{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:57:17Z","timestamp":1791896237608,"version":"4.3.4"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T00:00:00Z","timestamp":1745971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Given the global prevalence of vitamin D deficiency, this study examines the association between serum 25-hydroxyvitamin D (25(OH)D) levels and lipid profiles, including total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a cross-sectional analysis at the Yuhuan People\u2019s Hospital Physical Examination Center, 1535 asymptomatic individuals underwent anthropometric assessment and blood sampling. Serum 25(OH)D levels were quantified by a chemiluminescent immunoassay, while lipid parameters were evaluated by an enzymatic method on a fully automated analyzer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean serum 25(OH)D level of the participants was 49.6 \u00b1 15.3 nmol\/L, with 54.7% demonstrating vitamin D deficiency. Female participants had significantly lower mean 25(OH)D levels (46.2 \u00b1 13.7 nmol\/L) than males (54.1 \u00b1 16.0 nmol\/L, P &amp;lt; 0.001). After adjustment for age and BMI, multivariate ordinal logistic analysis revealed a 1.71-fold higher dyslipidemia-associated risk of vitamin D deficiency in the population (OR=1.71, 95% CI=1.07-2.79), more pronounced in females(OR=2.84, 95% CI=1.17-8.09) compared to males (OR=1.44, 95% CI=0.82-2.58). Notably, vitamin D deficiency was significantly associated with elevated LDL-C levels in females (OR=5.17, 95% CI=1.47-32.96), in contrast to males.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights a significant association between 25(OH)D deficiency and an increased risk of dyslipidemia, especially in females, highlighting the importance of considering gender-specific risk factors in the management of 25(OH)D deficiency.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1450924","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T04:12:42Z","timestamp":1745986362000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Association between dyslipidemia and vitamin D deficiency: a cross-sectional study in Chinese healthy 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