{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:42:46Z","timestamp":1792532566884,"version":"4.5.0"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T00:00:00Z","timestamp":1737676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>The protein tyrosine phosphatase receptors N and N2 are encoded by the <jats:italic>Ptprn<\/jats:italic> and <jats:italic>Ptprn2<\/jats:italic> genes expressed in neuroendocrine cells of the hypothalamus, pituitary gland, and diffuse neuroendocrine system, including the pancreas, lung, and intestine. Unlike other members of the protein tyrosine phosphatase receptor family, PTPRN and PTPRN2 lack protein tyrosine phosphatase activity due to mutation of two residues in their intracellular catalytic domains. However, during evolution these proteins acquired new cellular roles beyond tyrosine dephosphorylation in the centralized and diffuse neuroendocrine systems. Here we discuss the current understanding and lack of information about the actions of these proteins, focusing on neuroendocrine cells of the hypothalamus, pituitary, and pancreas.<\/jats:p>","DOI":"10.3389\/fendo.2025.1531723","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T07:14:55Z","timestamp":1737702895000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["What is known and unknown about the role of neuroendocrine genes Ptprn and Ptprn2"],"prefix":"10.3389","volume":"16","author":[{"given":"Stanko S.","family":"Stojilkovic","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srdjan J.","family":"Sokanovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Constantin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,1,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2039","article-title":"Protein tyrosine phosphatases: from genes, to function, to disease","volume":"7","author":"Tonks","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1677\/joe.1.06069","article-title":"Protein tyrosine phosphatases and signalling","volume":"185","author":"Stoker","year":"2005","journal-title":"J Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1002\/(SICI)1099-0895(199803)14:1<85::AID-DMR205>3.0.CO;2-I","article-title":"IA-2 and IA-2beta: the immune response in IDDM","volume":"14","author":"Notkins","year":"1998","journal-title":"Diabetes Metab Rev"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1089\/dna.1994.13.505","article-title":"Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma","volume":"13","author":"Lan","year":"1994","journal-title":"DNA Cell Biol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.6.2307","article-title":"Identification of a second transmembrane protein tyrosine phosphatase, IA-2beta, as an autoantigen in insulin-dependent diabetes mellitus: precursor of the 37-kDa tryptic fragment","volume":"93","author":"Lu","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5583","article-title":"Genomic structure and promoter sequence of the insulin-dependent diabetes mellitus autoantigen, IA-2 (PTPRN)","volume":"54","author":"Xie","year":"1998","journal-title":"Genomics"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051525","article-title":"Humoral autoreactivity to an alternatively spliced variant of ICA512\/IA-2 in Type I diabetes","volume":"43","author":"Park","year":"2000","journal-title":"Diabetologia"},{"key":"B8","doi-asserted-by":"publisher","first-page":"895","DOI":"10.2337\/diabetes.50.4.895","article-title":"Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity against the IA-2 type 1 diabetes autoantigen","volume":"50","author":"Diez","year":"2001","journal-title":"Diabetes"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.K09E-157","article-title":"Expression and function of IA-2 family proteins, unique neuroendocrine-specific protein-tyrosine phosphatases","volume":"56","author":"Torii","year":"2009","journal-title":"Endocr J"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1210\/endo.135.6.7988462","article-title":"Regulated endocrine-specific protein-18: a short-lived novel glucocorticoid-regulated endocrine protein","volume":"135","author":"Bloomquist","year":"1994","journal-title":"Endocrinology"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-07-0252","article-title":"RESP18, a homolog of the luminal domain IA-2, is found in dense core vesicles in pancreatic islet cells and is induced by high glucose","volume":"195","author":"Zhang","year":"2007","journal-title":"J Endocrinol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1210\/en.2019-00397","article-title":"Regulated endocrine-Specific protein-18, an emerging endocrine protein in physiology: A literature review","volume":"160","author":"Atari","year":"2019","journal-title":"Endocrinology"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2016.01.013","article-title":"Biochemical, biophysical, and functional properties of ICA512\/IA-2 RESP18 homology domain","volume":"1864","author":"Sosa","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"B14","doi-asserted-by":"publisher","first-page":"e2400560","DOI":"10.1002\/advs.202400560","article-title":"A novel ubiquitin ligaseaAdaptor PTPRN suppresses seizure susceptibility through endocytosis of