{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:03:41Z","timestamp":1793120621008,"version":"4.5.0"},"reference-count":156,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:00:00Z","timestamp":1734652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT180483, PJT168882"],"award-info":[{"award-number":["PJT180483, PJT168882"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["04543, 05267"],"award-info":[{"award-number":["04543, 05267"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>The placenta is a temporary organ that forms during pregnancy and is essential for fetal development and maternal health. As an endocrine organ, proper placental function requires continual production, folding, and transport of proteins and lipids. Central to these processes is the endoplasmic reticulum (ER), a dynamic organelle responsible for maintaining cellular protein and lipid synthesis and processing. ER stress occurs when there is an accumulation of unfolded or misfolded proteins, which triggers the activation of cellular pathways collectively called the unfolded protein response. Unfolded protein response pathways act to alleviate the misfolded protein burden and restore ER homeostasis, or if unresolved, initiate cell death. While prolonged ER stress has been linked to deficient placental function and adverse pregnancy outcomes, basal activation of unfolded protein response pathways is required for placental development and function. This review explores the importance of ER homeostasis in placental development and function, examining how disruptions in ER stress responses may contribute to adverse pregnancy outcomes.<\/jats:p>","DOI":"10.3389\/fendo.2024.1525189","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:11:20Z","timestamp":1734653480000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["A stress paradox: the dual role of the unfolded protein response in the placenta"],"prefix":"10.3389","volume":"15","author":[{"given":"Diba","family":"Chowdhury","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe E.","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lajoie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"Renaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2024,12,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1003821","article-title":"Placental syncytium forms a biophysical barrier against pathogen invasion","volume":"9","author":"Zeldovich","year":"2013","journal-title":"PloS Pathog"},{"key":"B2","doi-asserted-by":"publisher","first-page":"12266","DOI":"10.3390\/ijms222212266","article-title":"On placental toxicology studies and cerium dioxide nanoparticles","volume":"22","author":"Deval","year":"2021","journal-title":"IJMS"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1113\/tjp.2009.587.issue-14","article-title":"Placental efficiency and adaptation: endocrine regulation","volume":"587","author":"Fowden","year":"2009","journal-title":"J Physiol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0011","article-title":"Endocrine regulation of human fetal growth: the role of the mother, placenta, and fetus","volume":"27","author":"Murphy","year":"2006","journal-title":"Endocrine Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.rbmo.2015.10.005","article-title":"The endocrine function of human placenta: an overview","volume":"32","author":"Costa","year":"2016","journal-title":"Reprod BioMedicine Online"},{"key":"B6","doi-asserted-by":"publisher","first-page":"8003","DOI":"10.3390\/ijms23148003","article-title":"Human chorionic villous differentiation and placental development","volume":"23","author":"Kojima","year":"2022","journal-title":"IJMS"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.12717\/DR.2017.21.4.351","article-title":"A review of mechanisms of implantation","volume":"21","author":"Kim","year":"2017","journal-title":"Dev Reprod"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.674162","article-title":"Omics approaches to study formation and function of human placental syncytiotrophoblast","volume":"9","author":"Jaremek","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007698","article-title":"Genome amplification and cellular senescence are hallmarks of human placenta development","volume":"14","author":"Velicky","year":"2018","journal-title":"PloS Genet"},{"key":"B10","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocrine Rev"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70598-2","article-title":"Insulin-like growth factor binding protein-1 at the maternal-fetal interface and insulin-like growth factor-I, insulin-like growth factor-II, and insulin-like growth factor binding protein-1 in the circulation of women with severe preeclampsia","volume":"176","author":"Giudice","year":"1997","journal-title":"Am J Obstetrics Gynecology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1093\/biolre\/ioy049","article-title":"Hemochorial placentation: development, function, and adaptations\u2020","volume":"99","author":"Soares","year":"2018","journal-title":"Biol Reproduction"},{"key":"B13","doi-asserted-by":"publisher","first-page":"l2381","DOI":"10.1136\/bmj.l2381","article-title":"Pre-eclampsia: pathophysiology and clinical implications","volume":"5","author":"Burton","year":"2019","journal-title":"BMJ"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.10.815","article-title":"797: The role of inflammation in late-onset preeclampsia","volume":"206","author":"Ornaghi","year":"2012","journal-title":"Am J Obstetrics