{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T11:56:43Z","timestamp":1783771003078,"version":"3.55.0"},"reference-count":60,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81502789, 81973004, 21876116"],"award-info":[{"award-number":["81502789, 81973004, 21876116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202011008"],"award-info":[{"award-number":["SZSM202011008"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["\u7f16\u53f7\uff1a2023A1515012744"],"award-info":[{"award-number":["\u7f16\u53f7\uff1a2023A1515012744"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Bisphenol AF (BPAF), an alternative to Bisphenol A (BPA), is increasingly utilized in various industrial applications, yet its toxicological profile remains incompletely understood. This study aims to investigate the impact of BPAF exposure on obesity and lipid metabolism in male mice subjected to either a normal chow diet (ND) or a high-fat diet (HFD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Mice were exposed to BPAF at a concentration of 100 \u03bcg\/kg every other day for five months under different dietary conditions, and body weight, rectal temperature, and food intake were monitored regularly. After the mice were sacrificed, the hepatic lipid metabolism was analyzed by measuring serum, hepatic lipids and performing hepatic metabolomics; energy metabolism was elucidated by assessing thermogenic pathways in brown adipose tissue (BAT) and factors affecting ingestion in the hypothalamus; the development and pathways of obesity were indicated by exploring lipogenesis and lipolysis pathways and fat accumulation in white adipose tissue (WAT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histomorphometric analyses indicated that BPAF exposure induced drived fat deposition in white adipose tissue through adipocyte hypertrophy-mediated pathways in eWAT of ND and HFD mice, accompanied by weight gain in HFD mice. Energy metabolism analysis showed that BPAF exposure decreased resting body temperature and reduced thermogenic factor expression in BAT of ND and HFD mice, which may affect energy expenditure. Hepatic metabolomics analysis suggested that BPAF exposure interfered with hepatic lipid metabolism in ND and HFD mice, with elevated levels of hepatic triglycerides, total cholesterol, and free fatty acids in HFD mice. Transcript analysis revealed altered expression levels of genes regulating lipid metabolism in white adipose tissue of ND and HFD mice, with a down-regulation observed in p-HSL protein expression, indicative of a potential inhibition effects of BPAF on lipolysis signaling pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Chronic BPAF exposure differentially exacerbates fat deposition in mice fed normal or high-fat diets via affecting lipid metabolism. Given the widespread prevalence of obesity and the pervasive environmental presence of BPAF, our findings provide valuable insights into the metabolic toxicity of BPAF, thereby raise further concern on the safe utilization and precision prevention of this unique chemical.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fendo.2025.1571076","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T04:12:04Z","timestamp":1747282324000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Chronic BPAF exposure differentially enhances fat deposition in mice fed normal or high-fat diets via lipid metabolism dysregulation"],"prefix":"10.3389","volume":"16","author":[{"given":"Ziquan","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changfeng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guixuan","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangnan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suli","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajie","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02403-5","article-title":"Contemporary medical, device, and surgical therapies for obesity in adults","volume":"401","author":"Perdomo","year":"2023","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmy055","article-title":"Humans against obesity: who will win","volume":"10","author":"Caballero","year":"2019","journal-title":"Adv Nutr"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(22)00047-X","article-title":"Obesity in children and adolescents: epidemiology, causes, assessment, and management","volume":"10","author":"Jebeile","year":"2022","journal-title":"Lancet Diabetes Endocrinol"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0176-8","article-title":"Obesity: global epidemiology and pathogenesis","volume":"15","author":"Bl\u00fcher","year":"2019","journal-title":"Nat Rev Endocrinol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s13679-017-0240-4","article-title":"Endocrine disruptors and obesity","volume":"6","author":"Darbre","year":"2017","journal-title":"Curr Obes Rep"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.283735","article-title":"Handling of thermal receipts as a source of exposure to bisphenol