{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T04:42:31Z","timestamp":1792298551399,"version":"4.4.0"},"reference-count":175,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Infertility is becoming a major public health problem, with increasing frequency due to medical, environmental and societal causes. The increasingly late age of childbearing, growing exposure to endocrine disruptors and other reprotoxic products, and increasing number of medical reproductive dysfunctions (endometriosis, polycystic ovary syndrome, etc.) are among the most common causes. Fertility relies on fine-tuned control of both neuroendocrine function and reproductive behaviors, those are critically regulated by sex steroid hormones. Testosterone and estradiol exert organizational and activational effects throughout life to establish and activate the neural circuits underlying reproductive function. This regulation is mediated through estrogen receptors (ERs) and androgen receptor (AR). Estradiol acts mainly via nuclear estrogen receptors ER\u03b1 and ER\u03b2. The aim of this review is to summarize the genetic studies that have been undertaken to comprehend the specific contribution of ER\u03b1 and ER\u03b2 in the neural circuits underlying the regulation of the hypothalamic-pituitary-gonadal axis and the expression of reproductive behaviors, including sexual and parental behavior. Particular emphasis will be placed on the neural role of these receptors and the underlying sex differences.<\/jats:p>","DOI":"10.3389\/fendo.2024.1408677","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:29:16Z","timestamp":1719188956000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":27,"title":["Reproductive function and behaviors: an update on the role of neural estrogen receptors alpha and beta"],"prefix":"10.3389","volume":"15","author":[{"given":"Thomas","family":"Torres","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nolwenn","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakina","family":"Mhaouty-Kodja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydie","family":"Naul\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/B978-0-12-397175-3.00011-9","article-title":"Chapter 11 - physiology of the adult gonadotropin-releasing hormone neuronal network","volume-title":"Knobil and Neill\u2019s Physiology of Reproduction","author":"Herbison","year":"2015"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod64.3.735","article-title":"Negative feedback regulation of the secretion and actions of gonadotropin-releasing hormone in males","volume":"64","author":"Tilbrook","year":"2001","journal-title":"Biol Reprod"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2007.05.006","article-title":"Estrogen positive feedback to gonadotropin-releasing hormone (GnRH) neurons in the rodent: the case for the rostral periventricular area of the third ventricle (RP3V)","volume":"57","author":"Herbison","year":"2008","journal-title":"Brain Res Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1177\/1933719107301059","article-title":"Estrogen-induced hypothalamic synaptic plasticity and pituitary sensitization in the control of the estrogen-induced gonadotrophin surge","volume":"14","author":"Naftolin","year":"2007","journal-title":"Reprod Sci Thousand Oaks Calif"},{"key":"B5","doi-asserted-by":"publisher","first-page":"bqaa209","DOI":"10.1210\/endocr\/bqaa209","article-title":"Puberty, A sensitive window of hypothalamic development and plasticity","volume":"162","author":"Naul\u00e9","year":"2021","journal-title":"Endocrinology"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1569-09.2009","article-title":"Regulation of gonadotropin-releasing hormone secretion by kisspeptin\/dynorphin\/neurokinin B neurons in the arcuate nucleus of the mouse","volume":"29","author":"Navarro","year":"2009","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1775-08.2008","article-title":"Kisspeptin-GPR54 signaling is essential for preovulatory gonadotropin-releasing hormone neuron activation and the luteinizing hormone surge","volume":"28","author":"Clarkson","year":"2008","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/0018-506X(76)90008-8","article-title":"Sexual attractivity, proceptivity, and receptivity in female mammals","volume":"7","author":"Beach","year":"1976","journal-title":"Horm Behav"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(70)90167-8","article-title":"Hormonal control of sexual receptivity during the estrous cycle of the rat","volume":"5","author":"Powers","year":"1970","journal-title":"Physiol Behav"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1159\/000494558","article-title":"Sexual behavior: from hormonal regulation to endocrine disruption","volume":"107","author":"Mhaouty-Kodja","year":"2018","journal-title":"Neuroendocrinology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/183055a0","article-title":"Pheromones\u2019: a new term for a class of biologically active substances","volume":"183","author":"Karlson","year":"1959","journal-title":"Nature"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1038\/nature05404","article-title":"Pheromonal communication in vertebrates","volume":"444","author":"Brennan","year":"2006","journal-title":"Nature"},{"key":"B13","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/cne.901970107","article-title":"Connections of the corticomedial amygdala in the golden hamster. I. Efferents of the \u201cvomeronasal amygdala.