{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:44:35Z","timestamp":1792691075070,"version":"4.5.0"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T00:00:00Z","timestamp":1724889600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Bisphenol A (BPA), a characteristic endocrine disruptor, is a substance that seriously interferes with the human endocrine system and causes reproductive disorders and developmental abnormalities. However, its toxic effects on the gut-liver-hormone axis are still unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>Male and female rats were exposed to BPA (300 mg\/kg) by oral gavage for 60 consecutive days. H&amp;amp;E staining was used for histopathological evaluation, and the serum biochemical indexes were determined using an automatic analyzer. The 16S rRNA gene sequencing was used to detect the intestinal microbial diversity, and the GC-MS was used to analyze the contents of short-chain fatty acids (SCFAs) in colon contents. UPLC-QTOF MS was used to analyze the related metabolites. The ELISA method was used to assess the levels of serum inflammatory factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histopathological analysis indicated that the liver, heart, and testis were affected by BPA. There was a significant effect on alanine aminotransferase (ALT), triglyceride (TG), total cholesterol (TC), and low-density lipoprotein (LDL) in the male-BPA group (P &amp;lt; 0.05), and globulin (GLB), indirect bilirubin (IBIL), alkaline phosphatase (ALP), ALT, TG, TC, high-density lipoprotein (HDL), and creatinine (Cr) in the female-BPA group (P &amp;lt; 0.05). Metagenomics (16S rRNA gene sequencing) analysis indicated that BPA reduced the diversity and changed the composition of gut microbiota in rats significantly. Compared with the control and blank groups, the contents of caproic acid, isobutyric acid, isovaleric acid, and propanoic acid in the colon contents decreased in the male-BPA group (P &amp;lt; 0.05), and caproic acid, isobutyric acid, isovaleric acid, and valeric acid in the colon contents decreased in the female-BPA group (P &amp;lt; 0.05). Metabolomic analysis of the serum indicated that BPA could regulate bile acid levels, especially ursodeoxycholic acid (UDCA) and its conjugated forms. The contents of amino acids, hormones, and lipids were also significantly affected after exposure to BPA. The increase in interleukin-6 (IL-6), interleukin-23 (IL-23), and transforming growth factor-\u03b2 (TGF-\u03b2) in the serum of the male-BPA group suggests that BPA exposure affects the immune system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BPA exposure will cause toxicity to rats via disrupting the gut-liver-hormone axis.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1415216","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T05:04:56Z","timestamp":1724907896000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Subchronic toxic effects of bisphenol A on the gut-liver-hormone axis in rats via intestinal flora and metabolism"],"prefix":"10.3389","volume":"15","author":[{"given":"Jiaqi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ce","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingqin","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changlan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangcheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoli","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,8,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2012.678421","article-title":"BPA, an energy balance disruptor","volume":"55","author":"Le Corre","year":"2015","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2019.121488","article-title":"Hazards of bisphenol A (BPA) exposure: A systematic review of plant toxicology studies","volume":"384","author":"Xiao","year":"2020","journal-title":"J Hazard. Mater"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2015.09.002","article-title":"Exposure assessment of Bisphenol A intake from polymeric baby bottles in formula-fed infants aged less than one year","volume":"2","author":"Moghadam","year":"2015","journal-title":"Toxicol Rep"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.apcatb.2013.10.053","article-title":"Elimination of BPA endocrine disruptor by magnetic BiOBr@SiO2@Fe3O4 photocatalyst","author":"Zhang","year":"2014","journal-title":"Appl Catal. B"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.4143\/crt.2017.001","article-title":"Proteomic biomarkers for bisphenol A-early exposure and women\u2019s thyroid cancer","volume":"50","author":"Lee","year":"2018","journal-title":"Cancer Res Treat"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-21154-5","article-title":"Bisphenol A in edible tissues of rams exposed to repeated low-level dietary dose by high-performance liquid chromatography with fluorescence detection","volume":"29","author":"Cerkvenik-Flajs","year":"2022","journal-title":"Environ Sci pollut Res"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2010.03.028","article-title":"On-line solid phase extraction fast liquid chromatography-tandem mass spectrometry for the analysis of bisphenol A and its chlorinated derivatives in water samples","volume":"1217","author":"Gallart-Ayala","year":"2010","journal-title":"J