Na(V)1.2 sodium channels","volume":"11","author":"Wang","year":"2024","journal-title":"Adv Sci (Weinh)"},{"key":"B15","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuroscience.2014.03.023","article-title":"The dense core vesicle protein IA-2, but not IA-2beta, is required for active avoidance learning","volume":"269","author":"Carmona","year":"2014","journal-title":"Neuroscience"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1996.tb00564.x","article-title":"ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules","volume":"15","author":"Solimena","year":"1996","journal-title":"EMBO J"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.90543.2008","article-title":"Dense-core vesicle proteins IA-2 and IA-2{beta} affect renin synthesis and secretion through the {beta}-adrenergic pathway","volume":"296","author":"Kim","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5754","article-title":"Developmental expression and localization of IA-2 mRNA in mouse neuroendocrine tissues","volume":"288","author":"Shimizu","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2009.02.012","article-title":"Localization of insulinoma associated protein 2, IA-2 in mouse neuroendocrine tissues using two novel monoclonal antibodies","volume":"84","author":"Takeyama","year":"2009","journal-title":"Life Sci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00202","article-title":"Excitatory and inhibitory neurons in the hippocampus exhibit molecularly distinct large dense core vesicles","volume":"10","author":"Ramirez-Franco","year":"2016","journal-title":"Front Cell Neurosci"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/s1054-3589(08)60738-3","article-title":"ICA 512, a receptor tyrosine phosphatase-like protein, is concentrated in neurosecretory granule membranes","volume":"42","author":"Dirkx","year":"1998","journal-title":"Adv Pharmacol"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2021.09.029","article-title":"Knockdown of Ptprn-2 delays the onset of puberty in female rats","volume":"176","author":"Kang","year":"2021","journal-title":"Theriogenology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1038\/s41598-023-27497-4","article-title":"Common and female-specific roles of protein tyrosine phosphatase receptors N and N2 in mice reproduction","volume":"13","author":"Sokanovic","year":"2023","journal-title":"Sci Rep"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00001","article-title":"Identification of genes enriched in gnRH neurons by translating ribosome affinity purification and RNAseq in mice","volume":"159","author":"Burger","year":"2018","journal-title":"Endocrinology"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqab080","article-title":"Estrogen regulation of the molecular phenotype and active translatome of AVPV kisspeptin neurons","volume":"162","author":"Stephens","year":"2021","journal-title":"Endocrinology"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00677.x","article-title":"Post-translational modifications of ICA512, a receptor tyrosine phosphatase-like protein of secretory granules","volume":"11","author":"Hermel","year":"1999","journal-title":"Eur J Neurosci"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0638","article-title":"Disruption of the transmembrane dense core vesicle proteins IA-2 and IA-2beta causes female infertility","volume":"147","author":"Kubosaki","year":"2006","journal-title":"Endocrinology"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1210\/endo.139.6.6039","article-title":"Stabilization of the receptor protein tyrosine phosphatase-like protein ICA512 in GH4C1 cells upon treatment with estradiol, insulin, and epidermal growth factor","volume":"139","author":"Lee","year":"1998","journal-title":"Endocrinology"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00623","article-title":"Cell type- and sex-Dependent transcriptome profiles of rat anterior pituitary cells","volume":"10","author":"Fletcher","year":"2019","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1002\/glia.24267","article-title":"The astroglial and stem cell functions of adult rat folliculostellate cells","volume":"71","author":"Fletcher","year":"2023","journal-title":"Glia"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1210\/en.2016-1758","article-title":"The human adrenal gland proteome defined by transcriptomics and antibody-based profiling","volume":"158","author":"Bergman","year":"2017","journal-title":"Endocrinology"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1369\/0022155412466872","article-title":"Immunohistochemical analysis of IA-2 family of protein tyrosine phosphatases in rat gastrointestinal endocrine cells","volume":"61","author":"Gomi","year":"2013","journal-title":"J Histochem Cytochem"},{"key":"B33","article-title":"IA-2, a transmembrane protein tyrosine phosphatase, is expressed in human lung cancer cell lines with neuroendocrine phenotype","volume":"56","author":"Xie","year":"1996","journal-title":"Cancer Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb07415.x","article-title":"Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR","volume":"9","author":"Streuli","year":"1990","journal-title":"EMBO