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Current research is being conducted to understand the molecular mechanisms regulating these high-heterogeneous neoplasms originating from adenohypophysis, and single-cell RNA sequencing (scRNA-seq) technology is now playing an essential role in these studies due to its remarkable resolution at the single-cell level. This review describes recent studies on human PitNETs performed with scRNA-seq technology, highlighting the potential of this approach in revealing these tumor pathologies, behavior, and regulatory mechanisms.<\/jats:p>","DOI":"10.3389\/fendo.2024.1414223","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T04:55:57Z","timestamp":1721796957000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["scRNA sequencing technology for PitNET studies"],"prefix":"10.3389","volume":"15","author":[{"given":"Walaa","family":"Asaad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Utkina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Shcherbakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergey","family":"Popov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina","family":"Melnichenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Mokrysheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,7,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2020.04.002","article-title":"The epidemiology of pituitary adenomas","volume":"49","author":"Daly","year":"2020","journal-title":"Endocrinol Metab Clin North Am"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2022.03.017","article-title":"Pituitary adenoma incidence, management trends, and long-term outcomes: A 30-year population-based analysis","volume":"97","author":"Graffeo","year":"2022","journal-title":"Mayo Clinic Proc"},{"key":"B3","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1007\/s11604-023-01400-7","article-title":"Imaging of pituitary tumors: an update with the 5th WHO Classifications\u2014part 1. 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