{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T06:02:11Z","timestamp":1794463331675,"version":"4.9.1"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This study investigates the clinicopathological characteristics of papillary thyroid carcinoma (PTC) with coexisting Hashimoto\u2019s thyroiditis (HT) and further explores the risk factors for central lymph node metastasis (CLNM) in PTC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>A retrospective analysis was conducted on 415 PTC patients who underwent surgical treatment for thyroid cancer at the First Affiliated Hospital of Anhui University of Chinese Medicine from 2016 to 2022. Clinicopathological features were compared between PTC patients with and without HT. Univariate and multivariate logistic regression were used to analyze the risk factors of CLNM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>The PTC+HT group had a higher proportion of female patients (85.5%) than the PTC group (P&amp;lt;0.05). Univariate analysis revealed no statistically significant difference between the two groups in eight aspects (all P&amp;gt;0.05). Multivariate analysis showed that HT was positively associated with the total number of central lymph node (CLN) dissected, Thyroid-stimulating hormone (TSH), Thyroid peroxidase antibody (TPOAb), and Thyroglobulin antibodies (TgAb), while identified as a protective factor against invasion with an odds ratio of 0.422 (95%CI 0.209-0.853, P=0.016). Through univariate and multivariate logistic regression, we proved that tumor position, Capsule + Extrathyroidal extension (ETE), multifocal tumors, and the total number of CLN dissected were independent risk factors for CLNM. Multiple linear regression analysis told us that invasion (\u03b2= 0.093, p=0.048) had a positively predictive impact on CLN positive rate.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Female PTC patients are more prone to concurrent HT, which elevates the levels of TSH, TPOAb, and TgAb. HT not only promotes the longitudinal growth of nodules and PTC development, but also reduces the risk of invasion and CLNM. Therefore, we posit that the impact of HT on PTC patients is a \u201cdouble-edged sword\u201d. Isthmus, Capsule + ETE, multifocality, age &amp;lt; 55 years old, and male are high-risk factors for CLNM in PTC, while HT is regarded as a protective factor. Capsule + ETE is the primary risk factor affecting the CLN positive rate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2024.1420998","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T09:58:42Z","timestamp":1738835922000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Correlation analysis of Hashimoto\u2019s thyroiditis with papillary thyroid carcinoma occurrence and its central lymph node metastasis: a single center experience"],"prefix":"10.3389","volume":"15","author":[{"given":"Kang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dexuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoqun","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1186\/s13045-021-01213-z","article-title":"Global, regional, and national cancer incidence and death for 29 cancer groups in 2019 and trends analysis of the global cancer burden, 1990-2019","volume":"14","author":"Lin","year":"2021","journal-title":"J Hematol Oncol"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2018.01.014","article-title":"Thyroid disease around the world","volume":"51","author":"Maniakas","year":"2018","journal-title":"Otolaryngol Clin North Am"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2019.05.019","article-title":"Thyroid autoimmune disorders and cancer","volume":"64","author":"Ferrari","year":"2020","journal-title":"Semin Cancer Biol"},{"key":"B4","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1371\/journal.pone.0269995","article-title":"Association between Hashimoto thyroiditis and clinical outcomes of papillary thyroid carcinoma: A meta-analysis","volume":"17","author":"Tang","year":"2022","journal-title":"PloS One"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1530\/eje-12-0903","article-title":"The association between papillary thyroid carcinoma and histologically proven Hashimoto's thyroiditis: a meta-analysis","volume":"168","author":"Lee","year":"2013","journal-title":"Eur J Endocrinol"},{"key":"B6","article-title":"Impact of Hashimotoas thyroiditis on clinicopathologic features of papillary thyroid carcinoma associated with infiltration of tumor-infiltrating lymphocytes","volume":"11","author":"Wang","year":"2018","journal-title":"Int J Clin Exp Pathol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.07.032","article-title":"Chronic ulcerative colitis and colorectal cancer","volume":"345","author":"Rogler","year":"2014","journal-title":"Cancer Lett"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.4.526","article-title":"The risk of colorectal cancer in ulcerative colitis: a