{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T16:56:20Z","timestamp":1788886580935,"version":"build-2803163510"},"reference-count":81,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age, and presents a significant challenge to the global population. This review provides comprehensive evidence of interventions, including food and dietary supplements, aimed at reversing PCOS and improving fertility outcomes. Various dietary supplements are known to cause metabolic changes and hormonal regulation and have a potential impact on increasing pregnancy rates. Although some biochemical alterations have been observed, these metabolic changes do not directly reverse the disorder. Moreover, the lack of sufficient evidence does not convince clinicians to standardize dietary supplements as alternatives to medical or pharmacological interventions. This calls for a study of women with PCOS taking dietary supplements. In addition, unbiased studies of combinations of treatment options for supplements, including large cohort clinical trials, will lead to evidence-based medicine.<\/jats:p>","DOI":"10.3389\/fendo.2024.1456571","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:53:00Z","timestamp":1727398380000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":20,"title":["Dietary supplements in polycystic ovary syndrome\u2013current evidence"],"prefix":"10.3389","volume":"15","author":[{"given":"Ya","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qimao","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,9,27]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"89","DOI":"10.29063\/ajrh2022\/v26i8.9","article-title":"Polycystic ovary syndrome and metabolic disorders: A review of the literature","volume":"26","author":"Ali","year":"2022","journal-title":"Afr J Reprod Health"},{"key":"B2","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1038\/s41572-024-00511-3","article-title":"Polycystic ovary syndrome","volume":"10","author":"Stener-Victorin","year":"2024","journal-title":"Nat Rev Dis Primers"},{"key":"B3","doi-asserted-by":"publisher","first-page":"9240569","DOI":"10.1155\/2022\/9240569","article-title":"Association of insulin resistance and elevated androgen levels with polycystic ovarian syndrome (PCOS): A review of literature","volume":"2022","author":"Xu","year":"2022","journal-title":"J Healthc Eng"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.13992","article-title":"Effects of L-carnitine supplementation for women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"10","author":"Mohd Shukri","year":"2022","journal-title":"PeerJ"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1848","DOI":"10.3390\/nu13061848","article-title":"Polycystic Ovary Syndrome in Insulin-Resistant Adolescents with Obesity: The Role of Nutrition Therapy and Food Supplements as a Strategy to Protect Fertility","volume":"13","author":"Calcaterra","year":"2021","journal-title":"Nutrients"},{"key":"B6","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1186\/s12906-017-2011-x","article-title":"Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis","volume":"17","author":"Arentz","year":"2017","journal-title":"BMC Complement Altern Med"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-015-3950-4","article-title":"BMI and season are associated with vitamin D deficiency in women with impaired fertility: a two-centre analysis","volume":"293","author":"Dressler","year":"2016","journal-title":"Arch Gynecol Obstet"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-021-02342-7","article-title":"Antioxidant supplementations ameliorate PCOS complications: a review of RCTs and insights into the underlying mechanisms","volume":"38","author":"Gharaei","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1039\/D3FO02824K","article-title":"Efficacy of antioxidant supplementation in improving endocrine, hormonal, inflammatory, and metabolic statuses of PCOS: a meta-analysis and systematic review","volume":"15","author":"He","year":"2024","journal-title":"Food Funct"},{"key":"B10","doi-asserted-by":"publisher","first-page":"296","DOI":"10.3803\/EnM.2021.958","article-title":"An update on contraception in polycystic ovary syndrome","volume":"36","author":"Oguz","year":"2021","journal-title":"Endocrinol Metab (Seoul)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa839","article-title":"Update on PCOS: consequences, challenges, and guiding treatment","volume":"106","author":"Hoeger","year":"2021","journal-title":"J Clin Endocrinol Metab"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.808898","article-title":"Life modifications and PCOS: old story but new tales","volume":"13","author":"Gu","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-014-3433-z","article-title":"Focus on metabolic and nutritional correlates of polycystic ovary syndrome and update on nutritional management of these critical phenomena","volume":"290","author":"Rondanelli","year":"2014","journal-title":"Arch