Gynecology"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0223888","article-title":"Increased BMI has a linear association with late-onset preeclampsia: A population-based study","volume":"14","author":"Robillard","year":"2019","journal-title":"PloS One"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejcn.1600958","article-title":"Whole body protein turnover can be measured non-invasively in women using the end product method with [15N]glycine to show changes with the menstrual cycle and pregnancy","volume":"54","author":"Jackson","year":"2000","journal-title":"Eur J Clin Nutr"},{"key":"B17","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12014-021-09324-y","article-title":"Proteome profiling of human placenta reveals developmental stage-dependent alterations in protein signature","volume":"18","author":"Khorami Sarvestani","year":"2021","journal-title":"Clin Proteom"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.1032607","article-title":"The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment","volume":"16","author":"Sun","year":"2022","journal-title":"Front Neurosci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209038","article-title":"The unfolded protein response: from stress pathway to homeostatic regulation","volume":"334","author":"Walter","year":"2011","journal-title":"Science"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e11-12-0995","article-title":"Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells","volume":"23","author":"Lajoie","year":"2012","journal-title":"Mol Biol Cell"},{"key":"B21","doi-asserted-by":"publisher","first-page":"158449","DOI":"10.1016\/j.bbalip.2019.04.009","article-title":"Lipid bilayer stress and proteotoxic stress-induced unfolded protein response deploy divergent transcriptional and non-transcriptional programmes","volume":"1865","author":"Fun","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nature17041","article-title":"Protein misfolding in the endoplasmic reticulum as a conduit to human disease","volume":"529","author":"Wang","year":"2016","journal-title":"Nature"},{"key":"B23","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/j.molcel.2017.06.012","article-title":"Activation of the unfolded protein response by lipid bilayer stress","volume":"67","author":"Halbleib","year":"2017","journal-title":"Mol Cell"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.110.5.1501","article-title":"Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately","volume":"110","author":"Wiest","year":"1990","journal-title":"J Cell Biol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200907074","article-title":"Membrane expansion alleviates endoplasmic reticulum stress independently of the unfolded protein response","volume":"187","author":"Schuck","year":"2009","journal-title":"J Cell Biol"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1111\/febs.2019.286.issue-2","article-title":"Endoplasmic reticulum stress signalling \u2013 from basic mechanisms to clinical applications","volume":"286","author":"Almanza","year":"2019","journal-title":"FEBS J"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.42","article-title":"Heat shock response relieves ER stress","volume":"27","author":"Liu","year":"2008","journal-title":"EMBO J"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2010.12.002","article-title":"Endoplasmic reticulum stress in the pathogenesis of early-onset pre-eclampsia","volume":"1","author":"Burton","year":"2011","journal-title":"Pregnancy Hypertension: Int J Women\u2019s Cardiovasc Health"},{"key":"B29","doi-asserted-by":"publisher","first-page":"245ra92","DOI":"10.1126\/scitranslmed.3008808","article-title":"Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia","volume":"6","author":"Buhimschi","year":"2014","journal-title":"Sci Trans Med"},{"key":"B30","doi-asserted-by":"publisher","first-page":"null","DOI":"10.1038\/s41598-021-95611-5","article-title":"Novel blood test for early biomarkers of preeclampsia and Alzheimer\u2019s disease","volume":"11","author":"Cheng","year":"2021","journal-title":"Sci Rep"},{"key":"B31","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3390\/molecules29030610","article-title":"Protein misfolding in pregnancy: current insights, potential mechanisms, and implications for the pathogenesis of preeclampsia","volume":"29","author":"Medegan Fagla","year":"2024","journal-title":"Molecules"},{"key":"B32","doi-asserted-by":"publisher","first-page":"6183","DOI":"10.3390\/ijms20246183","article-title":"Protein misfolding during pregnancy: new approaches to preeclampsia diagnostics","volume":"20","author":"Gerasimova","year":"2019","journal-title":"IJMS"},{"key":"B33","doi-asserted-by":"publisher","first-page":"5783","DOI":"10.1038\/s41598-020-62805-2","article-title":"Cerebrospinal beta-amyloid peptides(1-40) and (1-42) in severe preeclampsia and HELLP syndrome \u2013 a pilot study","volume":"10","author":"Lederer","year":"2020","journal-title":"Sci Rep"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.799653","article-title":"Serum from preeclamptic women triggers endoplasmic reticulum stress pathway and expression of angiogenic factors in trophoblast cells","volume":"12","author":"Castro","year":"2022","journal-title":"Front Physiol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"15467","DOI":"10.14814\/phy2.15467","article-title":"Elevated homocysteine activates unfolded protein responses and causes aberrant trophoblast differentiation and mouse blastocyst development","volume":"10","author":"Capatina","year":"2022","journal-title":"Physiol