{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:50:51Z","timestamp":1753890651954,"version":"3.41.2"},"reference-count":62,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T00:00:00Z","timestamp":1745193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>In people with diabetes, the effect of sleeve gastrectomy on impaired sperm parameters, hormonal profile, and testis tissue remains controversial to some extent.<\/jats:p><\/jats:sec><jats:sec><jats:title>The context and purpose of the study<\/jats:title><jats:p>This study aimed to investigate the effects of sleeve gastrectomy on the hormonal profile, sperm parameters, and testis tissue in infertile rats with type II diabetes mellitus (TIIDM). This study included 32 rats with TIIDM with or without sleeve gastrectomy. All the rats underwent sperm, testis tissue, and serum hormone profile analyses before and 8 weeks after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant correlation between weight loss after sleeve gastrectomy and a decrease in glucose profile (p &amp;lt; 0.05). In the hormonal profile, testosterone improved significantly after 8 weeks following sleeve gastrectomy. There was a significant increase in sperm count (p &amp;lt; 0.05) and improved sperm morphology during the follow-up after sleeve gastrectomy. The analysis also showed significant changes in testis tissue after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Sleeve gastrectomy significantly improved testosterone deficiency, testis tissue, and sperm count in rats with TIIDM. Further prospective clinical studies are needed to show how bariatric surgery affects infertility in patients with TIIDM.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1558769","type":"journal-article","created":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T11:56:41Z","timestamp":1745236601000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic intervention restores fertility and sperm health in non-obese diabetic rats"],"prefix":"10.3389","volume":"16","author":[{"given":"Gamze","family":"Tumentemur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"Titiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alev Bobus","family":"Ors","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,4,21]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2458-8-200","article-title":"Obesity prevalence from a European perspective: a systematic review","volume":"8","author":"Berghofer","year":"2008","journal-title":"BMC Public Health"},{"key":"B2","first-page":"1","article-title":"Andrological characterization of the patient with diabetes mellitus","volume":"34","author":"La Vignera","year":"2009","journal-title":"Minerva Endocrinol"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.2174\/1573399810666140606111745","article-title":"Diabetes mellitus induced impairment of male reproductive functions: a review","volume":"10","author":"Jangir","year":"2014","journal-title":"Curr Diabetes Rev"},{"key":"B4","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.mce.2014.08.005","article-title":"Sperm glucose transport and metabolism in diabetic individuals","volume":"1","author":"Dias","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.2004.tb02845.x","article-title":"Insulin-dependent diabetes affects testicular function by FSH and LH-linked mechanisms","volume":"5","author":"Ballester","year":"2004","journal-title":"J andrology"},{"key":"B6","doi-asserted-by":"publisher","first-page":"596","DOI":"10.2337\/dc08-9017","article-title":"Economic costs of diabetes in the U.S","volume":"31","author":"Dall","year":"2007","journal-title":"Diabetes Care"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1177\/1933719112440747","article-title":"Bariatric surgery does not interfere with sperm quality\u2013a preliminary long-term study","volume":"19","author":"Reis","year":"2012","journal-title":"Reprod Sci"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2012.01300.x","article-title":"Dramatic reductionin sperm parameters following bariatric surgery: report of two cases","volume":"6","author":"Lazaros","year":"2012","journal-title":"Andrologia"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2014.10.014","article-title":"Time related increase in urinary testosterone levels and stable semen analysis parameters after bariatric surgery in men","volume":"2","author":"Legro","year":"2015","journal-title":"Reprod BioMed Online"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2016.08.008","article-title":"Effect of bariatric surgery on semen parameters and sex hormone concentrations: a prospective study","volume":"5","author":"El Bardisi","year":"2016","journal-title":"Reprod BioMed Online"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200111","article-title":"Bariatric surgery versus conventional medical therapy for type 2 diabetes","volume":"372","author":"Mingrone","year":"2015","journal-title":"New Engl J Med"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066254","article-title":"Effects of bariatric surgery on mortality in Swedish obese subjects","volume":"357","author":"Sjostr\u00f6m","year":"2007","journal-title":"N EnglJ Med"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.09.041","article-title":"Weight and type 2 diabetes after bariatric surgery: systematic review and meta analysis","volume":"122","author":"Buchwald","year":"2009","journal-title":"Am J Med"},{"key":"B14","first-page":"57","article-title":"Metabolic and bariatric surgery for obesity: a review","author":"Glatt","year":"2011","journal-title":"SD Med Spec"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-008-9485-z","article-title":"Symmetrical pouch dilatation after laparoscopic adjustable gastric banding: incidence and management","volume":"18","author":"Brown","year":"2008","journal-title":"Obes Surg"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31822c9dac","article-title":"First