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Metabolic shift prioritizes lipid oxidation over glucose metabolism, hence limiting the energy supply available to tumor cells and reducing their metabolic adaptability. Exercise also enhances mitochondrial function and aids the immune system, further bolstering its anti-cancer effects. Additionally, exercise mitigates cancer-related symptoms like fatigue, improves insulin sensitivity, and counteracts metabolic issues such as cachexia. Despite promising insights from studies, challenges persist in comprehending the molecular mechanisms of exercise\u2019s impact on lipid metabolism in cancer. Future research should aim to identify optimal exercise regimens for cancer patients, explore the combined effects of exercise and cancer treatments, and delve into the molecular pathways connecting exercise with tumor suppression. With its potential benefits, exercise could act as a supportive therapy alongside conventional cancer treatments, enhancing patient outcomes and quality of life.<\/jats:p>","DOI":"10.3389\/fendo.2025.1580559","type":"journal-article","created":{"date-parts":[[2025,5,23]],"date-time":"2025-05-23T04:10:39Z","timestamp":1747973439000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["Modulation of lipid metabolism by exercise: exploring its potential as a therapeutic target in cancer endocrinology"],"prefix":"10.3389","volume":"16","author":[{"given":"Haodong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongbeom","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,5,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000002260","article-title":"Burden and attributable risk factors of non-communicable diseases and subtypes in 204 countries and territories, 1990\u20132021: a systematic analysis for the global burden of disease study 2021","volume":"111","author":"Li","year":"2025","journal-title":"Int J Surgery."},{"key":"B2","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/s41392-024-01856-7","article-title":"Exploring treatment options in cancer: tumor treatment strategies","volume":"9","author":"Liu","year":"2024","journal-title":"Signal transduction targeted Ther"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15215135","article-title":"Exercise as a promising agent against","volume":"15","author":"Spanoudaki","year":"2023","journal-title":"Cancer: Evaluating Its Anti-Cancer Mol Mechanisms. 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