Rep"},{"key":"B36","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1038\/s41392-023-01570-w","article-title":"Endoplasmic reticulum stress: molecular mechanism and therapeutic targets","volume":"8","author":"Chen","year":"2023","journal-title":"Sig Transduct Target Ther"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0809677105","article-title":"Antioxidants reduce endoplasmic reticulum stress and improve protein secretion","volume":"105","author":"Malhotra","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.3390\/antiox11071275","article-title":"The effect of tauroursodeoxycholic acid (TUDCA) treatment on pregnancy outcomes and vascular function in a rat model of advanced maternal age","volume":"11","author":"Pasha","year":"2022","journal-title":"Antioxidants"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1002\/path.2014.234.issue-2","article-title":"Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early- and late-onset pre-eclampsia","volume":"234","author":"Yung","year":"2014","journal-title":"J Pathol"},{"key":"B40","doi-asserted-by":"publisher","first-page":"384","DOI":"10.3390\/biology10050384","article-title":"The unfolded protein response: an overview","volume":"10","author":"Read","year":"2021","journal-title":"Biol (Basel)"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.06.017","article-title":"The unfolded protein response and cell fate control","volume":"69","author":"Hetz","year":"2018","journal-title":"Mol Cell"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvp166","article-title":"Signalling pathways in the unfolded protein response: development from yeast to mammals","volume":"6","author":"Mori","year":"2009","journal-title":"J Biochem"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90648-A","article-title":"Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase","volume":"73","author":"Cox","year":"1993","journal-title":"Cell"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2013.06.005","article-title":"IRE1: ER stress sensor and cell fate executor","volume":"23","author":"Chen","year":"2013","journal-title":"Trends Cell Biol"},{"key":"B45","doi-asserted-by":"publisher","first-page":"3554","DOI":"10.1038\/ncomms4554","article-title":"Phosphoregulation of Ire1 RNase splicing activity","volume":"5","author":"Prischi","year":"2014","journal-title":"Nat Commun"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1038\/415092a","article-title":"IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA","volume":"415","author":"Calfon","year":"2002","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90553-3","article-title":"Degradation from the endoplasmic reticulum: disposing of newly synthesized proteins","volume":"54","author":"Lippincott-Schwartz","year":"1988","journal-title":"Cell"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1126\/science.1129631","article-title":"Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response","volume":"313","author":"Hollien","year":"2006","journal-title":"Science"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2014.02.008","article-title":"Getting RIDD of RNA: IRE1 in cell fate regulation","volume":"39","author":"Maurel","year":"2014","journal-title":"Trends Biochem Sci"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(01)00093-0","article-title":"The c-Jun N-terminal protein kinase family of mitogen-activated protein kinases (JNK MAPKs)","volume":"33","author":"Barr","year":"2001","journal-title":"Int J Biochem Cell Biol"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200521848","article-title":"The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis","volume":"2","author":"Zhang","year":"2005","journal-title":"J Clin Invest"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903775106","article-title":"Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability","volume":"106","author":"Iwawaki","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009575","article-title":"Transcriptional regulation of VEGF-A by the unfolded protein response pathway","volume":"5","author":"Ghosh","year":"2010","journal-title":"PloS One"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00570","article-title":"Regulation of placental development and its impact on fetal growth\u2014New insights from mouse models","volume":"9","author":"Woods","year":"2018","journal-title":"Front Endocrinol"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.13294\/j.aps.2020.0091","article-title":"Expression and regulation of XBP1 in mouse uterus during early pregnancy","volume":"73","author":"Guo","year":"2021","journal-title":"Sheng Li Xue Bao"},{"key":"B56","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.mce.2016.06.012","article-title":"Endoplasmic reticulum stress in mouse decidua during early pregnancy","volume":"434","author":"Gu","year":"2016","journal-title":"Mol Cell Endocrinology"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1101\/gad.14.2.152","article-title":"An essential role in liver development for transcription factor XBP-1","volume":"14","author":"Reimold","year":"2000","journal-title":"Genes Dev"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1107394108","article-title":"PKA phosphorylation couples hepatic inositol-requiring enzyme 1\u03b1 to glucagon signaling in glucose metabolism","volume":"108","author":"Mao","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"B59","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1242\/jcs.111.7.995","article-title":"Cyclic AMP-dependent protein kinases