Gynecol Obstet"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00346","article-title":"Nutrition and female fertility: an interdependent correlation","volume":"10","author":"Silvestris","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.15167\/2421-4248\/jpmh2022.63.2S3.2762","article-title":"Dietary supplements for polycystic ovary syndrome","volume":"63","author":"Kiani","year":"2022","journal-title":"J Prev Med Hyg"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-019-00312-0","article-title":"A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS)","volume":"27","author":"Moini Jazani","year":"2019","journal-title":"Daru"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.736867","article-title":"Effects of tea consumption on anthropometric parameters, metabolic indexes and hormone levels of women with polycystic ovarian syndrome: A systematic review and meta-analysis of randomized controlled trials","volume":"12","author":"Shen","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1055\/a-1160-9902","article-title":"The effects of vitamin D on metabolic profiles in women with polycystic ovary syndrome: A systematic review","volume":"52","author":"Williams","year":"2020","journal-title":"Horm Metab Res"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-017-9407-2","article-title":"Shedding new light on female fertility: The role of vitamin D","volume":"18","author":"Muscogiuri","year":"2017","journal-title":"Rev Endocr Metab Disord"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/jsxmed\/qdad176","article-title":"Total and bioavailable 25-hydroxyvitamin D is not associated with improved sexual dysfunction following vitamin D supplementation in women with polycystic ovarian syndrome: a pilot study","volume":"21","author":"Eickman","year":"2024","journal-title":"J Sex Med"},{"key":"B21","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1186\/s12958-018-0413-3","article-title":"The effects of vitamin D supplementation on metabolic profiles and gene expression of insulin and lipid metabolism in infertile polycystic ovary syndrome candidates for in vitro fertilization","volume":"16","author":"Dastorani","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.3390\/nu12061567","article-title":"The association between vitamin D and anti-mullerian hormone: A systematic review and meta-analysis","volume":"12","author":"Moridi","year":"2020","journal-title":"Nutrients"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1148556","article-title":"Effects of vitamin D supplementation on ovulation and pregnancy in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"14","author":"Yang","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-125148","article-title":"The effects of vitamin D supplementation on biomarkers of inflammation and oxidative stress among women with polycystic ovary syndrome: A systematic review and meta-analysis of randomized controlled trials","volume":"50","author":"Akbari","year":"2018","journal-title":"Horm Metab Res"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3390\/nu7064139","article-title":"The role of vitamin D in reproductive health\u2013a Trojan Horse or the Golden Fleece","volume":"7","author":"Dabrowski","year":"2015","journal-title":"Nutrients"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2018.1431160","article-title":"The relationship between female reproductive functions and vitamin D","volume":"37","author":"Arslan","year":"2018","journal-title":"J Am Coll Nutr"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2022.2079629","article-title":"Vitamin E supplementation improves testosterone, glucose- and lipid-related metabolism in women with polycystic ovary syndrome: a meta-analysis of randomized clinical trials","volume":"38","author":"Yalle-Vasquez","year":"2022","journal-title":"Gynecol Endocrinol"},{"key":"B28","doi-asserted-by":"publisher","first-page":"5770","DOI":"10.1038\/s41598-022-09082-3","article-title":"Effect of vitamin E supplementation on cardiometabolic risk factors, inflammatory and oxidative markers and hormonal functions in PCOS (polycystic ovary syndrome): a systematic review and meta-analysis","volume":"12","author":"Tefagh","year":"2022","journal-title":"Sci Rep"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1875","DOI":"10.3390\/nu15081875","article-title":"Myo-inositol and D-chiro-inositol as modulators of ovary steroidogenesis: A narrative review","volume":"15","author":"Bizzarri","year":"2023","journal-title":"Nutrients"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2015.10.014","article-title":"The effect of FT500 Plus((R)) on ovarian stimulation in PCOS women","volume":"59","author":"Alviggi","year":"2016","journal-title":"Reprod Toxicol"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.09.001","article-title":"Inositol in polycystic ovary syndrome: restoring fertility through a pathophysiology-based approach","volume":"29","author":"Lagana","year":"2018","journal-title":"Trends