{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:44:44Z","timestamp":1793187884507,"version":"4.5.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ50027, 2023JJ50250, 2023JJ50244"],"award-info":[{"award-number":["2022JJ50027, 2023JJ50250, 2023JJ50244"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The aim of this study was to investigate the effects of blood flow-restrictive resistance training (BFR-RT) on improving metabolic abnormalities, blood pressure (BP), obesity, and 10-year atherosclerotic cardiovascular disease (ASCVD) risk in middle-aged patients with type 2 diabetes mellitus (T2DM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted a parallel-group, single blind randomized controlled trial. Participants who met the inclusion criteria were randomly divided into control group, BFR-RT group and aerobic exercise (AE) group. Control group received health education and follow-up; Two exercise groups received supervised collective training for a period of six months, three times per week. AE group trained at moderate-intensity for 60 minutes each time, while BFR-RT group trained at low-intensity for 40 minutes each time. The primary outcomes were change in 10-year ASCVD risk index and level, and the secondary outcomes included changes in fasting plasma glucose (FPG), glycosylated hemoglobin (HbA1c), blood lipids, BP, and obesity level within and across the three groups at baseline, the third and sixth months of intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Result<\/jats:title>\n                    <jats:p>Among 93 individuals (control group, n=31; AE, n=30; BFR-RT, n=32) were analyzed. At baseline, there were no significant differences in various indicators among the three groups (p&amp;gt;0.05). After intervention, the 10-year ASCVD risk index and risk level of both exercise groups significantly decreased compared to the control group and baseline (p&amp;lt;0.05), and the risk reduction became more pronounced over time. In the sixth month of intervention, the 10-year ASCVD risk index in the AE group decreased by 27.40%, and that in the BFR-RT group decreased by 26.78%. Meanwhile, apart from lipoprotein (a) and diastolic blood pressure, both exercise groups showed significant improvements in FPG, HbA1c, dyslipidemia, systolic blood pressure, and obesity indicators compared to the control group and baseline (p&amp;lt;0.05). There was no significant difference in various indicators between the two exercise groups (p&amp;gt;0.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>BFR-RT could reduce the 10-year ASCVD risk in middle-aged T2DM patients for by improving metabolic abnormalities, BP and obesity, and its effect was similar to that of moderate-intensity AE.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Clinical trial registration<\/jats:title>\n                    <jats:p>\n                      <jats:uri>https:\/\/www.chictr.org.cn\/showproj.html?proj=178886<\/jats:uri>\n                      , identifier ChiCTR2300074357.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2024.1482985","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:32:47Z","timestamp":1727742767000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["The effect of blood flow-restrictive resistance training on the risk of atherosclerotic cardiovascular disease in middle-aged patients with type 2 diabetes: a randomized controlled trial"],"prefix":"10.3389","volume":"15","author":[{"given":"Xiaojun","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuandong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinyu","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulian","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yating","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liduo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenfang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binghua","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sijie","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32374-6","article-title":"\u201cThe Lancet Commission on diabetes: using data to transform diabetes care and patient lives.\u201d","volume":"396","author":"Chan","year":"2021","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-022-01243-x","article-title":"The prevalence of cardiovascular disease in adults with type 2 diabetes in China: results from the cross-sectional CAPTURE study","volume":"13","author":"Hong","year":"2022","journal-title":"Diabetes Ther"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001040","article-title":"Comprehensive management of cardiovascular risk factors for adults with type 2 diabetes: A scientific statement from the american heart association","volume":"145","author":"Joseph","year":"2022","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.pcad.2023.04.008","article-title":"Exercise and cardiovascular health: A state-of-the-art review","volume":"79","author":"Isath","year":"2023","journal-title":"Prog Cardiovasc Dis"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br J Sports Med"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad170","article-title":"Exercise benefits in cardiovascular diseases: from mechanisms to clinical