{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:49:29Z","timestamp":1787618969132,"version":"build-2736575974"},"reference-count":198,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:00:00Z","timestamp":1751414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009590","name":"Gansu Education Department","doi-asserted-by":"publisher","award":["\u7f16\u53f7\uff1a20250VZC-052, \u7f16\u53f7\uff1a2025A-108"],"award-info":[{"award-number":["\u7f16\u53f7\uff1a20250VZC-052, \u7f16\u53f7\uff1a2025A-108"]}],"id":[{"id":"10.13039\/501100009590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018554","name":"Science and Technology Program of Gansu Province","doi-asserted-by":"publisher","award":["\u7f16\u53f7\uff1a23YFFA0068"],"award-info":[{"award-number":["\u7f16\u53f7\uff1a23YFFA0068"]}],"id":[{"id":"10.13039\/501100018554","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012585","name":"Open Foundation of Key Laboratory of Dunhuang Medicine and Transformation","doi-asserted-by":"publisher","award":["DHYX24-18\u578b"],"award-info":[{"award-number":["DHYX24-18\u578b"]}],"id":[{"id":"10.13039\/501100012585","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Endocrinol."],"abstract":"<jats:p>Osteoporosis (OP) is a common clinical systemic bone disease, with insidious onset and usually causes serious complications such as fractures. Studies have found that the dysfunction of a variety of bone cells will lead to enhanced bone resorption and reduced bone formation capacity, thus resulting in the imbalance of bone homeostasis and OP disease. As a class of regulatory death mode that affects cell function, programmed cell death (PCD) has been proved to play an important role in maintaining various bone cells growth activities and maintaining bone homeostasis. In addition, several studies have shown that mitochondria are important regulators of a variety of PCD, and various drugs can target mitochondria to regulate the programmed death of bone cells, which is of great significance to further explore the pathogenesis of OP and look for new and efficient drugs for OP.<\/jats:p>","DOI":"10.3389\/fendo.2025.1576597","type":"journal-article","created":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:14:34Z","timestamp":1751415274000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["Mitochondria: a key regulator of programmed cell death in OP"],"prefix":"10.3389","volume":"16","author":[{"given":"Kexin","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhandong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangman","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,7,2]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-017-3909-3","article-title":"Worldwide prevalence and incidence of osteoporotic vertebral fractures","volume":"28","author":"Ballane","year":"2017","journal-title":"Osteoporos Int"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-019-0164-5","article-title":"The molecular machinery of regulated cell death","volume":"29","author":"Tang","year":"2019","journal-title":"Cell Res"},{"key":"B3","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/cdd.2014.137","article-title":"Essential versus accessory aspects of cell death: recommendations of the NCCD 2015","volume":"22","author":"Galluzzi","year":"2015","journal-title":"Cell Death Differ"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2018","article-title":"Fundamental mechanisms of regulated cell death and implications for heart disease","volume":"99","author":"Del Re","year":"2019","journal-title":"Physiol Rev"},{"key":"B5","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1038\/s41418-017-0012-4","article-title":"Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018","volume":"25","author":"Galluzzi","year":"2018","journal-title":"Cell Death Differ"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0270-8","article-title":"Emerging connectivity of programmed cell death pathways and its physiological implications","volume":"21","author":"Bedoui","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B7","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol Pathol"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1972.33","article-title":"Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics","volume":"26","author":"Kerr","year":"1972","journal-title":"Br J Cancer"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.767221","article-title":"The multifaceted regulation of mitochondrial dynamics during mitosis","volume":"9","author":"Pangou","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.832356","article-title":"Mitochondria related cell death modalities and disease","volume":"10","author":"Tian","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/s0955-0674(98)80146-4","article-title":"Cellular responses to DNA damage","volume":"10","author":"Wang","year":"1998","journal-title":"Curr Opin Cell Biol"},{"key":"B12","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.arr.2015.04.002","article-title":"Programmed cell death in aging","volume":"23","author":"Tower","year":"2015","journal-title":"Ageing Res Rev"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-023-03476-6","article-title":"ROS-induced lipid peroxidation modulates cell death outcome: mechanisms behind apoptosis, autophagy, and ferroptosis","volume":"97","author":"Wang","year":"2023","journal-title":"Arch Toxicol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41580-019-0173-8","article-title":"Mitochondria as multifaceted regulators of cell death","volume":"21","author":"Bock","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"B15","first-page":"1004","article-title":"Exploiting the extrinsic and the intrinsic apoptotic pathways for cancer therapeutics","volume":"1","author":"Belkacemi","year":"2018"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401963","article-title":"Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario","volume":"13","author":"Chipuk","year":"2006","journal-title":"Cell Death Differ"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041038","article-title":"The mitochondrial pathway of apoptosis: part I: MOMP and beyond","volume":"14","author":"Green","year":"2022","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"B18","doi-asserted-by":"publisher","first-page":"12732","DOI":"10.3390\/ijms232112732","article-title":"Antimicrobial peptides mediate apoptosis by changing mitochondrial membrane permeability","volume":"23","author":"Wang","year":"2022","journal-title":"Int J Mol Sci"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.12.008","article-title":"Life with or without AIF","volume":"35","author":"Hangen","year":"2010","journal-title":"Trends Biochem Sci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmab007","article-title":"Interleukin 35 protects