and human trophoblast cell differentiation in vitro","volume":"111","author":"Keryer","year":"1998","journal-title":"J Cell Sci"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2005.06.029","article-title":"Stimulation of GCMa and syncytin via cAMP mediated PKA signaling in human trophoblastic cells under normoxic and hypoxic conditions","volume":"579","author":"Knerr","year":"2005","journal-title":"FEBS Letters"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.11.113","article-title":"CREB is activated by ER stress and modulates the unfolded protein response by regulating the expression of IRE1\u03b1 and PERK","volume":"469","author":"Kikuchi","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"key":"B62","doi-asserted-by":"publisher","first-page":"651","DOI":"10.1038\/s41419-019-1905-6","article-title":"The fine-tuning of endoplasmic reticulum stress response and autophagy activation during trophoblast syncytialization","volume":"10","author":"Bastida-Ruiz","year":"2019","journal-title":"Cell Death Dis"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M609490200","article-title":"Coordinate regulation of phospholipid biosynthesis and secretory pathway gene expression in XBP-1(S)-induced endoplasmic reticulum biogenesis","volume":"282","author":"Sriburi","year":"2007","journal-title":"J Biol Chem"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.8.9.1805","article-title":"The unfolded protein response coordinates the production of endoplasmic reticulum protein and endoplasmic reticulum membrane","volume":"8","author":"Cox","year":"1997","journal-title":"MBoC"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/ni907","article-title":"Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1","volume":"4","author":"Iwakoshi","year":"2003","journal-title":"Nat Immunol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2009.117","article-title":"XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells","volume":"28","author":"Hu","year":"2009","journal-title":"EMBO J"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.16.11765","article-title":"Disulfide bond formation is not required for human chorionic gonadotropin subunit association","volume":"275","author":"Singh","year":"2000","journal-title":"J Biol Chem"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)69030-7","article-title":"Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin","volume":"256","author":"Mise","year":"1981","journal-title":"J Biol Chem"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)85444-3","article-title":"Protein folding and assembly in vitro parallel intracellular folding and assembly. Catalysis of folding and assembly of the human chorionic gonadotropin alpha beta dimer by protein disulfide isomerase","volume":"268","author":"Huth","year":"1993","journal-title":"J Biol Chem"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.09.003","article-title":"IRE1\u03b1-XBP1s induces PDI expression to increase MTP activity for hepatic VLDL assembly and lipid homeostasis","volume":"16","author":"Wang","year":"2012","journal-title":"Cell Metab"},{"key":"B71","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.immuni.2004.06.010","article-title":"XBP1, downstream of blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation","volume":"21","author":"Shaffer","year":"2004","journal-title":"Immunity"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.019","article-title":"Fine-tuned and cell-cycle-restricted expression of fusogenic protein syncytin-2 maintains functional placental syncytia","volume":"21","author":"Lu","year":"2017","journal-title":"Cell Rep"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s44319-024-00197-4","article-title":"The IRE1\u03b1\/XBP1 signaling axis drives myoblast fusion in adult skeletal muscle","volume":"25","author":"Joshi","year":"2024","journal-title":"EMBO Rep"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302302200","article-title":"The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase C\u03b1","volume":"278","author":"Tigges","year":"2003","journal-title":"J Biol Chem"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0141-0","article-title":"IRE1\u03b1 governs cytoskeleton remodelling and cell migration through a direct interaction with filamin A","volume":"20","author":"Urra","year":"2018","journal-title":"Nat Cell Biol"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1002\/cm.21165","article-title":"Cell fusion mediates dramatic alterations in the actin cytoskeleton, focal adhesions, and E-cadherin in trophoblastic cells","volume":"71","author":"Ishikawa","year":"2014","journal-title":"Cytoskeleton"},{"key":"B77","doi-asserted-by":"publisher","first-page":"113540","DOI":"10.1016\/j.celrep.2023.113540","article-title":"The ER stress sensor IRE1 interacts with STIM1 to promote store-operated calcium entry, T cell activation, and muscular differentiation","volume":"42","author":"Carreras-Sureda","year":"2023","journal-title":"Cell Rep"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1038\/nature04147","article-title":"STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane","volume":"437","author":"Zhang","year":"2005","journal-title":"Nature"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029353","article-title":"Inhibition of akt activity and calcium channel function coordinately drive cell-cell fusion in the beWO choriocarcinoma placental cell line","volume":"7","author":"Vatish","year":"2012","journal-title":"PloS One"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.702046","article-title":"Transcriptomic