\u201d","volume":"197","author":"Kevetter","year":"1981","journal-title":"J Comp Neurol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2009.06638.x","article-title":"A direct main olfactory bulb projection to the \u2018vomeronasal\u2019 amygdala in female mice selectively responds to volatile pheromones from males","volume":"29","author":"Kang","year":"2009","journal-title":"Eur J Neurosci"},{"key":"B15","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/j.yhbeh.2007.03.030","article-title":"Sexual behavior in male rodents","volume":"52","author":"Hull","year":"2007","journal-title":"Horm Behav"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2011.11.002","article-title":"Brain\u2013spinal cord neural circuits controlling male sexual function and behavior","volume":"72","author":"Sakamoto","year":"2012","journal-title":"Neurosci Res"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-45525-4_21","article-title":"Physiology of somatosensory and estrogenic control over the lordosis reflex","author":"Kow","year":"1981","journal-title":"Exp Brain Res"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-15-05723.2001","article-title":"Progesterone blockade of estrogen activation of mu-opioid receptors regulates reproductive behavior","volume":"21","author":"Sinchak","year":"2001","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2015.05.021","article-title":"Fathering in rodents: Neurobiological substrates and consequences for offspring","volume":"77","author":"Bales","year":"2016","journal-title":"Horm Behav"},{"key":"B20","doi-asserted-by":"publisher","first-page":"100765","DOI":"10.1016\/j.yfrne.2019.100765","article-title":"The parental brain and behavior: A target for endocrine disruption","volume":"54","author":"Keller","year":"2019","journal-title":"Front Neuroendocrinol"},{"key":"B21","volume-title":"The neurobiology of parental behavior [Internet]","author":"Numan","year":"2003"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1111\/jne.13307","article-title":"Integration of olfactory and auditory cues eliciting parental behavior","volume":"35","author":"McRae","year":"2023","journal-title":"J Neuroendocrinol"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2559","DOI":"10.3390\/ijms23052559","article-title":"Behavioral effects of exposure to phthalates in female rodents: evidence for endocrine disruption","volume":"23","author":"Adam","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1126\/science.156.3781.1512","article-title":"Nonhormonal basis of maternal behavior in the rat","volume":"156","author":"Rosenblatt","year":"1967","journal-title":"Science"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/endo-65-3-369","article-title":"Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female Guinea pig","volume":"65","author":"Phoenix","year":"1959","journal-title":"Endocrinology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2009.03.009","article-title":"The Organizational Hypothesis: Reflections on the 50th anniversary of the publication of Phoenix, Goy, Gerall, and Young (1959)","volume":"55","author":"Wallen","year":"2009","journal-title":"Horm Behav"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07511.x","article-title":"Organized for sex \u2013 steroid hormones and the developing hypothalamus","volume":"32","author":"Lenz","year":"2010","journal-title":"Eur J Neurosci"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-20-09104.2002","article-title":"The aromatase knock-out mouse provides new evidence that estradiol is required during development in the female for the expression of sociosexual behaviors in adulthood","volume":"22","author":"Bakker","year":"2002","journal-title":"J Neurosci"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1524907113","article-title":"Pubertal activation of estrogen receptor \u03b1 in the medial amygdala is essential for the full expression of male social behavior in mice","volume":"113","author":"Sano","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2013.05.010","article-title":"Sexual differentiation of the adolescent rodent brain: Hormonal influences and developmental mechanisms","volume":"64","author":"Juraska","year":"2013","journal-title":"Horm Behav"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1708","article-title":"Testosterone Programs Adult Social Behavior before and during, But Not after, Adolescence","volume":"150","author":"Schulz","year":"2009","journal-title":"Endocrinology"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1210\/endo-111-2-522","article-title":"Changes in aromatase activity in the rat brain during embryonic, neonatal, and infantile development*","volume":"111","author":"George","year":"1982","journal-title":"Endocrinology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/0960-0760(93)90254-T","article-title":"Aromatase activity in the rat brain: Hormonal regulation and sex differences","volume":"44","author":"Roselli","year":"1993","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2017.08.001","article-title":"Role of the androgen receptor in the central nervous system","volume":"465","author":"Mhaouty-Kodja","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/0022-4731(88)90283-X","article-title":"Assignment of estradiol receptor gene to mouse chromosome 10","volume":"31","author":"Sluyser","year":"1988","journal-title":"J Steroid Biochem"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1210\/mend.11.3.9902","article-title":"Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor \u03b2","volume":"11","author":"Tremblay","year":"1997","journal-title":"Mol Endocrinol"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1002\/1096-9861(20001113)427:2<185::AID-CNE2>3.0.CO;2-G","article-title":"Estrogen-regulated progestin receptors are found in the midbrain raphe but not hippocampus of estrogen receptor alpha (ER)? gene-disrupted mice","volume":"427","author":"Alves","year":"2000","journal-title":"J Comp Neurol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0488","article-title":"Regulation of kiss1 gene expression in the brain of the female mouse","volume":"146","author":"Smith","year":"2005","journal-title":"Endocrinology"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0763-09.2009","article-title":"Regulation of Kiss1 and Dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways","volume":"29","author":"Gottsch","year":"2009","journal-title":"J Neurosci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"148055","DOI":"10.1016\/j.gene.2023.148055","article-title":"Dynamic regulation of BDNF gene expression by estradiol and