cardiomyocytes following ischemia\/reperfusion-induced apoptosis via activation of mitochondrial STAT3","volume":"53","author":"Zhou","year":"2021","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.19-0372","article-title":"GARP is a key molecule for mesenchymal stromal cell responses to TGF-\u03b2 and fundamental to control mitochondrial ROS levels","volume":"9","author":"Carrillo-G\u00e1lvez","year":"2020","journal-title":"Stem Cells Transl Med"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2025.117284","article-title":"The resveratrol attenuates reactive oxygen species mediated DNA damage in cardiac malformations caused by 4-tert-octylphenol","volume":"498","author":"Wang","year":"2025","journal-title":"Toxicol Appl Pharmacol"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-1105-x","article-title":"Cell apoptosis induced by zinc deficiency in osteoblastic MC3T3-E1 cells via a mitochondrial-mediated pathway","volume":"361","author":"Guo","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.4103\/cjp.Cjp_7_19","article-title":"Different susceptibilities of osteoclasts and osteoblasts to glucocorticoid-induced oxidative stress and mitochondrial alterations","volume":"62","author":"Chen","year":"2019","journal-title":"Chin J Physiol"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.4103\/cjp.Cjp_51_20","article-title":"Glucocorticoid transiently upregulates mitochondrial biogenesis in the osteoblast","volume":"63","author":"Hsu","year":"2020","journal-title":"Chin J Physiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"e2611","DOI":"10.7717\/peerj.2611","article-title":"Iron overload induced death of osteoblasts in vitro: involvement of the mitochondrial apoptotic pathway","volume":"4","author":"Tian","year":"2016","journal-title":"PeerJ"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.3193","article-title":"Mitochondrial point mutation m.3243A>G associates with lower bone mineral density, thinner cortices, and reduced bone strength: A case-control study","volume":"32","author":"Langdahl","year":"2017","journal-title":"J Bone Miner Res"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2017.04.001","article-title":"The clinical characteristics of patients with mitochondrial tRNA Leu(UUR)m.3243A > G mutation: Compared with type 1 diabetes and early onset type 2 diabetes","volume":"31","author":"Zhu","year":"2017","journal-title":"J Diabetes Complications"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.26355\/eurrev_201812_16499","article-title":"Mitochondrial protein OPA mediates osteoporosis induced by radiation through the P38 signaling pathway","volume":"22","author":"Wang","year":"2018","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"B30","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.3892\/etm.2021.10751","article-title":"Metformin attenuates H(2)O(2)-induced osteoblast apoptosis by regulating SIRT3 via the PI3K\/AKT pathway","volume":"22","author":"Yang","year":"2021","journal-title":"Exp Ther Med"},{"key":"B31","doi-asserted-by":"publisher","first-page":"11933","DOI":"10.1038\/s41598-020-68890-7","article-title":"Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors","volume":"10","author":"Kim","year":"2020","journal-title":"Sci Rep"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2017.3160","article-title":"Naringin inhibits vascular endothelial cell apoptosis via endoplasmic reticulum stress\u2212 and mitochondrial\u2212mediated pathways and promotes intraosseous angiogenesis in ovariectomized rats","volume":"40","author":"Shangguan","year":"2017","journal-title":"Int J Mol Med"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.07.048","article-title":"Inhibitory effect of vanillin on RANKL-induced osteoclast formation and function through activating mitochondrial-dependent apoptosis signaling pathway","volume":"208","author":"Chen","year":"2018","journal-title":"Life Sci"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2017.07.030","article-title":"Euphorbia factor L1 inhibits osteoclastogenesis by regulating cellular redox status and induces Fas-mediated apoptosis in osteoclast","volume":"112","author":"Hong","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4101738","article-title":"AKT-GSK3\u03b2 Signaling pathway regulates mitochondrial dysfunction-associated OPA1 cleavage contributing to osteoblast apoptosis: preventative effects of hydroxytyrosol","volume":"2019","author":"Cai","year":"2019","journal-title":"Oxid Med Cell Longev"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1159\/000457945","article-title":"Attenuation of oxidative stress-induced osteoblast apoptosis by curcumin is associated with preservation of mitochondrial functions and increased Akt-GSK3\u03b2 Signaling","volume":"41","author":"Dai","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"B37","article-title":"Tanshinone IIA blocks dexamethasone-induced apoptosis in osteoblasts through inhibiting Nox4-derived ROS production","volume":"8","author":"Li","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.S65410","article-title":"Sulforaphane reverses glucocorticoid-induced apoptosis in osteoblastic cells through regulation of the Nrf2 pathway","volume":"8","author":"Lin","year":"2014","journal-title":"Drug Des Devel Ther"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2015.2258","article-title":"Puerarin attenuates glucocorticoid-induced apoptosis of hFOB1.19 cells through the JNK- and Akt-mediated mitochondrial apoptotic pathways","volume":"36","author":"Yu","year":"2015","journal-title":"Int J Mol Med"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.2131\/jts.39.803","article-title":"Grape seed proanthocyanidins inhibit H2O2-induced osteoblastic MC3T3-E1 cell apoptosis via ameliorating H2O2-induced mitochondrial dysfunction","volume":"39","author":"Zhang","year":"2014","journal-title":"J Toxicol Sci"},{"key":"B41","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1038\/s41419-018-0718-3","article-title":"RAGE-dependent mitochondria pathway: a novel target of silibinin against apoptosis of osteoblastic cells induced by advanced glycation end products","volume":"9","author":"Mao","year":"2018","journal-title":"Cell Death Dis"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2019.10267","article-title":"Crocin protects against dexamethasone\u2212induced osteoblast apoptosis by inhibiting the ROS\/Ca2+\u2212mediated mitochondrial pathway","volume":"20","author":"Nie","year":"2019","journal-title":"Mol Med Rep"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.17054","article-title":"Notoginsenoside R1 attenuates oxidative stress-induced osteoblast dysfunction through JNK signalling pathway","volume":"25","author":"Li","year":"2021","journal-title":"J Cell Mol Med"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01907","article-title":"Selenium-containing