{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:52:29Z","timestamp":1753890749771,"version":"3.41.2"},"reference-count":8,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>A 51-year-old female patient with diabetes mellitus and hypertension, exhibiting poor control of blood sugar and blood pressure, was unexpectedly found to have multiple large adrenal nodules, excessive cortisol secretion, and adrenocorticotropic hormone inhibition. Cortisol levels remained unresponsive to both low-dose and high-dose dexamethasone tests, leading to a diagnosis of primary bilateral macronodular adrenal hyperplasia. Concurrently, elevated blood calcium and parathyroid hormone levels, along with 99mTc-methoxyisobutyl isonitrile (99mTc-MIBI) imaging revealing increased 99mTc-MIBI uptake in the right inferior parathyroid gland, suggest the consideration of primary hyperparathyroidism. This case is presented in light of the uncommon clinical coexistence of primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism.<\/jats:p>","DOI":"10.3389\/fendo.2024.1383987","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:18:06Z","timestamp":1734322686000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Case report: A 51-year-old diabetic patient with primary bilateral macronodular adrenal hyperplasia and primary hyperparathyroidism"],"prefix":"10.3389","volume":"15","author":[{"given":"Yuan","family":"Zhong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenxi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1007\/s12020-021-02645-w","article-title":"Update on primary bilateral macronodular adrenal hyperplasia (PBMAH)","volume":"71","author":"Bouys","year":"2021","journal-title":"Endocrine"},{"key":"B2","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1210\/edrv.22.1.0420","article-title":"Ectopic and abnormal hormone receptors in adrenal Cushing\u2019s syndrome","volume":"22","author":"Lacroix","year":"2001","journal-title":"Endocr Rev"},{"key":"B3","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/j.tem.2004.08.007","article-title":"Cushing\u2019s syndrome variant secondary to aberrant hormone receptors","volume":"15","author":"Lacroix","year":"2004","journal-title":"Trends Endocrinol Metab"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMe1312792","article-title":"Heredity and cortisol regulation in bilateral macronodular adrenal\u00a0hyperplasia","volume":"369","author":"Lacroix","year":"2013","journal-title":"N Engl J Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1215245","article-title":"Intraadrenal corticotropin in bilateral macronodular adrenal hyperplasia","volume":"369","author":"Louiset","year":"2013","journal-title":"N Engl J Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.48.677","article-title":"A natural\u00a0history of adrenocorticotropin-independent bilateral adrenal macronodular hyperplasia (AIMAH) from preclinical to clinically overt Cushing\u2019s syndrome","volume":"48","author":"Ohashi","year":"2001","journal-title":"Endocr J"},{"key":"B7","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1210\/endrev\/bnac034","article-title":"Clinical, pathophysiologic, genetic, and therapeutic progress in primary bilateral macronodular adrenal hyperplasia","volume":"44","author":"Bertherat","year":"2023","journal-title":"Endocr Rev"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.12182\/20230160513","article-title":"Value of baseline calcitonin for differential diagnosis of medullary thyroid cancer","volume":"54","author":"Liu","year":"2023","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1383987\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T04:18:10Z","timestamp":1734322690000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1383987\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,16]]},"references-count":8,"alternative-id":["10.3389\/fendo.2024.1383987"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2024.1383987","relation":{},"ISSN":["1664-2392"],"issn-type":[{"type":"electronic","value":"1664-2392"}],"subject":[],"published":{"date-parts":[[2024,12,16]]},"article-number":"1383987"}}