lncRNA HOTAIR","volume":"897","author":"Deb","year":"2023","journal-title":"Gene"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2012.08.004","article-title":"Estradiol signaling in the regulation of reproduction and energy balance","volume":"33","author":"Sinchak","year":"2012","journal-title":"Front Neuroendocrinol"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2009.04.011","article-title":"Membrane estradiol signaling in the brain","volume":"30","author":"Micevych","year":"2009","journal-title":"Front Neuroendocrinol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0592-07.2007","article-title":"Membrane estrogen receptor-\u03b1 Interactions with metabotropic glutamate receptor 1a modulate female sexual receptivity in rats","volume":"27","author":"Dewing","year":"2007","journal-title":"J Neurosci"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0847","article-title":"Protein kinase C signaling in the hypothalamic arcuate nucleus regulates sexual receptivity in female rats","volume":"149","author":"Dewing","year":"2008","journal-title":"Endocrinology"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.08.012","article-title":"Membrane estrogen receptors activate the metabotropic glutamate receptors mGluR5 and mGluR3 to bidirectionally regulate CREB phosphorylation in female rat striatal neurons","volume":"170","author":"Grove-Strawser","year":"2010","journal-title":"Neuroscience"},{"key":"B46","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/bs.irn.2022.11.001","article-title":"The interaction of membrane estradiol receptors and metabotropic glutamate receptors in adaptive and maladaptive estradiol-mediated motivated behaviors in females","volume":"168","author":"Johnson","year":"2023","journal-title":"Int Rev Neurobiol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2012.00063\/abstract","article-title":"Sex-specific modulation of gene expression networks in murine hypothalamus","volume":"6","author":"Mozhui","year":"2012","journal-title":"Front Neurosci"},{"key":"B48","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.brainres.2010.06.038","article-title":"Distribution of estrogen receptor \u03b2 containing cells in the brains of bacterial artificial chromosome transgenic mice","volume":"1351","author":"Milner","year":"2010","journal-title":"Brain Res"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-221069","article-title":"Immunolocalization of estrogen receptor \u03b2 in the mouse brain: comparison with estrogen receptor \u03b1","volume":"144","author":"Mitra","year":"2003","journal-title":"Endocrinology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(97)00351-3","article-title":"Differential distribution and regulation of estrogen receptor-alpha and -beta mRNA within the female rat brain","volume":"54","author":"Osterlund","year":"1998","journal-title":"Brain Res Mol Brain Res"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971201)388:4<507::AID-CNE1>3.0.CO;2-6","article-title":"Comparative distribution of estrogen receptor-alpha and -beta mRNA in the rat central nervous system","volume":"388","author":"Shughrue","year":"1997","journal-title":"J Comp Neurol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.052707299","article-title":"Sexually dimorphic expression of estrogen receptor beta in the anteroventral periventricular nucleus of the rat preoptic area: implication in luteinizing hormone surge","volume":"99","author":"Orikasa","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2010.02.012","article-title":"Multiple ER\u03b2 antisera label in ER\u03b2 knockout and null mouse tissues","volume":"188","author":"Snyder","year":"2010","journal-title":"J Neurosci Methods"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23400","article-title":"Estrogen receptor \u03b2 expression in the mouse forebrain: age and sex differences","volume":"522","author":"Zuloaga","year":"2014","journal-title":"J Comp Neurol"},{"key":"B55","doi-asserted-by":"publisher","first-page":"136973","DOI":"10.1016\/j.neulet.2022.136973","article-title":"Sex and age differences in the distribution of estrogen receptors in mice","volume":"793","author":"Lana","year":"2023","journal-title":"Neurosci Lett"},{"key":"B56","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0165-3806(83)90197-9","article-title":"Perinatal development of estrogen receptors in mouse brain assessed by radioautography, nuclear isolation and receptor assay","volume":"11","author":"Gerlach","year":"1983","journal-title":"Dev Brain Res"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1239","article-title":"Differential control of sex differences in estrogen receptor \u03b1 in the bed nucleus of the Stria terminalis and anteroventral periventricular nucleus","volume":"154","author":"Kelly","year":"2013","journal-title":"Endocrinology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1006\/frne.2001.0219","article-title":"New evidence for estrogen receptors in gonadotropin-releasing hormone neurons","volume":"22","author":"Herbison","year":"2001","journal-title":"Front Neuroendocrinol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.9.7788","article-title":"Detection of estrogen receptor-beta messenger ribonucleic acid and 125I-estrogen binding sites in luteinizing hormone-releasing hormone neurons of the rat brain","volume":"141","author":"Hrabovszky","year":"2000","journal-title":"Endocrinology"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2819","article-title":"Gonadotropin-releasing hormone neurons express estrogen receptor-beta","volume":"92","author":"Hrabovszky","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2003.01115.x","article-title":"Oestrogen receptor-alpha and -beta immunoreactivity in gonadotropin-releasing hormone neurones after ovariectomy and chronic exposure to oestradiol","volume":"15","author":"Legan","year":"2003","journal-title":"J Neuroendocrinol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.11.7146","article-title":"Detection of estrogen receptor alpha and beta messenger ribonucleic