Chromatogr A"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1039\/c0ay00540a","article-title":"Dummy molecularly imprinted polymer for selective screening of trace bisphenols in river","volume":"3","author":"Yin","year":"2011","journal-title":"Anal Methods"},{"key":"B9","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1016\/j.chroma.2013.12.074","article-title":"Simultaneous determination of seven bisphenols in environmental water and solid samples by liquid chromatography-electrospray tandem mass spectrometry","volume":"1328","author":"Yang","year":"2014","journal-title":"J Chromatogr A"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3967\/bes2014.076","article-title":"Simultaneous determination of bisphenols and alkylphenols in water by solid phase extraction and ultra performance liquid chromatography-tandem mass spectrometry","volume":"27","author":"Shan","year":"2014","journal-title":"Biomed Environ Sci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.aca.2015.12.034","article-title":"Analytical methods for the determination of mixtures of bisphenols and derivatives in human and environmental exposure sources and biological fuids. A Review","volume":"908","author":"Caballero-Casero","year":"2016","journal-title":"Anal Chim Acta"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042125","article-title":"Paternal inheritance of bisphenol A cardiotoxic effects: the implications of sperm epigenome","volume":"22","author":"Lomb\u00f3","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1205823","article-title":"Bisphenol A exposure during adulthood causes augmentation of follicular atresia and luteal regression by decreasing 17\u03b2-estradiol synthesis via downregulation of aromatase in rat ovary","volume":"121","author":"Lee","year":"2013","journal-title":"Environ Health Persp"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.11.027","article-title":"Bisphenol A alternatives bisphenol S and bisphenol F interfere with thyroid hormone signaling pathway in vitro and in vivo","volume":"237","author":"Zhang","year":"2018","journal-title":"Environ pollut"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184382","article-title":"Maternal exposure to bisphenol A combined with high-fat diet-induced programmed hypertension in adult male rat offspring: effects of resveratrol","volume":"20","author":"Hsu","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00904-3","article-title":"The gut-liver axis and gut microbiota in health and liver disease. Nature reviews","volume":"21","author":"Hsu","year":"2023","journal-title":"Microbiol"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.69833","article-title":"Dynamics of the gut-liver axis in rats with varying fibrosis severity","volume":"18","author":"Xiang","year":"2022","journal-title":"Int J Biol Sci"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.636803","article-title":"Depletion of gut microbiota impairs gut barrier function and antiviral immune defense in the liver","volume":"12","author":"Guo","year":"2021","journal-title":"Front Immunol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2021.126707","article-title":"Gut microbiota exaggerates triclosan-induced liver injury via gut-liver axis","volume":"421","author":"Zhang","year":"2022","journal-title":"J Hazard. Mater"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2016.1203502","article-title":"Sex differences and hormonal effects on gut microbiota composition in mice","volume":"7","author":"Org","year":"2016","journal-title":"Gut Microbes"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2015.10.022","article-title":"Diets high in fiber and vegetable protein are associated with low lumbar bone mineral density in young athletes with oligoamenorrhea","volume":"116","author":"Barron","year":"2016","journal-title":"J Acad Nutr Diet"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01356-2","article-title":"Estrogen receptor \u03b2 deficiency impairs gut microbiota: a possible mechanism of IBD-induced anxiety-like behavior","volume":"10","author":"Ma","year":"2022","journal-title":"Microbiome"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106260","article-title":"Systems toxicogenomics of prenatal low-dose BPA exposure on liver metabolic pathways, gut microbiota, and metabolic health in mice","volume":"146","author":"Diamante","year":"2021","journal-title":"Environ Int"},{"key":"B24","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1186\/s40779-022-00397-w","article-title":"Oral administration of asparagine and 3-indolepropionic acid prolongs survival time of rats with traumatic colon injury","volume":"9","author":"Cao","year":"2022","journal-title":"Mil. Med Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.863407","article-title":"Messengers from the gut: gut microbiota-derived metabolites on host regulation","volume":"13","author":"Li","year":"2022","journal-title":"Front Microbiol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30513","article-title":"Deficiency of both farnesoid X receptor and takeda G protein-coupled receptor 5 exacerbated liver fibrosis in mice","volume":"70","author":"Ferrell","year":"2019","journal-title":"Hepatology"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00012","article-title":"Naturally