal-title":"Peptides"},{"key":"B154","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1038\/s41467-020-14384-z","article-title":"Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase","volume":"11","author":"Byun","year":"2020","journal-title":"Nat Commun"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154746","article-title":"Aescin can alleviate NAFLD through Keap1-Nrf2 by activating antioxidant and autophagy","volume":"113","author":"Yu","year":"2023","journal-title":"Phytomedicine"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9100924","article-title":"Involvement of HO-1 and autophagy in the protective effect of magnolol in hepatic steatosis-induced NLRP3 inflammasome activation in vivo and in vitro","volume":"9","author":"Kuo","year":"2020","journal-title":"Antioxidants (Basel)"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13107","article-title":"Curcumol inhibits ferritinophagy to restrain hepatocyte senescence through YAP\/NCOA4 in non-alcoholic fatty liver disease","volume":"54","author":"Qi","year":"2021","journal-title":"Cell Prolif"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112578","article-title":"1,3-dichloro-2-propanol induced hepatic lipid accumulation by inhibiting autophagy via AKT\/mTOR\/FOXO1 pathway in mice","volume":"157","author":"Fan","year":"2021","journal-title":"Food Chem Toxicol"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.14218\/JCTH.2021.00050","article-title":"Icaritin attenuates lipid accumulation by increasing energy expenditure and autophagy regulated by phosphorylating AMPK","volume":"9","author":"Wu","year":"2021","journal-title":"J Clin Transl Hepatol"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7344","article-title":"Scutellarin ameliorates hepatic lipid accumulation by enhancing autophagy and suppressing IRE1\u03b1\/XBP1 pathway","volume":"36","author":"Zhang","year":"2022","journal-title":"Phytother Res"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1080\/21623945.2021.1983241","article-title":"Verapamil induces autophagy to improve liver regeneration in non-alcoholic fatty liver mice","volume":"10","author":"Lai","year":"2021","journal-title":"Adipocyte"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S317701","article-title":"Doxazosin attenuates liver fibrosis by inhibiting autophagy in hepatic stellate cells via activation of the PI3K\/Akt\/mTOR signaling pathway","volume":"15","author":"Xiu","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.107492","article-title":"The SGLT2 inhibitor empagliflozin negatively regulates IL-17\/IL-23 axis-mediated inflammatory responses in T2DM with NAFLD via the AMPK\/mTOR\/autophagy pathway","volume":"94","author":"Meng","year":"2021","journal-title":"Int Immunopharmacol"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11992","article-title":"Imatinib suppresses activation of hepatic stellate cells by targeting STAT3\/IL-6 pathway through miR-124","volume":"47","author":"Alavifard","year":"2023","journal-title":"Cell Biol Int"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155516","article-title":"Metformin-induced TTP mediates communication between Kupffer cells and hepatocytes to alleviate hepatic steatosis by regulating lipophagy and necroptosis","volume":"141","author":"Park","year":"2023","journal-title":"Metabolism"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109895","article-title":"Scoparone improves hepatic inflammation and autophagy in mice with nonalcoholic steatohepatitis by regulating the ROS\/P38\/Nrf2 axis and PI3K\/AKT\/mTOR pathway in macrophages","volume":"125","author":"Liu","year":"2020","journal-title":"BioMed Pharmacother"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105797","article-title":"Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4\/NF-\u03baB signaling pathway in mice","volume":"75","author":"Liu","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2018.06.005","article-title":"Alisol A 24-acetate ameliorates nonalcoholic steatohepatitis by inhibiting oxidative stress and stimulating autophagy through the AMPK\/mTOR pathway","volume":"291","author":"Wu","year":"2018","journal-title":"Chem Biol Interact"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2022.0110","article-title":"Beneficial effects of a curcumin derivative and transforming growth factor-\u03b2 Receptor I inhibitor combination on nonalcoholic steatohepatitis","volume":"47","author":"Ha","year":"2023","journal-title":"Diabetes Metab J"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.30487","article-title":"Curcumin inhibits the activity and induces apoptosis of activated hepatic stellate cell by suppressing autophagy","volume":"124","author":"Shu","year":"2023","journal-title":"J Cell Biochem"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2023.5243","article-title":"Dihydroartemisinin inhibits the activation and proliferation of hepatic stellate cells by regulating miR\u221229b\u22123p","volume":"51","author":"Huan","year":"2023","journal-title":"Int J Mol Med"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.959495","article-title":"Glycyrrhetinic acid regulates impaired macrophage autophagic flux in the treatment of non-alcoholic fatty liver disease","volume":"13","author":"Fan","year":"2022","journal-title":"Front Immunol"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00230.2021","article-title":"MAPK p38\/Ulk1 pathway inhibits autophagy and induces IL-1\u03b2 expression in hepatic stellate cells","volume":"322","author":"Jin","year":"2022","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"B174","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.lfs.2017.03.012","article-title":"Palmitic acid elicits hepatic stellate