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Endocrinol."],"abstract":"<jats:p>Although numerous Mendelian randomization studies on risk factors have been conducted in male medicine, a systematic synthesis of these findings is still lacking. This review searched relevant literature in PubMed and the Web of Science published before May 2024; systematically summarized the progress in the application of Mendelian randomization in male infertility, erectile dysfunction, prostate cancer, and prostatitis; summarized and classified the risk factors affecting men\u2019s health, such as the gut microbiota, modifiable risk factors and related diseases; and presented some problems and solutions that were presented in these studies. 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