{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T03:04:03Z","timestamp":1784775843441,"version":"3.55.0"},"reference-count":34,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Choline kinase alpha (ChoK\u03b1) is a therapeutic target being developed for a variety of diseases, from cancer to rheumatoid arthritis and from parasites to bacterial infections. Nevertheless, the therapeutic potential of this drug target seems not exhausted and may end up as a possible solution for a larger variety of conditions. Here we present our working model for how ChoK\u03b1 could play a role in obesity and for how drugs being developed as therapeutics for other diseases using ChoK\u03b1 as a target, could be repurposed as prophylactic treatments for obesity. We also present preliminary observations in support of our model.<\/jats:p>","DOI":"10.3389\/fendo.2024.1492753","type":"journal-article","created":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T04:31:47Z","timestamp":1730867507000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Is choline kinase alpha a drug target for obesity?"],"prefix":"10.3389","volume":"15","author":[{"given":"Juan Carlos","family":"Lacal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salam 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