{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:19:55Z","timestamp":1793319595158,"version":"4.5.0"},"reference-count":31,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"Objective<\/jats:title>In this study, we aimed to explore the relationship between postprandial triglyceride (TG) and postprandial thyroid stimulating hormone (TSH) levels and compare the postprandial TSH levels in participants with normal lipid tolerance and reduced lipid tolerance.<\/jats:p><\/jats:sec>Methods<\/jats:title>A total of 81 eligible participants were enrolled and given a high-fat meal of 1500 kcal, and blood samples were collected at 2, 4, 6, and 8 hours. Fasting blood glucose, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and fasting and postprandial TG, triiodothyronine (T3), tetraiodothyronine (T4), and TSH levels were tested. Based on the postprandial serum TG level, participants were divided into the normal lipid tolerance group (NFT) and the decreased lipid tolerance group (IFT).<\/jats:p><\/jats:sec>Results<\/jats:title>Postprandial TG levels increased in both the NFT and IFT groups and then decreased over time. A higher and delayed peak of postprandial TG was observed in the IFT group, and there were statistically significant differences in TG levels at each time point in both groups. The area under the curve (TGAUC) was an independent influencing factor for the area under the curve (TSHAUC) of TSH. Postprandial TSH levels in both groups reached a trough at 2 h and peaked at 6 h, with a higher peak in the IFT group. Except for 2 h, TSH levels were significantly different at all other time points. There was no statistically significant difference in T3 or T4 levels between the two groups, with opposite trends for TSH.<\/jats:p><\/jats:sec>Conclusion<\/jats:title>After a high-fat meal is consumed, the postprandial TSH level is influenced by the postprandial TG level, which may be the reason for the decreased thyroid function in the population with reduced lipid tolerance.<\/jats:p><\/jats:sec>Clinical Trial Registration<\/jats:title>http:\/\/www.chictr.org.cn\/index.aspx<\/jats:ext-link>, identifier ChiCTR1800019514.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1522928","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:14:00Z","timestamp":1739423640000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Postprandial triglyceride levels affecting postprandial thyroid stimulating hormone levels may be responsible for the increased postprandial thyroid stimulating hormone levels in people with reduced lipid tolerance"],"prefix":"10.3389","volume":"16","author":[{"given":"Peipei","family":"Tian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaojing","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilin","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dandan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangyao","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,13]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1749","article-title":"The incidence of ischemic heart disease and mortality in people with subclinical hypothyroidism: reanalysis of the Whickham Survey cohort","volume":"95","author":"Razvi","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2010.1361","article-title":"Subclinical hypothyroidism and the risk of coronary heart disease and mortality","volume":"304","author":"Rodondi","year":"2010","journal-title":"Jama"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.055654","article-title":"Effect of long-term marine \u0277-3 fatty acids supplementation on the risk of atrial fibrillation in randomized controlled trials of cardiovascular outcomes: A systematic review and meta-analysis","volume":"144","author":"Gencer","year":"2021","journal-title":"Circulation"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.20745","article-title":"Association of subclinical hypothyroidism and cardiovascular disease with mortality","volume":"3","author":"Inoue","year":"2020","journal-title":"JAMA Netw Open"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2017.10.021","article-title":"Subclinical hypothyroidism is associated with adverse prognosis in heart failure patients","volume":"34","author":"Sato","year":"2018","journal-title":"Can J Cardiol"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-1039","article-title":"Subclinical hypothyroidism and survival: the effects of heart failure and race","volume":"98","author":"Rhee","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000500","article-title":"Thyroid disease and the metabolic syndrome","volume":"26","author":"Mehran","year":"2019","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1159\/000342994","article-title":"Thyroid function and obesity","volume":"1","author":"Laurberg","year":"2012","journal-title":"Eur Thyroid J"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.104079","article-title":"Hypothyroidism in metabolic syndrome","volume":"16","author":"Kota","year":"2012","journal-title":"Indian J Endocrinol Metab"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-011-0545-4","article-title":"Prevalence of endocrine disorders in morbidly obese patients and the effects of bariatric surgery on endocrine and metabolic parameters","volume":"22","author":"Jankovic","year":"2012","journal-title":"Obes Surg"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3987","article-title":"Lipotoxicity, a potential risk factor for the increasing prevalence of subclinical hypothyroidism","volume":"100","author":"Zhao","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"B12","doi-asserted-by":"publisher","first-page":"6754","DOI":"10.1038\/s41598-017-07004-2","article-title":"Metabolic syndrome is associated with