{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:43:55Z","timestamp":1792176235135,"version":"4.4.0"},"reference-count":73,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Polycystic ovary syndrome (PCOS) has been extensively studied as a common female endocrine disease. In recent years, the relationship between circadian rhythm and PCOS has gradually drawn attention, although the precise nature of this connection remains unclear. The aim of this study was to explore further links between circadian rhythm and PCOS and to identify potential mediators of the pathogenesis of PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>We analyzed the available data on PCOS and circadian rhythm disorders. Consequently, we identified potential transcription factors (NPAS2, INSIG1, H3F3B, SCML1) through bioinformatics and verified them in a well-established PCOS mouse model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Luteinizing hormone (LH), testosterone (T), and melatonin (ML) exhibited substantial changes in the PCOS patients compared to healthy controls, with ML serving as a crucial biomarker in circadian rhythms. PCR results from ovarian tissues demonstrated altered expression of circadian core oscillator in the PCOS mouse model, with NPAS2 expression aligning with the bioinformatics analysis trend. We used quercetin (QUE) as a treatment and observed that it improved the disturbed expression of circadian core oscillations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our research revealed the correlation between circadian rhythm disruptions and PCOS, identified potential targets, and provided unique insights into the pathogenesis of circadian rhythm-related PCOS. The improvement of circadian core oscillations in the QUE group offers a novel strategy for the treatment of PCOS.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1545789","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:14:09Z","timestamp":1747887249000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring the potential association and experimental validation of disrupted circadian rhythms with polycystic ovary syndrome via meta-analysis and bioinformatics: a possible pathogenic mechanism"],"prefix":"10.3389","volume":"16","author":[{"given":"Wenjia","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanmei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lushan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenye","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caifei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,22]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"B2","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.fertnstert.2016.05.003","article-title":"Criteria, prevalence, and phenotypes of polycystic ovary syndrome","volume":"106","author":"Lizneva","year":"2016","journal-title":"Fertil Steril"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dey256","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"33","author":"Teede","year":"2018","journal-title":"Hum Reprod"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.4103\/jhrs.JHRS_95_18","article-title":"The prevalence of polycystic ovary syndrome: A brief systematic review","volume":"13","author":"Deswal","year":"2020","journal-title":"J Hum Reprod Sci"},{"key":"B5","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1186\/s12916-020-01861-x","article-title":"Updated adolescent diagnostic criteria for polycystic ovary syndrome: impact on prevalence and longitudinal body mass index trajectories from birth to adulthood","volume":"18","author":"Tay","year":"2020","journal-title":"BMC Med"},{"key":"B6","doi-asserted-by":"publisher","first-page":"e3054","DOI":"10.1002\/dmrr.v34.8","article-title":"Polycystic ovary syndrome and the risk of cardiometabolic complications in longitudinal studies","volume":"34","author":"Jacewicz-\u015awi\u0119cka","year":"2018","journal-title":"Diabetes Metab Res Rev"},{"key":"B7","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1055\/s-2007-992921","article-title":"Polycystic ovary syndrome in the Indian Subcontinent","volume":"26","author":"Allahbadia","year":"2008","journal-title":"Semin Reprod Med"},{"key":"B8","doi-asserted-by":"publisher","first-page":"106159","DOI":"10.1016\/j.envint.2020.106159","article-title":"Environmental chemicals affect circadian rhythms: An underexplored effect influencing health and fitness in animals and humans","volume":"149","author":"Zheng","year":"2021","journal-title":"Environ Int"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2024.2353857","article-title":"The environment and the internal clocks: The study of their relationships from prehistoric to modern times","volume":"41","author":"Touitou","year":"2024","journal-title":"Chronobiol Int"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-018-0026-z","article-title":"Generation of circadian rhythms in the suprachiasmatic nucleus","volume":"19","author":"Hastings","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"B11","doi-asserted-by":"publisher","first-page":"106901","DOI":"10.1016\/j.imlet.2024.106901","article-title":"Immunoregulatory properties of melatonin in the humoral immune system: A narrative review","author":"Calvo","year":"2024","journal-title":"Immunol Lett"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153128","article-title":"Central and peripheral circadian clocks in mammals","volume":"35","author":"Mohawk","year":"2012","journal-title":"Annu Rev Neurosci"},{"key":"B13","doi-asserted-by":"publisher","first-page":"R93","DOI":"10.1530\/JME-19-0153","article-title":"Circadian clock genes and the