{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:50:57Z","timestamp":1786420257280,"version":"build-2736575974"},"reference-count":26,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T00:00:00Z","timestamp":1749686400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Many studies have shown that vitamin D deficiency and vitamin D receptor TaqI gene polymorphisms are associated with susceptibility to diabetic nephropathy in various populations. The objective of this study was to determine the impact of vitamin D deficiency and vitamin D receptor <jats:italic>TaqI<\/jats:italic> gene polymorphism on the risk of diabetic nephropathy complications in T2DM at the Debre Tabor Comprehensive Specialized Hospital, Northwest Ethiopia<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 210 participants, including 70 diabetic patients with nephropathy, 70 diabetic patients without nephropathy, and 70 healthy controls, participated in an age\u2014and sex-matched hospital-based case-control study. Demographic and clinical data were assessed to determine the related risk factors. DNA was extracted from blood samples and subjected to polymerase chain reaction and agarose gel electrophoresis analysis to determine the <jats:italic>TaqI<\/jats:italic> genotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Vitamin D deficiency was detected in our investigation, and it was much more prevalent in diabetic nephropathy patients than type 2 diabetic patients and controls (OR = 5.05, 95% CL = 2.03\u201312.53; <jats:italic>P &amp;lt;<\/jats:italic> 0.001). Moreover, both the <jats:italic>TaqI<\/jats:italic> tt genotype (OR: 2.48; 95% CL: 1.15-5.37; P=0.020) and t allele (OR: 1.70; 95% CL: 1.13-2.57; P=0.010) were substantially more prevalent in diabetic nephropathy patients than in type 2 diabetic patients and controls, indicating that it may be a major risk factor for the development of diabetic nephropathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings point to a potential link between vitamin D deficiency and diabetic nephropathy complications. Moreover, <jats:italic>TaqI<\/jats:italic> gene polymorphisms have been linked to an increased risk of developing the disease in the Ethiopian population under study.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1567716","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T04:10:53Z","timestamp":1749701453000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin D deficiency and VDR TaqI polymorphism on diabetic nephropathy risk among type 2 diabetes patients"],"prefix":"10.3389","volume":"16","author":[{"given":"Addisu","family":"Melake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misganaw 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