acids in adult gonadotropin-releasing hormone neurons","volume":"140","author":"Skynner","year":"1999","journal-title":"Endocrinology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.23.11162","article-title":"Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene","volume":"90","author":"Lubahn","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2012.07.016","article-title":"Generation of ER\u03b1-floxed and knockout mice using the Cre\/LoxP system","volume":"424","author":"Antonson","year":"2012","journal-title":"Biochem Biophys Res Commun"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-008-9928-9","article-title":"Generation and characterization of a complete null estrogen receptor alpha mouse using Cre\/LoxP technology","volume":"321","author":"Chen","year":"2009","journal-title":"Mol Cell Biochem"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.19.4277","article-title":"Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes","volume":"127","author":"Dupont","year":"2000","journal-title":"Dev Camb Engl"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0706933104","article-title":"Estrogen receptor-alpha expression in the mammary epithelium is required for ductal and alveolar morphogenesis in mice","volume":"104","author":"Feng","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-163428","article-title":"Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene","volume":"24","author":"Hewitt","year":"2010","journal-title":"FASEB J Off Publ Fed Am Soc Exp Biol"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.07.023","article-title":"Definition of estrogen receptor pathway critical for estrogen positive feedback to gonadotropin-releasing hormone neurons and fertility","volume":"52","author":"Wintermantel","year":"2006","journal-title":"Neuron"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.11.8895349","article-title":"Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility","volume":"137","author":"Eddy","year":"1996","journal-title":"Endocrinology"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1997.1390","article-title":"Estrogen receptor function as revealed by knockout studies: neuroendocrine and behavioral aspects","volume":"31","author":"Rissman","year":"1997","journal-title":"Horm Behav"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1385\/ENDO:11:2:137","article-title":"Steroid feedback on gonadotropin release and pituitary gonadotropin subunit mRNA in mice lacking a functional estrogen receptor alpha","volume":"11","author":"Wersinger","year":"1999","journal-title":"Endocrine"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1210\/me.2002-0398","article-title":"Characterization of the hypothalamic-pituitary-gonadal axis in estrogen receptor (ER) Null mice reveals hypergonadism and endocrine sex reversal in females lacking ERalpha but not ERbeta","volume":"17","author":"Couse","year":"2003","journal-title":"Mol Endocrinol Baltim Md"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1159\/000073703","article-title":"Critical role for estrogen receptor alpha in negative feedback regulation of gonadotropin-releasing hormone mRNA expression in the female mouse","volume":"78","author":"Dorling","year":"2003","journal-title":"Neuroendocrinology"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611514104","article-title":"Nonclassical estrogen receptor alpha signaling mediates negative feedback in the female mouse reproductive axis","volume":"104","author":"Glidewell-Kenney","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1210\/me.2001-0174","article-title":"An estrogen receptor (ER)alpha deoxyribonucleic acid-binding domain knock-in mutation provides evidence for nonclassical ER pathway signaling in vivo","volume":"16","author":"Jakacka","year":"2002","journal-title":"Mol Endocrinol Baltim Md"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0673","article-title":"Estrogen response element-independent estrogen receptor (ER)-alpha signaling does not rescue sexual behavior but restores normal testosterone secretion in male ERalpha knockout mice","volume":"148","author":"McDevitt","year":"2007","journal-title":"Endocrinology"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0520","article-title":"Classical estrogen receptor alpha signaling mediates negative and positive feedback on gonadotropin-releasing hormone neuron firing","volume":"149","author":"Christian","year":"2008","journal-title":"Endocrinology"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-1943","article-title":"Effects of neuron-specific estrogen receptor (ER) \u03b1 and ER\u03b2 deletion on the acute estrogen negative feedback mechanism in adult female mice","volume":"155","author":"Cheong","year":"2014","journal-title":"Endocrinology"},{"key":"B80","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1038\/s42003-022-03324-w","article-title":"Deletion of neural estrogen receptor alpha induces sex differential effects on reproductive behavior in mice","volume":"5","author":"Trouillet","year":"2022","journal-title":"Commun Biol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1928","article-title":"ER\u03b1 in Tac2 neurons regulates puberty onset in female mice","volume":"157","author":"Greenwald-Yarnell","year":"2016","journal-title":"Endocrinology"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1851","article-title":"Positive, but not negative feedback actions of estradiol in adult female mice require estrogen receptor \u03b1 in kisspeptin neurons","volume":"156","author":"Dubois","year":"2015","journal-title":"Endocrinology"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012406108","article-title":"Timing and completion of puberty in female mice depend on estrogen receptor alpha-signaling in kisspeptin neurons","volume":"107","author":"Mayer","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"B84","doi-asserted-by":"publisher","first-page":"7433","DOI":"10.1038\/s41467-022-35243-z","article-title":"Definition of the estrogen negative feedback pathway controlling the GnRH