protein from selenium-enriched spirulina platensis attenuates cisplatin-induced apoptosis in MC3T3-E1 mouse preosteoblast by inhibiting mitochondrial dysfunction and ROS-mediated oxidative damage","volume":"9","author":"Sun","year":"2018","journal-title":"Front Physiol"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.17179\/excli2020-2376","article-title":"Cytoprotective effects of fermented oyster extracts against oxidative stress-induced DNA damage and apoptosis through activation of the Nrf2\/HO-1 signaling pathway in MC3T3-E1 osteoblasts","volume":"19","author":"Park","year":"2020","journal-title":"Excli J"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2011.641","article-title":"Simvastatin protects human osteosarcoma cells from oxidative stress-induced apoptosis through mitochondrial-mediated signaling","volume":"5","author":"Zhao","year":"2012","journal-title":"Mol Med Rep"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1159\/000447841","article-title":"Astragalus polysaccharide attenuated iron overload-induced dysfunction of mesenchymal stem cells via suppressing mitochondrial ROS","volume":"39","author":"Yang","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.833040","article-title":"Proteus mirabilis Vesicles Induce Mitochondrial Apoptosis by Regulating miR96-5p\/Abca1 to Inhibit Osteoclastogenesis and Bone Loss","volume":"13","author":"Wang","year":"2022","journal-title":"Front Immunol"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-021-00784-2","article-title":"Inhibition of HMGB1 reduced high glucose-induced BMSCs apoptosis via activation of AMPK and regulation of mitochondrial functions","volume":"77","author":"Liu","year":"2021","journal-title":"J Physiol Biochem"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-020-00660-z","article-title":"HNGF6A inhibits oxidative stress-induced MC3T3-E1 cell apoptosis and osteoblast phenotype inhibition by targeting circ_0001843\/miR-214 pathway","volume":"106","author":"Zhu","year":"2020","journal-title":"Calcif Tissue Int"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio711","article-title":"Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury","volume":"1","author":"Degterev","year":"2005","journal-title":"Nat Chem Biol"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.04.024","article-title":"The coming decade of cell death research: five riddles","volume":"177","author":"Green","year":"2019","journal-title":"Cell"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106672","article-title":"Inhibition of Drp1-dependent mitochondrial fission by natural compounds as a therapeutic strategy for organ injuries","volume":"188","author":"Rahmani","year":"2023","journal-title":"Pharmacol Res"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14329","article-title":"RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome","volume":"8","author":"Zhang","year":"2017","journal-title":"Nat Commun"},{"key":"B55","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.freeradbiomed.2023.03.021","article-title":"Necroptosis signaling and mitochondrial dysfunction cross-talking facilitate cell death mediated by chelerythrine in glioma","volume":"202","author":"Wang","year":"2023","journal-title":"Free Radic Biol Med"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.11.030","article-title":"The mitochondrial phosphatase PGAM5 functions at the convergence point of multiple necrotic death pathways","volume":"148","author":"Wang","year":"2012","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2024.123585","article-title":"The necroptosis-mediated imbalance of mitochondrial dynamics is involved in DEHP-induced toxicity to immature testes via the PGAM5-DRP1 interaction","volume":"346","author":"Zhou","year":"2024","journal-title":"Environ pollut"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2020.151144","article-title":"PGAM5: A crucial role in mitochondrial dynamics and programmed cell death","volume":"100","author":"Cheng","year":"2021","journal-title":"Eur J Cell Biol"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052905","article-title":"Downregulation of mitochondrial fusion protein expression affords protection from canonical necroptosis in H9c2 cardiomyoblasts","volume":"25","author":"Toda","year":"2024","journal-title":"Int J Mol Sci"},{"key":"B60","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3892\/ijmm.2023.5301","article-title":"Role of RIPK3\u2212CaMKII\u2212mPTP signaling pathway\u2212mediated necroptosis in cardiovascular diseases (Review)","volume":"52","author":"Chen","year":"2023","journal-title":"Int J Mol Med"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-025-02108-x","article-title":"Necroptosis in myocardial ischaemia-reperfusion injury: current update on mechanisms, therapeutic targets, and translational potential","volume":"30","author":"Dabravolski","year":"2025","journal-title":"Apoptosis"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00732-5","article-title":"TEAD1 protects against necroptosis in postmitotic cardiomyocytes through regulation of nuclear DNA-encoded mitochondrial genes","volume":"28","author":"Liu","year":"2021","journal-title":"Cell Death Differ"},{"key":"B63","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1038\/s41419-020-03239-6","article-title":"mtDNA-STING pathway promotes necroptosis-dependent enterocyte injury in intestinal ischemia reperfusion","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.10.034","article-title":"Widespread mitochondrial depletion via mitophagy does not compromise necroptosis","volume":"5","author":"Tait","year":"2013","journal-title":"Cell Rep"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.790613","article-title":"Comparison of necroptosis with apoptosis for OVX-induced osteoporosis","volume":"8","author":"He","year":"2021","journal-title":"Front Mol Biosci"},{"key":"B66","doi-asserted-by":"publisher","first-page":"33803","DOI":"10.1038\/srep33803","article-title":"Necrostatin-1 treatment inhibits osteocyte necroptosis and trabecular deterioration in ovariectomized rats","volume":"6","author":"Cui","year":"2016","journal-title":"Sci Rep"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2022.153244","article-title":"Benzo[a]pyrene exposure promotes RIP1-mediated necroptotic death of osteocytes and the JNK\/IL-18 pathway activation via generation of reactive oxygen species","volume":"476","author":"Zhang","year":"2022","journal-title":"Toxicology"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1295382","article-title":"ROS-mediated necroptosis is involved in iron overload-induced osteoblastic cell death","volume":"2020","author":"Tian","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.12122\/j.issn.1673-4254.2019.09.05","article-title":"Interaction