an increased incidence of subclinical hypothyroidism - A Cohort Study","volume":"7","author":"Chang","year":"2017","journal-title":"Sci Rep"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/j.jacc.2017.08.006","article-title":"Plasma lipids in non-fasting patients and signal values of laboratory results","volume":"171","author":"Nordestgaard","year":"2009","journal-title":"Ugeskr Laeger"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e3182160726","article-title":"Triglycerides and cardiovascular disease: a scientific statement from the American Heart Association","volume":"123","author":"Miller","year":"2011","journal-title":"Circulation"},{"key":"B15","volume-title":"2023 exceptional surveillance of cardiovascular disease: risk assessment and reduction, including lipid modification (NICE guideline CG181)","author":"Wierzbicki","year":"2023"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.4103\/2230-8210.139237","article-title":"Does fasting or postprandial state affect thyroid function testing","volume":"18","author":"Nair","year":"2014","journal-title":"Indian J Endocrinol Metab"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1330075","article-title":"Influence of meal composition on the postprandial response of the pituitary-thyroid axis","volume":"133","author":"Kamat","year":"1995","journal-title":"Eur J Endocrinol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.11613\/BM.2019.020702","article-title":"Impact of an Andean breakfast on biochemistry and immunochemistry laboratory tests: an evaluation on behalf COLABIOCLI WG-PRE-LATAM","volume":"29","author":"Bajana","year":"2019","journal-title":"Biochem Med (Zagreb)"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1000-3614.2023.03.001","article-title":"Guidelines on blood lipid management in China (2023)","volume":"38","author":"Zengwu","year":"2023","journal-title":"China Circ Magazine"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.2174\/157016111795495549","article-title":"Assessment and clinical relevance of non-fasting and postprandial triglycerides: an expert panel statement","volume":"9","author":"Kolovou","year":"2011","journal-title":"Curr Vasc Pharmacol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2011.12.004","article-title":"Novel qualitative aspects of tissue fatty acids related to metabolic regulation: lessons from Elovl6 knockout","volume":"51","author":"Shimano","year":"2012","journal-title":"Prog Lipid Res"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.060889","article-title":"Ventricular assist device implantation corrects myocardial lipotoxicity, reverses insulin resistance, and normalizes cardiac metabolism in patients with advanced heart failure","volume":"125","author":"Chokshi","year":"2012","journal-title":"Circulation"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.11.1768","article-title":"Mechanisms of liver and muscle insulin resistance induced by chronic high-fat feeding","volume":"46","author":"Oakes","year":"1997","journal-title":"Diabetes"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.82","article-title":"Dietary high-fat lard intake induces thyroid dysfunction and abnormal morphology in rats","volume":"35","author":"Shao","year":"2014","journal-title":"Acta Pharmacol Sin"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1670","article-title":"Thyroid dysfunction associated with follicular cell steatosis in obese male mice and humans","volume":"156","author":"Lee","year":"2015","journal-title":"Endocrinology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00194.2018","article-title":"ER stress contributes to high-fat diet-induced decrease of thyroglobulin and hypothyroidism","volume":"316","author":"Zhang","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/9781119707677.ch4","article-title":"Serum TSH variability in normal individuals: the influence of time of sample collection","volume":"100","author":"Scobbo","year":"2004","journal-title":"W V Med J"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2014.0589","article-title":"Circadian and circannual rhythms in thyroid hormones: determining the TSH and free T4 reference intervals based upon time of day, age, and sex","volume":"25","author":"Ehrenkranz","year":"2015","journal-title":"Thyroid"},{"key":"B29","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/BF03345210","article-title":"Elevated circulating somatostatin levels in acromegaly","volume":"26","author":"Arosio","year":"2003","journal-title":"J Endocrinol Invest"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.4065\/73.9.837","article-title":"Effect of thyroid hormone replacement on lipoprotein(a), lipids, and apolipoproteins in subjects with hypothyroidism","volume":"73","author":"Martinez-Triguero","year":"1998","journal-title":"Mayo Clin Proc"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-0202","article-title":"Rapid activation by 3,5,3\u2019-L-triiodothyronine of adenosine 5\u2019-monophosphate-activated protein kinase\/acetyl-coenzyme a carboxylase and akt\/protein kinase B signaling pathways: relation to changes in fuel metabolism and myosin heavy-chain protein content in rat gastrocnemius muscle in vivo","volume":"149","author":"de Lange","year":"2008","journal-title":"Endocrinology"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1522928\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:14:03Z","timestamp":1739423643000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1522928\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":31,"alternative-id":["10.3389\/fendo.2025.1522928"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1522928","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]},"article-number":"1522928"}}