{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T13:42:57Z","timestamp":1791726177671,"version":"4.3.4"},"reference-count":24,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T00:00:00Z","timestamp":1712534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies suggest a link between the Klotho protein, sex hormones, and insulin-like growth factor-1 (IGF-1), indicating that \u03b1-Klotho levels may rise during puberty, including in central precocious puberty (CPP) cases. This study aimed to explore \u03b1-Klotho levels in girls with CPP to assess its potential as a diagnostic and monitoring tool for this condition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 139 girls, comprising 82 patients diagnosed with CPP and 57 healthy prepubertal controls, were enrolled in this study. From March 2020 to May 2023, we assessed both \u03b1-Klotho levels and clinical parameters. \u03b1-Klotho concentrations were measured using an \u03b1-Klotho ELISA kit. For the girls with CPP, we additionally analyzed samples taken 6 months after GnRH agonist treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>\u03b1-Klotho levels were higher in the CPP group compared with the control (CPP group: 2529 \u00b1 999 ng\/mL; control group: 1802 \u00b1 675 pg\/mL) (P &amp;lt; 0.001), and its level modest decreased after 6 months of GnRH agonist treatment (2147\u00b1 789 pg\/mL) (P &amp;lt; 0.001). The association between \u03b1-Klotho and IGF-1 SDS, follicular stimulating hormone and baseline luteinizing hormone was assessed by partial correlation after adjusting for age, BMI SDS (r= 0.416, p= &amp;lt;0.001; r= 0.261, p= 0.005; r= 0.278, p= 0.002), respectively. Receiver operating characteristic curve analysis identified an \u03b1-Klotho cut-off differentiating CPP from controls, with a cut-off of 1914 pg\/mL distinguishing girls with CPP from controls with a sensitivity of 69.5% and specificity of 70.2%; the area under the curve was 0.723.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings of our study are the first step towards deciphering the role of \u03b1-Klotho in puberty induction. With additional data and further research, \u03b1-Klotho could potentially be utilized as a significant diagnostic and monitoring tool for CPP.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1383812","type":"journal-article","created":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T04:24:13Z","timestamp":1712550253000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["\u03b1-Klotho levels in girls with central precocious puberty: potential as a diagnostic and monitoring marker"],"prefix":"10.3389","volume":"15","author":[{"given":"Jun-Hong","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eu-Seon","family":"Noh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Il 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