{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:58:47Z","timestamp":1770465527848,"version":"3.49.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>We present the evolution of GHD in adolescent males with persistent growth failure, in whom the diagnosis was established after a second GH stimulation test (GST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of children who presented for short stature (height less &amp;lt; 2SD for mean\/mid-parental height) and\/or growth failure (sustained growth velocity &amp;lt; 0 SD) to pediatric endocrinology at Mount Sinai Kravis Children\u2019s Hospital, New York and who had 2 GSTs. Data collected from electronic medical records were analyzed using SPSS v28.0<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 53 patients included, 42 were males. Average GH peak on initial GST was 15.48 \u00b1 4.92 ng\/ml, at 10.07 \u00b1 2.65 years, mean height -1.68 \u00b1 0.56SD(28% had &amp;lt;2SD), IGF-1 -1.00 \u00b1 0.88SD. After 2.23 \u00b1 1.22 years, at 12.04 \u00b1 2.41years, height SDs decreased to -1.82 \u00b1 0.63SD and IGF-1 was -1.08 \u00b1 0.84SD. At repeat GST, average GH peak was 7.59 \u00b1 2.12 ng\/dL, with 36% \u22647 ng\/dl and 32% in puberty. 12 males reached adult height of 0.08 \u00b1 0.69 SD with a mean height gain of 1.83 \u00b1 0.56SD(p&amp;lt;0.005), IGF-1 of -1.15 \u00b1 0.81SD after 4.64 \u00b1 1.4 years of GH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We offer evidence for Evolving Growth Hormone Deficiency (EGHD) through repeat GST in children with persistent growth slowdown, even with pubertal progression; emphasizing the need for careful longitudinal follow-up to make accurate diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1398171","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T14:23:45Z","timestamp":1714573425000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Evolving growth hormone deficiency: proof of concept"],"prefix":"10.3389","volume":"15","author":[{"given":"Sri Nikhita","family":"Chimatapu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swathi","family":"Sethuram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie G.","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Klomhaus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassie","family":"Mintz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin O.","family":"Savage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Rapaport","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,5,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6084.427","article-title":"Prevalence of severe growth hormone deficiency","volume":"2","author":"Vimpani","year":"1977","journal-title":"BMJ"},{"key":"B2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/MED.0b013e32834ec952","article-title":"Diagnosis of growth hormone deficiency in childhood","volume":"19","author":"Stanley","year":"2012","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B3","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S1096-6374(98)80001-4","article-title":"Pharmacological testing for the diagnosis of growth hormone deficiency","volume":"8","author":"Carel","year":"1998","journal-title":"Growth Horm IGF Res"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(95)70019-6","article-title":"Guidelines for the use of growth hormone in children with short stature. 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