A","volume":"311","author":"Ehrlich","year":"2014","journal-title":"JAMA"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2017.06.026","article-title":"Worldwide human daily intakes of bisphenol A (BPA) estimated from global urinary concentration data (2000-2016) and its risk analysis","volume":"230","author":"Huang","year":"2017","journal-title":"Environ Pollut"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.122419","article-title":"Bisphenol A and its analogs in muscle and liver of fish from the North East Atlantic Ocean in relation to microplastic contamination. Exposure and risk to human consumers","volume":"393","author":"Barboza","year":"2020","journal-title":"J Hazard Mater"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.147263","article-title":"Bisphenols\u2019 occurrence in bivalves as sentinel of environmental contamination","volume":"785","author":"Baralla","year":"2021","journal-title":"Sci Total Environ"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2019.108575","article-title":"The adverse health effects of bisphenol A and related toxicity mechanisms","volume":"176","author":"Ma","year":"2019","journal-title":"Environ Res"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2024.104467","article-title":"Exploring novel insights into the molecular mechanisms underlying Bisphenol A-induced toxicity: A persistent threat to human health","volume":"108","author":"Ahmad","year":"2024","journal-title":"Environ Toxicol Pharmacol"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030908","article-title":"Current evidence on bisphenol A exposure and the molecular mechanism involved in related pathological conditions","volume":"15","author":"Della Rocca","year":"2023","journal-title":"Pharmaceutics"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/app132413163","article-title":"Protective effects of perinatal resveratrol on bisphenol A exposure-induced cardiovascular alterations and hepatic steatosis in adult offspring mice: A histopathological study","volume":"13","author":"Sirasanagandla","year":"2023","journal-title":"Appl Sci"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2011.02.005","article-title":"Epigenetic perspective on the developmental effects of bisphenol A","volume":"25","author":"Kundakovic","year":"2011","journal-title":"Brain Behav Immun"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.2174\/0929867328666211206111835","article-title":"Perinatal exposure to bisphenol A and developmental programming of the cardiovascular changes in the offspring","volume":"29","author":"Sirasanagandla","year":"2022","journal-title":"Curr Med Chem"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00648","article-title":"Timing of exposure and bisphenol-A: implications for diabetes development","volume":"9","author":"Tudur\u00ed","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1021\/es302004w","article-title":"Occurrence of eight bisphenol analogues in indoor dust from the United States and several Asian countries: implications for human exposure","volume":"46","author":"Liao","year":"2012","journal-title":"Environ Sci Technol"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.146905","article-title":"Biomonitoring of occupational exposure to bisphenol A, bisphenol S and bisphenol F: A systematic review","volume":"783","author":"Bousoumah","year":"2021","journal-title":"Sci Total Environ"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b03283","article-title":"Acute toxicity, teratogenic, and estrogenic effects of bisphenol A and its alternative replacements bisphenol S, bisphenol F, and bisphenol AF in zebrafish embryo-larvae","volume":"51","author":"Moreman","year":"2017","journal-title":"Environ Sci Technol"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.5b05387","article-title":"Bisphenol analogues other than BPA: environmental occurrence, human exposure, and toxicity-A review","volume":"50","author":"Chen","year":"2016","journal-title":"Environ Sci Technol"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.129273","article-title":"A targeted review on fate, occurrence, risk and health implications of bisphenol analogues","volume":"268","author":"Catenza","year":"2021","journal-title":"Chemosphere"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152742","article-title":"Bisphenol AF elevates procoagulant platelets by inducing necroptosis via RIPK1-inflammasome axis","volume":"454","author":"Vishalakshi","year":"2021","journal-title":"Toxicology"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010818-021304","article-title":"Environmental obesogens: mechanisms and controversies","volume":"59","author":"Heindel","year":"2019","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/S2542-5196(17)30049-9","article-title":"Bisphenol A substitutes and obesity in US adults: analysis of a population-based, cross-sectional study","volume":"1","author":"Liu","year":"2017","journal-title":"Lancet Planet Health"},{"key":"B25","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4093\/dmj.2018.0045","article-title":"Association