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Endocrinol."],"abstract":"<jats:p>As an important gas signaling molecule, hydrogen sulfide (H<jats:sub>2<\/jats:sub>S) affects multiple organ systems, including the nervous, cardiovascular, digestive, and genitourinary, reproductive systems. In particular, H<jats:sub>2<\/jats:sub>S not only regulates female reproductive function but also holds great promise in the treatment of male reproductive diseases and disorders, such as erectile dysfunction, prostate cancer, varicocele, and infertility. In this review, we summarize the relationship between H<jats:sub>2<\/jats:sub>S and male reproductive organs, including the penis, testis, prostate, vas deferens, and epididymis. As lower urinary tract symptoms have a significant impact on penile erection disorders, we also address the potential ameliorative effects of H<jats:sub>2<\/jats:sub>S in erectile dysfunction resulting from bladder disease. Additionally, we discuss the regulatory role of H<jats:sub>2<\/jats:sub>S in cavernous smooth muscle relaxation, which involves the NO\/cGMP pathway, the RhoA\/Rho-kinase pathway, and K<jats:sup>+<\/jats:sup> channel activation. Recently, various compounds that can alleviate erectile dysfunction have been reported to be at least partly dependent on H<jats:sub>2<\/jats:sub>S. Therefore, understanding the role of H<jats:sub>2<\/jats:sub>S in the male reproductive system may help develop novel strategies for the clinical treatment of male reproductive system diseases.<\/jats:p>","DOI":"10.3389\/fendo.2024.1377090","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T11:39:41Z","timestamp":1717069181000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":12,"title":["Role of hydrogen sulfide in the male reproductive system"],"prefix":"10.3389","volume":"15","author":[{"given":"Yunjia","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caiyun","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyou","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xutao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-021-02071-z","article-title":"Microenvironment for spermatogenesis and sperm maturation","volume":"157","author":"Miyaso","year":"2022","journal-title":"Histochem Cell Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"103183","DOI":"10.1016\/j.jri.2020.103183","article-title":"Bacterial infection of the male reproductive system causing infertility","volume":"142","author":"Farsimadan","year":"2020","journal-title":"J Reprod Immunol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.alcohol.2021.08.003","article-title":"Male subfertility effects of sub-chronic ethanol exposure during stress in a rat model","volume":"96","author":"Fozooni","year":"2021","journal-title":"Alcohol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"152780","DOI":"10.1016\/j.tox.2021.152780","article-title":"Environmental pollutants exposure and male reproductive toxicity: The role of epigenetic modifications","volume":"456","author":"Han","year":"2021","journal-title":"Toxicology"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22783","article-title":"miRNA-138\u20135p suppresses cigarette smoke-induced apoptosis in testicular cells by targeting Caspase-3 through the Bcl-2 signaling pathway","volume":"35","author":"He","year":"2021","journal-title":"J Biochem Mol Toxicol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1111\/1753-0407.12181","article-title":"Role of oxidative stress-induced systemic and cavernosal molecular alterations in the progression of diabetic erectile dysfunction","volume":"7","author":"Castela","year":"2015","journal-title":"J Diabetes"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297922050030","article-title":"Oxidative stress and redox-dependent signaling in prostate cancer","volume":"87","author":"Kalinina","year":"2022","journal-title":"Biochem (Mosc)"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.22037\/uj.v0i0.4740","article-title":"Evaluation of oxidative stress in testis and sperm of rat following induced varicocele","volume":"16","author":"Erfani","year":"2019","journal-title":"Urol. 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