Endocrinol Metab"},{"key":"B32","doi-asserted-by":"publisher","first-page":"3379","DOI":"10.3390\/nu12113379","article-title":"Inositol and non-Alcoholic fatty liver disease: A systematic review on deficiencies and supplementation","volume":"12","author":"Pani","year":"2020","journal-title":"Nutrients"},{"key":"B33","doi-asserted-by":"publisher","first-page":"103770","DOI":"10.1016\/j.rbmo.2023.103770","article-title":"Nutritional supplements and IVF: an evidence-based approach","volume":"48","author":"Hart","year":"2024","journal-title":"Reprod BioMed Online"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-018-4861-y","article-title":"Myo-inositol supplementation reduces the amount of gonadotropins and length of ovarian stimulation in women undergoing IVF: a systematic review and meta-analysis of randomized controlled trials","volume":"298","author":"Lagana","year":"2018","journal-title":"Arch Gynecol Obstet"},{"key":"B35","doi-asserted-by":"publisher","first-page":"CD012378","DOI":"10.1002\/14651858.CD012378.pub2","article-title":"Inositol for subfertile women with polycystic ovary syndrome","volume":"12","author":"Showell","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3746\/pnf.2023.28.2.121","article-title":"Effect of selenium supplementation on biochemical markers of women with polycystic ovarian syndrome: A systematic review","volume":"28","author":"Kazempour","year":"2023","journal-title":"Prev Nutr Food Sci"},{"key":"B37","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1186\/s12902-023-01286-6","article-title":"Effects of selenium supplementation on Polycystic Ovarian Syndrome: a systematic review and meta-analysis on randomized clinical trials","volume":"23","author":"Zhao","year":"2023","journal-title":"BMC Endocr Disord"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-024-10223-5","article-title":"Gut microbiota and polycystic ovary syndrome (PCOS): understanding the pathogenesis and the role of probiotics as a therapeutic strategy","author":"Salehi","year":"2024","journal-title":"Probiotics Antimicrob Proteins"},{"key":"B39","doi-asserted-by":"publisher","first-page":"110781","DOI":"10.1016\/j.diabres.2023.110781","article-title":"Exploring the role of gut microbiota in obesity and PCOS: Current updates and future prospects","volume":"202","author":"Zhang","year":"2023","journal-title":"Diabetes Res Clin Pract"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1080\/13813455.2021.1871760","article-title":"A comprehensive systematic review of the effectiveness of Akkermansia muciniphila, a member of the gut microbiome, for the management of obesity and associated metabolic disorders","volume":"129","author":"Roshanravan","year":"2023","journal-title":"Arch Physiol Biochem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"100993","DOI":"10.1016\/j.fbio.2021.100993","article-title":"Recent developments in probiotics: An emphasis on Bifidobacterium","volume":"41","author":"Sharma","year":"2021","journal-title":"Food Biosci"},{"key":"B42","doi-asserted-by":"publisher","first-page":"3144","DOI":"10.3390\/nu15143144","article-title":"Probiotics and polycystic ovary syndrome: A perspective for management in adolescents with obesity","volume":"15","author":"Calcaterra","year":"2023","journal-title":"Nutrients"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16388","article-title":"Probiotics: are they beneficial","volume":"54","author":"Fehily","year":"2024","journal-title":"Intern Med J"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2021.1951155","article-title":"Effects of probiotics, prebiotics, and synbiotics on polycystic ovary syndrome: a systematic review and meta-analysis","volume":"63","author":"Li","year":"2023","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B45","doi-asserted-by":"publisher","first-page":"2651","DOI":"10.3390\/microorganisms11112651","article-title":"Prebiotics, probiotics, and synbiotics-A research hotspot for pediatric obesity","volume":"11","author":"Borka Balas","year":"2023","journal-title":"Microorganisms"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-019-0434-9","article-title":"Effect of probiotics and synbiotics on selected anthropometric and biochemical measures in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"74","author":"Hadi","year":"2020","journal-title":"Eur J Clin Nutr"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-02033-1","article-title":"The effect of probiotics, prebiotics, and synbiotics on hormonal and inflammatory indices in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"59","author":"Shamasbi","year":"2020","journal-title":"Eur J Nutr"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-020-02233-0","article-title":"Therapy with probiotics and synbiotics for polycystic ovarian syndrome: a systematic review and meta-analysis","volume":"59","author":"Cozzolino","year":"2020","journal-title":"Eur J