pulse generator in female mice","volume":"13","author":"McQuillan","year":"2022","journal-title":"Nat Commun"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2428-17.2017","article-title":"Glutamatergic transmission to hypothalamic kisspeptin neurons is differentially regulated by estradiol through estrogen receptor \u03b1 in adult female mice","volume":"38","author":"Wang","year":"2018","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1159\/000107521","article-title":"Tachykinin family genes and their receptors are differentially expressed in the hypothyroid ovary and pituitary","volume":"20","author":"Ghosh","year":"2007","journal-title":"Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.103.017111","article-title":"A role for tachykinins in female mouse and rat reproductive function","volume":"69","author":"Pintado","year":"2003","journal-title":"Biol Reprod"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1606","article-title":"Developmental and endocrine regulation of kisspeptin expression in mouse Leydig cells","volume":"156","author":"Salehi","year":"2015","journal-title":"Endocrinology"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1776-15.2015","article-title":"Expression of ESR1 in glutamatergic and GABAergic neurons is essential for normal puberty onset, estrogen feedback, and fertility in female mice","volume":"35","author":"Cheong","year":"2015","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B90","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.yhbeh.2017.07.001","article-title":"Estrogen receptor alpha is required in GABAergic, but not glutamatergic, neurons to masculinize behavior","volume":"95","author":"Wu","year":"2017","journal-title":"Horm Behav"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1128","article-title":"Estrogen-negative feedback and estrous cyclicity are critically dependent upon estrogen receptor-\u03b1 expression in the arcuate nucleus of adult female mice","volume":"155","author":"Yeo","year":"2014","journal-title":"Endocrinology"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.43999","article-title":"Genetic dissection of the different roles of hypothalamic kisspeptin neurons in regulating female reproduction","volume":"8","author":"Wang","year":"2019","journal-title":"eLife"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.26.15677","article-title":"Generation and reproductive phenotypes of mice lacking estrogen receptor beta","volume":"95","author":"Krege","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2003.09.002","article-title":"Lack of functional estrogen receptor beta gene disrupts pubertal male sexual behavior","volume":"44","author":"Temple","year":"2003","journal-title":"Horm Behav"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-13-05771.2003","article-title":"Estrogen receptor beta mediates rapid estrogen actions on gonadotropin-releasing hormone neurons in vivo","volume":"23","author":"Abrah\u00e1m","year":"2003","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0712029105","article-title":"Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant","volume":"105","author":"Antal","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.3.4979","article-title":"Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta","volume":"138","author":"Kuiper","year":"1997","journal-title":"Endocrinology"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.11.5496","article-title":"Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse","volume":"138","author":"Couse","year":"1997","journal-title":"Endocrinology"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddv430","article-title":"Delayed pubertal onset and prepubertal Kiss1 expression in female mice lacking central oestrogen receptor beta","volume":"24","author":"Naul\u00e9","year":"2015","journal-title":"Hum Mol Genet"},{"key":"B100","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.yhbeh.2016.01.014","article-title":"Revisiting the neural role of estrogen receptor beta in male sexual behavior by conditional mutagenesis","volume":"80","author":"Naul\u00e9","year":"2016","journal-title":"Horm Behav"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00173.2018","article-title":"Impairments in the reproductive axis of female mice lacking estrogen receptor \u03b2 in GnRH neurons","volume":"315","author":"Novaira","year":"2018","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1232","article-title":"Estradiol acts directly and indirectly on multiple signaling pathways to phosphorylate cAMP-response element binding protein in GnRH neurons","volume":"153","author":"Cheong","year":"2012","journal-title":"Endocrinology"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1476","article-title":"Behavioral effects of estrogen receptor gene disruption in male mice","volume":"94","author":"Ogawa","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.12.6358","article-title":"Modifications of testosterone-dependent behaviors by estrogen receptor-alpha gene disruption in male mice","volume":"139","author":"Ogawa","year":"1998","journal-title":"Endocrinology"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.250473597","article-title":"Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO)","volume":"97","author":"Ogawa","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1997.1419","article-title":"Masculine sexual behavior is disrupted in male and female mice lacking a functional estrogen receptor alpha gene","volume":"32","author":"Wersinger","year":"1997","journal-title":"Horm Behav"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0305303101","article-title":"Brain masculinization requires androgen receptor function","volume":"101","author":"Sato","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.1996.0052","article-title":"Reproductive functions illustrating direct and indirect effects of genes on behavior","volume":"30","author":"Ogawa","year":"1996","journal-title":"Horm Behav"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-11-04248.2000","article-title":"Dopamine