{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:22:28Z","timestamp":1784326948686,"version":"3.55.0"},"reference-count":37,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Some studies suggest a potential link between cardiovascular health, lipid, and overactive bladder (OAB). Life\u2019s Crucial 9 (LC9) is a recently developed method for assessing cardiovascular health, while the Atherogenic Index of Plasma (AIP) represents a novel marker of atherosclerotic lipid profiles. However, the relationship between Life\u2019s Crucial 9 and overactive bladder and the role of Atherogenic Index of Plasma in the relationship between Life\u2019s Crucial 9 and overactive bladder is unclear. This study investigates the relationship between Life\u2019s Crucial 9 and overactive bladder and evaluates whether Atherogenic Index of Plasma influences this association.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study conducted a cross-sectional analysis of 25,628 U.S. participants in the NHANES database from 2005-2018. Firstly, we used multivariate logistic regression to investigate the relationship between Life\u2019s Crucial 9 and overactive bladder. Subsequently, subgroup analysis and restricted cubic splines (RCS) were further used to verify their relationship. Additionally, mediation analysis was conducted to explore the potential role of Atherogenic Index of Plasma levels in the association between Life\u2019s Crucial 9 and overactive bladder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 25,628 participants were included in this study, among whom 5,150 reported overactive bladder events. After using multivariate logistic regression to adjust for age, sex, race, marital status, education level, poverty-to-income ratio (PIR), smoking, alcohol consumption, hypertension, diabetes, and hypercholesterolemia, a 10-unit increase in Life\u2019s Crucial 9 was associated with a 28% reduction in overactive bladder incidence (OR = 0.72, 95% CI: 0.69-0.76), while a 1-unit increase in Atherogenic Index of Plasma was associated with a 7% increase in overactive bladder incidence (OR = 1.07, 95% CI: 1.01-1.14). Similar results were obtained when Life\u2019s Crucial 9 and Atherogenic Index of Plasma were categorized into tertiles, with a significant trend (P for trend &amp;lt; 0.05). Restricted cubic spline analysis revealed a linear negative correlation between Life\u2019s Crucial 9 and overactive bladder incidence. Mediation analysis further indicated that 6.49% of the relationship between Life\u2019s Crucial 9 and overactive bladder was mediated by Atherogenic Index of Plasma (P = 0.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study found a significant negative correlation between Life\u2019s Crucial 9 and overactive bladder, with Atherogenic Index of Plasma partially mediating this relationship. These findings highlight the potential link between cardiovascular health and overactive bladder, underscoring the role of Life\u2019s Crucial 9 in reducing overactive bladder incidence, possibly through its effects on lowering lipid levels.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1505712","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T05:12:08Z","timestamp":1740719528000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Atherogenic Index of Plasma mediates the association between Life\u2019s Crucial 9 with overactive bladder: a secondary data analysis from 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