report from the American College of Surgeons Bariatric Surgery Center Network: laparoscopic sleeve gastrectomy has morbidity and effectiveness positioned between the band and the bypass","volume":"254","author":"Hutter","year":"2011","journal-title":"Ann Surg"},{"key":"B17","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2482-12-13","article-title":"Complications and nutrient deficiencies two years after sleeve gastrectomy","volume":"12","author":"Pech","year":"2012","journal-title":"BMC Surg"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.2015.70.issue-1","article-title":"Streptozotocin-induced diabetic models in mice and rats","volume":"70","author":"Furman","year":"2015","journal-title":"Curr Protoc Pharmacol"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1258\/002367707779399518","article-title":"Anthropometrical parameters and markers of obesity in rats","volume":"41","author":"Novelli","year":"2007","journal-title":"Laboratory Animals"},{"key":"B20","article-title":"Rat models in metabolic surgery: A review of bariatric surgery studies","volume":"35","author":"Bu\u011fra","year":"2019","journal-title":"Turkish J Surg"},{"key":"B21","first-page":"19","article-title":"Sprague-dawley rats","volume-title":"The Laboratory Rat (Second Edition)","author":"Giknis","year":"2006"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2005.05.004","article-title":"Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening","volume":"52","author":"Srinivasan","year":"2005","journal-title":"Pharmacol Res"},{"key":"B23","article-title":"Diabetes associated male reproductive dysfunctions: prevalence, diagnosis and risk factors","volume":"8","author":"Singh","year":"2016","journal-title":"Int J Drug Dev Res"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-009-9565-6","article-title":"Is male fertility associated with type 2 diabetes mellitus","volume":"4","author":"Bener","year":"2009","journal-title":"Int Urol Nephrol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.2000.1876","article-title":"Testis glutathione peroxidase and phospholipid hydroperoxide glutathione peroxidase activities in aminoguanidineTreated diabetic rats","volume":"379","author":"\u00dcnl\u00fc\u00e7er\u00e7i","year":"2000","journal-title":"Acad Press"},{"key":"B26","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/S0009-8981(03)00322-X","article-title":"Antioxidant role of mulberry [Morus indica L. cv. Anantha] leaves in streptozotocin-diabetic rats","volume":"338","author":"Andallu","year":"2003","journal-title":"Clinica Chimica Acta"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1006","article-title":"Effects of melatonin on oxidative antioxidative status of tissues in streptozotocin-induced diabetic rats","volume":"21","author":"Aksoy","year":"2003","journal-title":"Cell Biochem Funct"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2009.00937.x","article-title":"Diabetic rat testes: morphological and functional alterations","volume":"41","author":"Ricci","year":"2009","journal-title":"Andrologia"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1159\/000118032","article-title":"Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats","volume":"40","author":"Guneli","year":"2008","journal-title":"Eur Surg Res"},{"key":"B30","first-page":"57","article-title":"Protective effects of quercetin on spermatogenesis in streptozotocin-induced diabetic rat","volume":"29","author":"Khaki","year":"2009","journal-title":"J Medicinal Plants"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e31825fe905","article-title":"Laparoscopic sleeve gastrectomy for super obese patients: forty-eight percent excess weight loss after 6 to 8 years with 93% follow-up","volume":"256","author":"Eid","year":"2012","journal-title":"Ann Surg"},{"key":"B32","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.soard.2011.10.019","article-title":"International sleeve gastrectomy expert panel consensus statement: best practice guidelines based on experience of >12,000 cases","volume":"8","author":"Rosenthal","year":"2012","journal-title":"Surg Obes Relat Dis"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-016-2526-0","article-title":"Comparison of the effect of gastric bypass and sleeve gastrectomy on metabolic syndrome and its components in a cohort: Tehran obesity treatment study [TOTS","volume":"27","author":"Barzin","year":"2017","journal-title":"Obes Surg"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3319717724941","DOI":"10.1177\/0003319717724941","article-title":"Sleeve gastrectomy: Managing the morbidity of obesity","author":"Mason","year":"2017","journal-title":"Angiology"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2012.12.007","article-title":"Evidence for a metabolic mechanism in the improvement of type 2 diabetes after sleeve gastrectomy in a rodent model","volume":"9","author":"Kadera","year":"2013","journal-title":"Surg Obes Relat Dis"},{"key":"B36","article-title":"Effects of sleeve gastrectomy on lipid and energy metabolism in ZDF rats via PI3K\/AKT pathway","volume":"11","author":"Ying","year":"2018","journal-title":"Am J Transl Res"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-013-3272-1","article-title":"Sub-sleeve gastrectomy achieves good diabetes control without weight loss in a non-obese diabetic rat model","volume":"28","author":"Dong","year":"2014","journal-title":"Surg Endosc"},{"key":"B38","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.phymed.2012.12.004","article-title":"Synergistic interaction of ferulic acid with commercial hypoglycemic drugs in streptozotocin induced diabetic rats","volume":"6","author":"Prabhakara","year":"2013","journal-title":"Phytomedicine"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3181\/00379727-214-44064","article-title":"The effect of diabetes