J"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/febs.v287.19","article-title":"The dead phosphatases society: a review of the emerging roles of pseudophosphatases","volume":"287","author":"Reiterer","year":"2020","journal-title":"FEBS J"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1549","article-title":"Substitution of two variant residues in the protein tyrosine phosphatase-like PTP35\/IA-2 sequence reconstitutes catalytic activity","volume":"227","author":"Magistrelli","year":"1996","journal-title":"Biochem Biophys Res Commun"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68051820.x","article-title":"PTP NE-6: a brain-enriched receptor-type protein tyrosine phosphatase with a divergent catalytic domain","volume":"68","author":"Fitzgerald","year":"1997","journal-title":"J Neurochem"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208228200","article-title":"Multimerization of the protein-tyrosine phosphatase (PTP)-like insulin-dependent diabetes mellitus autoantigens IA-2 and IA-2beta with receptor PTPs (RPTPs)","volume":"277","author":"Gross","year":"2002","journal-title":"Inhibition RPTPalpha Enzymatic Activity J Biol Chem"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.suppl_2.S46","article-title":"Dense core vesicle proteins IA-2 and IA-2beta: metabolic alterations in double knockout mice","volume":"54","author":"Kubosaki","year":"2005","journal-title":"Diabetes"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.066563","article-title":"The neurosecretory vesicle protein phogrin functions as a phosphatidylinositol phosphatase to regulate insulin secretion","volume":"285","author":"Caromile","year":"2010","journal-title":"J Biol Chem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"62","DOI":"10.15252\/embj.201591973","article-title":"PTPRN2 and PLCbeta1 promote metastatic breast cancer cell migration through PI(4,5)P2-dependent actin remodeling","volume":"35","author":"Sengelaub","year":"2016","journal-title":"EMBO J"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0408887102","article-title":"The dense core transmembrane vesicle protein IA-2 is a regulator of vesicle number and insulin secretion","volume":"102","author":"Harashima","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.6.1842","article-title":"Targeted disruption of the protein tyrosine phosphatase-like molecule IA-2 results in alterations in glucose tolerance tests and insulin secretion","volume":"51","author":"Saeki","year":"2002","journal-title":"Diabetes"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.30.18161","article-title":"Molecular cloning of phogrin, a protein-tyrosine phosphatase homologue localized to insulin secretory granule membranes","volume":"271","author":"Wasmeier","year":"1996","journal-title":"J Biol Chem"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1166076","article-title":"Germline loss-of-function PAM variants are enriched in subjects with pituitary hypersecretion","volume":"14","author":"Trivellin","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M600443-MCP200","article-title":"Proteomics analysis of insulin secretory granules","volume":"6","author":"Brunner","year":"2007","journal-title":"Mol Cell Proteomics"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1021\/pr1003104","article-title":"Proteomics of dense core secretory vesicles reveal distinct protein categories for secretion of neuroeffectors for cell-cell communication","volume":"9","author":"Wegrzyn","year":"2010","journal-title":"J Proteome Res"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1042\/bj3330193","article-title":"Secretory-granule dynamics visualized in vivo with a phogrin-green fluorescent protein chimaera","volume":"333","author":"Pouli","year":"1998","journal-title":"Biochem J"},{"key":"B49","article-title":"Targeting of a phogrin-green fluorescent protein chimaera to insulin secretory granules of pancreatic beta-cells in transgenic mice","volume":"28","author":"Bright","year":"2002","journal-title":"Diabetes Metab"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.15.4013","article-title":"Dephosphorylation of beta2-syntrophin and Ca2+\/mu-calpain-mediated cleavage of ICA512 upon stimulation of insulin secretion","volume":"20","author":"Ort","year":"2001","journal-title":"EMBO J"},{"key":"B51","doi-asserted-by":"publisher","first-page":"e12929","DOI":"10.1371\/journal.pone.0012929","article-title":"beta2-Syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules","volume":"5","author":"Schubert","year":"2010","journal-title":"PLoS One"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2016.05.015","article-title":"The F-actin modifier villin regulates insulin granule dynamics and exocytosis downstream of islet cell autoantigen 512","volume":"5","author":"Mziaut","year":"2016","journal-title":"Mol Metab"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.200700969","article-title":"Flow cytometry-assisted purification and proteomic analysis of the corticotropes dense-core secretory granules","volume":"8","author":"Gauthier","year":"2008","journal-title":"Proteomics"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1074\/mcp.M900044-MCP200","article-title":"Snapshot