between necroptosis and apoptosis in MC3T3-E1 cell death induced by dexamethasone","volume":"39","author":"Feng","year":"2019","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5540149","article-title":"RIPK1 Coordinates Bone Marrow Mesenchymal Stem Cell Survival by Maintaining Mitochondrial Homeostasis via p53","volume":"2021","author":"Tian","year":"2021","journal-title":"Stem Cells Int"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v14.i9.729","article-title":"Intercellular mitochondrial transfer as a means of revitalizing injured glomerular endothelial cells","volume":"14","author":"Tang","year":"2022","journal-title":"World J Stem Cells"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.12047\/j.cjap.6370.2022.114","article-title":"Effects of cigarette smoke extract on mitochondrial function of macrophages","volume":"38","author":"Wei","year":"2022","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2017.12.024","article-title":"The release of microparticles and mitochondria from RAW 264.7 murine macrophage cells undergoing necroptotic cell death in vitro","volume":"363","author":"Spencer","year":"2018","journal-title":"Exp Cell Res"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2018.9229","article-title":"Parathyroid hormone 1\u221234 inhibits senescence in rat nucleus pulposus cells by activating autophagy via the m\u2212TOR pathway","volume":"18","author":"Wang","year":"2018","journal-title":"Mol Med Rep"},{"key":"B75","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1186\/s13075-018-1701-1","article-title":"Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice","volume":"20","author":"Xiao","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8810698","article-title":"Reactive oxygen species regulate endoplasmic reticulum stress and ER-mitochondrial Ca(2+) crosstalk to promote programmed necrosis of rat nucleus pulposus cells under compression","volume":"2021","author":"Lin","year":"2021","journal-title":"Oxid Med Cell Longev"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2014.09.005","article-title":"Protective effects of necrostatin-1 on glucocorticoid-induced osteoporosis in rats","author":"Feng","year":"2014","journal-title":"J Steroid Biochem Mol Biol"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.994307","article-title":"Necroptosis of nucleus pulposus cells involved in intervertebral disc degeneration through MyD88 signaling","volume":"13","author":"Fan","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2021.02.008","article-title":"Targeting oxidative stress with amobarbital to prevent intervertebral disc degeneration: Part I. in vitro and ex vivo studies","volume":"21","author":"Seol","year":"2021","journal-title":"Spine J"},{"key":"B80","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10495-018-1455-x","article-title":"Critical contribution of RIPK1 mediated mitochondrial dysfunction and oxidative stress to compression-induced rat nucleus pulposus cells necroptosis and apoptosis","volume":"23","author":"Chen","year":"2018","journal-title":"Apoptosis"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/6976317","article-title":"Synergistic utilization of necrostatin-1 and Z-VAD-FMK efficiently promotes the survival of compression-induced nucleus pulposus cells via alleviating mitochondrial dysfunction","volume":"2020","author":"Chen","year":"2020","journal-title":"BioMed Res Int"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.4110\/in.2022.22.e14","article-title":"Mitochondrial transplantation ameliorates the development and progression of osteoarthritis","volume":"22","author":"Lee","year":"2022","journal-title":"Immune Netw"},{"key":"B83","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.neuroscience.2014.02.007","article-title":"Necroptosis inhibitor necrostatin-1 promotes cell protection and physiological function in traumatic spinal cord injury","volume":"266","author":"Wang","year":"2014","journal-title":"Neuroscience"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2014.12.061","article-title":"Necrostatin-1 mitigates mitochondrial dysfunction post-spinal cord injury","volume":"289","author":"Wang","year":"2015","journal-title":"Neuroscience"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.11.034","article-title":"LPS protects macrophages from AIF-independent parthanatos by downregulation of PARP1 expression, induction of SOD2 expression, and a metabolic shift to aerobic glycolysis","volume":"131","author":"Regdon","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"B86","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/s12964-023-01108-1","article-title":"Pyroptosis, ferroptosis, and autophagy cross-talk in glioblastoma opens up new avenues for glioblastoma treatment","volume":"21","author":"Wan","year":"2023","journal-title":"Cell Commun Signal"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541","article-title":"Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling","volume":"526","author":"Kayagaki","year":"2015","journal-title":"Nature"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514","article-title":"Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death","volume":"526","author":"Shi","year":"2015","journal-title":"Nature"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2023.101782","article-title":"Pyroptosis: A road to next-generation cancer immunotherapy","volume":"68","author":"Fang","year":"2023","journal-title":"Semin Immunol"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjz020","article-title":"Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation","volume":"11","author":"Wang","year":"2019","journal-title":"J Mol Cell Biol"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1156583","article-title":"From mitochondria to sarcopenia: role of 17\u03b2-estradiol and testosterone","volume":"14","author":"Tian","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1230168","article-title":"New therapeutic directions in type II diabetes and its complications: mitochondrial dynamics","volume":"14","author":"Wang","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.6338-11.2012","article-title":"Mitofusin2 mutations disrupt axonal mitochondrial positioning and promote axon degeneration","volume":"32","author":"Misko","year":"2012","journal-title":"J Neurosci"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107032","article-title":"FK866 alleviates cerebral pyroptosis and inflammation mediated by Drp1 in a rat cardiopulmonary resuscitation model","volume":"89","author":"Zou","year":"2020","journal-title":"Int Immunopharmacol"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04270-9","article-title":"Inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 alleviates atherosclerosis through the modulation of M1 