{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:58:26Z","timestamp":1753891106974,"version":"3.41.2"},"reference-count":33,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T00:00:00Z","timestamp":1746403200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Metastasis of thyroid carcinoma to the paranasal sinuses is extremely rare. Herein, a case of clinically occult thyroid cancer arising from a long-standing thyroid nodule that metastasized to the sphenoid sinus is presented, accompanied by a literature review.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case presentation<\/jats:title><jats:p>A 48-year-old woman visited to the otorhinolaryngology department with visual disturbance and partial nasal obstruction. Computed tomography imaging revealed a tumor in the right sphenoid sinus with adjacent bony destruction, suggestive of paranasal sinus cancer. Thyroid ultrasonography (US) was performed to identify the primary cancer, revealing a thyroid nodule previously diagnosed as a benign follicular nodule 11 years prior. Histopathological examination confirmed minimally invasive follicular thyroid carcinoma (FTC) and poorly differentiated thyroid carcinoma with sphenoid sinus metastasis. Lenvatinib therapy was initiated after total thyroidectomy and radioactive iodine (RAI) therapy, achieving stable disease for 29 months. The patient ultimately succumbed to newly developed brain metastasis with cerebral infarction, 31 months after the initial diagnosis. A literature review of 19 cases revealed that FTC was the most common type (68.5%), followed by papillary thyroid carcinoma (31.6%). Among the 12 cases with assessable clinical outcomes, three patients achieved remission, while nine had persistent disease, with four confirmed deaths.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Diagnosis of paranasal sinus metastasis from thyroid cancer is often delayed due to its rarity and is commonly associated with widespread disseminated disease, resulting in a poor prognosis. Careful follow-up of large thyroid nodules and clinical suspicion of unusual metastasis is essential for early detection of malignancy and metastasis. Multidisciplinary collaboration and various treatment approaches can improve treatment efficacy.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1550831","type":"journal-article","created":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T04:10:30Z","timestamp":1746418230000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Challenging diagnosis and treatment of rare paranasal sinus metastasis from thyroid cancer: a case report and literature review"],"prefix":"10.3389","volume":"16","author":[{"given":"Jee Hee","family":"Yoon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Yong","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A Ram","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Sun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Cheol","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"797","DOI":"10.1089\/thy.2012.0329","article-title":"Changes in the clinicopathological characteristics and outcomes of thyroid cancer in Korea over the past four decades","volume":"23","author":"Cho","year":"2013","journal-title":"Thyroid"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1089\/thy.2015.0020","article-title":"2015 american thyroid association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the american thyroid association guidelines task force on thyroid nodules and differentiated thyroid cancer","volume":"26","author":"Haugen","year":"2016","journal-title":"Thyroid"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2018.33.2.287","article-title":"Prognosis of differentiated thyroid carcinoma with initial distant metastasis: A multicenter study in korea","volume":"33","author":"Kim","year":"2018","journal-title":"Endocrinol Metab (Seoul)"},{"key":"B4","doi-asserted-by":"publisher","first-page":"533","DOI":"10.21037\/atm.2019.09.137","article-title":"Synergic effects of histology subtype, tumor size, and lymph node metastasis on distant metastasis in differentiated thyroid cancer","volume":"7","author":"Liu","year":"2019","journal-title":"Ann Transl Med"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-3-501","article-title":"Distant metastases in differentiated thyroid carcinoma: a multivariate analysis of prognostic variables","volume":"67","author":"Ruegemer","year":"1988","journal-title":"J Clin Endocrinol Metab"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0238207","article-title":"Unusual metastases from differentiated thyroid cancers: A multicenter study in Korea","volume":"15","author":"Yoon","year":"2020","journal-title":"PloS One"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-3401","article-title":"Papillary thyroid cancer: time course of recurrences during postsurgery surveillance","volume":"98","author":"Durante","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1002\/hed.v38.12","article-title":"Metastases to nasal cavity and paranasal sinuses","volume":"38","author":"L\u00f3pez","year":"2016","journal-title":"Head Neck"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1002\/lary.1979.89.issue-8","article-title":"Metastatic tumors to the sphenoid sinus","volume":"89","author":"Barrs","year":"1979","journal-title":"Laryngoscope"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1177\/019459988008800211","article-title":"Follicular adenocarcinoma of the thyroid in the maxillary sinus","volume":"88","author":"Cinberg","year":"1980","journal-title":"Otolaryngol Head Neck Surg (1979)"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1177\/000348948309200319","article-title":"X-ray study of the month. 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