{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:13:11Z","timestamp":1787026391406,"version":"build-2736575974"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"\n Introduction<\/jats:title>\n Obesity is thought to be accompanied by chronic, low-grade, inflammation. The adipocytes are present in the subcutaneous and visceral fat tissue and contribute to the bone marrow cell compartment. Therefore, it poses a question whether the factors influencing adipocyte functions also have an impact on the hematopoietic function of the bone marrow. The aim of our study was to evaluate the association between erythrocyte parameters, the proinflammatory Th17 lymphocytes, and IR markers in children with excessive body weight.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n A total of 27 overweight\/obese and 15 normal-weight children aged 8\u201318 years were enrolled in the study. The analysis included anthropometric measurements, evaluation of Th17 cell frequency, erythrocyte parameters, and carbohydrate metabolism parameters.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n In overweight\/obese children, erythrocyte count (\n p<\/jats:italic>\n = 0.00002), hemoglobin (HGB) concentration (\n p<\/jats:italic>\n = 0.005), and frequency of Th17 cells (\n p<\/jats:italic>\n = 0.048) were higher. Anthropometric parameters correlated with erythrocyte parameters, as well as Th17 cell frequency in all children. The erythrocyte count correlated with the Th17 subset (\n p<\/jats:italic>\n = 0.01,\n r<\/jats:italic>\n = 0.38). Moreover, in all children, the correlation between erythrocyte and fasting insulin (FI) (\n p<\/jats:italic>\n = 0.00005,\n r<\/jats:italic>\n = 0.58), HOMA-IR (\n p<\/jats:italic>\n = 0.00005,\n r<\/jats:italic>\n = 0.58), and QUICKI (\n p<\/jats:italic>\n = 0.000042,\n r<\/jats:italic>\n = \u22120.59), as well as between HGB and FI (\n p<\/jats:italic>\n = 0.037,\n r<\/jats:italic>\n = 0.32), HOMA-IR (\n p<\/jats:italic>\n = 0.37,\n r<\/jats:italic>\n = 0.32), and QUICKI (\n p<\/jats:italic>\n = 0.049,\n r<\/jats:italic>\n = \u22120.31) was found. In the overweight\/obese group, erythrocyte count correlated with insulin 2 h after the oral glucose tolerance test (OGTT) (\n p<\/jats:italic>\n = 0.04,\n r<\/jats:italic>\n = 0.4), while HGB correlated with glucose and insulin 2 h after OGTT (\n p<\/jats:italic>\n = 0.018,\n r<\/jats:italic>\n = 0.45;\n p<\/jats:italic>\n = 0.04,\n r<\/jats:italic>\n = 0.44, respectively).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Our study confirmed that the erythrocyte parameters are higher in children with obesity and are positively correlated with insulin resistance and proinflammatory Th17 lymphocyte. Thus, it can be concluded that erythrocyte parameters reflect the risk of developing IR in response to chronic inflammation associated with obesity. These are simple, easily accessible, and repeatable tests that, in the assessment of obese patients, may herald the developing metabolic syndrome and serve as a helpful additional tool for assessing the effectiveness of treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.3389\/fendo.2024.1456203","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T23:49:35Z","timestamp":1731541775000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Inflammatory Th17 cells are correlated with insulin resistance and erythrocyte parameters in overweight and obese children"],"prefix":"10.3389","volume":"15","author":[{"given":"Dorota","family":"Artemniak-Wojtowicz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Rumi\u0144ska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stelmaszczyk-Emmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Paluchowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata Ewa","family":"Pyr\u017cak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Ma\u0142gorzata","family":"Kucharska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,11,14]]},"reference":[{"key":"B1","volume-title":"Draft recommendations for the prevention and management of obesity over the life course, including potential targets","year":"2021"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.5114\/ceji.2019.89608","article-title":"Changes in leukocyte profile and C-reactive protein concentration in overweight and obese adolescents after reduction of body weight","volume":"44","author":"Rumi\u0144ska","year":"2019","journal-title":"Cent Eur J Immunol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00241","article-title":"Early inflammatory status related to pediatric obesity","volume":"18","author":"M\u0103rginean","year":"2019","journal-title":"Front Pediatr"},{"key":"B4","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1186\/s12902-023-01423-1","article-title":"Associations of obesity and body shape with erythrocyte and reticulocyte parameters in the UK Biobank cohort","volume":"23","author":"Christakoudi","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1467-789X.2011.00938.x","article-title":"The relationship between obesity and hypoferraemia in adults: a systematic review","volume":"13","author":"Cheng","year":"2012","journal-title":"Obes Rev"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2343","article-title":"Immunological complications of obesity","volume":"13","author":"Kanneganti","year":"2012","journal-title":"Nat Immunol"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-55-6-1209","article-title":"Natural and biosynthetic insulin stimulates the growth of human erythroid progenitors in vitro","volume":"55","author":"Bersch","year":"1982","journal-title":"J Clin Endocrinol Metab"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-13-989","article-title":"Association between erythrocyte parameters and metabolic syndrome in urban Han Chinese: a longitudinal cohort study","author":"Wu","year":"2013","journal-title":"BMC Public Health"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-019792","article-title":"Association of erythrocyte parameters with metabolic syndrome in the Pearl River Delta region of China: a cross-sectional study","volume":"8","author":"Huang","year":"2018","journal-title":"BMJ Open"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s001250100634","article-title":"New aspects of the insulin resistance syndrome: impact on haematological parameters","volume":"44","author":"Barbieri","year":"2001","journal-title":"Diabetologia"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2010-1385","article-title":"Association between high red blood cell distribution width and metabolic syndrome. 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