implementation","volume":"44","author":"Valenzuela","year":"2023","journal-title":"Eur Heart J"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.2147\/PPA.S374120","article-title":"Exercise adherence and compliance and its related factors among elderly patients with type 2 diabetes in China: A cross-sectional study","volume":"16","author":"Zhu","year":"2022","journal-title":"Patient Preference Adherence"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002800","article-title":"Exercise\/physical activity in individuals with type 2 diabetes: A consensus statement from the american college of sports medicine","volume":"54","author":"Kanaley","year":"2022","journal-title":"Med Sci Sports Exercise"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.12114\/j.issn.1007-9572.2024.A0019","article-title":"Guideline for exercise therapy of type 2 diabetes mellitus in China (2024 edition)","volume":"27","author":"Guo","year":"2024","journal-title":"Chin Gen Practice"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2020.11.010","article-title":"Effects of blood flow restriction exercise and possible applications in type 2 diabetes","volume":"32","author":"Saatmann","year":"2021","journal-title":"Trends Endocrinol Metab"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1252052","article-title":"Effects of blood flow restriction training on muscle fitness and cardiovascular risk of obese college students","volume":"14","author":"Su","year":"2023","journal-title":"Front Physiol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1475-097X.2012.01158.x","article-title":"Haemostatic and inflammatory responses to blood flow-restricted exercise in patients with ischaemic heart disease: a pilot study","volume":"33","author":"Madarame","year":"2012","journal-title":"Clin Physiol Funct Imaging"},{"key":"B13","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1186\/s12877-023-04592-9","article-title":"Comparing the efficacy of low-load resistance exercise combined with blood flow restriction versus conventional-load resistance exercise in Chinese community-dwelling older people with sarcopenic obesity: a study protocol for a randomised controlled trial","volume":"23","author":"Zhuang","year":"2023","journal-title":"BMC Geriatr"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.808622","article-title":"A useful blood flow restriction training risk stratification for exercise and rehabilitation","volume":"13","author":"Nascimento","year":"2022","journal-title":"Front Physiol"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.4085\/418-20","article-title":"Blood flow restriction training","volume":"56","author":"Lorenz","year":"2021","journal-title":"J Athletic Training"},{"key":"B16","unstructured":"Definition and diagnosis of diabetes mellitus and intermediate hyperglycaemia. Report of a WHO\/IDF consultation2006"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e318213fefb","article-title":"Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults","volume":"43","author":"Garber","year":"2011","journal-title":"Med Sci Sports Exercise"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60484-9","article-title":"Diabetes mellitus, fasting blood glucose concentration, and risk of vascular disease: a collaborative meta-analysis of 102 prospective studies","volume":"375","author":"Sarwar","year":"2010","journal-title":"Lancet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.3969\/j.issn.1006\u20436187.2022.01.002","article-title":"Clinical guidelines for the prevention and treatment of type 2 diabetes in the elderly in China (2022)","volume":"30","year":"2022","journal-title":"Chin J Diabetes"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-023-05958-9","article-title":"Strength training is more effective than aerobic exercise for improving glycaemic control and body composition in people with normal-weight type 2 diabetes: a randomised controlled trial","volume":"66","author":"Kobayashi","year":"2023","journal-title":"Diabetologia"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.022367","article-title":"Predicting the 10-year risks of atherosclerotic cardiovascular disease in chinese population","volume":"134","author":"Yang","year":"2016","journal-title":"Circulation"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cdtm.2016.10.001","article-title":"Risk stratification of atherosclerotic cardiovascular disease in Chinese adults","volume":"2","author":"Yang","year":"2016","journal-title":"Chronic Dis Trans Med"},{"key":"B23","doi-asserted-by":"publisher","first-page":"458","DOI":"10.3390\/ijms17040458","article-title":"Apolipoprotein A1-unique peptide as a diagnostic biomarker for acute ischemic stroke","volume":"17","author":"Zhao","year":"2016","journal-title":"Int J Mol Sci"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1000-3614.2022.10.002","article-title":"Chinese expert consensus on the risk assessment and management of panvascular disease in patients with type 2 diabetes mellitus (2022 edition)","volume":"37","year":"2022","journal-title":"Chin Circ J"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2006.05.004","article-title":"The apolipoprotein story","volume":"7","author":"Sacks","year":"2006","journal-title":"Atheroscler