drivers of differentiation, maturation, and polyploidy in human extravillous trophoblast","volume":"9","author":"Morey","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-05-1916","article-title":"Developmental regulation of yolk sac hematopoiesis by Kr\u00fcppel-like factor 6","volume":"107","author":"Matsumoto","year":"2006","journal-title":"Blood"},{"key":"B82","doi-asserted-by":"publisher","first-page":"3683","DOI":"10.3390\/ijms22073683","article-title":"Alpha-1 antitrypsin-induced endoplasmic reticulum stress promotes invasion by extravillous trophoblasts","volume":"22","author":"Yoshida","year":"2021","journal-title":"IJMS"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2022.10.003","article-title":"Endoplasmic reticulum stress-regulated high temperature requirement A1 (HTRA1) modulates invasion and angiogenesis-related genes in human trophoblasts","volume":"150","author":"Yoshida","year":"2022","journal-title":"J Pharmacol Sci"},{"key":"B84","doi-asserted-by":"publisher","first-page":"44988","DOI":"10.1038\/srep44988","article-title":"LOXL2 drives epithelial-mesenchymal transition via activation of IRE1-XBP1 signalling pathway","volume":"7","author":"Cuevas","year":"2017","journal-title":"Sci Rep"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1080\/19336918.2016.1170258","article-title":"Epithelial-mesenchymal transition during extravillous trophoblast differentiation","volume":"10","author":"Davies J","year":"2016","journal-title":"Cell Adhesion Migration"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2011.08.005","article-title":"Increased endoplasmic reticulum stress in decidual tissue from pregnancies complicated by fetal growth restriction with and without pre-eclampsia","volume":"32","author":"Lian","year":"2011","journal-title":"Placenta"},{"key":"B87","doi-asserted-by":"publisher","first-page":"12274","DOI":"10.1038\/s41598-018-29779-8","article-title":"Impact of the Reticular Stress and Unfolded Protein Response on the inflammatory response in endometrial stromal cells","volume":"8","author":"Grasso","year":"2018","journal-title":"Sci Rep"},{"key":"B88","doi-asserted-by":"publisher","first-page":"3894","DOI":"10.1038\/srep03894","article-title":"Uterine selection of human embryos at implantation","volume":"4","author":"Brosens","year":"2014","journal-title":"Sci Rep"},{"key":"B89","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1038\/jhh.2016.17","article-title":"eNOS\/iNOS and endoplasmic reticulum stress-induced apoptosis in the placentas of patients with preeclampsia","volume":"31","author":"Du","year":"2017","journal-title":"J Hum Hypertens"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2021.09.001","article-title":"The unfolded protein response and apoptotic regulation in the human placenta due to maternal cigarette smoking and pre-eclampsia","volume":"105","author":"Thomson","year":"2021","journal-title":"Reprod Toxicology"},{"key":"B91","doi-asserted-by":"publisher","first-page":"null","DOI":"10.3390\/ijms23105644","article-title":"Hypoxia-reoxygenation impairs autophagy-lysosomal machinery in primary human trophoblasts mimicking placental pathology of early-onset preeclampsia","volume":"23","author":"Cheng","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B92","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1002\/cbin.11165","article-title":"Human placenta-derived mesenchymal stem cells inhibit apoptosis of granulosa cells induced by IRE1\u03b1 pathway in autoimmune POF mice","volume":"43","author":"Li","year":"2019","journal-title":"Cell Biol Int"},{"key":"B93","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.tjog.2014.11.002","article-title":"Expression of markers of endoplasmic reticulum stress-induced apoptosis in the placenta of women with early and late onset severe pre-eclampsia","volume":"54","author":"Fu","year":"2015","journal-title":"Taiwanese J Obstetrics Gynecology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"e22388","DOI":"10.1096\/fj.202101844RR","article-title":"Gestational cholestasis induced intrauterine growth restriction through triggering IRE1\u03b1-mediated apoptosis of placental trophoblast cells","volume":"36","author":"Gao","year":"2022","journal-title":"FASEB J"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122633","article-title":"Endoplasmic reticulum stress is increased in adipose tissue of women with gestational diabetes","volume":"10","author":"Liong","year":"2015","journal-title":"PloS One"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1023327","article-title":"Obesity impacts placental function through activation of p-IRE1a-XBP1s signaling","volume":"11","author":"Shen","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/s41419-023-06415-6","article-title":"Palmitate induces integrated stress response and lipoapoptosis in trophoblasts","volume":"15","author":"Sahoo","year":"2024","journal-title":"Cell Death Dis"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gaaa061","article-title":"Palmitic acid induces inflammation in placental trophoblasts and impairs their migration toward smooth muscle cells through plasminogen activator inhibitor-1","volume":"26","author":"Rampersaud","year":"2020","journal-title":"Mol Hum Reproduction"},{"key":"B99","doi-asserted-by":"publisher","first-page":"100081","DOI":"10.1016\/j.crtox.2022.100081","article-title":"The effect of ethanol and nicotine on ER stress in human placental villous explants","volume":"3","author":"Huovinen","year":"2022","journal-title":"Curr