Nutr"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-020-01906-3","article-title":"Does coenzyme Q(10) supplementation improve fertility outcomes in women undergoing assisted reproductive technology procedures? A systematic review and meta-analysis of randomized-controlled trials","volume":"37","author":"Florou","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-022-01038-2","article-title":"Efficacy and safety of coenzyme Q10 supplementation in the treatment of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"30","author":"Zhang","year":"2023","journal-title":"Reprod Sci"},{"key":"B51","article-title":"Flaxseed supplementation reduces plasma lipoprotein(a) levels: A meta-analysis","volume":"27","author":"Sahebkar","year":"2021","journal-title":"Altern Ther Health Med"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2022.11.020","article-title":"The effect of folic acid supplementation on body weight and body mass index: A systematic review and meta-analysis of randomized controlled trials","volume":"53","author":"Jafari","year":"2023","journal-title":"Clin Nutr ESPEN"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.5935\/1518-0557.20190033","article-title":"Effects of L-carnitine on polycystic ovary syndrome","volume":"23","author":"Salehpour","year":"2019","journal-title":"JBRA Assist Reprod"},{"key":"B54","doi-asserted-by":"publisher","first-page":"2464","DOI":"10.3390\/nu12082464","article-title":"The role of zinc in selected female reproductive system disorders","volume":"12","author":"Nasiadek","year":"2020","journal-title":"Nutrients"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.52586\/5046","article-title":"Choline supplementation influences ovarian follicular development","volume":"26","author":"Zhan","year":"2021","journal-title":"Front Biosci (Landmark Ed)"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14166","article-title":"Cinnamon, an effective anti-obesity agent: Evidence from an umbrella meta-analysis","volume":"46","author":"Keramati","year":"2022","journal-title":"J Food Biochem"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13543","article-title":"The effect of cinnamon supplementation on glycemic control in women with polycystic ovary syndrome: A systematic review and meta-analysis","volume":"45","author":"Heshmati","year":"2021","journal-title":"J Food Biochem"},{"key":"B58","doi-asserted-by":"publisher","first-page":"112741","DOI":"10.1016\/j.jep.2020.112741","article-title":"Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis","volume":"254","author":"Heydarpour","year":"2020","journal-title":"J Ethnopharmacol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2021.1988559","article-title":"Clinical evidence of the effects of carnitine supplementation on body weight, glycemic control and serum lipids in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"38","author":"Liao","year":"2022","journal-title":"Gynecol Endocrinol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1111\/jog.14858","article-title":"The impact of timing for estrogen supplementation in polycystic ovary syndrome patients undergoing primed in vitro maturation","volume":"47","author":"Hatirnaz","year":"2021","journal-title":"J Obstet Gynaecol Res"},{"key":"B61","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1002\/ptr.v36.1","article-title":"The effects of curcumin as dietary supplement for patients with polycystic ovary syndrome: An updated systematic review and meta-analysis of randomized clinical trials","volume":"36","author":"Abdelazeem","year":"2022","journal-title":"Phytother Res"},{"key":"B62","doi-asserted-by":"publisher","first-page":"684","DOI":"10.3390\/nu13020684","article-title":"Effects of curcumin on glycemic control and lipid profile in polycystic ovary syndrome: systematic review with meta-analysis and trial sequential analysis","volume":"13","author":"Chien","year":"2021","journal-title":"Nutrients"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nutres.2018.04.003","article-title":"Chromium supplementation does not improve weight loss or metabolic and hormonal variables in patients with polycystic ovary syndrome: A systematic review","volume":"56","author":"Maleki","year":"2018","journal-title":"Nutr Res"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1111\/jog.2018.44.issue-1","article-title":"Chromium supplementation in women with polycystic ovary syndrome: Systematic review and meta-analysis","volume":"44","author":"Tang","year":"2018","journal-title":"J Obstet Gynaecol Res"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2017.04.008","article-title":"Chromium supplementation and polycystic ovary syndrome: A systematic review and meta-analysis","volume":"42","author":"Fazelian","year":"2017","journal-title":"J Trace Elem Med Biol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-105288","article-title":"The effect of n-3 polyunsaturated fatty acid supplementation on androgen status in patients with polycystic ovary syndrome: A systematic review