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Studies have shown that the diversity of gut microbiota after menopause is lower than that before menopause, and the weakening of microbial decomposition will lead to the decrease of circulating estrogen, gradually resulting in disorders of lipid metabolism, cognitive decline, osteoporosis and other diseases. Gut microbiota play a key role in regulating estrogen levels. By secreting \u03b2-glucuronidase, it increases the reabsorption of estrogen in the enterohepatic circulation and mediates phytoestrogen metabolism, regulates estrogen homeostasis in the host and affects disease development and prognosis. Therefore, the gut microbiota is an overall regulator of women\u2019s estrogen status during menopause and an untapped new area for improving women\u2019s postmenopausal health. Changing the gut microbiota through specific prebiotics, probiotics, etc., and then affecting estrogen levels provides exciting opportunities for future therapeutic applications.<\/jats:p>","DOI":"10.3389\/fendo.2025.1562332","type":"journal-article","created":{"date-parts":[[2025,6,9]],"date-time":"2025-06-09T06:08:21Z","timestamp":1749449301000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":47,"title":["Gut microbiota has the potential to improve health of menopausal women by regulating 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