transcriptional architecture of the clock mechanism","volume":"63","author":"Cox","year":"2019","journal-title":"J Mol Endocrinol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00825-5","article-title":"The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator","volume":"110","author":"Preitner","year":"2002","journal-title":"Cell"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.07.018","article-title":"A functional genomics strategy reveals Rora as a component of the mammalian circadian clock","volume":"43","author":"Sato","year":"2004","journal-title":"Neuron"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/ng1738","article-title":"Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions","volume":"38","author":"Ripperger","year":"2006","journal-title":"Nat Genet"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1101\/gad.578810","article-title":"Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1","volume":"24","author":"Stratmann","year":"2010","journal-title":"Genes Dev"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1038\/ng1504","article-title":"System-level identification of transcriptional circuits underlying mammalian circadian clocks","volume":"37","author":"Ueda","year":"2005","journal-title":"Nat Genet"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1016\/j.fertnstert.2019.01.037","article-title":"Female sleep patterns, shift work, and fecundability in a North American preconception cohort study","volume":"111","author":"Willis","year":"2019","journal-title":"Fertil Steril"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02385","article-title":"Morning circadian misalignment is associated with insulin resistance in girls with obesity and polycystic ovarian syndrome","volume":"104","author":"Simon","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1159\/000430218","article-title":"Circadian clock gene plays a key role on ovarian cycle and spontaneous abortion","volume":"37","author":"Li","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2004.07.055","article-title":"Circadian clock mutation disrupts estrous cyclicity and maintenance of pregnancy","volume":"14","author":"Miller","year":"2004","journal-title":"Curr Biol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2023.2241902","article-title":"Comparing MitoQ10 and heat therapy: Evaluating mechanisms and therapeutic potential for polycystic ovary syndrome induced by circadian rhythm disruption","volume":"40","author":"Amin","year":"2023","journal-title":"Chronobiol Int"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.954186","article-title":"Long-term environmental exposure of darkness induces hyperandrogenism in PCOS via melatonin receptor 1A and aromatase reduction","volume":"10","author":"Chu","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B25","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/s12905-022-01661-w","article-title":"Women with polycystic ovary syndrome (PCOS) have reduced melatonin concentrations in their follicles and have mild sleep disturbances","volume":"22","author":"Li","year":"2022","journal-title":"BMC Womens Health"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deac139","article-title":"Derailed peripheral circadian genes in polycystic ovary syndrome patients alters peripheral conversion of androgens synthesis","volume":"37","author":"Johnson","year":"2022","journal-title":"Hum Reprod"},{"key":"B27","doi-asserted-by":"publisher","first-page":"2763","DOI":"10.3390\/biomedicines11102763","article-title":"Overnight melatonin concentration and sleep quality are associated with the clinical features of polycystic ovary syndrome","volume":"11","author":"Evans","year":"2023","journal-title":"Biomedicines"},{"key":"B28","doi-asserted-by":"publisher","first-page":"903","DOI":"10.3390\/ijms25020903","article-title":"The role of microRNA, long non-coding RNA and circular RNA in the pathogenesis of polycystic ovary syndrome: A literature review","volume":"25","author":"Nasser","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B29","doi-asserted-by":"publisher","first-page":"e12844","DOI":"10.1111\/jpi.12844","article-title":"Evening chronotype is associated with hormonal and metabolic disorders in polycystic ovary syndrome","volume":"74","author":"Barrea","year":"2023","journal-title":"J Pineal Res"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.918805","article-title":"Therapeutic potential of exosomes\/miRNAs in polycystic ovary syndrome induced by the alteration of circadian rhythms","volume":"13","author":"Chen","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B31","doi-asserted-by":"publisher","first-page":"6678398","DOI":"10.1155\/2021\/6678398","article-title":"The treatment with complementary and alternative traditional chinese medicine for menstrual disorders with polycystic ovary syndrome","volume":"2021","author":"Zhang","year":"2021","journal-title":"Evid Based Complement Alternat Med"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.1006678","article-title":"Quercetin and polycystic ovary syndrome","volume":"13","author":"Ma","year":"2022","journal-title":"Front Pharmacol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/s13048-020-0616-z","article-title":"Quercetin and polycystic ovary syndrome, current evidence and future directions: a systematic review","volume":"13","author":"Pourteymour Fard Tabrizi","year":"2020","journal-title":"J Ovarian Res"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2021.08.015","article-title":"Mechanism of quercetin on the improvement of ovulation disorder and regulation of ovarian CNP\/NPR2 in PCOS model