{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T14:36:35Z","timestamp":1782311795184,"version":"3.54.5"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T00:00:00Z","timestamp":1763942400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Age cut-off of 55 years has been included in the eighth edition of the American Joint Committee on Cancer (AJCC) TNM staging, since it led to better prediction of disease-specific survival (DSS) of patients with differentiated thyroid cancer (DTC). However, optimal age cut-off in DTC patients from Middle Eastern ethnicity has not been fully explored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed a large cohort of 1721 adult DTC patients. The optimal age cut-off value was determined using several age cut-offs (between 20 and 85 years) to assess DSS. Harrel\u2019s C-Index, Akaike information criterion (AIC) and Bayesian Information Criterion (BIC) were used to assess statistical model performance of the TNM staging system (eighth edition), with different age cut-offs for prediction of DSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age of patients at diagnosis was 39.9 years (inter-quartile range 31.0 \u2013 51.7 years) and 75.5% (1299\/1721) were female. Median follow up was 9.3 years and 10 years DSS was 97.1%. For DTC overall, an age cut-off of 50 years had the best statistical model performance. On receiver operating characteristic curve analysis, the optimal age cut-off for prediction of DSS was 50.5 years (area under the curve = 0.872, p &amp;lt; 0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In this large cohort of Middle Eastern DTC patients, an age cut-off of 50 years was more appropriate for TNM staging to achieve better predictability for DSS. Therefore, implementation of different age cut-off for DTC in Middle Eastern patients could improve the predictive value for TNM staging system, allowing for better therapeutic and surveillance approach for these patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fendo.2025.1494154","type":"journal-article","created":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T05:15:11Z","timestamp":1763961311000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Optimal cut-off age for AJCC staging system in Middle Eastern differentiated thyroid cancer"],"prefix":"10.3389","volume":"16","author":[{"given":"Sandeep Kumar","family":"Parvathareddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul 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