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This review delves into the neurobiological mechanisms connecting stress-induced neuroinflammation with PMS\/PMDD. Additionally, it traces the conceptual development and historical context of PMS\/PMDD. The review further evaluates clinical evidence on the association between PMS\/PMDD and stress, along with findings from both clinical and animal studies that link these disorders to inflammatory processes. Additionally, the neurobiological pathways by which inflammatory responses may play a role in the pathogenesis of PMS\/PMDD were elucidated, including their interactions with the hypothalamic-pituitary-ovary (HPO) axis, serotonin\u2014kynurenine (5-HT\u2014KYN) system, GABAergic system, brain-derived neurotrophic factor (BDNF), hypothalamic-pituitary-adrena(HPA)axis and. 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