{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:30:46Z","timestamp":1785540646435,"version":"3.56.0"},"reference-count":42,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Acromegaly is associated with increased vertebral fracture (VF) risk regardless of bone mineral density (BMD). However, the vertebral trabecular compartment is still low; a possible contributor to this may be impaired glucose metabolism (GM) which frequently complicates acromegaly. Additionally, soft tissue thickness may confound bone imaging in acromegaly patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to assess the association of GM with BMD, trabecular bone score adjusted for BMI (TBS<jats:sub>BMI<\/jats:sub>), and trabecular bone score adjusted for tissue thickness (TBS<jats:sub>TT<\/jats:sub>) among acromegaly subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>A cross-sectional study was performed among 70 consecutive acromegaly patients (24 male\/46 female, aged 55.1 years) divided in two subgroups: abnormal GM (<jats:italic>n<\/jats:italic> = 35) and normal GM (<jats:italic>n<\/jats:italic> = 35). Using DXA, BMD, TBS<jats:sub>BMI<\/jats:sub>, TBS<jats:sub>TT<\/jats:sub>, and VF screening were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all subjects, TBS<jats:sub>TT<\/jats:sub> was higher (mean 9.5%) than TBS<jats:sub>BMI<\/jats:sub>. Abnormal GM subjects had lower TBS<jats:sub>BMI<\/jats:sub> (1.166 \u00b1 0.15) than normal GM subjects (1.232 \u00b1 0.12; <jats:italic>p<\/jats:italic> &amp;lt; 0.05). No between-group difference in TBS<jats:sub>TT<\/jats:sub> or BMD was observed. In a multiple regression model, the best predictor of TBS<jats:sub>TT<\/jats:sub> was HbA1c (<jats:italic>p<\/jats:italic> = 0.002). None of the DXA measures or GM parameters was a significant predictor of VF (<jats:italic>n<\/jats:italic> = 7).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The abnormal GM acromegaly subjects had lower TBS<jats:sub>BMI<\/jats:sub> than those with normal GM. TBS<jats:sub>TT<\/jats:sub> was higher than TBS<jats:sub>BMI<\/jats:sub>, and no between-group difference based on GM status was observed. TBS<jats:sub>TT<\/jats:sub> was significantly associated with GM parameters, notably HbA1c. The relationship of TBS<jats:sub>TT<\/jats:sub> with GM parameters may imply an effect of GM on trabecular bone microstructure in patients with acromegaly; a further study is indicated.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1448566","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T11:51:01Z","timestamp":1734004261000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of trabecular bone score corrected for tissue thickness with glucose metabolism in 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