occurring TPE-CA maintains gut microbiota and bile acids homeostasis via FXR signaling modulation of the liver-gut axis. Front","volume":"11","author":"Liu","year":"2020","journal-title":"Pharmacol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.781148","article-title":"Altered intestinal microbiomes and lipid metabolism in patients with prolonged disorders of consciousness","volume":"13","author":"Yu","year":"2022","journal-title":"Front Immunol"},{"key":"B30","unstructured":"Bisphenol A material safety data sheet2004"},{"key":"B31","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s12950-017-0153-8","article-title":"Overexpression of aquaporin 4 in articular chondrocytes exacerbates the severity of adjuvant-induced arthritis in rats: an in vivo and in vitro study","volume":"14","author":"Cai","year":"2017","journal-title":"J Inflamm"},{"key":"B32","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bbi.2016.09.003","article-title":"Sex-specific effects of docosahexaenoic acid (DHA) on the microbiome and behavior of socially-isolated mice","volume":"59","author":"Davis","year":"2017","journal-title":"Brain Behav Immun"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1126\/science.1233521","article-title":"Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity","volume":"339","author":"Markle","year":"2013","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.bbcan.2014.01.004","article-title":"Tumor-induced perturbations of cytokines and immune cell networks","volume":"1845","author":"Burkholder","year":"2014","journal-title":"Biochim Biophy. Acta"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2019.110575","article-title":"Occurrence of Bisphenol A and its analogues in some foodstuff marketed in Europe","volume":"131","author":"Russo","year":"2019","journal-title":"Food Chem Toxicol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfi074","article-title":"Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds","volume":"84","author":"Kitamura","year":"2005","journal-title":"Toxicol Sci"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-018-2299-1","article-title":"Ameliorative effect of ginseng extract on phthalate and bisphenol A reprotoxicity during pregnancy in rats","volume":"25","author":"Saadeldin","year":"2018","journal-title":"Environ Sci pollut Res"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11081486","article-title":"Effects of dietary lysophospholipid inclusion on the growth performance, nutrient digestibility, nitrogen utilization, and blood metabolites of finishing beef cattle","volume":"11","author":"Zhang","year":"2022","journal-title":"Antioxidants"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.843971","article-title":"Urine phthalate levels and liver function in US adolescents: analyses of NHANES 2007-2016","volume":"10","author":"Xiang","year":"2022","journal-title":"Front Public. Health"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13759","article-title":"Predictive value of different bilirubin subtypes for clinical outcomes in patients with acute ischemic stroke receiving thrombolysis therapy","volume":"28","author":"Peng","year":"2022","journal-title":"CNS Neurosci Ther"},{"key":"B41","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1186\/1742-4933-10-15","article-title":"Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a \u201cchi","volume":"10","author":"Cornelius","year":"2013","journal-title":"Immun Ageing"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00518-22","article-title":"FXR signaling-mediated bile acid metabolism is critical for alleviation of cholesterol gallstones by lactobacillus strains","volume":"10","author":"Ye","year":"2022","journal-title":"Microbiol Spectr"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3390\/nu14132749","article-title":"GOS ameliorates nonalcoholic fatty liver disease induced by high fat and high sugar diet through lipid metabolism and intestinal microbes","volume":"14","author":"Qiu","year":"2022","journal-title":"Nutrients"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2021.07.001","article-title":"Dietary nano-selenium alleviated intestinal damage of juvenile grass carp induced by high-fat diet: Insight from intestinal morphology, tight junction, inflammation, anti-oxidization and intestinal microbiota","volume":"8","author":"Liu","year":"2022","journal-title":"Anim. Nutr"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-021-11358-z","article-title":"Research progress on gut microbiota in patients with gastric cancer, esophageal cancer, and small intestine cancer","volume":"105","author":"Chen","year":"2021","journal-title":"Appl Microbiol Biotechnol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2023.02.019","article-title":"Dietary fish oil improves autistic behaviors and gut homeostasis by altering the gut microbial composition in a mouse model of fragile X syndrome","volume":"110","author":"Guo","year":"2023","journal-title":"Brain Behav Immun"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2022.1034537","article-title":"Immune mechanism of gut microbiota and its metabolites in the occurrence and development of cardiovascular diseases","volume":"13","author":"Lu","year":"2022","journal-title":"Front