of bisphenol A and its substitutes, bisphenol F and bisphenol S, with obesity in United States children and adolescents","volume":"43","author":"Liu","year":"2019","journal-title":"Diabetes Metab J"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.11.076","article-title":"Association between exposure to a mixture of phenols, pesticides, and phthalates and obesity: Comparison of three statistical models","volume":"123","author":"Zhang","year":"2019","journal-title":"Environ Int"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-023-27578-x","article-title":"Bisphenol A substitutes and childhood obesity at 7 years: a cross-sectional study in Shandong, China","volume":"30","author":"Chen","year":"2023","journal-title":"Environ Sci Pollut Res Int"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.161521","article-title":"BPA and its alternatives BPF and BPAF exaggerate hepatic lipid metabolism disorders in male mice fed a high fat diet","volume":"867","author":"Sun","year":"2023","journal-title":"Sci Total Environ"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.125092","article-title":"Obesogen effect of bisphenol S alters mRNA expression and DNA methylation profiling in male mouse liver","volume":"241","author":"Brulport","year":"2020","journal-title":"Chemosphere"},{"key":"B30","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1016\/j.chemosphere.2018.08.076","article-title":"Effects of perinatal exposure to BPA and its alternatives (BPS, BPF and BPAF) on hepatic lipid and glucose homeostasis in female mice adolescent offspring","volume":"212","author":"Meng","year":"2018","journal-title":"Chemosphere"},{"key":"B31","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.tox.2016.05.023","article-title":"Obesogen effects after perinatal exposure of 4,4\u2019-sulfonyldiphenol (Bisphenol S) in C57BL\/6 mice","author":"Ivry Del Moral","year":"2016","journal-title":"Toxicology"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2019.01.116","article-title":"Effects of perinatal exposure to BPA, BPF and BPAF on liver function in male mouse offspring involving in oxidative damage and metabolic disorder","volume":"247","author":"Meng","year":"2019","journal-title":"Environ Pollut"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.06.001","article-title":"Effects of Bisphenol S on hypothalamic neuropeptides regulating feeding behavior and apelin\/APJ system in mice","volume":"161","author":"Rezg","year":"2018","journal-title":"Ecotoxicol Environ Saf"},{"key":"B34","doi-asserted-by":"publisher","first-page":"17","DOI":"10.2337\/db09-0929","article-title":"Leucine deprivation decreases fat mass by stimulation of lipolysis in white adipose tissue and upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue","volume":"59","author":"Cheng","year":"2010","journal-title":"Diabetes"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.186","article-title":"Early-life exposure to EDCs: role in childhood obesity and neurodevelopment","volume":"13","author":"Braun","year":"2017","journal-title":"Nat Rev Endocrinol"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.632324","article-title":"Mechanism of action of acupuncture in obesity: A perspective from the hypothalamus","volume":"12","author":"Wang","year":"2021","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B37","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/obr.12116","article-title":"Brown adipose tissue as an anti-obesity tissue in humans","volume":"15","author":"Chechi","year":"2014","journal-title":"Obes Rev"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2010.105","article-title":"Brown adipose tissue, whole-body energy expenditure, and thermogenesis in healthy adult men","volume":"19","author":"Yoneshiro","year":"2011","journal-title":"Obesity (Silver Spring)"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2024.108513","article-title":"Cadmium exposure causes transcriptomic dysregulation in adipose tissue and associated shifts in serum metabolites","volume":"185","author":"Zhu","year":"2024","journal-title":"Environ Int"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-023-00786-y","article-title":"Physiological and pathological roles of lipogenesis","volume":"5","author":"Jeon","year":"2023","journal-title":"Nat Metab"},{"key":"B41","doi-asserted-by":"publisher","first-page":"810","DOI":"10.1016\/j.molcel.2019.12.003","article-title":"Lipid droplet-derived monounsaturated fatty acids traffic via PLIN5 to allosterically activate SIRT1","volume":"77","author":"Najt","year":"2020","journal-title":"Mol Cell"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00489-2","article-title":"Peroxisomal \u03b2-oxidation acts as a sensor for intracellular fatty acids and regulates lipolysis","volume":"3","author":"Ding","year":"2021","journal-title":"Nat Metab"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2021.116630","article-title":"Long-term exposure to low doses of bisphenol S has hypoglycaemic effect in adult male mice by promoting insulin sensitivity and