Res Toxicology"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.10.032","article-title":"Exposure to ethanol and nicotine induces stress responses in human placental BeWo cells","volume":"224","author":"Repo J","year":"2014","journal-title":"Toxicol Letters"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00019\/abstract","article-title":"Brucella suis Vaccine Strain 2 Induces Endoplasmic Reticulum Stress that Affects Intracellular Replication in Goat Trophoblast Cells In vitro","volume":"6","author":"Wang","year":"2016","journal-title":"Front Cell Infect Microbiol"},{"key":"B102","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1038\/s41420-020-00379-8","article-title":"Zika virus infection induces endoplasmic reticulum stress and apoptosis in placental trophoblasts","volume":"7","author":"Muthuraj","year":"2021","journal-title":"Cell Death Discovery"},{"key":"B103","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/S1097-2765(00)80330-5","article-title":"Perk is essential for translational regulation and cell survival during the unfolded protein response","volume":"5","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/16729","article-title":"Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase","volume":"397","author":"Harding","year":"1999","journal-title":"Nature"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2015.183","article-title":"Protein kinase R-like ER kinase and its role in endoplasmic reticulum stress-decided cell fate","volume":"6","author":"Liu","year":"2015","journal-title":"Cell Death Dis"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00108-8","article-title":"Regulated translation initiation controls stress-induced gene expression in mammalian cells","volume":"6","author":"Harding","year":"2000","journal-title":"Mol Cell"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1112253","article-title":"A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response","volume":"16","author":"Neill","year":"2023","journal-title":"Front Mol Neurosci"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1210\/en.2003-0236","article-title":"PERK eIF2\u03b1 Kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver","volume":"144","author":"Li","year":"2003","journal-title":"Endocrinology"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00264-7","article-title":"Diabetes mellitus and exocrine pancreatic dysfunction in perk\u2013\/\u2013 mice reveals a role for translational control in secretory cell survival","volume":"7","author":"Harding","year":"2001","journal-title":"Mol Cell"},{"key":"B110","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1016\/S0143-4004(80)80016-6","article-title":"An ultrastructural and ultrahistochemical study of the human placenta in maternal pre-eclampsia","volume":"1","author":"Jones","year":"1980","journal-title":"Placenta"},{"key":"B111","doi-asserted-by":"publisher","first-page":"105911","DOI":"10.1016\/j.isci.2022.105911","article-title":"Perturbation of placental protein glycosylation by endoplasmic reticulum stress promotes maladaptation of maternal hepatic glucose metabolism","volume":"26","author":"Yung","year":"2023","journal-title":"iScience"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1002\/path.2012.228.issue-4","article-title":"Endoplasmic reticulum stress disrupts placental morphogenesis: implications for human intrauterine growth restriction","volume":"228","author":"Yung","year":"2012","journal-title":"J Pathol"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1021\/bi0008682","article-title":"Phosphorylation of Serine 51 in Initiation Factor 2\u03b1 (eIF2\u03b1) Promotes Complex Formation between eIF2\u03b1(P) and eIF2B and Causes Inhibition in the Guanine Nucleotide Exchange Activity of eIF2B","volume":"39","author":"Sudhakar","year":"2000","journal-title":"Biochemistry"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00265-9","article-title":"Translational control is required for the unfolded protein response and in vivo glucose homeostasis","volume":"7","author":"Scheuner","year":"2001","journal-title":"Mol Cell"},{"key":"B115","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.molcel.2017.01.020","article-title":"The ER stress sensor PERK coordinates ER-plasma membrane contact site formation through interaction with filamin-A and F-actin remodeling","volume":"65","author":"Van Vliet","year":"2017","journal-title":"Mol Cell"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2018.10.015","article-title":"Role of endoplasmic reticulum stress in proinflammatory cytokine\u2013mediated inhibition of trophoblast invasion in placenta-related complications of pregnancy","volume":"189","author":"Lee","year":"2019","journal-title":"Am J Pathology"},{"key":"B117","unstructured":"Ovarian steroid dependence of endoplasmic reticulum stress involvement in endometrial cell apoptosis during the human endometrial cycle\n          \n          \n            \n              Choi\n              JY\n            \n            \n              Jo\n              MW\n            \n            \n              Lee\n              EY\n            \n            \n              Lee\n              DY\n            \n            \n              Choi\n              DS\n            \n          \n          \n          2018"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1111\/jog.2018.44.issue-3","article-title":"Progesterone inhibited endoplasmic reticulum stress associated apoptosis induced by interleukin-1\u03b2 via the