polarization","volume":"21","author":"Su","year":"2023","journal-title":"J Transl Med"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.110651","article-title":"TRPV4-mediated mitochondrial dysfunction induces pyroptosis and cartilage degradation in osteoarthritis via the Drp1-HK2 axis","volume":"123","author":"Yan","year":"2023","journal-title":"Int Immunopharmacol"},{"key":"B97","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1186\/s13075-023-03095-7","article-title":"Deubiquitinase USP16 induces gouty arthritis via Drp1-dependent mitochondrial fission and NLRP3 inflammasome activation","volume":"25","author":"Wang","year":"2023","journal-title":"Arthritis Res Ther"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2020.8257","article-title":"Loop between NLRP3 inflammasome and reactive oxygen species","volume":"36","author":"Dominic","year":"2022","journal-title":"Antioxid Redox Signal"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/nature09663","article-title":"A role for mitochondria in NLRP3 inflammasome activation","volume":"469","author":"Zhou","year":"2011","journal-title":"Nature"},{"key":"B100","doi-asserted-by":"publisher","first-page":"e1012387","DOI":"10.1371\/journal.ppat.1012387","article-title":"RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis","volume":"20","author":"Guan","year":"2024","journal-title":"PloS Pathog"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.01.009","article-title":"Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis","volume":"36","author":"Shimada","year":"2012","journal-title":"Immunity"},{"key":"B102","doi-asserted-by":"publisher","first-page":"e1011381","DOI":"10.1371\/journal.ppat.1011381","article-title":"Salmonella Enteritidis T1SS protein SiiD inhibits NLRP3 inflammasome activation via repressing the mtROS-ASC dependent pathway","volume":"19","author":"Guo","year":"2023","journal-title":"PloS Pathog"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102305","article-title":"XBP1 deficiency promotes hepatocyte pyroptosis by impairing mitophagy to activate mtDNA-cGAS-STING signaling in macrophages during acute liver injury","volume":"52","author":"Liu","year":"2022","journal-title":"Redox Biol"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.172715","article-title":"Liraglutide ameliorates non-alcoholic steatohepatitis by inhibiting NLRP3 inflammasome and pyroptosis activation via mitophagy","volume":"864","author":"Yu","year":"2019","journal-title":"Eur J Pharmacol"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2020.123034","article-title":"Arsenic induces hepatic insulin resistance via mtROS-NLRP3 inflammasome pathway","volume":"399","author":"Jia","year":"2020","journal-title":"J Hazard Mater"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117765109","article-title":"Critical role for calcium mobilization in activation of the NLRP3 inflammasome","volume":"109","author":"Murakami","year":"2012","journal-title":"Proc Natl Acad Sci U.S.A"},{"key":"B107","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1016\/j.immuni.2022.06.007","article-title":"Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling","volume":"55","author":"Xian","year":"2022","journal-title":"Immunity"},{"key":"B108","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41420-022-01046-w","article-title":"Mitochondrial damage and activation of the cytosolic DNA sensor cGAS-STING pathway lead to cardiac pyroptosis and hypertrophy in diabetic cardiomyopathy mice","volume":"8","author":"Yan","year":"2022","journal-title":"Cell Death Discov"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrep.2023.101496","article-title":"Study on the mechanism of NLRP3 effect on the skeleton of de-ovalized mice","volume":"35","author":"Yang","year":"2023","journal-title":"Biochem Biophys Rep"},{"key":"B110","article-title":"USP1 inhibits NF-\u03baB\/NLRP3 induced pyroptosis through TRAF6 in osteoblastic MC3T3-E1 cells","volume":"22","author":"Sun","year":"2022","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2022.10.009","article-title":"Suppression of the NLRP3 inflammasome through activation of the transient receptor potential channel melastatin 2 promotes osteogenesis in tooth extraction sockets of periodontitis","volume":"193","author":"Li","year":"2023","journal-title":"Am J Pathol"},{"key":"B112","doi-asserted-by":"publisher","first-page":"2365","DOI":"10.1016\/j.devcel.2022.09.013","article-title":"Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption","volume":"57","author":"Li","year":"2022","journal-title":"Dev Cell"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-021-01511-1","article-title":"LncRNA H19 mitigates oxidized low-density lipoprotein induced pyroptosis via caspase-1 in raw 264.7 cells","volume":"44","author":"Liu","year":"2021","journal-title":"Inflammation"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1128700","article-title":"Apilimod activates the NLRP3 inflammasome through lysosome-mediated mitochondrial damage","volume":"14","author":"Hou","year":"2023","journal-title":"Front Immunol"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.2c00192","article-title":"Mitochondria-targeting polymer micelle of dichloroacetate induced pyroptosis to enhance osteosarcoma immunotherapy","volume":"16","author":"Jin","year":"2022","journal-title":"ACS Nano"},{"key":"B116","doi-asserted-by":"publisher","first-page":"e21757","DOI":"10.1096\/fj.202100085R","article-title":"Gasdermins mediate cellular release of mitochondrial DNA during pyroptosis and apoptosis","volume":"35","author":"de Torre-Minguela","year":"2021","journal-title":"FASEB J"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2021.112772","article-title":"Bisphenol A induces pyroptotic cell death via ROS\/NLRP3\/Caspase-1 pathway in osteocytes MLO-Y4","volume":"159","author":"Zhang","year":"2022","journal-title":"Food Chem Toxicol"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-020-0928-y","article-title":"BMPR2 promotes fatty acid oxidation and protects white adipocytes from cell death in mice","volume":"3","author":"Qian","year":"2020","journal-title":"Commun Biol"},{"key":"B119","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1186\/s12967-023-04266-5","article-title":"Mitochondrial DNA induces nucleus pulposus cell pyroptosis via the TLR9-NF-\u03baB-NLRP3 axis","volume":"21","author":"Lu","year":"2023","journal-title":"J Transl Med"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.012023","article-title":"The tethering function of mitofusin2 controls osteoclast differentiation by modulating the Ca(2+)-NFATc1 axis","volume":"295","author":"Ballard","year":"2020","journal-title":"J Biol Chem"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00163","article-title":"Icariin protects bone marrow mesenchymal stem cells against iron overload