peptidomics of the regulated secretory pathway","volume":"8","author":"Sasaki","year":"2009","journal-title":"Mol Cell Proteomics"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200408172","article-title":"Nuclear translocation of an ICA512 cytosolic fragment couples granule exocytosis and insulin expression in {beta}-cells","volume":"167","author":"Trajkovski","year":"2004","journal-title":"J Cell Biol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1395","article-title":"Synergy of glucose and growth hormone signalling in islet cells through ICA512 and STAT5","volume":"8","author":"Mziaut","year":"2006","journal-title":"Nat Cell Biol"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710931105","article-title":"ICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs","volume":"105","author":"Mziaut","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.676287","article-title":"Expression and tumor-Promoting effect of tyrosine phosphatase receptor type N (PTPRN) in human glioma","volume":"11","author":"Wang","year":"2021","journal-title":"Front Oncol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-2718","article-title":"Aberrant expression of proPTPRN2 in cancer cells confers resistance to apoptosis","volume":"75","author":"Sorokin","year":"2015","journal-title":"Cancer Res"},{"key":"B60","doi-asserted-by":"publisher","first-page":"102274","DOI":"10.1016\/j.coph.2022.102274","article-title":"Pituitary gonadotroph-specific patterns of gene expression and hormone secretion","volume":"66","author":"Constantin","year":"2022","journal-title":"Curr Opin Pharmacol"},{"key":"B61","doi-asserted-by":"publisher","first-page":"102316","DOI":"10.1016\/j.coph.2022.102316","article-title":"Targeting KNDy neurons to control GnRH pulses","volume":"67","author":"Constantin","year":"2022","journal-title":"Curr Opin Pharmacol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-00653","article-title":"The gonadotropin-releasing hormone pulse generator","volume":"159","author":"Herbison","year":"2018","journal-title":"Endocrinology"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.06.025","article-title":"Discovery of the hypothalamic gonadotropin-releasing hormone pulse generator and of its physiologic significance. 1992","volume":"193","author":"Knobil","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1210\/en.2018-01047","article-title":"Characterization of gnRH pulse generator activity in male mice using GCaMP fiber photometry","volume":"160","author":"Han","year":"2019","journal-title":"Endocrinology"},{"key":"B65","doi-asserted-by":"publisher","first-page":"e13094","DOI":"10.1111\/jne.13094","article-title":"Neuroendocrine control of gonadotropin-releasing hormone: Pulsatile and surge modes of secretion","volume":"34","author":"Goodman","year":"2022","journal-title":"J Neuroendocrinol"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00126","article-title":"Developmental programming of hypothalamic neuronal circuits: impact on energy balance control","volume":"9","author":"Gali Ramamoorthy","year":"2015","journal-title":"Front Neurosci"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.coemr.2022.100364","article-title":"Pituitary corticotroph identity and receptor-mediated signaling: a transcriptomics perspective","volume":"25","author":"Stojilkovic","year":"2022","journal-title":"Curr Opin Endocr Metab Res"},{"key":"B68","doi-asserted-by":"publisher","first-page":"T99","DOI":"10.1530\/JME-15-0289","article-title":"60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expression","volume":"56","author":"Drouin","year":"2016","journal-title":"J Mol Endocrinol"},{"key":"B69","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1210\/endocr\/bqae076","article-title":"Protein tyrosine phosphatase receptors N and N2 control pituitary melanotroph development and POMC expression","author":"Constantin","year":"2024","journal-title":"Endocrinology"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00282-3","article-title":"A pituitary cell-restricted T box factor, Tpit, activates POMC transcription in cooperation with Pitx homeoproteins","volume":"104","author":"Lamolet","year":"2001","journal-title":"Cell"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-017-0035-2","article-title":"Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate","volume":"50","author":"Mayran","year":"2018","journal-title":"Nat Genet"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1101\/gad.200436.112","article-title":"The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling","volume":"26","author":"Budry","year":"2012","journal-title":"Genes Dev"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1531723\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T07:14:58Z","timestamp":1737702898000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1531723\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,24]]},"references-count":72,"alternative-id":["10.3389\/fendo.2025.1531723"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1531723","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,24]]},"article-number":"1531723"}}