{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T05:34:36Z","timestamp":1759815276683,"version":"3.41.2"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T00:00:00Z","timestamp":1738800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to investigate the relationship between metabolic dysfunction-associated fatty liver disease (MAFLD) and sex hormones and sex hormone-binding globulin (SHBG) in boys with obesity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective analysis of metabolic indicators and sex hormone levels in boys with obesity who sought medical attention at the First People\u2019s Hospital of Lianyungang City from January 2020 to December 2023. Based on abdominal ultrasound results, they were categorized into a simple obesity group and MAFLD group, and differences between the two groups were compared. Utilizing logistic regression analysis to explore the risk factors for developing MAFLD, and through the construction of Receiver Operating Characteristic (ROC) curves, conducting a preliminary assessment of the diagnostic value for MAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 155 male children with obesity were included in the study, mean age of 11.07 \u00b1 1.53 years. Children in the MAFLD group had higher levels of height[(159.49 \u00b1 12.73)cm vs.(155.55 \u00b1 10.50)cm], weight[(82.32 \u00b1 18.75)kg vs.(68.28 \u00b1 15.00)kg], BMI[(32.08 \u00b1 4.49)kg\/m<jats:sup>2<\/jats:sup> vs.(27.85 \u00b1 4.21)kg\/m<jats:sup>2<\/jats:sup>],fasting insulin[33.42(24.07,43.93)uIU\/ml vs.23.91(15.72,31.52)uIU\/ml],HOMA-IR[7.27(5.26,10.71) vs.4.87(3.27,6.86)],fastingC-peptide[1409.00(1175.00,1668.00)pmol\/L vs.1020.00(849.05,1303.00)pmol\/L], WBC[(7.85 \u00b1 1.80)\u00d710<jats:sup>9<\/jats:sup>\/L vs.(7.15 \u00b1 1.42)\u00d710<jats:sup>9<\/jats:sup>\/L], HbA1c[5.40(5.30,5.70)% vs.(5.30(5.20,5.60)%],ALT[48.00(27.00,80.00)U\/L vs.19.00(15.00,26.50)U\/L], and AST[31.00(24.00,60.00)U\/L vs.21.00(18.50, 26.00)U\/L] compared to the simple obesity group (P&amp;lt;0.05). Children in the MAFLD group had lower levels of HDL[(1.05 \u00b1 0.21)mmol\/L vs.(1.16 \u00b1 0.26)mmol\/L], testosterone [42.41(30.33,143.28)ng\/dl vs.125.41(23.41,221.57)ng\/dl], and SHBG[13.20(9.10,17.30)nmol\/l vs.19.60(13.50,29.85)nmol\/l] compared to the simple obesity group (P&amp;lt;0.05). Logistic regression showed that BMI, testosterone, and SHBG were independent risk factors for MAFLD in boys, and ROC curve analysis indicated their potential value in the early diagnosis of MAFLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BMI, testosterone, and SHBG are independent risk factors for the occurrence of MAFLD in boys with obesity. To control the occurrence of MAFLD, it is essential to address the root cause of the high growth rate of obesity. The roles of testosterone and SHBG in MAFLD merit further research.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1446049","type":"journal-article","created":{"date-parts":[[2025,2,6]],"date-time":"2025-02-06T05:22:58Z","timestamp":1738819378000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The value of sex hormones and sex hormone-binding globulin in metabolic dysfunction-associated fatty liver disease among boys with 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