induced dysfunction through mitochondrial fusion and fission, PI3K\/AKT\/mTOR and MAPK pathways","volume":"10","author":"Yao","year":"2019","journal-title":"Front Pharmacol"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.28498","article-title":"Hydrogen sulfide attenuates homocysteine-induced osteoblast dysfunction by inhibiting mitochondrial toxicity","volume":"234","author":"Zhai","year":"2019","journal-title":"J Cell Physiol"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2021.115941","article-title":"Osteolineage depletion of mitofusin2 enhances cortical bone formation in female mice","volume":"148","author":"Zarei","year":"2021","journal-title":"Bone"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2023.1135767","article-title":"Identification of mitochondria-related key gene and association with immune cells infiltration in intervertebral disc degeneration","volume":"14","author":"Guo","year":"2023","journal-title":"Front Genet"},{"key":"B125","doi-asserted-by":"publisher","first-page":"e13442","DOI":"10.1111\/cpr.13442","article-title":"Intercellular mitochondrial transfer alleviates pyroptosis in dental pulp damage","volume":"56","author":"Wang","year":"2023","journal-title":"Cell Prolif"},{"key":"B126","doi-asserted-by":"publisher","first-page":"3896","DOI":"10.3390\/ijms24043896","article-title":"Oxidized mitochondrial DNA engages TLR9 to activate the NLRP3 inflammasome in myelodysplastic syndromes","volume":"24","author":"Ward","year":"2023","journal-title":"Int J Mol Sci"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1111\/cns.14221","article-title":"Elamipretide reduces pyroptosis and improves functional recovery after spinal cord injury","volume":"29","author":"Jiang","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1080\/10715762.2021.2018426","article-title":"The mitochondrial antioxidant SS-31 attenuated lipopolysaccharide-induced apoptosis and pyroptosis of nucleus pulposus cells via scavenging mitochondrial ROS and maintaining the stability of mitochondrial dynamics","volume":"55","author":"Peng","year":"2021","journal-title":"Free Radic Res"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01060-3","article-title":"Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX\/GSDME pathway","volume":"44","author":"Liang","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01094-7","article-title":"Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy","volume":"44","author":"Luo","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"B131","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1186\/s12967-023-04313-1","article-title":"Targeting macrophagic PIM-1 alleviates osteoarthritis by inhibiting NLRP3 inflammasome activation via suppressing mitochondrial ROS\/Cl(-) efflux signaling pathway","volume":"21","author":"Zhang","year":"2023","journal-title":"J Transl Med"},{"key":"B132","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.cmet.2019.06.016","article-title":"The DNA repair nuclease MRE11A functions as a mitochondrial protector and prevents T cell pyroptosis and tissue inflammation","volume":"30","author":"Li","year":"2019","journal-title":"Cell Metab"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.2147\/jir.S320912","article-title":"Resveratrol relieves gouty arthritis by promoting mitophagy to inhibit activation of NLRP3 inflammasomes","volume":"14","author":"Fan","year":"2021","journal-title":"J Inflammation Res"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-01028-9","article-title":"Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases","volume":"44","author":"Feng","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxab016","article-title":"1\u2019-Acetoxychavicol acetate inhibits NLRP3-dependent inflammasome activation via mitochondrial ROS suppression","volume":"33","author":"Sok","year":"2021","journal-title":"Int Immunol"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2022.10.047","article-title":"Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function","volume":"636","author":"Fan","year":"2022","journal-title":"Biochem Biophys Res Commun"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00685-9","article-title":"Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer\u2019s disease","volume":"28","author":"Bao","year":"2021","journal-title":"Cell Death Differ"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0699-0","article-title":"Redox homeostasis maintained by GPX4 facilitates STING activation","volume":"21","author":"Jia","year":"2020","journal-title":"Nat Immunol"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: an iron-dependent form of nonapoptotic cell death","volume":"149","author":"Dixon","year":"2012","journal-title":"Cell"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.04.002","article-title":"Targeting ferroptosis to iron out cancer","volume":"35","author":"Hassannia","year":"2019","journal-title":"Cancer Cell"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A regulated cell death nexus linking metabolism, redox biology, and disease","volume":"171","author":"Stockwell","year":"2017","journal-title":"Cell"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"Yang","year":"2014","journal-title":"Cell"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.03.005","article-title":"Ferroptosis: A flexible constellation of related biochemical mechanisms","volume":"83","author":"Dixon","year":"2023","journal-title":"Mol Cell"},{"key":"B144","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.ceb.2017.11.001","article-title":"To eat or not to eat-the metabolic flavor of ferroptosis","volume":"51","author":"Gao","year":"2018","journal-title":"Curr Opin Cell Biol"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115892","article-title":"The mitochondrial regulation in ferroptosis signaling pathway and its potential strategies for cancer","volume":"169","author":"Sun","year":"2023","journal-title":"BioMed Pharmacother"},{"key":"B146","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.molcel.2018.10.042","article-title":"Role of mitochondria in ferroptosis","volume":"73","author":"Gao","year":"2019","journal-title":"Mol Cell"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1134\/s0006297915110085","article-title":"Stages of cell cannibalism\u2013entosis\u2013in normal human keratinocyte culture","volume":"80","author":"Garanina","year":"2015","journal-title":"Biochem (Mosc)"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.153964","article-title":"Salidroside inhibits doxorubicin-induced cardiomyopathy by modulating a ferroptosis-dependent pathway","volume":"99","author":"Chen","year":"2022","journal-title":"Phytomedicine"},{"key":"B149","doi-asserted-by":"publisher","first-page":"e14663","DOI":"10.1111\/cns.14663","article-title":"Mitochondrial ferritin