Microbiol"},{"key":"B48","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1914377","article-title":"Infant gut microbiota modulation by human milk disaccharides in humanized microbiome mice","volume":"13","author":"Rubio-Del-Campo","year":"2021","journal-title":"Gut Microbes"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.3390\/nu9060533","article-title":"Effects of commercial apple varieties on human gut microbiota composition and metabolic output using an in vitro colonic model","volume":"9","author":"Koutsos","year":"2017","journal-title":"Nutrients"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000013225","article-title":"Association of fecal and plasma levels of short-chain fatty acids with gut microbiota and clinical severity in parkinson disease patients","volume":"98","author":"Chen","year":"2022","journal-title":"Neurology"},{"key":"B51","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1080\/19490976.2021.1894070","article-title":"The impact of the gut microbiota on the reproductive and metabolic endocrine system","volume":"13","author":"Qi","year":"2021","journal-title":"Gut Microbes"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2017-02799","article-title":"Gut microbiota and the polycystic ovary syndrome: influence of sex, sex hormones, and obesity","volume":"103","author":"Insenser","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1210\/er.2016-1067","article-title":"Dihydrotestosterone: biochemistry, physiology, and clinical implications of elevated blood levels","volume":"38","author":"Swerdloff","year":"2017","journal-title":"Endocr. Rev"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-253","article-title":"Fecal microbial determinants of fecal and systemic estrogens and estrogen metabolites: a cross-sectional study","volume":"10","author":"Flores","year":"2012","journal-title":"J Transl Med"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i12.1492","article-title":"Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT\/mTOR\/SREBP-1 signaling pathway","volume":"25","author":"Hu","year":"2019","journal-title":"World J Gastroenterol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2021.100288","article-title":"Hepatic bile acid transport increases in the postprandial state: A functional 11 C-CSar PET\/CT study in healthy humans","volume":"3","author":"\u00d8rntoft","year":"2021","journal-title":"JHEP Rep"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05336-9","article-title":"Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism","volume":"9","author":"Zarrinpar","year":"2018","journal-title":"Nat Commun"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23031126","article-title":"Roux-en-Y gastric bypass (RYGB) surgery during high liquid sucrose diet leads to gut microbiota-related systematic alterations","volume":"23","author":"Zizmare","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1958-6","article-title":"High-fat diet feeding and palmitic acid increase CRC growth in \u03b22AR-dependent manner","volume":"10","author":"Fatima","year":"2019","journal-title":"Cell Death Dis"},{"key":"B60","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/s00253-016-8006-6","article-title":"Interaction of gut microbiota with bile acid metabolism and its influence on disease states","volume":"101","author":"Staley","year":"2017","journal-title":"Appl Microb Biotechnol"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.918505","article-title":"Active peptide AR-9 from eupolyphaga sinensis reduces blood lipid and hepatic lipid accumulation by restoring gut flora and its metabolites in a high fat diet-induced hyperlipidemia rat","volume":"13","author":"Wang","year":"2022","journal-title":"Front Pharmacol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2019.01.001","article-title":"Computational drug repurposing for inflammatory bowel disease using genetic information","volume":"17","author":"Grenier","year":"2019","journal-title":"Comput Struct Biotechnol J"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.05.030","article-title":"Liver infiltrating T cells regulate bile acid metabolism in experimental cholangitis","volume":"71","author":"Glaser","year":"2019","journal-title":"J Hepatol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073832","article-title":"Crocetin prolongs recovery period of DSS-induced colitis via altering intestinal microbiome and increasing intestinal permeability","volume":"23","author":"Feng","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.983501","article-title":"The anti-aging effects of Renshen Guben on thyrotoxicosis mice: Improving immunosenescence, hypoproteinemia, lipotoxicity, and intestinal flora","volume":"13","author":"Feng","year":"2022","journal-title":"Front Immunol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1415216\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T05:05:02Z","timestamp":1724907902000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1415216\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,29]]},"references-count":65,"alternative-id":["10.3389\/fendo.2024.1415216"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2024.1415216","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,29]]},"article-number":"1415216"}}