repressing gluconeogenesis","volume":"277","author":"Guo","year":"2021","journal-title":"Environ Pollut"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.137066","article-title":"In vivo hypoglycemic effects of bisphenol F exposure in high-fat diet mice","volume":"311","author":"Lv","year":"2023","journal-title":"Chemosphere"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-022-03377-0","article-title":"Effects of low-dose bisphenol AF on mammal testis development via complex mechanisms: alterations are detectable in both infancy and adulthood","volume":"96","author":"Li","year":"2022","journal-title":"Arch Toxicol"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.jes.2023.05.014","article-title":"Transcriptomic analysis reveals the effects of maternal exposure to bisphenol AF on hypothalamic development in male neonatal mice","volume":"141","author":"Lv","year":"2024","journal-title":"J Environ Sci (China)"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b03336","article-title":"Bisphenol AF and Bisphenol B Exert Higher Estrogenic Effects than Bisphenol A via G Protein-Coupled Estrogen Receptor Pathway","volume":"51","author":"Cao","year":"2017","journal-title":"Environ Sci Technol"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00175.2019","article-title":"Bisphenol AF promotes inflammation in human white adipocytes","volume":"318","author":"Chernis","year":"2020","journal-title":"Am J Physiol Cell Physiol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110614","article-title":"Perinatal exposure to bisphenol A (BPA) impairs neuroendocrine mechanisms regulating food intake and kisspetin system in adult male rats. Evidences of metabolic disruptor hypothesis","volume":"499","author":"Stoker","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"B50","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.aca.2020.11.024","article-title":"High-coverage lipidomics for functional lipid and pathway analyses","volume":"1147","author":"Lam","year":"2021","journal-title":"Anal Chim Acta"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22105363","article-title":"BPA, BPAF and TMBPF alter adipogenesis and fat accumulation in human mesenchymal stem cells, with implications for obesity","volume":"22","author":"Cohen","year":"2021","journal-title":"Int J Mol Sci"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2018.10.129","article-title":"Endocrine activities and adipogenic effects of bisphenol AF and its main metabolite","volume":"215","author":"Skledar","year":"2019","journal-title":"Chemosphere"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00493-6","article-title":"Lipolysis: cellular mechanisms for lipid mobilization from fat stores","volume":"3","author":"Grabner","year":"2021","journal-title":"Nat Metab"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2022.114771","article-title":"Metabolomics study on liver of db\/db mice treated with curcumin using UPLC-Q-TOF-MS","volume":"215","author":"Jiang","year":"2022","journal-title":"J Pharmaceutical Biomed Anal"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.11.002","article-title":"Docosapentaenoic acid derived metabolites and mediators - The new world of lipid mediator medicine in a nutshell","volume":"785","author":"Weylandt","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1021\/pr100892r","article-title":"Metabolomic analysis of livers and serum from high-fat diet induced obese mice","volume":"10","author":"Kim","year":"2011","journal-title":"J Proteome Res"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101326","article-title":"Cyp2c-deficiency depletes muricholic acids and protects against high-fat diet-induced obesity in male mice but promotes liver damage","volume":"53","author":"Oteng","year":"2021","journal-title":"Mol Metab"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3390\/metabo13080899","article-title":"Untargeted metabolomics and body mass in adolescents: A cross-sectional and longitudinal analysis","volume":"13","author":"Singh","year":"2023","journal-title":"Metabolites"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.129907","article-title":"Metabolites of Clostridium leptum fermenting flaxseed polysaccharide alleviate obesity in rats","volume":"264","author":"Li","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1042\/CS20220572","article-title":"Molecular mechanisms of metabolic associated fatty liver disease (MAFLD): functional analysis of lipid metabolism pathways","volume":"136","author":"Badmus","year":"2022","journal-title":"Clin Sci (Lond)"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1571076\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T04:12:05Z","timestamp":1747282325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1571076\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,15]]},"references-count":60,"alternative-id":["10.3389\/fendo.2025.1571076"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1571076","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,15]]},"article-number":"1571076"}}