{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:10:55Z","timestamp":1793315455771,"version":"4.5.0"},"reference-count":380,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>The body instinctively responds to external stimuli by increasing energy metabolism and initiating immune responses upon receiving stress signals. Corticosterone (CORT), a glucocorticoid (GC) that regulates secretion along the hypothalamic-pituitary-adrenal (HPA) axis, mediates neurotransmission and humoral regulation. Due to the widespread expression of glucocorticoid receptors (GR), the effects of CORT are almost ubiquitous in various tissue cells. Therefore, on the one hand, CORT is a molecular signal that activates the body\u2019s immune system during stress and on the other hand, due to the chemical properties of GCs, the anti-inflammatory properties of CORT act as stabilizers to control the body\u2019s response to stress. Inflammation is a manifestation of immune activation. CORT plays dual roles in this process by both promoting inflammation and exerting anti-inflammatory effects in immune regulation. As a stress hormone, CORT levels fluctuate with the degree and duration of stress, determining its effects and the immune changes it induces. The immune system is essential for the body to resist diseases and maintain homeostasis, with immune imbalance being a key factor in the development of various diseases. Therefore, understanding the role of CORT and its mechanisms of action on immunity is crucial. This review addresses this important issue and summarizes the interactions between CORT and the immune system.<\/jats:p>","DOI":"10.3389\/fendo.2025.1448750","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T05:31:30Z","timestamp":1742448690000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":50,"title":["Corticosterone effects induced by stress and immunity and inflammation: mechanisms of communication"],"prefix":"10.3389","volume":"16","author":[{"given":"Jingyu","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqing","family":"Ao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1177\/1535370219883634","article-title":"Biobehavioral utility of mindfulness-based art therapy: Neurobiological underpinnings and mental health impacts","volume":"245","author":"Beerse","year":"2020","journal-title":"Exp Biol Med (Maywood)"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.v56.10","article-title":"Early-life social stress induces permanent alterations in plasticity and perineuronal nets in the mouse anterior cingulate cortex","volume":"56","author":"Catale","year":"2022","journal-title":"Eur J Neurosci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1038\/nrn3918","article-title":"Stress and the social brain: behavioral effects and neurobiological mechanisms","volume":"16","author":"Sandi","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"B4","doi-asserted-by":"publisher","first-page":"114180","DOI":"10.1016\/j.bbr.2022.114180","article-title":"Acute and long-term sex-dependent effects of social instability stress on anxiety-like and social behaviors in Wistar rats","volume":"438","author":"Graf","year":"2023","journal-title":"Behav Brain Res"},{"key":"B5","doi-asserted-by":"publisher","first-page":"100437","DOI":"10.1016\/j.ynstr.2022.100437","article-title":"Characterizing the behavioral and neuroendocrine features of susceptibility and resilience to social stress","volume":"17","author":"Murra","year":"2022","journal-title":"Neurobiol Stress"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00014-5","article-title":"Prevalence of symptoms of anxiety and depression in patients with inflammatory bowel disease: a systematic review and meta-analysis","volume":"6","author":"Barberio","year":"2021","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"737","DOI":"10.3390\/biom12050737","article-title":"Innate immunity: A balance between disease and adaption to stress","volume":"12","author":"Faenza","year":"2022","journal-title":"Biomolecules"},{"key":"B8","doi-asserted-by":"publisher","first-page":"170958","DOI":"10.1016\/j.peptides.2023.170958","article-title":"The impact of inflammatory stress on hypothalamic kisspeptin neurons: Mechanisms underlying inflammation-associated infertility in humans and domestic animals","volume":"162","author":"Magata","year":"2023","journal-title":"Peptides"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adh0183","article-title":"Chronic stress hinders sensory axon regeneration via impairing mitochondrial cristae and OXPHOS","volume":"9","author":"Ruan","year":"2023","journal-title":"Sci Adv"},{"key":"B10","doi-asserted-by":"publisher","first-page":"826","DOI":"10.1038\/s41598-020-80637-y","article-title":"Chronic stress and corticosterone exacerbate alcohol-induced tissue injury in the gut-liver-brain axis","volume":"11","author":"Shukla","year":"2021","journal-title":"Sci Rep"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2023.2211767","article-title":"Pharmacological treatment of generalized anxiety disorder: current practice and future directions","volume":"23","author":"Fagan","year":"2023","journal-title":"Expert Rev Neurother"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.22744","article-title":"Anxiety disorders: A review","volume":"328","author":"Szuhany","year":"2022","journal-title":"JAMA"},{"key":"B13","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1111\/bjc.12333","article-title":"Global prevalence of depression and elevated depressive symptoms among adolescents: A systematic review and meta-analysis","volume":"61","author":"Shorey","year":"2022","journal-title":"Br J Clin Psychol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.24875\/CIRU.20000561","article-title":"Lozano-Alcazar J et\u00a0al. 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