rats","volume":"121","author":"Zheng","year":"2022","journal-title":"J Formos Med Assoc"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1153289","article-title":"Effect of quercetin on steroidogenesis and folliculogenesis in ovary of mice with experimentally-induced polycystic ovarian syndrome","volume":"14","author":"Shah","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2022.06.026","article-title":"The effect of quercetin in the maturation media on cumulus-granulosa cells and the developmental competence of bovine oocytes","volume":"189","author":"Davoodian","year":"2022","journal-title":"Theriogenology"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e22527","DOI":"10.1002\/jbt.22527","article-title":"Quercetin alleviated H(2) O(2) -induced apoptosis and steroidogenic impairment in goat luteinized granulosa cells","volume":"34","author":"Li","year":"2020","journal-title":"J Biochem Mol Toxicol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00273","article-title":"Effects of melatonin supplementation on hormonal, inflammatory, genetic, and oxidative stress parameters in women with polycystic ovary syndrome","volume":"10","author":"Jamilian","year":"2019","journal-title":"Front Endocrinol"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3329\/bjms.v22i4.67124","article-title":"Melatonin enhances ovarian response in infertile women with polycystic ovary syndrome: A randomized controlled trial","volume":"22","author":"Akter","year":"2023","journal-title":"Bangladesh J Med Sci"},{"key":"B40","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12986-021-00586-9","article-title":"Metabolic and hormonal effects of melatonin and\/or magnesium supplementation in women with polycystic ovary syndrome: a randomized, double-blind, placebo-controlled trial","volume":"18","author":"Alizadeh","year":"2021","journal-title":"Nutr Metab"},{"key":"B41","doi-asserted-by":"publisher","first-page":"8218650","DOI":"10.1155\/2019\/8218650","article-title":"Melatonin reduces androgen production and upregulates heme oxygenase-1 expression in granulosa cells from PCOS patients with hypoestrogenia and hyperandrogenia","volume":"2019","author":"Yu","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/edm2.2019.2.issue-3","article-title":"Phenotypic spectrum of polycystic ovary syndrome and their relationship to the circadian biomarkers, melatonin and cortisol","volume":"2","author":"Lim","year":"2019","journal-title":"Endocrinol Diabetes Metab"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.37506\/v20\/i1\/2020\/mlu\/194504","article-title":"Evaluation the serum level of melatonin in Iraqi patients with polycystic ovarian syndrome","volume":"20","author":"Abduljabbar Hameed","year":"2020","journal-title":"Medico-Legal Update"},{"key":"B44","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.trsl.2020.02.003","article-title":"Altered circadian clock as a novel therapeutic target for constant darkness-induced insulin resistance and hyperandrogenism of polycystic ovary syndrome","volume":"219","author":"Li","year":"2020","journal-title":"Transl Res"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0775","article-title":"A role for androgens in regulating circadian behavior and the suprachiasmatic nucleus","volume":"148","author":"Karatsoreos","year":"2007","journal-title":"Endocrinology"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-0961-2","article-title":"Effects of BMAL1-SIRT1-positive cycle on estrogen synthesis in human ovarian granulosa cells: an implicative role of BMAL1 in PCOS","volume":"53","author":"Zhang","year":"2016","journal-title":"Endocrine"},{"key":"B47","doi-asserted-by":"publisher","first-page":"943694","DOI":"10.1155\/2015\/943694","article-title":"Manifestation of hyperandrogenism in the continuous light exposure-induced PCOS rat model","volume":"2015","author":"Kang","year":"2015","journal-title":"BioMed Res Int"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/nn1884","article-title":"CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock","volume":"10","author":"DeBruyne","year":"2007","journal-title":"Nat Neurosci"},{"key":"B49","doi-asserted-by":"publisher","first-page":"20","DOI":"10.3390\/biology11010020","article-title":"The association between circadian clock gene polymorphisms and metabolic syndrome: A systematic review and meta-analysis","volume":"11","author":"\u0160krlec","year":"2021","journal-title":"Biol (Basel)"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03358-w","article-title":"REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity","volume":"592","author":"Ding","year":"2021","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nature11048","article-title":"Regulation of circadian behaviour and metabolism by REV-ERB-\u03b1 and REV-ERB-\u03b2","volume":"485","author":"Cho","year":"2012","journal-title":"Nature"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.658112","article-title":"Circadian clock genes REV-ERBs inhibits granulosa cells apoptosis by regulating mitochondrial biogenesis and autophagy in polycystic ovary syndrome","volume":"9","author":"Sun","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.61","article-title":"Feedback regulation of cholesterol synthesis: sterol-accelerated ubiquitination and degradation of HMG CoA reductase","volume":"18","author":"DeBose-Boyd","year":"2008","journal-title":"Cell Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.06.014","article-title":"Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis","volume":"16","author":"Liu","year":"2012","journal-title":"Cell