Suppl"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.01.027","article-title":"Apolipoprotein B and non-HDL cholesterol better reflect residual risk than LDL cholesterol in statin-treated patients","volume":"77","author":"Johannesen","year":"2021","journal-title":"J Am Coll Cardiol"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00708.2019","article-title":"The effects of exercise training on lipid metabolism and coronary heart disease","volume":"319","author":"Muscella","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/S2666-7568(22)00247-1","article-title":"Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): a prospective cohort study","volume":"4","author":"Lopez-Jaramillo","year":"2023","journal-title":"Lancet Healthy Longev"},{"key":"B29","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1186\/s12933-023-02030-z","article-title":"The triglyceride-glucose index is a predictor for cardiovascular and all-cause mortality in CVD patients with diabetes or pre-diabetes: evidence from NHANES 2001-2018","volume":"22","author":"Zhang","year":"2023","journal-title":"Cardiovasc Diabetol"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(21)00045-0","article-title":"Epidemiology and determinants of obesity in China","volume":"9","author":"Pan","year":"2021","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.metabol.2019.06.003","article-title":"Blood flow-restricted training enhances thigh glucose uptake during exercise and muscle antioxidant function in humans","volume":"98","author":"Christiansen","year":"2019","journal-title":"Metabolism"},{"key":"B32","doi-asserted-by":"publisher","first-page":"e13045","DOI":"10.1111\/apha.2018.223.issue-2","article-title":"Increased FXYD1 and PGC-1\u03b1 mRNA after blood flow-restricted running is related to fibre type-specific AMPK signalling and oxidative stress in human muscle","volume":"223","author":"Christiansen","year":"2018","journal-title":"Acta Physiol"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1113\/eph.2018.103.issue-7","article-title":"Functional high-intensity exercise training ameliorates insulin resistance and cardiometabolic risk factors in type 2 diabetes","volume":"103","author":"Fealy","year":"2018","journal-title":"Exp Physiol"},{"key":"B34","doi-asserted-by":"publisher","first-page":"2717","DOI":"10.3390\/ijms20112717","article-title":"Exercise and sirtuins: A way to mitochondrial health in skeletal muscle","volume":"20","author":"Vargas-Ortiz","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/apha.v239.2","article-title":"Hormonal, immune, and oxidative stress responses to blood flow-restricted exercise","volume":"239","author":"Hjortshoej","year":"2023","journal-title":"Acta Physiol (Oxf)"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e11051","article-title":"Acute effects of low load resistance training with blood flow restriction on serum growth hormone, insulin-like growth factor-1, and testosterone in patients with mild to moderate unilateral knee osteoarthritis","volume":"8","author":"Chen","year":"2022","journal-title":"Heliyon"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1039591","article-title":"Effects of blood flow restriction training on anthropometric and blood lipids in overweight\/obese adults: Meta-analysis","volume":"13","author":"Sun","year":"2022","journal-title":"Front Physiol"},{"key":"B38","doi-asserted-by":"publisher","first-page":"e13769","DOI":"10.1111\/apha.v234.2","article-title":"Aerobic-interval exercise with blood flow restriction potentiates early markers of metabolic health in man","volume":"234","author":"Christiansen","year":"2022","journal-title":"Acta Physiol"},{"key":"B39","doi-asserted-by":"publisher","first-page":"38","DOI":"10.3760\/cma.j.cn112148-20221011-00791","article-title":"Value of glycosylated hemoglobin A1c and apolipoprotein A\u22121 ratio on predicting outcome of patients with acute coronary syndrome","volume":"51","author":"Wang","year":"2023","journal-title":"Chin J Cardiovasc Dis"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2337\/dc12-1411","article-title":"Glycation of apoprotein A-I is associated with coronary artery plaque progression in type 2 diabetic patients","volume":"36","author":"Pu","year":"2013","journal-title":"Diabetes Care"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2015.133","article-title":"Effects of aerobic and resistance training on abdominal fat, apolipoproteins and high-sensitivity C-reactive protein in adolescents with obesity: the HEARTY randomized clinical trial","volume":"39","author":"Alberga","year":"2015","journal-title":"Int J Obes (Lond)"},{"key":"B42","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1186\/s12967-023-04070-1","article-title":"Identification of serum exosomal metabolomic and proteomic profiles for remote ischemic preconditioning","volume":"21","author":"Du","year":"2023","journal-title":"J Transl Med"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9650-y","article-title":"The effects of resistance training on ApoB\/ApoA-I ratio, Lp(a) and inflammatory markers in patients with type 2 