activates masculine sexual behavior independent of the estrogen receptor alpha","volume":"20","author":"Wersinger","year":"2000","journal-title":"J Neurosci Off J Soc Neurosci"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2000.00578.x","article-title":"Effects of female pheromones on gonadotropin-releasing hormone gene expression and luteinizing hormone release in male wild-type and oestrogen receptor-alpha knockout mice","volume":"12","author":"Gore","year":"2000","journal-title":"J Neuroendocrinol"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1159\/000127154","article-title":"Reversal of sex roles in genetic female mice by disruption of estrogen receptor gene","volume":"64","author":"Ogawa","year":"1996","journal-title":"Neuroendocrinology"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.12.6357","article-title":"Roles of estrogen receptor-alpha gene expression in reproduction-related behaviors in female mice","volume":"139","author":"Ogawa","year":"1998","journal-title":"Endocrinology"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01089.x","article-title":"Double oestrogen receptor alpha and beta knockout mice reveal differences in neural oestrogen-mediated progestin receptor induction and female sexual behaviour","volume":"15","author":"Kudwa","year":"2003","journal-title":"J Neuroendocrinol"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1210\/endo.138.1.4985","article-title":"Estrogen receptors are essential for female sexual receptivity","volume":"138","author":"Rissman","year":"1997","journal-title":"Endocrinology"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1210\/mend.9.11.8584021","article-title":"Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene","volume":"9","author":"Couse","year":"1995","journal-title":"Mol Endocrinol Baltim Md"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14646","article-title":"Role for the membrane estrogen receptor alpha in the sexual differentiation of the brain","volume":"52","author":"Khbouz","year":"2020","journal-title":"Eur J Neurosci"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12131","article-title":"Differential effects of site-specific knockdown of estrogen receptor \u03b1 in the medial amygdala, medial pre-optic area, and ventromedial nucleus of the hypothalamus on sexual and aggressive behavior of male mice","volume":"37","author":"Sano","year":"2013","journal-title":"Eur J Neurosci"},{"key":"B118","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1038\/s41467-017-02648-0","article-title":"Medial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender","volume":"9","author":"Wei","year":"2018","journal-title":"Nat Commun"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2995-0","article-title":"Distinct hypothalamic control of same- and opposite-sex mounting behaviour in mice","volume":"589","author":"Karigo","year":"2021","journal-title":"Nature"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1038\/nature13169","article-title":"Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus","volume":"509","author":"Lee","year":"2014","journal-title":"Nature"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/nature09736","article-title":"Functional identification of an aggression locus in the mouse hypothalamus","volume":"470","author":"Lin","year":"2011","journal-title":"Nature"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05057-6","article-title":"Transformations of neural representations in a social behaviour network","volume":"608","author":"Yang","year":"2022","journal-title":"Nature"},{"key":"B123","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1016\/j.cell.2018.12.041","article-title":"Limbic neurons shape sex recognition and social behavior in sexually naive males","volume":"176","author":"Bayless","year":"2019","journal-title":"Cell"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603045103","article-title":"RNAi-mediated silencing of estrogen receptor \u03b1 in the ventromedial nucleus of hypothalamus abolishes female sexual behaviors","volume":"103","author":"Musatov","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1159\/000255766","article-title":"Estrogen-induced sexual incentive motivation, proceptivity and receptivity depend on a functional estrogen receptor alpha in the ventromedial nucleus of the hypothalamus but not in the amygdala","volume":"91","author":"Spiteri","year":"2010","journal-title":"Neuroendocrinology"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.10.025","article-title":"Periodic remodeling in a neural circuit governs timing of female sexual behavior","volume":"179","author":"Inoue","year":"2019","journal-title":"Cell"},{"key":"B127","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.bbr.2012.01.048","article-title":"The role of the estrogen receptor \u03b1 in the medial preoptic area in sexual incentive motivation, proceptivity and receptivity, anxiety, and wheel running in female rats","volume":"230","author":"Spiteri","year":"2012","journal-title":"Behav Brain Res"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1214094109","article-title":"siRNA silencing of estrogen receptor-\u03b1 expression specifically in medial preoptic area neurons abolishes maternal care in female mice","volume":"109","author":"Ribeiro","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.22.12887","article-title":"Survival of reproductive behaviors in estrogen receptor beta gene-deficient (betaERKO) male and female mice","volume":"96","author":"Ogawa","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500752102","article-title":"A previously uncharacterized role for estrogen receptor beta: defeminization of male brain and behavior","volume":"102","author":"Kudwa","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1006\/hbeh.2002.1773","article-title":"Genotype\/age interactions on aggressive behavior in gonadally intact estrogen receptor beta knockout (betaERKO) male mice","volume":"41","author":"Nomura","year":"2002","journal-title":"Horm