GRP78\/PERK\/CHOP pathway in BeWo cells","volume":"44","author":"Liu","year":"2018","journal-title":"J Obstet Gynaecol"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2008.071193","article-title":"Evidence of placental translation inhibition and endoplasmic reticulum stress in the etiology of human intrauterine growth restriction","volume":"173","author":"Yung","year":"2008","journal-title":"Am J Pathology"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-00820","article-title":"IUGR is associated with marked hyperphosphorylation of decidual and maternal plasma IGFBP-1","volume":"104","author":"Gupta","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"B121","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s10142-023-01077-1","article-title":"Mechanism of histone deacetylase HDAC2 in FOXO3-mediated trophoblast pyroptosis in preeclampsia","volume":"23","author":"Liu","year":"2023","journal-title":"Funct Integr Genomics"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpz006","article-title":"Dysregulation of HDAC9 represses trophoblast cell migration and invasion through TIMP3 activation in preeclampsia","volume":"32","author":"Xie","year":"2019","journal-title":"Am J Hypertension"},{"key":"B123","doi-asserted-by":"publisher","first-page":"11899","DOI":"10.3390\/ijms241511899","article-title":"Dysregulation of Histone Deacetylases Inhibits Trophoblast Growth during Early Placental Development Partially through TFEB-Dependent Autophagy-Lysosomal Pathway","volume":"24","author":"Wang","year":"2023","journal-title":"IJMS"},{"key":"B124","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1038\/s41419-020-2500-6","article-title":"Histone deacetylase 1 and 2 drive differentiation and fusion of progenitor cells in human placental trophoblasts","volume":"11","author":"Jaju Bhattad","year":"2020","journal-title":"Cell Death Dis"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1530\/REP-19-0539","article-title":"The endocannabinoid 2-arachidonoylglycerol promotes endoplasmic reticulum stress in placental cells","volume":"160","author":"Almada","year":"2020","journal-title":"Reproduction"},{"key":"B126","doi-asserted-by":"publisher","first-page":"126785","DOI":"10.1016\/j.chemosphere.2020.126785","article-title":"Cadmium down-regulates 11\u03b2-HSD2 expression and elevates active glucocorticoid level via PERK\/p-eIF2\u03b1 pathway in placental trophoblasts","volume":"254","author":"Shi","year":"2020","journal-title":"Chemosphere"},{"key":"B127","doi-asserted-by":"publisher","first-page":"112632","DOI":"10.1016\/j.ecoenv.2021.112632","article-title":"Gestational cadmium exposure impairs placental angiogenesis via activating GC\/GR signaling","volume":"224","author":"Shi","year":"2021","journal-title":"Ecotoxicology Environ Safety"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.10.11.3787","article-title":"Mammalian transcription factor ATF6 is synthesized as a transmembrane protein and activated by proteolysis in response to endoplasmic reticulum stress","volume":"10","author":"Haze","year":"1999","journal-title":"MBoC"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701213200","article-title":"Effects of the isoform-specific characteristics of ATF6\u03b1 and ATF6\u03b2 on endoplasmic reticulum stress response gene expression and cell viability","volume":"282","author":"Thuerauf","year":"2007","journal-title":"J Biol Chem"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)00133-7","article-title":"ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs","volume":"6","author":"Ye","year":"2000","journal-title":"Mol Cell"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e25937","article-title":"Molecular mechanism of ATF6 in unfolded protein response and its role in disease","volume":"10","author":"Lei","year":"2024","journal-title":"Heliyon"},{"key":"B132","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12929-018-0453-1","article-title":"A lifetime of stress: ATF6 in development and homeostasis","volume":"25","author":"Hillary","year":"2018","journal-title":"J BioMed Sci"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.07.018","article-title":"Transcriptional induction of mammalian ER quality control proteins is mediated by single or combined action of ATF6\u03b1 and XBP1","volume":"13","author":"Yamamoto","year":"2007","journal-title":"Dev Cell"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2007.07.005","article-title":"ATF6\u03b1 Optimizes long-term endoplasmic reticulum function to protect cells from chronic stress","volume":"13","author":"Wu","year":"2007","journal-title":"Dev Cell"},{"key":"B135","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s12958-016-0199-0","article-title":"Expression and regulation of ATF6\u03b1 in the mouse uterus during embryo implantation","volume":"14","author":"Xiong","year":"2016","journal-title":"Reprod Biol Endocrinol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M300923200","article-title":"A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6","volume":"278","author":"Okada","year":"2003","journal-title":"J Biol Chem"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040596","article-title":"Involvement of membrane GRP78 in trophoblastic cell fusion","volume":"7","author":"Fradet","year":"2012","journal-title":"PloS One"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0878-3","article-title":"Mutant p53 improves cancer cells\u2019 resistance to endoplasmic reticulum stress by sustaining activation of the UPR regulator