diabetes","volume":"42","author":"Kadoglou","year":"2012","journal-title":"Endocrine"},{"key":"B44","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s12933-023-02115-9","article-title":"The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003-2018","volume":"23","author":"Dang","year":"2024","journal-title":"Cardiovasc Diabetol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000000930","article-title":"Influence of blood flow restriction during low-intensity resistance exercise on the postexercise hypotensive response","volume":"29","author":"Maior","year":"2015","journal-title":"J Strength Cond Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"79","DOI":"10.2478\/hukin-2014-0092","article-title":"The acute effect of resistance exercise with blood flow restriction with hemodynamic variables on hypertensive subjects","volume":"43","author":"Araujo","year":"2014","journal-title":"J Hum Kinet"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01324","article-title":"Hemodynamic responses to low-load blood flow restriction and unrestricted high-load resistance exercise in older women","volume":"9","author":"Scott","year":"2018","journal-title":"Front Physiol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00208.2015","article-title":"Blood flow restriction training and the exercise pressor reflex: a call for concern","volume":"309","author":"Spranger","year":"2015","journal-title":"Am J Physiology-Heart Circulatory Physiol"},{"key":"B49","doi-asserted-by":"publisher","first-page":"H90","DOI":"10.1152\/ajpheart.00468.2019","article-title":"Clinical safety of blood flow-restricted training? A comprehensive review of altered muscle metaboreflex in cardiovascular disease during ischemic exercise","volume":"318","author":"Cristina-Oliveira","year":"2020","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1055\/s-0043-109555","article-title":"The cardiovascular and perceptual response to very low load blood flow restricted exercise","volume":"38","author":"Jessee","year":"2017","journal-title":"Int J Sports Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003307","article-title":"Impact of blood flow restriction exercise on central hemodynamics and fluid regulating hormones","volume":"56","author":"Thompson","year":"2024","journal-title":"Med Sci Sports Exerc"},{"key":"B52","doi-asserted-by":"publisher","first-page":"19152","DOI":"10.1038\/s41598-023-44523-7","article-title":"Effect of continuous and intermittent blood flow restriction deep-squat training on thigh muscle activation and fatigue levels in male handball players","volume":"13","author":"Wang","year":"2023","journal-title":"Sci Rep"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000002156","article-title":"Effect of cuff pressure on blood flow during blood flow-restricted rest and exercise","volume":"52","author":"Crossley","year":"2020","journal-title":"Med Sci Sports Exerc"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1123\/ijspp.2021-0523","article-title":"Muscle fatigue is attenuated when applying intermittent compared with continuous blood flow restriction during endurance cycling","volume":"17","author":"Corvino","year":"2022","journal-title":"Int J Sports Physiol Perform"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1002\/ejhf.v23.9","article-title":"The ergoreflex: how the skeletal muscle modulates ventilation and cardiovascular function in health and disease","volume":"23","author":"Aimo","year":"2021","journal-title":"Eur J Heart Fail"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.4495","article-title":"Association of exercise preconditioning with immediate cardioprotection: A review","volume":"3","author":"Thijssen","year":"2018","journal-title":"JAMA Cardiol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-022-00641-2","article-title":"Exerkines in health, resilience and disease","volume":"18","author":"Chow","year":"2022","journal-title":"Nat Rev Endocrinol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"3249","DOI":"10.3390\/ijms20133249","article-title":"Effects on the Profile of Circulating miRNAs after Single Bouts of Resistance Training with and without Blood Flow Restriction-A Three-Arm, Randomized Crossover Trial","volume":"20","author":"Vogel","year":"2019","journal-title":"Int J Mol Sci"},{"key":"B59","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1080\/17461391.2017.1422281","article-title":"The acute angiogenic signalling response to low-load resistance exercise with blood flow restriction","volume":"18","author":"Ferguson","year":"2018","journal-title":"Eur J Sport Sci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1007\/s00395-014-0453-6","article-title":"Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop","volume":"110","author":"Pickard","year":"2015","journal-title":"Basic Res Cardiol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1482985\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:32:52Z","timestamp":1727742772000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1482985\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":60,"alternative-id":["10.3389\/fendo.2024.1482985"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2024.1482985","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"article-number":"1482985"}}