Behav"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1217668109","article-title":"Estrogen dependent activation function of ER\u03b2 is essential for the sexual behavior of mouse females","volume":"109","author":"Antal","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301416","article-title":"Antisense oligodeoxynucleotides for estrogen receptor-beta and alpha attenuate estradiol\u2019s modulation of affective and sexual behavior, respectively","volume":"33","author":"Walf","year":"2008","journal-title":"Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0155-15.2016","article-title":"Effects of prepubertal or adult site-specific knockdown of estrogen receptor \u03b2 in the medial preoptic area and medial amygdala on social behaviors in male mice","volume":"3","author":"Nakata","year":"2016","journal-title":"eNeuro"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2305950120","article-title":"Activity of estrogen receptor \u03b2 expressing neurons in the medial amygdala regulates preference toward receptive females in male mice","volume":"120","author":"Takenawa","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.03.045","article-title":"Estrogen receptors \u03b1 and \u03b2 in the central amygdala and the ventromedial nucleus of the hypothalamus: Sociosexual behaviors, fear and arousal in female rats during emotionally challenging events","volume":"367","author":"Le Mo\u00ebne","year":"2019","journal-title":"Behav Brain Res"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00243","article-title":"The role of estrogen receptor \u03b2 in the dorsal raphe nucleus on the expression of female sexual behavior in C57BL\/6J mice","volume":"9","author":"Sano","year":"2018","journal-title":"Front Endocrinol"},{"key":"B138","doi-asserted-by":"publisher","first-page":"6242","DOI":"10.1038\/s41598-020-63427-4","article-title":"Effects of neural estrogen receptor beta deletion on social and mood-related behaviors and underlying mechanisms in male mice","volume":"10","author":"Dombret","year":"2020","journal-title":"Sci Rep"},{"key":"B139","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1159\/000054576","article-title":"Maternal Behavior Stimulates c-fos Activity within Estrogen Receptor Alpha-Containing Neurons in Lactating Rats","volume":"72","author":"Lonstein","year":"2000","journal-title":"Neuroendocrinology"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0564","article-title":"Natural variations in maternal care are associated with estrogen receptor \u03b1 Expression and estrogen sensitivity in the medial preoptic area","volume":"144","author":"Champagne","year":"2003","journal-title":"Endocrinology"},{"key":"B141","doi-asserted-by":"publisher","first-page":"112797","DOI":"10.1016\/j.physbeh.2020.112797","article-title":"The role of the estrogen receptor-\u03b1 gene, Esr1, in maternal-like behavior in juvenile female and male rats","volume":"216","author":"Moran","year":"2020","journal-title":"Physiol Behav"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2019.02.002","article-title":"Estrogen receptor-alpha knockouts and maternal memory in nulliparous rats","volume":"110","author":"Gallagher","year":"2019","journal-title":"Horm Behav"},{"key":"B143","article-title":"Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes","volume":"51","author":"Korach","year":"1996","journal-title":"Recent Prog Horm Res"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1210\/en.2013-2150","article-title":"Generation of Esr1-knockout rats using zinc finger nuclease-mediated genome editing","volume":"155","author":"Rumi","year":"2014","journal-title":"Endocrinology"},{"key":"B145","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.neuron.2018.02.019","article-title":"A hypothalamic midbrain pathway essential for driving maternal behaviors","volume":"98","author":"Fang","year":"2018","journal-title":"Neuron"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/nature13307","article-title":"Galanin neurons in the medial preoptic area govern parental behaviour","volume":"509","author":"Wu","year":"2014","journal-title":"Nature"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0027-0","article-title":"Functional circuit architecture underlying parental behaviour","volume":"556","author":"Kohl","year":"2018","journal-title":"Nature"},{"key":"B148","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1126\/science.adi0576","article-title":"Hormone-mediated neural remodeling orchestrates parenting onset during pregnancy","volume":"382","author":"Ammari","year":"2023","journal-title":"Science"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06147-9","article-title":"Antagonistic circuits mediating infanticide and maternal care in female mice","volume":"618","author":"Mei","year":"2023","journal-title":"Nature"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(02)00087-8","article-title":"Sensory, hormonal, and neural control of maternal aggression in laboratory rodents","volume":"26","author":"Lonstein","year":"2002","journal-title":"Neurosci Biobehav Rev"},{"key":"B151","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1126\/science.adh8489","article-title":"Hypothalamic control of innate social behaviors","volume":"382","author":"Mei","year":"2023","journal-title":"Science"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4644","article-title":"Esr1+ cells in the ventromedial hypothalamus control female aggression","volume":"20","author":"Hashikawa","year":"2017","journal-title":"Nat Neurosci"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3109\/07435809709031849","article-title":"The duration of estradiol and progesterone exposure prior to progesterone withdrawal regulates oxytocin Mrna levels in the paraventricular nucleus of the rat","volume":"23","author":"Amico","year":"1997","journal-title":"Endocr Res"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2015.00160\/abstract","article-title":"Oxytocin and estrogen receptor \u03b2 in the brain: an overview","volume":"6","author":"Acevedo-Rodriguez","year":"2015","journal-title":"Front