alleviates ferroptosis in a kainic acid-induced mouse epilepsy model by regulating iron homeostasis: Involvement of nuclear factor erythroid 2-related factor 2","volume":"30","author":"Song","year":"2024","journal-title":"CNS Neurosci Ther"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004680","article-title":"A Combined Model of Human iPSC-Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome","volume":"8","author":"Guo","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2023.07.026","article-title":"STING\/ACSL4 axis-dependent ferroptosis and inflammation promote hypertension-associated chronic kidney disease","volume":"31","author":"Gao","year":"2023","journal-title":"Mol Ther"},{"key":"B152","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1038\/s41419-022-04997-1","article-title":"Hsp90 induces Acsl4-dependent glioma ferroptosis via dephosphorylating Ser637 at Drp1","volume":"13","author":"Miao","year":"2022","journal-title":"Cell Death Dis"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.698679","article-title":"STING1 promotes ferroptosis through MFN1\/2-dependent mitochondrial fusion","volume":"9","author":"Li","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"B154","doi-asserted-by":"publisher","first-page":"e2303872","DOI":"10.1002\/advs.202303872","article-title":"Sonodynamic therapy of NRP2 monoclonal antibody-guided MOFs@COF targeted disruption of mitochondrial and endoplasmic reticulum homeostasis to induce autophagy-dependent ferroptosis","volume":"10","author":"Zhao","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2656","article-title":"Iron overload-induced ferroptosis of osteoblasts inhibits osteogenesis and promotes osteoporosis: An in vitro and in vivo study","volume":"74","author":"Jiang","year":"2022","journal-title":"IUBMB Life"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.2c05632","article-title":"A novel anti-osteoporosis mechanism of VK2: interfering with ferroptosis via AMPK\/SIRT1 pathway in type 2 diabetic osteoporosis","volume":"71","author":"Jin","year":"2023","journal-title":"J Agric Food Chem"},{"key":"B157","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1007\/s12011-021-02627-z","article-title":"Mitochondrial ferritin deficiency promotes osteoblastic ferroptosis via mitophagy in type 2 diabetic osteoporosis","volume":"200","author":"Wang","year":"2022","journal-title":"Biol Trace Elem Res"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9067610","article-title":"Melatonin suppresses ferroptosis induced by high glucose via activation of the Nrf2\/HO-1 signaling pathway in type 2 diabetic osteoporosis","volume":"2020","author":"Ma","year":"2020","journal-title":"Oxid Med Cell Longev"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.06.236","article-title":"Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation","volume":"188","author":"Luo","year":"2022","journal-title":"Free Radic Biol Med"},{"key":"B160","doi-asserted-by":"publisher","first-page":"e13194","DOI":"10.1111\/cpr.13194","article-title":"Gut microbiota modulates osteoclast glutathione synthesis and mitochondrial biogenesis in mice subjected to ovariectomy","volume":"55","author":"Yuan","year":"2022","journal-title":"Cell Prolif"},{"key":"B161","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1038\/s41420-023-01653-1","article-title":"\u03b4-Tocotrienol preconditioning improves the capability of bone marrow-derived mesenchymal stem cells in promoting wound healing by inhibiting BACH1-related ferroptosis","volume":"9","author":"He","year":"2023","journal-title":"Cell Death Discov"},{"key":"B162","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1186\/s13287-023-03371-y","article-title":"Exogenous melatonin ameliorates steroid-induced osteonecrosis of the femoral head by modulating ferroptosis through GDF15-mediated signaling","volume":"14","author":"Li","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.04.028","article-title":"Sciadopitysin protects osteoblast function via its antioxidant activity in MC3T3-E1 cells","volume":"58","author":"Suh","year":"2013","journal-title":"Food Chem Toxicol"},{"key":"B164","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1038\/s41392-022-01300-8","article-title":"Epigenetic and post-translational modifications in autophagy: biological functions and therapeutic targets","volume":"8","author":"Shu","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-022-00588-3","article-title":"Macroautophagy in CNS health and disease","volume":"23","author":"Griffey","year":"2022","journal-title":"Nat Rev Neurosci"},{"key":"B167","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1038\/cdd.2012.72","article-title":"Ubiquitination and selective autophagy","volume":"20","author":"Shaid","year":"2013","journal-title":"Cell Death Differ"},{"key":"B168","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/cdd.2012.81","article-title":"The pathways of mitophagy for quality control and clearance of mitochondria","volume":"20","author":"Ashrafi","year":"2013","journal-title":"Cell Death Differ"},{"key":"B169","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1038\/s41419-022-04906-6","article-title":"Mitochondrial autophagy: molecular mechanisms and implications for cardiovascular disease","volume":"13","author":"Li","year":"2022","journal-title":"Cell Death Dis"},{"key":"B170","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.semcdb.2024.02.001","article-title":"The interplay between mitochondrial dynamics and autophagy: From a key homeostatic mechanism to a driver of pathology","author":"Lacombe","year":"2024","journal-title":"Semin Cell Dev Biol"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2422","article-title":"Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells","volume":"14","author":"Liu","year":"2012","journal-title":"Nat Cell Biol"},{"key":"B172","doi-asserted-by":"publisher","first-page":"2029","DOI":"10.1016\/j.devcel.2021.06.003","article-title":"Mitochondrial-derived vesicles compensate for loss of LC3-mediated mitophagy","volume":"56","author":"Towers","year":"2021","journal-title":"Dev Cell"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1038\/ncb2837","article-title":"Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells","volume":"15","author":"Chu","year":"2013","journal-title":"Nat Cell Biol"},{"key":"B174","doi-asserted-by":"publisher","first-page":"e106283","DOI":"10.15252\/embj.2020106283","article-title":"ATAD3B is a mitophagy receptor mediating clearance of oxidative stress-induced damaged mitochondrial DNA","volume":"40","author":"Shu","year":"2021","journal-title":"EMBO J"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2022.2084862","article-title":"Mitochondria ROS and mitophagy in acute kidney