Metab"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06983-9","article-title":"7-Dehydrocholesterol dictates ferroptosis sensitivity","volume":"626","author":"Li","year":"2024","journal-title":"Nature"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06878-9","article-title":"7-Dehydrocholesterol is an endogenous suppressor of ferroptosis","volume":"626","author":"Freitas","year":"2024","journal-title":"Nature"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2016.09.003","article-title":"DHCR7: A vital enzyme switch between cholesterol and vitamin D production","volume":"64","author":"Prabhu","year":"2016","journal-title":"Prog Lipid Res"},{"key":"B58","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.3390\/nu15112547","article-title":"Liver-specific bmal1 depletion reverses the beneficial effects of nobiletin on liver cholesterol homeostasis in mice fed with high-fat diet","volume":"15","author":"Lu","year":"2023","journal-title":"Nutrients"},{"key":"B59","doi-asserted-by":"publisher","first-page":"101235","DOI":"10.1016\/j.plipres.2023.101235","article-title":"Lipid metabolism around the body clocks","volume":"91","author":"Petrenko","year":"2023","journal-title":"Prog Lipid Res"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.050","article-title":"Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism","volume":"158","author":"Masri","year":"2014","journal-title":"Cell"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.04.040","article-title":"Reprogramming of rhythmic liver metabolism by intestinal clock","volume":"79","author":"Chen","year":"2023","journal-title":"J Hepatol"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1530\/REP-23-0225","article-title":"BMAL1 positively correlates with genes regulating steroidogenesis in human luteinized granulosa cells","volume":"167","author":"Kawamura","year":"2024","journal-title":"Reproduction"},{"key":"B63","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.stem.2018.08.007","article-title":"Single-cell RNA sequencing analysis reveals sequential cell fate transition during human spermatogenesis","volume":"23","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der140","article-title":"Evidence that carbonyl stress by methylglyoxal exposure induces DNA damage and spindle aberrations, affects mitochondrial integrity in mammalian oocytes and contributes to oocyte ageing","volume":"26","author":"Tatone","year":"2011","journal-title":"Hum Reprod"},{"key":"B65","doi-asserted-by":"publisher","first-page":"110913","DOI":"10.1016\/j.mce.2020.110913","article-title":"Developmental programming: Prenatal testosterone-induced changes in epigenetic modulators and gene expression in metabolic tissues of female sheep","volume":"514","author":"Guo","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"B66","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1186\/s12944-024-02237-3","article-title":"Cross-talk between oxidative stress and lipid metabolism regulators reveals molecular clusters and immunological characterization in polycystic ovarian syndrome","volume":"23","author":"Tan","year":"2024","journal-title":"Lipids Health Dis"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.theriogenology.2017.05.010","article-title":"Bmal1 interference impairs hormone synthesis and promotes apoptosis in porcine granulosa cells","volume":"99","author":"Wang","year":"2017","journal-title":"Theriogenology"},{"key":"B68","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/s13048-022-00964-8","article-title":"Investigation of the mechanisms and experimental verification of Cuscuta-Salvia in the treatment of polycystic ovary syndrome (PCOS) via network pharmacology","volume":"15","author":"Zhang","year":"2022","journal-title":"J Ovarian Res"},{"key":"B69","doi-asserted-by":"publisher","first-page":"116418","DOI":"10.1016\/j.biopha.2024.116418","article-title":"Therapeutic effects and molecular mechanisms of quercetin in gynecological disorders","volume":"173","author":"Jian","year":"2024","journal-title":"BioMed Pharmacother"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.22074\/cellj.2018.4577","article-title":"Oral quercetin supplementation enhances adiponectin receptor transcript expression in polycystic ovary syndrome patients: A randomized placebo-controlled double-blind clinical trial","volume":"19","author":"Rezvan","year":"2018","journal-title":"Cell J"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-118705","article-title":"Effects of quercetin on adiponectin-mediated insulin sensitivity in polycystic ovary syndrome: A randomized placebo-controlled double-blind clinical trial","volume":"49","author":"Rezvan","year":"2017","journal-title":"Horm Metab Res"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2018.1493678","article-title":"The effects of phytochemicals on circadian rhythm and related diseases","volume":"59","author":"Xu","year":"2019","journal-title":"Crit Rev Food Sci Nutr"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO00661D","article-title":"Health benefits of dietary chronobiotics: beyond resynchronizing internal clocks","volume":"12","author":"Huang","year":"2021","journal-title":"Food Funct"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1545789\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T04:14:10Z","timestamp":1747887250000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1545789\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,22]]},"references-count":73,"alternative-id":["10.3389\/fendo.2025.1545789"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1545789","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,22]]},"article-number":"1545789"}}