and meta-analysis of clinical trials","volume":"48","author":"Hajishafiee","year":"2016","journal-title":"Horm Metab Res"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-1050","article-title":"Efficacy of omega-3 fatty acid supplementation on cardiovascular risk factors in patients with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"10","author":"Xia","year":"2021","journal-title":"Ann Palliat Med"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520003207","article-title":"Influence of n-3 fatty acid supplementation on inflammatory and oxidative stress markers in patients with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"125","author":"Tosatti","year":"2021","journal-title":"Br J Nutr"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-023-07310-3","article-title":"Expert consensus on the role of supplementation in obstetrics and gynecology using modified delphi method","volume":"309","author":"Soliman","year":"2024","journal-title":"Arch Gynecol Obstet"},{"key":"B70","doi-asserted-by":"publisher","first-page":"757","DOI":"10.3390\/nu12030757","article-title":"Probiotics dietary supplementation for modulating endocrine and fertility microbiota dysbiosis","volume":"12","author":"Lopez-Moreno","year":"2020","journal-title":"Nutrients"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.5603\/gpl.96864","article-title":"How important are elements in polycystic ovary syndrome? Should they be supplemented? A systematic review","volume":"95","author":"Pokorska-Niewiada","year":"2024","journal-title":"Ginekol Pol"},{"key":"B72","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.fertnstert.2016.05.011","article-title":"Environmental determinants of polycystic ovary syndrome","volume":"106","author":"Merkin","year":"2016","journal-title":"Fertil Steril"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajcnut.2023.12.005","article-title":"Food, nutrition, and fertility: from soil to fork","volume":"119","author":"Maitin-Shepard","year":"2024","journal-title":"Am J Clin Nutr"},{"key":"B74","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s12905-022-01828-5","article-title":"Falsely elevated serum estradiol in woman of reproductive age led to unnecessary intervention and delayed fertility opportunity: a case report and literature review","volume":"22","author":"Zhang","year":"2022","journal-title":"BMC Womens Health"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.2174\/0929867323666161202150008","article-title":"Vitamin D\/VDR, probiotics, and gastrointestinal diseases","volume":"24","author":"Shang","year":"2017","journal-title":"Curr Med Chem"},{"key":"B76","doi-asserted-by":"publisher","first-page":"111","DOI":"10.3390\/nu13010111","article-title":"The health effects of vitamin D and probiotic co-supplementation: A systematic review of randomized controlled trials","volume":"13","author":"Abboud","year":"2020","journal-title":"Nutrients"},{"key":"B77","doi-asserted-by":"publisher","first-page":"623\u201331","DOI":"10.1080\/09513590.2022.2089106","article-title":"Nutraceuticals and polycystic ovary syndrome: a systematic review of the literature","volume":"38","author":"Menichini","year":"2022","journal-title":"Gynecol Endocrinol"},{"key":"B78","doi-asserted-by":"publisher","first-page":"19927","DOI":"10.1038\/s41598-022-24467-0","article-title":"A meta-analysis of effects of vitamin E supplementation alone and in combination with omega-3 or magnesium on polycystic ovary syndrome","volume":"12","author":"Heidari","year":"2022","journal-title":"Sci Rep"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.974042","article-title":"The effect of magnesium alone or its combination with other supplements on the markers of inflammation, OS and metabolism in women with polycystic ovarian syndrome (PCOS): A systematic review","volume":"13","author":"Li","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1810657","article-title":"Impact of myoinositol with metformin and myoinositol alone in infertile PCOS women undergoing ovulation induction cycles - randomized controlled trial","volume":"37","author":"Prabhakar","year":"2021","journal-title":"Gynecol Endocrinol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2022.2136160","article-title":"Effectiveness of inositol, metformin and their combination in women with PCOS undergoing assisted reproduction: systematic review and meta-analysis","volume":"38","author":"Unanyan","year":"2022","journal-title":"Gynecol Endocrinol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1456571\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:53:03Z","timestamp":1727398383000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1456571\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,27]]},"references-count":81,"alternative-id":["10.3389\/fendo.2024.1456571"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2024.1456571","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,27]]},"article-number":"1456571"}}