injury","volume":"19","author":"Su","year":"2023","journal-title":"Autophagy"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2021.1975914","article-title":"The multifaceted regulation of mitophagy by endogenous metabolites","volume":"18","author":"Zhang","year":"2022","journal-title":"Autophagy"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00368.2011","article-title":"Mitochondrial autophagy by Bnip3 involves Drp1-mediated mitochondrial fission and recruitment of Parkin in cardiac myocytes","volume":"301","author":"Lee","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201007013","article-title":"Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin","volume":"191","author":"Tanaka","year":"2010","journal-title":"J Cell Biol"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2019.12.009","article-title":"Mfn2 is involved in intervertebral disc degeneration through autophagy modulation","volume":"28","author":"Chen","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593084","article-title":"Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway","volume":"35","author":"Sebasti\u00e1n","year":"2016","journal-title":"EMBO J"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.46627","article-title":"The role of autophagy and mitophagy in bone metabolic disorders","volume":"16","author":"Wang","year":"2020","journal-title":"Int J Biol Sci"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101963","article-title":"LRRc17 controls BMSC senescence via mitophagy and inhibits the therapeutic effect of BMSCs on ovariectomy-induced bone loss","volume":"43","author":"Liu","year":"2021","journal-title":"Redox Biol"},{"key":"B183","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1038\/s41419-023-05595-5","article-title":"PINK1\/Parkin-mediated mitophagy inhibits osteoblast apoptosis induced by advanced oxidation protein products","volume":"14","author":"Li","year":"2023","journal-title":"Cell Death Dis"},{"key":"B184","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1038\/s41419-022-04903-9","article-title":"Ferutinin induces osteoblast differentiation of DPSCs via induction of KLF2 and autophagy\/mitophagy","volume":"13","author":"Maity","year":"2022","journal-title":"Cell Death Dis"},{"key":"B185","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1186\/s13287-021-02656-4","article-title":"PINK1 deficiency impairs osteoblast differentiation through aberrant mitochondrial homeostasis","volume":"12","author":"Lee","year":"2021","journal-title":"Stem Cell Res Ther"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.103023","article-title":"PINK1 restrains periodontitis-induced bone loss by preventing osteoclast mitophagy impairment","volume":"69","author":"Jang","year":"2024","journal-title":"Redox Biol"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.146728","article-title":"Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency","volume":"6","author":"Ling","year":"2021","journal-title":"JCI Insight"},{"key":"B188","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1016\/j.bioactmat.2024.12.010","article-title":"Copper doped bioactive glass promotes matrix vesicles-mediated biomineralization via osteoblast mitophagy and mitochondrial dynamics during bone regeneration","volume":"46","author":"Ling","year":"2025","journal-title":"Bioact Mater"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.111519","article-title":"The inhibition of PINK1\/Drp1-mediated mitophagy by hyperglycemia leads to impaired osteoblastogenesis in diabetes","volume":"28","author":"Chen","year":"2025","journal-title":"iScience"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117086","article-title":"Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis","volume":"184","author":"Zhu","year":"2024","journal-title":"Bone"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.12.235","article-title":"Apelin-13 induces mitophagy in bone marrow mesenchymal stem cells to suppress intracellular oxidative stress and ameliorate osteoporosis by activation of AMPK signaling pathway","volume":"163","author":"Chen","year":"2021","journal-title":"Free Radic Biol Med"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12308","article-title":"The HIV proteins Tat and Nef promote human bone marrow mesenchymal stem cell senescence and alter osteoblastic differentiation","volume":"14","author":"Beaupere","year":"2015","journal-title":"Aging Cell"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.12659\/msm.908705","article-title":"Effects of 17\u03b2-estradiol on mitophagy in the murine MC3T3-E1 osteoblast cell line is mediated via G protein-coupled estrogen receptor and the ERK1\/2 signaling pathway","volume":"24","author":"Sun","year":"2018","journal-title":"Med Sci Monit"},{"key":"B194","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1186\/s13287-023-03271-1","article-title":"MiR-21-5p regulates the dynamic of mitochondria network and rejuvenates the senile phenotype of bone marrow stromal cells (BMSCs) isolated from osteoporotic SAM\/P6 mice","volume":"14","author":"Sikora","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.10888","article-title":"High magnesium prevents matrix vesicle-mediated mineralization in human bone marrow-derived mesenchymal stem cells via mitochondrial pathway and autophagy","volume":"42","author":"Li","year":"2018","journal-title":"Cell Biol Int"},{"key":"B196","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/s41419-020-2238-1","article-title":"P53 and Parkin co-regulate mitophagy in bone marrow mesenchymal stem cells to promote the repair of early steroid-induced osteonecrosis of the femoral head","volume":"11","author":"Zhang","year":"2020","journal-title":"Cell Death Dis"},{"key":"B197","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1038\/s41467-019-13668-3","article-title":"Mitochondrial TCA cycle metabolites control physiology and disease","volume":"11","author":"Mart\u00ednez-Reyes","year":"2020","journal-title":"Nat Commun"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/4608165","article-title":"AT1R-mediated apoptosis of bone marrow mesenchymal stem cells is associated with mtROS production and mtDNA reduction","volume":"2019","author":"Zhang","year":"2019","journal-title":"Oxid Med Cell Longev"}],"container-title":["Frontiers in Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1576597\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T00:14:42Z","timestamp":1751415282000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fendo.2025.1576597\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,2]]},"references-count":198,"alternative-id":["10.3389\/fendo.2025.1576597"],"URL":"https:\/\/doi.org\/10.3389\/fendo.2025.1576597","relation":{},"ISSN":["1664-2392"],"issn-type":[{"value":"1664-2392","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7,2]]},"article-number":"1576597"}}