{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:30:46Z","timestamp":1791469846262,"version":"4.3.4"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:00:00Z","timestamp":1737417600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To clarify whether intrauterine adhesions (IUAs) affect endometrial receptivity (ER) on the day of ovulation and to compare patients with mild and moderate-severe adhesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This prospective cohort study included 592 infertile women with IUAs who underwent frozen-thawed embryo transfer (FET). Patients were divided into groups with or without IUAs; and pregnant and nonpregnant populations based on whether a clinical pregnancy was achieved. The ultrasound ER parameters on the ovulation day were compared. Patients with IUAs were then divided into mild or moderate-severe IUA subgroups according to IUA degree.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proportions of patients with Type B plus Type C endometrial morphology (94% vs. 75%, P&amp;lt;0.001), an endometrial thickness\u22658mm (97% vs. 81%, P&amp;lt;0.001), an endometrial volume\u22652ml (94% vs. 67%, P&amp;lt;0.001), a frequency of endometrial peristalsis\u22652 times\/min (84% vs. 53%, P&amp;lt;0.001), low subendometrial volume (11.54 \u00b1 2.94 vs. 9.57 \u00b1 2.35, P&amp;lt;0.001) and subendometrial vascularization flow index (VFI) values (2.70 \u00b1 3.10 vs. 2.23 \u00b1 2.23, P=0.033) and a low live birth rate (65% vs. 56%, P=0.039) were significantly higher in the group without IUAs than in the group with IUAs. The group with moderate-severe IUAs had lower proportion of patients with an endometrial thickness\u22658mm (73% vs. 89%, P=0.008) and an endometrial volume \u22652ml (58% vs. 78%, P=0.005), a lower frequency of endometrial peristalsis\u22652 times\/min (42% vs. 65%, P=0.003), and low subendometrial volume (9.22 \u00b1 2.29 vs. 9.97 \u00b1 2.36, P=0.023) and subendometrial flow index (FI) (31.48 \u00b1 3.64 vs. 33.43 \u00b1 4.17, P=0.002) values than the group with mild IUAs; a high antral follicle count (AFC), basal follicle-stimulating hormone (FSH), and anti-M\u00fcllerian hormone (AMH) levels and an endometrial thickness\u22658mm were independent predictors of clinical pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IUAs can affect ER on the ovulation day and the live birth rate during natural cycles. Moderate-severe IUAs have a greater impact on ER than mild adhesions do; however, if these adhesions are treated properly, they do not have adverse effects on the clinical pregnancy rate. A high AFC, basal FSH and AMH levels and an endometrial thickness \u22658 mm were found to be independent predictors of clinical pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2024.1489839","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T05:43:48Z","timestamp":1737438228000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":8,"title":["The impact of intrauterine adhesions on endometrial receptivity in patients undergoing in vitro fertilization-embryo transfer"],"prefix":"10.3389","volume":"15","author":[{"given":"Yan","family":"Ouyang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangqin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxiang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyao","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xihong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s10397-014-0832-x","article-title":"Anti-adhesion barrier gels following\u00a0operative hysteroscopy for treating female infertility: A systematic review and meta-analysis","volume":"11","author":"Bosteels","year":"2014","journal-title":"Gynecological Surg"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmig.2013.07.018","article-title":"Efficacy of estrogen therapy in patients with intrauterine adhesions: systematic review","volume":"21","author":"Johary","year":"2014","journal-title":"J Minimally Invasive Gynecology"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/s0015-0282(16)46268-0","article-title":"Intrauterine adhesions: an updated appraisal","volume":"37","author":"Schenker","year":"1982","journal-title":"Fertility Sterility"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.02.096","article-title":"Asherman syndrome-one century later","volume":"89","author":"Yu","year":"2008","journal-title":"Fertility Sterility"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/uog.8950","article-title":"A new method for analysis of non-pregnant uterine peristalsis using transvaginal ultrasound","volume":"38","author":"Meirzon","year":"2011","journal-title":"Ultrasound Obstet Gynecol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/s10397-017-1007-3","article-title":"AAGL practice report: practice guidelines on intrauterine adhesions developed in collaboration with the European Society of Gynaecological Endoscopy (ESGE)","volume":"14","author":"Abbott","year":"2017","journal-title":"Gynecol Surg"},{"key":"B7","article-title":"Evaluation of implantation and clinical pregnancy rates after endometrial scratching in women with recurrent implantation failure","author":"Pecorino","year":"2018","journal-title":". 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