ATF6","volume":"38","author":"Sicari","year":"2019","journal-title":"Oncogene"},{"key":"B139","doi-asserted-by":"publisher","first-page":"110948","DOI":"10.1016\/j.mce.2020.110948","article-title":"VIP conditions human endometrial receptivity by privileging endoplasmic reticulum stress through ATF6\u03b1 pathway","volume":"516","author":"Soczewski","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2017.61","article-title":"Placental growth factor and pre-eclampsia","volume":"31","author":"Chau","year":"2017","journal-title":"J Hum Hypertens"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1002\/path.2016.238.issue-4","article-title":"Placental endoplasmic reticulum stress negatively regulates transcription of placental growth factor via ATF4 and ATF6\u03b2: implications for the pathophysiology of human pregnancy complications","volume":"238","author":"Mizuuchi","year":"2016","journal-title":"J Pathology"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1113\/tjp.v599.17","article-title":"Excessive endoplasmic reticulum stress drives aberrant mouse trophoblast differentiation and placental development leading to pregnancy loss","volume":"599","author":"Capatina","year":"2021","journal-title":"J Physiol"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2010.06.022","article-title":"Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress","volume":"397","author":"Lee","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0282442","article-title":"The effect of tauroursodeoxycholic Acid (TUDCA) treatment on placental endoplasmic reticulum (ER) stress in a rat model of advanced maternal age","volume":"18","author":"Pasha","year":"2023","journal-title":"PloS One"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.08.034","article-title":"Amyloid-\u03b2 pathology is attenuated by tauroursodeoxycholic acid treatment in APP\/PS1 mice after disease onset","volume":"36","author":"Dion\u00edsio","year":"2015","journal-title":"Neurobiol Aging"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1090039","article-title":"Insights by which TUDCA is a potential therapy against adiposity","volume":"14","author":"Freitas","year":"2023","journal-title":"Front Endocrinol"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.repbio.2015.01.004","article-title":"Tauroursodeoxycholic acid improves the implantation and live-birth rates of mouse embryos","volume":"15","author":"Lin","year":"2015","journal-title":"Reprod Biol"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2013.08.001","article-title":"4-Phenylbutyric acid protects against neuronal cell death by primarily acting as a chemical chaperone rather than histone deacetylase inhibitor","volume":"23","author":"Mimori","year":"2013","journal-title":"Bioorganic Medicinal Chem Letters"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4040-2","article-title":"Placental endoplasmic reticulum stress in gestational diabetes: the potential for therapeutic intervention with chemical chaperones and antioxidants","volume":"59","author":"Yung","year":"2016","journal-title":"Diabetologia"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1002\/mrd.23742","article-title":"Phenylbutyric acid inhibits hypoxia-induced trophoblast apoptosis and autophagy in preeclampsia via the PERK\/ATF-4\/CHOP pathway","volume":"91","author":"Li","year":"2024","journal-title":"Mol Reprod Devel"},{"key":"B151","doi-asserted-by":"publisher","first-page":"18415","DOI":"10.1038\/s41598-021-97799-y","article-title":"Oxidative stress-induced impairment of trophoblast function causes preeclampsia through the unfolded protein response pathway","volume":"11","author":"Mukherjee","year":"2021","journal-title":"Sci Rep"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.157203","article-title":"Targeting IRE1 endoribonuclease activity alleviates cardiovascular lesions in a murine model of Kawasaki disease vasculitis","volume":"7","author":"Marek-Iannucci","year":"2022","journal-title":"JCI Insight"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1322557","article-title":"Population pharmacokinetic model for oral ORIN1001 in Chinese patients with advanced solid tumors","volume":"15","author":"Li","year":"2024","journal-title":"Front Pharmacol"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.3080","article-title":"A phase 1\/2 trial of ORIN1001, a first-in-class IRE1 inhibitor, in patients with advanced solid tumors","volume":"39","author":"Gabrail","year":"2021","journal-title":"JCO"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-1182","article-title":"PERK inhibition by HC-5404 sensitizes renal cell carcinoma tumor models to antiangiogenic tyrosine kinase inhibitors","volume":"29","author":"Stokes","year":"2023","journal-title":"Clin Cancer Res"},{"key":"B156","doi-asserted-by":"publisher","first-page":"a032870","DOI":"10.1101\/cshperspect.a032870","article-title":"Role of eIF2\u03b1 Kinases in translational control and adaptation to cellular stress","volume":"10","author":"Wek","year":"2018","journal-title":"Cold Spring Harb Perspect Biol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1525189\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T00:11:30Z","timestamp":1734653490000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2024.1525189\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,20]]},"references-count":156,"alternative-id":["10.3389\/fendo.2024.1525189"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2024.1525189","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,20]]},"article-number":"1525189"}}