meta-analysis","volume":"48","author":"Eaden","year":"2001","journal-title":"Gut"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.02.021","article-title":"Mechanisms of HBV-induced hepatocellular carcinoma","volume":"64","author":"Levrero","year":"2016","journal-title":"J Hepatol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1515\/hsz-2017-0118","article-title":"Chronic viral hepatitis and its association with liver cancer","volume":"398","author":"Tu","year":"2017","journal-title":"Biol Chem"},{"key":"B12","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.canlet.2013.08.016","article-title":"Helicobacter pylori-induced gastric inflammation and gastric cancer","volume":"345","author":"Wang","year":"2014","journal-title":"Cancer Lett"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i18.5461","article-title":"Helicobacter pylori associated chronic gastritis, clinical syndromes, precancerous lesions, and\u00a0pathogenesis of gastric cancer development","volume":"20","author":"Watari","year":"2014","journal-title":"World J Gastroenterol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1955.01270080137023","article-title":"Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland","volume":"70","author":"Dailey","year":"1955","journal-title":"AMA Arch surgery"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.772071","article-title":"The impact of coexistent hashimoto\u2019s\u00a0thyroiditis on central compartment lymph node metastasis in papillary thyroid carcinoma","volume":"12","author":"Liu","year":"2021","journal-title":"Front Endocrinol"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.17108","article-title":"Predicting central cervical lymph node metastasis in papillary thyroid carcinoma with Hashimoto\u2019s thyroiditis: a practical nomogram based on retrospective study","volume":"12","author":"Wang","year":"2024","journal-title":"PeerJ"},{"key":"B17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.3892\/ol.2023.13734","article-title":"Association between papillary thyroid carcinoma and lymphocytic thyroiditis: A retrospective study","volume":"25","author":"Wu","year":"2023","journal-title":"Oncol Lett"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.868606","article-title":"Hashimoto\u2019s thyroiditis is associated with central lymph node metastasis in classical papillary thyroid cancer: analysis from a high-volume single-center experience","volume":"13","author":"Zeng","year":"2022","journal-title":"Front Endocrinol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 American thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer the american thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"B20","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.surg.2018.04.078","article-title":"Stage migration with the new American Joint Committee on Cancer (AJCC) staging system (8th edition) for differentiated thyroid cancer","volume":"165","author":"Shaha","year":"2019","journal-title":"Surgery"},{"key":"B21","doi-asserted-by":"publisher","first-page":"313","DOI":"10.3322\/caac.21609","article-title":"Erratum: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"70","author":"Bray","year":"2020","journal-title":"CA Cancer J Clin"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2022.0040","article-title":"Thyroid carcinoma, version 2.2022, NCCN clinical practice guidelines in oncology","volume":"20","author":"Haddad","year":"2022","journal-title":"J Natl Compr Canc Netw"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdz400","article-title":"Thyroid cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up\u2020","volume":"30","author":"Filetti","year":"2019","journal-title":"Ann Oncol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.2719","article-title":"Trends in thyroid cancer incidence and mortality in the United States, 1974-2013","volume":"317","author":"Lim","year":"2017","journal-title":"JAMA-J Am Med Assoc"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102649","article-title":"Hashimoto\u2019s thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential Malignant transformation","volume":"19","author":"Ralli","year":"2020","journal-title":"Autoimmun Rev"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-20-0049","article-title":"Co-aggregation and heritability of organ-specific autoimmunity: a population-based twin study","volume":"182","author":"Skov","year":"2020","journal-title":"Eur J Endocrinol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0256","article-title":"Selenium supplementation significantly reduces thyroid autoantibody levels in patients with chronic autoimmune thyroiditis: A systematic review and meta-analysis","volume":"26","author":"Wichman","year":"2016","journal-title":"Thyroid: Off J Am Thyroid Assoc"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01477-1","article-title":"An update on the pathogenesis of Hashimoto\u2019s thyroiditis","volume":"44","author":"Weetman","year":"2021","journal-title":"J\u00a0Endocrinol Invest"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1967\/s002449910408","article-title":"Hashimoto's