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Exosomes, extracellular vesicles measuring 40\u2013160 nm in diameter, are critical mediators of intercellular communication. Among their bioactive components, microRNAs (miRNAs) have garnered attention for their role in the pathogenesis of Osteoporosis. Through complementary binding to the 3\u2032 untranslated regions of target genes, miRNAs regulate key processes such as bone formation, bone resorption, angiogenesis, and bone immunity. This review provides a comprehensive summary of the regulatory roles and underlying mechanisms of miRNAs in osteoporosis, offering insights into potential therapeutic strategies.<\/jats:p>","DOI":"10.3389\/fendo.2025.1544944","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T04:10:21Z","timestamp":1755576621000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Progress in understanding the role and mechanism of miRNAs in 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