cell activation through inflammasomes and hedgehog signaling","volume":"176","author":"Duan","year":"2017","journal-title":"Life Sci"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14463","article-title":"Resveratrol inhibits hepatic stellate cell activation by regulating autophagy and apoptosis through the SIRT1 and JNK signaling pathways","volume":"46","author":"Zhang","year":"2022","journal-title":"J Food Biochem"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.938856","article-title":"Salvianolic acid B inhibits autophagy and activation of hepatic stellate cells induced by TGF-\u03b21 by downregulating the MAPK pathway","volume":"13","author":"Jiang","year":"2022","journal-title":"Front Pharmacol"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115673","article-title":"Vanillic acid alleviates liver fibrosis through inhibiting autophagy in hepatic stellate cells via the MIF\/CD74 signaling pathway","volume":"168","author":"Qin","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v29.i33.4975","article-title":"Angiotensin-converting enzyme 2 improves liver fibrosis in mice by regulating autophagy of hepatic stellate cells","volume":"29","author":"Wu","year":"2023","journal-title":"World J Gastroenterol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.15639","article-title":"Lp-PLA2 silencing ameliorates inflammation and autophagy in nonalcoholic steatohepatitis through inhibiting the JAK2\/STAT3 pathway","volume":"11","author":"Yao","year":"2023","journal-title":"PeerJ"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.000885","article-title":"Maresin 1 attenuates NAFLD by suppression of endoplasmic reticulum stress via AMPK-SERCA2b pathway","volume":"293","author":"Jung","year":"2018","journal-title":"J Biol Chem"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12731","article-title":"TIM-4 interference in Kupffer cells against CCL4-induced liver fibrosis by mediating Akt1\/Mitophagy signalling pathway","volume":"53","author":"Wu","year":"2020","journal-title":"Cell Prolif"},{"key":"B182","doi-asserted-by":"publisher","first-page":"990","DOI":"10.4049\/jimmunol.1900117","article-title":"Tim-4 inhibits NLRP3 inflammasome via the LKB1\/AMPK\u03b1 Pathway in macrophages","volume":"203","author":"Liu","year":"2019","journal-title":"J Immunol"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.602574","article-title":"Liraglutide alleviates hepatic steatosis by activating the TFEB-regulated autophagy-lysosomal pathway","volume":"8","author":"Fang","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154798","article-title":"Fenofibrate, a PPAR\u03b1 agonist, reduces hepatic fat accumulation through the upregulation of TFEB-mediated lipophagy","volume":"120","author":"Yoo","year":"2021","journal-title":"Metabolism"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.12.012","article-title":"Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"B186","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.fct.2018.02.019","article-title":"Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a\/XBP1s pathway","volume":"114","author":"Zhu","year":"2018","journal-title":"Food Chem Toxicol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154235","article-title":"Phillygenin ameliorates nonalcoholic fatty liver disease via TFEB-mediated lysosome biogenesis and lipophagy","volume":"103","author":"Zhou","year":"2022","journal-title":"Phytomedicine"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.10.010","article-title":"LAMP3 regulates hepatic lipid metabolism through activating PI3K\/Akt pathway","volume":"470","author":"Liao","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"B189","doi-asserted-by":"publisher","first-page":"992","DOI":"10.3748\/wjg.v24.i9.992","article-title":"Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury","volume":"24","author":"Zheng","year":"2018","journal-title":"World J Gastroenterol"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110990","article-title":"Baicalein attenuates impairment of hepatic lysosomal acidification induced by high fat diet via maintaining V-ATPase assembly","volume":"136","author":"Zhu","year":"2020","journal-title":"Food Chem Toxicol"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105964","article-title":"Ajugol enhances TFEB-mediated lysosome biogenesis and lipophagy to alleviate non-alcoholic fatty liver disease","volume":"174","author":"Zhang","year":"2021","journal-title":"Pharmacol Res"},{"key":"B192","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.apsb.2021.07.021","article-title":"Therapeutic regulation of autophagy in hepatic metabolism","volume":"12","author":"Byrnes","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"B193","doi-asserted-by":"publisher","first-page":"2573","DOI":"10.1038\/s41467-023-38165-6","article-title":"Restoration of lysosomal acidification rescues autophagy and metabolic dysfunction in non-alcoholic fatty liver disease","volume":"14","author":"Zeng","year":"2023","journal-title":"Nat Commun"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.01.026","article-title":"Autophagy in liver diseases: Time for translation","volume":"70","author":"Allaire","year":"2019","journal-title":"J Hepatol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1374644\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T04:38:54Z","timestamp":1723091934000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1374644\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,8]]},"references-count":194,"alternative-id":["10.3389\/fendo.2024.1374644"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2024.1374644","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,8]]},"article-number":"1374644"}}