thyroiditis and papillary thyroid carcinoma. Are cytokeratin 19 and P63 proteins of any diagnostic value","volume":"19","author":"Divani","year":"2016","journal-title":"Hell J Nucl Med"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2017.08.012","article-title":"Hashimoto\u2019s thyroiditis - an independent risk factor for papillary carcinoma","volume":"84","author":"Uhliarova","year":"2018","journal-title":"Braz J Otorhinolaryngol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2022.74","article-title":"Association between hashimoto\u2019s thyroiditis and papillary thyroid cancer: A single center experience","volume":"18","author":"Danis","year":"2022","journal-title":"Acta Endocrinol (Buchar)"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2023.12.023","article-title":"Clinical impact of coexistent chronic lymphocytic thyroiditis on central lymph node metastasis in low- to intermediate-risk papillary thyroid carcinoma: The MASTER study","volume":"175","author":"Heo","year":"2024","journal-title":"Surgery"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.959595","article-title":"Association between hashimoto thyroiditis and differentiated thyroid cancer: A single-center experience","volume":"12","author":"Cappellacci","year":"2022","journal-title":"Front Oncol"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-11-56","article-title":"Hashimoto\u2019s Thyroiditis, microcalcification and raised thyrotropin levels within normal range are associated with thyroid cancer","volume":"11","author":"Ye","year":"2013","journal-title":"World J Surg Oncol"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1530\/erc-11-0028","article-title":"Hashimoto\u2019s thyroiditis is associated with papillary thyroid carcinoma: role of TSH and of treatment with L-thyroxine","volume":"18","author":"Fiore","year":"2011","journal-title":"Endocr-Relat Cancer"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2014.01.007","article-title":"Hashimoto thyroiditis: Clinical and diagnostic criteria","volume":"13","author":"Caturegli","year":"2014","journal-title":"Autoimmun Rev"},{"key":"B37","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13044-018-0046-9","article-title":"Role of the T and B lymphocytes in pathogenesis of autoimmune thyroid diseases","volume":"11","author":"Rydzewska","year":"2018","journal-title":"Thyroid Res"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2021.07.011","article-title":"The effects of chronic lymphocytic thyroiditis on clinicopathologic factors in papillary thyroid cancer","volume":"27","author":"Sakiz","year":"2021","journal-title":"Endocr Pract"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-023-05332-7","article-title":"Hashimoto\u2019s thyroiditis is negatively associated with lymph node metastasis in PTMC","volume":"149","author":"Huang","year":"2023","journal-title":"J Cancer Res Clin Oncol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2018.04.046","article-title":"Risk factors of central lymph node metastasis in papillary thyroid carcinoma: A retrospective cohort study","volume":"54","author":"Tang","year":"2018","journal-title":"Int J Surg"},{"key":"B41","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s12902-021-00923-2","article-title":"Lymph node metastasis of papillary thyroid carcinoma in the context of Hashimoto's thyroiditis","volume":"22","author":"Wang","year":"2022","journal-title":"BMC Endocr Disord"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1007\/s13193-022-01515-9","article-title":"Hashimoto\u2019s thyroiditis and papillary cancer thyroid coexistence exerts a protective effect: a single centre experience","volume":"13","author":"Battistella","year":"2022","journal-title":"Indian J Surg Oncol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5835-6","article-title":"Risk factor analysis for predicting cervical lymph node metastasis in papillary thyroid carcinoma: a study of 966 patients","volume":"19","author":"Liu","year":"2019","journal-title":"BMC Cancer"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.38.1.4450","article-title":"Utility and significance of clinical risk factor scoring model in predicting central compartment lymph node metastasis (CLNM) in patients with papillary thyroid cancer (PTC)","volume":"38","author":"Shen","year":"2022","journal-title":"Pak J Med Sci"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1420998\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T09:58:46Z","timestamp":1738835926000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1420998\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,6]]},"references-count":44,"alternative-id":["10.3389\/fendo.2024.1420998"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2024.1420998","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.3389\/fendo.2024.1420998.s001","asserted-by":"subject"}]},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,6]]},"article-number":"1420998"}}