{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:02:16Z","timestamp":1779379336143,"version":"3.53.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>While some studies have suggested a link between gut microbiota (GM) and abortion, the causal relationship remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To explore the causal relationship between GM and abortion, including spontaneous abortion (SA) and habitual abortion (HA), we performed a two-sample Mendelian randomization (MR) analysis. We used summary statistics data from MiBioGen and FinnGen for genome-wide association studies (GWAS), with GM data as the exposure variable and abortion data as the outcome variable.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the absence of heterogeneity and horizontal pleiotropy, the inverse-variance weighted (IVW) method identified five genetically predicted GM genera linked to the risk of abortions. <jats:italic>Lactococcus<\/jats:italic> was negatively correlated with the risk of SA, whereas the <jats:italic>Eubacterium fissicatena<\/jats:italic> group was positively correlated with the risk of SA. Genetic predictions of <jats:italic>Coprococcus3<\/jats:italic> and <jats:italic>Odoribacter<\/jats:italic> were linked to a reduced risk of HA, while the <jats:italic>Eubacterium ruminantium<\/jats:italic> group was associated with an increased risk of HA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study suggests a genetic causal relationship between specific GM and two types of abortions, improving our understanding of the pathological relationship between GM and abortion.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1415730","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T05:05:01Z","timestamp":1720587901000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessing causal relationships between gut microbiota and abortion: evidence from two sample Mendelian randomization 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