Endocrinol"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01726.x","article-title":"Brain oxytocin: a key regulator of emotional and social behaviours in both females and males","volume":"20","author":"Neumann","year":"2008","journal-title":"J Neuroendocrinol"},{"key":"B156","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1002\/cne.20457","article-title":"Estrogen receptor-?, but not estrogen receptor-?, is expressed in prolactin neurons of the female rat paraventricular and supraoptic nuclei: Comparison with other neuropeptides","volume":"484","author":"Suzuki","year":"2005","journal-title":"J Comp Neurol"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2826.2003.01061.x","article-title":"Oxytocin, but not oxytocin receptor, is regulated by oestrogen receptor \u03b2 in the female mouse hypothalamus: regulatory role for ER\u03b2","volume":"15","author":"Patisaul","year":"2003","journal-title":"J Neuroendocrinol"},{"key":"B158","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S0169-328X(02)00525-9","article-title":"Estrogen receptor-\u03b2 regulates transcript levels for oxytocin and arginine vasopressin in the hypothalamic paraventricular nucleus of male mice","volume":"109","author":"Nomura","year":"2002","journal-title":"Mol Brain Res"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1126\/science.aau5324","article-title":"Molecular, spatial, and functional single-cell profiling of the hypothalamic preoptic region","volume":"362","author":"Moffitt","year":"2018","journal-title":"Science"},{"key":"B160","doi-asserted-by":"publisher","first-page":"896","DOI":"10.1016\/j.cell.2013.04.017","article-title":"Sexually dimorphic neurons in the ventromedial hypothalamus govern mating in both sexes and aggression in males","volume":"153","author":"Yang","year":"2013","journal-title":"Cell"},{"key":"B161","doi-asserted-by":"publisher","first-page":"955","DOI":"10.1016\/j.neuron.2017.06.046","article-title":"Social control of hypothalamus-mediated male aggression","volume":"95","author":"Yang","year":"2017","journal-title":"Neuron"},{"key":"B162","doi-asserted-by":"publisher","first-page":"713","DOI":"10.1016\/j.cell.2019.09.020","article-title":"Multimodal analysis of cell types in a hypothalamic node controlling social behavior","volume":"179","author":"Kim","year":"2019","journal-title":"Cell"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1038\/nature23885","article-title":"Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex","volume":"550","author":"Remedios","year":"2017","journal-title":"Nature"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1817503116","article-title":"Connectional architecture of a mouse hypothalamic circuit node controlling social behavior","volume":"116","author":"Lo","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2021.12.002","article-title":"Make war not love: The neural substrate underlying a state-dependent switch in female social behavior","volume":"110","author":"Liu","year":"2022","journal-title":"Neuron"},{"key":"B166","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.cell.2021.12.031","article-title":"A functional cellular framework for sex and estrous cycle-dependent gene expression and behavior","volume":"185","author":"Knoedler","year":"2022","journal-title":"Cell"},{"key":"B167","doi-asserted-by":"publisher","first-page":"3862","DOI":"10.1016\/j.cell.2023.07.021","article-title":"A neural circuit for male sexual behavior and reward","volume":"186","author":"Bayless","year":"2023","journal-title":"Cell"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199410203311604","article-title":"Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man","volume":"331","author":"Smith","year":"1994","journal-title":"N Engl J Med"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/796290","article-title":"ESR1 rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure","volume":"35","author":"Paskulin","year":"2013","journal-title":"Dis Markers"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1303611","article-title":"Delayed puberty and estrogen resistance in a woman with estrogen receptor \u03b1 variant","volume":"369","author":"Quaynor","year":"2013","journal-title":"N Engl J Med"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-014-0212-5","article-title":"Association of polymorphisms in estrogen receptors (ESR1 and ESR2) with male infertility: a meta-analysis and systematic review","volume":"31","author":"Ge","year":"2014","journal-title":"J Assist Reprod Genet"},{"key":"B172","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1186\/s13048-014-0114-2","article-title":"ESR1 and ESR2 gene polymorphisms are associated with human reproduction outcomes in Brazilian women","volume":"7","author":"de Mattos","year":"2014","journal-title":"J Ovarian Res"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00769","article-title":"Early-onset complete ovarian failure and lack of puberty in a woman with mutated estrogen receptor \u03b2 (ESR2)","volume":"103","author":"Lang-Muritano","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-2749","article-title":"Familial multiplicity of estrogen insensitivity associated with a loss-of-function ESR1 mutation","volume":"102","author":"Bernard","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2017.163","article-title":"Biallelic and monoallelic ESR2 variants associated with 46,XY disorders of sex development","volume":"20","author":"Baetens","year":"2018","journal-title":"Genet Med Off J Am Coll Med Genet"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1408677\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:29:23Z","timestamp":1719188963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1408677\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,24]]},"references-count":175,"alternative-id":["10.3389\/fendo.2024.1408677"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2024.1408677","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,24]]},"article-number":"1408677"}}