mellitus on endocrine and reproductive function","volume":"1","author":"Steger","year":"1997","journal-title":"Proc Soc Exp Biol Med"},{"volume-title":"Streptozotosin (stz) ile diyabet olu\u015fturulmu\u015f s\u0131\u00e7anlarda kuersetin\u201fin testis dokusuna etkisi","year":"2017","author":"\u00d6zcan","key":"B40"},{"key":"B41","article-title":"The ultrastructural changes of the sertoli and leydig cells following streptozotocin induced diabetes","volume":"1","author":"Kianifard","year":"2012","journal-title":"Iranian J basic Med Sci"},{"volume-title":"Diyabet Tan\u0131 ve Tedavi Rehberi","year":"2013","key":"B42"},{"year":"2019","key":"B43"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.4161\/tisb.23992","article-title":"Diabetes, insulin-mediated glucose metabolism and Sertoli\/blood-testis barrier function","volume":"1","author":"Alves","year":"2013","journal-title":"Tissue Barriers"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s002400000134","article-title":"Apoptotic germ-cell death and testicular damage in experimental diabetes: prevention by endothelin antagonism","volume":"5","author":"Cai","year":"2000","journal-title":"Urological Res"},{"key":"B46","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ejphar.2014.02.010","article-title":"The effects of different doses of silibinin in combination with methotrexate on testicular tissue of mice","volume":"730","author":"Oufi","year":"2014","journal-title":"Eur J Pharmacol"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.4067\/S0717-95022012000400045","article-title":"Assessment of spermatozoa morphology under light microscopy with different histologic stains and comparison of morphometric measurements","volume":"4","author":"Aksoy","year":"2012","journal-title":"Int J Morphol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2605.2006.00682.x","article-title":"Sexual behaviour, sperm quantity and quality after short-term streptozotocin-induced hyperglycaemia in rats","volume":"4","author":"Scarano","year":"2005","journal-title":"Int J Androl"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0804","article-title":"Frequent occurrence of hypogonadotropic hypogonadism in type 2 diabetes","volume":"89","author":"Dhindsa","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1200111","article-title":"Bariatric surgery versus conventional medical therapy for type 2 diabetes","volume":"17","author":"Mingrone","year":"2012","journal-title":"N Engl J Med"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s11695-016-2204-2","article-title":"Bariatric surgery in China: How is this new concept going","volume":"26","author":"Du","year":"2016","journal-title":"Obes Surg"},{"key":"B52","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1093\/humrep\/deh707","article-title":"Secondary male factor infertility after Roux-enY gastric bypass for morbid obesity: case report","volume":"4","author":"Di Frega","year":"2005","journal-title":"Hum Reprod"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2011.10.014","article-title":"Sperm parameters and male fertility after bariatric surgery: three case series","volume":"24","author":"Sermondade","year":"2012","journal-title":"Reprod BiomedOnline"},{"key":"B54","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.2337\/dc21-S002","article-title":"Standards of medical care in diabetes\u20142021","volume":"44","year":"2021","journal-title":"Diabetes Care"},{"key":"B55","unstructured":"Peynirci\n              H\n            \n          \n          Edirne\n          Trakya \u00dcniversitesi T\u0131p Fak\u00fcltesi \u0130\u00e7 Hastal\u0131klar\u0131 Anabilim Dal\u0131\n          Deneysel diabetik nefropatide irbesartan, antioksidan ve kombinasyon tedavilerinin kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131\n          \n          2010"},{"key":"B56","first-page":"1","article-title":"Tip 1 diabet","volume":"5","author":"Abac\u0131","year":"2007","journal-title":"G\u00fcncel Pediatri"},{"year":"","author":"Zimmet","key":"B57"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0382","article-title":"Clinical outcomes of metabolic surgery: efficacy of glycemic control, weight loss, and remission of diabetes","volume":"39","author":"Schauer","year":"2016","journal-title":"Diabetes Care"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3275\/8469","article-title":"Circulating free testosterone in obese men after bariatric surgery increases in parallel with insulin sensitivity","volume":"4","author":"Botella-Carretero","year":"2013","journal-title":"J Endocrinol Invest"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1381\/096089201321336647","article-title":"Pregnancies after adjustable gastric banding","volume":"11","author":"Weiss","year":"2001","journal-title":"Obes Surg"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.12659\/MSMBR.910862","article-title":"Effect of bariatric surgery on semen parameters: A systematic review and meta-analysis","volume":"24","author":"Yong","year":"2018","journal-title":"Med Sci Monit Basic Res"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00769","article-title":"Obesity, male reproductive function and bariatric surgery","volume":"9","author":"Di Vincenzo","year":"2018","journal-title":"Front Endocrinol"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1558769\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,21]],"date-time":"2025-04-21T11:56:44Z","timestamp":1745236604000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1558769\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,21]]},"references-count":62,"alternative-id":["10.3389\/fendo.2025.1558769"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1558769","relation":{},"ISSN":["1664-2392"],"issn-type":[{"type":"electronic","value":"1664-2392"}],"subject":[],"published":{"date-parts":[[2025,4,21]]},"article-number":"1558769"}}